Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
Identifieur interne : 000463 ( Main/Corpus ); précédent : 000462; suivant : 000464Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
Auteurs : Elmi N. Zainuddin ; Renate Mentel ; Victor Wray ; Rolf Jansen ; Manfred Nimtz ; Michael Lalk ; Sabine MundtSource :
- Journal of natural products [ 0163-3864 ] ; 2007.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Depsipeptides (chemistry), Depsipeptides (isolation & purification), Depsipeptides (pharmacology), Germany, Influenza A virus (drug effects), Inhibitory Concentration 50, Microcystis (chemistry), Molecular Structure, Nuclear Magnetic Resonance, Biomolecular.
- MESH :
- chemical , chemistry : Antiviral Agents, Depsipeptides.
- chemical , isolation & purification : Antiviral Agents, Depsipeptides.
- chemical , pharmacology : Antiviral Agents, Depsipeptides.
- geographic : Germany.
- chemistry : Microcystis.
- drug effects : Influenza A virus.
- Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular.
Abstract
Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
DOI: 10.1021/np060303s
PubMed: 17602586
Links to Exploration step
pubmed:17602586Le document en format XML
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<author><name sortKey="Zainuddin, Elmi N" sort="Zainuddin, Elmi N" uniqKey="Zainuddin E" first="Elmi N" last="Zainuddin">Elmi N. Zainuddin</name>
<affiliation><nlm:affiliation>Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.</nlm:affiliation>
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<author><name sortKey="Mentel, Renate" sort="Mentel, Renate" uniqKey="Mentel R" first="Renate" last="Mentel">Renate Mentel</name>
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<author><name sortKey="Wray, Victor" sort="Wray, Victor" uniqKey="Wray V" first="Victor" last="Wray">Victor Wray</name>
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<author><name sortKey="Jansen, Rolf" sort="Jansen, Rolf" uniqKey="Jansen R" first="Rolf" last="Jansen">Rolf Jansen</name>
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<author><name sortKey="Nimtz, Manfred" sort="Nimtz, Manfred" uniqKey="Nimtz M" first="Manfred" last="Nimtz">Manfred Nimtz</name>
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<author><name sortKey="Lalk, Michael" sort="Lalk, Michael" uniqKey="Lalk M" first="Michael" last="Lalk">Michael Lalk</name>
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<author><name sortKey="Mundt, Sabine" sort="Mundt, Sabine" uniqKey="Mundt S" first="Sabine" last="Mundt">Sabine Mundt</name>
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<term>Influenza A virus (drug effects)</term>
<term>Inhibitory Concentration 50</term>
<term>Microcystis (chemistry)</term>
<term>Molecular Structure</term>
<term>Nuclear Magnetic Resonance, Biomolecular</term>
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<front><div type="abstract" xml:lang="en">Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.</div>
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<Title>Journal of natural products</Title>
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<ArticleTitle>Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.</ArticleTitle>
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<Abstract><AbstractText>Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.</AbstractText>
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<ForeName>Elmi N</ForeName>
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