Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.
Identifieur interne : 000411 ( Main/Corpus ); précédent : 000410; suivant : 000412Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.
Auteurs : Janine Reiche ; Brunhilde SchweigerSource :
- Journal of clinical microbiology [ 1098-660X ] ; 2009.
English descriptors
- KwdEn :
- Amino Acid Sequence, Child, Preschool, Cluster Analysis, Genotype, Germany (epidemiology), Humans, Infant, Molecular Epidemiology, Molecular Sequence Data, Mutation, Missense, Nasal Cavity (virology), Nasopharynx (virology), Pharynx (virology), Phylogeny, Point Mutation, Polymorphism, Genetic, RNA, Viral (genetics), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (virology), Respiratory Syncytial Virus, Human (classification), Respiratory Syncytial Virus, Human (genetics), Respiratory Syncytial Virus, Human (isolation & purification), Reverse Transcriptase Polymerase Chain Reaction (methods), Sequence Alignment, Sequence Analysis, DNA.
- MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : Germany.
- classification : Respiratory Syncytial Virus, Human.
- epidemiology : Respiratory Syncytial Virus Infections.
- genetics : Respiratory Syncytial Virus, Human.
- isolation & purification : Respiratory Syncytial Virus, Human.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- virology : Nasal Cavity, Nasopharynx, Pharynx, Respiratory Syncytial Virus Infections.
- Amino Acid Sequence, Child, Preschool, Cluster Analysis, Genotype, Humans, Infant, Molecular Epidemiology, Molecular Sequence Data, Mutation, Missense, Phylogeny, Point Mutation, Polymorphism, Genetic, Sequence Alignment, Sequence Analysis, DNA.
Abstract
The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study the molecular epidemiology of RSV, more than 1,400 RSV isolates from human nasopharyngeal aspirates or nasal or throat swabs from patients with respiratory illness were identified and differentiated by TaqMan reverse transcription-PCR into groups A and B. RSV group A was dominant in seven out of nine epidemic seasons. Phylogenetic analysis revealed that RSV group A genotypes GA2 and GA5 circulated from 1998 to 2007. Genotype GA7 was present in only two seasons (1999 to 2000 and 2002 to 2003). Comparison of the synonymous mutation/nonsynonymous mutation ratios showed greater evidence for selection pressure for genotype GA2 (1.18) than for GA5 (4.34). Partial protein sequences were predicted to encode G proteins of 298 amino acids in length and in a few cases of G proteins of 297 amino acids in length. Amino acid analysis also revealed genotype-specific amino acid substitutions: two substitutions for genotype GA2, seven for GA5, and three for GA7. Two to four putative, genotype-specific N-linked glycosylation sites were determined. Predicted O-glycosylation sites included 22 to 34 residues. This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons.
DOI: 10.1128/JCM.02286-08
PubMed: 19386848
Links to Exploration step
pubmed:19386848Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.</title>
<author><name sortKey="Reiche, Janine" sort="Reiche, Janine" uniqKey="Reiche J" first="Janine" last="Reiche">Janine Reiche</name>
<affiliation><nlm:affiliation>FG12-Virale Infektionen, NRZ Influenza, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19386848</idno>
<idno type="pmid">19386848</idno>
<idno type="doi">10.1128/JCM.02286-08</idno>
<idno type="wicri:Area/Main/Corpus">000411</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000411</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.</title>
<author><name sortKey="Reiche, Janine" sort="Reiche, Janine" uniqKey="Reiche J" first="Janine" last="Reiche">Janine Reiche</name>
<affiliation><nlm:affiliation>FG12-Virale Infektionen, NRZ Influenza, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name>
</author>
</analytic>
<series><title level="j">Journal of clinical microbiology</title>
<idno type="eISSN">1098-660X</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Child, Preschool</term>
<term>Cluster Analysis</term>
<term>Genotype</term>
<term>Germany (epidemiology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Mutation, Missense</term>
<term>Nasal Cavity (virology)</term>
<term>Nasopharynx (virology)</term>
<term>Pharynx (virology)</term>
<term>Phylogeny</term>
<term>Point Mutation</term>
<term>Polymorphism, Genetic</term>
<term>RNA, Viral (genetics)</term>
<term>Respiratory Syncytial Virus Infections (epidemiology)</term>
<term>Respiratory Syncytial Virus Infections (virology)</term>
<term>Respiratory Syncytial Virus, Human (classification)</term>
<term>Respiratory Syncytial Virus, Human (genetics)</term>
<term>Respiratory Syncytial Virus, Human (isolation & purification)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (methods)</term>
<term>Sequence Alignment</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasal Cavity</term>
<term>Nasopharynx</term>
<term>Pharynx</term>
<term>Respiratory Syncytial Virus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Child, Preschool</term>
<term>Cluster Analysis</term>
<term>Genotype</term>
<term>Humans</term>
<term>Infant</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Mutation, Missense</term>
<term>Phylogeny</term>
<term>Point Mutation</term>
<term>Polymorphism, Genetic</term>
<term>Sequence Alignment</term>
<term>Sequence Analysis, DNA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study the molecular epidemiology of RSV, more than 1,400 RSV isolates from human nasopharyngeal aspirates or nasal or throat swabs from patients with respiratory illness were identified and differentiated by TaqMan reverse transcription-PCR into groups A and B. RSV group A was dominant in seven out of nine epidemic seasons. Phylogenetic analysis revealed that RSV group A genotypes GA2 and GA5 circulated from 1998 to 2007. Genotype GA7 was present in only two seasons (1999 to 2000 and 2002 to 2003). Comparison of the synonymous mutation/nonsynonymous mutation ratios showed greater evidence for selection pressure for genotype GA2 (1.18) than for GA5 (4.34). Partial protein sequences were predicted to encode G proteins of 298 amino acids in length and in a few cases of G proteins of 297 amino acids in length. Amino acid analysis also revealed genotype-specific amino acid substitutions: two substitutions for genotype GA2, seven for GA5, and three for GA7. Two to four putative, genotype-specific N-linked glycosylation sites were determined. Predicted O-glycosylation sites included 22 to 34 residues. This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19386848</PMID>
<DateCompleted><Year>2009</Year>
<Month>07</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-660X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>47</Volume>
<Issue>6</Issue>
<PubDate><Year>2009</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical microbiology</Title>
<ISOAbbreviation>J. Clin. Microbiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.</ArticleTitle>
<Pagination><MedlinePgn>1800-10</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/JCM.02286-08</ELocationID>
<Abstract><AbstractText>The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study the molecular epidemiology of RSV, more than 1,400 RSV isolates from human nasopharyngeal aspirates or nasal or throat swabs from patients with respiratory illness were identified and differentiated by TaqMan reverse transcription-PCR into groups A and B. RSV group A was dominant in seven out of nine epidemic seasons. Phylogenetic analysis revealed that RSV group A genotypes GA2 and GA5 circulated from 1998 to 2007. Genotype GA7 was present in only two seasons (1999 to 2000 and 2002 to 2003). Comparison of the synonymous mutation/nonsynonymous mutation ratios showed greater evidence for selection pressure for genotype GA2 (1.18) than for GA5 (4.34). Partial protein sequences were predicted to encode G proteins of 298 amino acids in length and in a few cases of G proteins of 297 amino acids in length. Amino acid analysis also revealed genotype-specific amino acid substitutions: two substitutions for genotype GA2, seven for GA5, and three for GA7. Two to four putative, genotype-specific N-linked glycosylation sites were determined. Predicted O-glycosylation sites included 22 to 34 residues. This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reiche</LastName>
<ForeName>Janine</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>FG12-Virale Infektionen, NRZ Influenza, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schweiger</LastName>
<ForeName>Brunhilde</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName>
<AccessionNumberList><AccessionNumber>FJ391237</AccessionNumber>
<AccessionNumber>FJ391238</AccessionNumber>
<AccessionNumber>FJ391239</AccessionNumber>
<AccessionNumber>FJ391240</AccessionNumber>
<AccessionNumber>FJ391241</AccessionNumber>
<AccessionNumber>FJ391242</AccessionNumber>
<AccessionNumber>FJ391243</AccessionNumber>
<AccessionNumber>FJ391244</AccessionNumber>
<AccessionNumber>FJ391245</AccessionNumber>
<AccessionNumber>FJ391246</AccessionNumber>
<AccessionNumber>FJ391247</AccessionNumber>
<AccessionNumber>FJ391248</AccessionNumber>
<AccessionNumber>FJ391249</AccessionNumber>
<AccessionNumber>FJ391250</AccessionNumber>
<AccessionNumber>FJ391251</AccessionNumber>
<AccessionNumber>FJ391252</AccessionNumber>
<AccessionNumber>FJ391253</AccessionNumber>
<AccessionNumber>FJ391254</AccessionNumber>
<AccessionNumber>FJ391255</AccessionNumber>
<AccessionNumber>FJ391256</AccessionNumber>
<AccessionNumber>FJ391257</AccessionNumber>
<AccessionNumber>FJ391258</AccessionNumber>
<AccessionNumber>FJ391259</AccessionNumber>
<AccessionNumber>FJ391260</AccessionNumber>
<AccessionNumber>FJ391261</AccessionNumber>
<AccessionNumber>FJ391262</AccessionNumber>
<AccessionNumber>FJ391263</AccessionNumber>
<AccessionNumber>FJ391264</AccessionNumber>
<AccessionNumber>FJ391265</AccessionNumber>
<AccessionNumber>FJ391266</AccessionNumber>
<AccessionNumber>FJ391267</AccessionNumber>
<AccessionNumber>FJ391268</AccessionNumber>
<AccessionNumber>FJ391269</AccessionNumber>
<AccessionNumber>FJ391270</AccessionNumber>
<AccessionNumber>FJ391271</AccessionNumber>
<AccessionNumber>FJ391272</AccessionNumber>
<AccessionNumber>FJ391273</AccessionNumber>
<AccessionNumber>FJ391274</AccessionNumber>
<AccessionNumber>FJ391275</AccessionNumber>
<AccessionNumber>FJ391276</AccessionNumber>
<AccessionNumber>FJ391277</AccessionNumber>
<AccessionNumber>FJ391278</AccessionNumber>
<AccessionNumber>FJ391279</AccessionNumber>
<AccessionNumber>FJ391280</AccessionNumber>
<AccessionNumber>FJ391281</AccessionNumber>
<AccessionNumber>FJ391282</AccessionNumber>
<AccessionNumber>FJ391283</AccessionNumber>
<AccessionNumber>FJ391284</AccessionNumber>
<AccessionNumber>FJ391285</AccessionNumber>
<AccessionNumber>FJ391286</AccessionNumber>
<AccessionNumber>FJ391287</AccessionNumber>
<AccessionNumber>FJ391288</AccessionNumber>
<AccessionNumber>FJ391289</AccessionNumber>
<AccessionNumber>FJ391290</AccessionNumber>
<AccessionNumber>FJ391291</AccessionNumber>
<AccessionNumber>FJ391292</AccessionNumber>
<AccessionNumber>FJ391293</AccessionNumber>
<AccessionNumber>FJ391294</AccessionNumber>
<AccessionNumber>FJ391295</AccessionNumber>
<AccessionNumber>FJ391296</AccessionNumber>
<AccessionNumber>FJ391297</AccessionNumber>
<AccessionNumber>FJ391298</AccessionNumber>
<AccessionNumber>FJ391299</AccessionNumber>
<AccessionNumber>FJ391300</AccessionNumber>
<AccessionNumber>FJ391301</AccessionNumber>
<AccessionNumber>FJ391302</AccessionNumber>
<AccessionNumber>FJ391303</AccessionNumber>
<AccessionNumber>FJ391304</AccessionNumber>
<AccessionNumber>FJ391305</AccessionNumber>
<AccessionNumber>FJ391306</AccessionNumber>
<AccessionNumber>FJ391307</AccessionNumber>
<AccessionNumber>FJ391308</AccessionNumber>
<AccessionNumber>FJ391309</AccessionNumber>
<AccessionNumber>FJ391310</AccessionNumber>
<AccessionNumber>FJ391311</AccessionNumber>
<AccessionNumber>FJ391312</AccessionNumber>
<AccessionNumber>FJ391313</AccessionNumber>
<AccessionNumber>FJ391314</AccessionNumber>
<AccessionNumber>FJ391315</AccessionNumber>
<AccessionNumber>FJ391316</AccessionNumber>
<AccessionNumber>FJ391317</AccessionNumber>
<AccessionNumber>FJ391318</AccessionNumber>
<AccessionNumber>FJ391319</AccessionNumber>
<AccessionNumber>FJ391320</AccessionNumber>
<AccessionNumber>FJ391321</AccessionNumber>
<AccessionNumber>FJ391322</AccessionNumber>
<AccessionNumber>FJ391323</AccessionNumber>
<AccessionNumber>FJ391324</AccessionNumber>
<AccessionNumber>FJ391325</AccessionNumber>
<AccessionNumber>FJ391326</AccessionNumber>
<AccessionNumber>FJ391327</AccessionNumber>
<AccessionNumber>FJ391328</AccessionNumber>
<AccessionNumber>FJ391329</AccessionNumber>
<AccessionNumber>FJ391330</AccessionNumber>
<AccessionNumber>FJ391331</AccessionNumber>
<AccessionNumber>FJ391332</AccessionNumber>
<AccessionNumber>FJ391333</AccessionNumber>
<AccessionNumber>FJ391334</AccessionNumber>
<AccessionNumber>FJ391335</AccessionNumber>
<AccessionNumber>FJ391336</AccessionNumber>
<AccessionNumber>FJ391337</AccessionNumber>
<AccessionNumber>FJ391338</AccessionNumber>
<AccessionNumber>FJ391339</AccessionNumber>
<AccessionNumber>FJ391340</AccessionNumber>
<AccessionNumber>FJ391341</AccessionNumber>
<AccessionNumber>FJ391342</AccessionNumber>
<AccessionNumber>FJ391343</AccessionNumber>
<AccessionNumber>FJ391344</AccessionNumber>
<AccessionNumber>FJ391345</AccessionNumber>
<AccessionNumber>FJ391346</AccessionNumber>
<AccessionNumber>FJ391347</AccessionNumber>
<AccessionNumber>FJ391348</AccessionNumber>
<AccessionNumber>FJ391349</AccessionNumber>
<AccessionNumber>FJ391350</AccessionNumber>
<AccessionNumber>FJ391351</AccessionNumber>
<AccessionNumber>FJ391352</AccessionNumber>
<AccessionNumber>FJ391353</AccessionNumber>
<AccessionNumber>FJ391354</AccessionNumber>
<AccessionNumber>FJ391355</AccessionNumber>
<AccessionNumber>FJ391356</AccessionNumber>
<AccessionNumber>FJ391357</AccessionNumber>
<AccessionNumber>FJ391358</AccessionNumber>
<AccessionNumber>FJ391359</AccessionNumber>
<AccessionNumber>FJ391360</AccessionNumber>
<AccessionNumber>FJ391361</AccessionNumber>
<AccessionNumber>FJ391362</AccessionNumber>
<AccessionNumber>FJ391363</AccessionNumber>
<AccessionNumber>FJ391364</AccessionNumber>
<AccessionNumber>FJ391365</AccessionNumber>
<AccessionNumber>FJ391366</AccessionNumber>
<AccessionNumber>FJ391367</AccessionNumber>
<AccessionNumber>FJ391368</AccessionNumber>
<AccessionNumber>FJ391369</AccessionNumber>
<AccessionNumber>FJ391370</AccessionNumber>
<AccessionNumber>FJ391371</AccessionNumber>
<AccessionNumber>FJ391372</AccessionNumber>
<AccessionNumber>FJ391373</AccessionNumber>
<AccessionNumber>FJ391374</AccessionNumber>
<AccessionNumber>FJ391375</AccessionNumber>
<AccessionNumber>FJ391376</AccessionNumber>
<AccessionNumber>FJ391377</AccessionNumber>
<AccessionNumber>FJ391378</AccessionNumber>
<AccessionNumber>FJ391379</AccessionNumber>
<AccessionNumber>FJ391380</AccessionNumber>
<AccessionNumber>FJ391381</AccessionNumber>
<AccessionNumber>FJ391382</AccessionNumber>
<AccessionNumber>FJ391383</AccessionNumber>
<AccessionNumber>FJ391384</AccessionNumber>
<AccessionNumber>FJ391385</AccessionNumber>
<AccessionNumber>FJ391386</AccessionNumber>
<AccessionNumber>FJ391387</AccessionNumber>
<AccessionNumber>FJ391388</AccessionNumber>
<AccessionNumber>FJ391389</AccessionNumber>
<AccessionNumber>FJ391390</AccessionNumber>
<AccessionNumber>FJ391391</AccessionNumber>
<AccessionNumber>FJ391392</AccessionNumber>
<AccessionNumber>FJ391393</AccessionNumber>
<AccessionNumber>FJ391394</AccessionNumber>
<AccessionNumber>FJ391395</AccessionNumber>
<AccessionNumber>FJ391396</AccessionNumber>
<AccessionNumber>FJ391397</AccessionNumber>
<AccessionNumber>FJ391398</AccessionNumber>
<AccessionNumber>FJ391399</AccessionNumber>
<AccessionNumber>FJ391400</AccessionNumber>
<AccessionNumber>FJ391401</AccessionNumber>
<AccessionNumber>FJ391402</AccessionNumber>
<AccessionNumber>FJ391403</AccessionNumber>
<AccessionNumber>FJ391404</AccessionNumber>
<AccessionNumber>FJ391405</AccessionNumber>
<AccessionNumber>FJ391406</AccessionNumber>
<AccessionNumber>FJ391407</AccessionNumber>
<AccessionNumber>FJ391408</AccessionNumber>
<AccessionNumber>FJ391409</AccessionNumber>
<AccessionNumber>FJ391410</AccessionNumber>
<AccessionNumber>FJ391411</AccessionNumber>
<AccessionNumber>FJ391412</AccessionNumber>
<AccessionNumber>FJ391413</AccessionNumber>
<AccessionNumber>FJ391414</AccessionNumber>
<AccessionNumber>FJ391415</AccessionNumber>
<AccessionNumber>FJ391416</AccessionNumber>
<AccessionNumber>FJ391417</AccessionNumber>
<AccessionNumber>FJ391418</AccessionNumber>
<AccessionNumber>FJ391419</AccessionNumber>
<AccessionNumber>FJ391420</AccessionNumber>
<AccessionNumber>FJ391421</AccessionNumber>
<AccessionNumber>FJ391422</AccessionNumber>
<AccessionNumber>FJ391423</AccessionNumber>
<AccessionNumber>FJ391424</AccessionNumber>
<AccessionNumber>FJ391425</AccessionNumber>
<AccessionNumber>FJ391426</AccessionNumber>
<AccessionNumber>FJ391427</AccessionNumber>
<AccessionNumber>FJ391428</AccessionNumber>
<AccessionNumber>FJ391429</AccessionNumber>
<AccessionNumber>FJ391430</AccessionNumber>
<AccessionNumber>FJ391431</AccessionNumber>
<AccessionNumber>FJ391432</AccessionNumber>
<AccessionNumber>FJ391433</AccessionNumber>
<AccessionNumber>FJ391434</AccessionNumber>
<AccessionNumber>FJ391435</AccessionNumber>
<AccessionNumber>FJ391436</AccessionNumber>
<AccessionNumber>FJ391437</AccessionNumber>
<AccessionNumber>FJ391438</AccessionNumber>
<AccessionNumber>FJ391439</AccessionNumber>
<AccessionNumber>FJ391440</AccessionNumber>
<AccessionNumber>FJ391441</AccessionNumber>
<AccessionNumber>FJ391442</AccessionNumber>
<AccessionNumber>FJ391443</AccessionNumber>
<AccessionNumber>FJ391444</AccessionNumber>
<AccessionNumber>FJ391445</AccessionNumber>
<AccessionNumber>FJ391446</AccessionNumber>
<AccessionNumber>FJ391447</AccessionNumber>
<AccessionNumber>FJ391448</AccessionNumber>
<AccessionNumber>FJ391449</AccessionNumber>
<AccessionNumber>FJ391450</AccessionNumber>
<AccessionNumber>FJ391451</AccessionNumber>
<AccessionNumber>FJ391452</AccessionNumber>
<AccessionNumber>FJ391453</AccessionNumber>
<AccessionNumber>FJ391454</AccessionNumber>
<AccessionNumber>FJ391455</AccessionNumber>
<AccessionNumber>FJ391456</AccessionNumber>
<AccessionNumber>FJ391457</AccessionNumber>
<AccessionNumber>FJ391458</AccessionNumber>
<AccessionNumber>FJ391459</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2009</Year>
<Month>04</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Clin Microbiol</MedlineTA>
<NlmUniqueID>7505564</NlmUniqueID>
<ISSNLinking>0095-1137</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009296" MajorTopicYN="N">Nasal Cavity</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010614" MajorTopicYN="N">Pharynx</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017354" MajorTopicYN="N">Point Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011110" MajorTopicYN="Y">Polymorphism, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018113" MajorTopicYN="N">Respiratory Syncytial Virus, Human</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>4</Month>
<Day>24</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>4</Month>
<Day>24</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2009</Year>
<Month>7</Month>
<Day>17</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">19386848</ArticleId>
<ArticleId IdType="pii">JCM.02286-08</ArticleId>
<ArticleId IdType="doi">10.1128/JCM.02286-08</ArticleId>
<ArticleId IdType="pmc">PMC2691087</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Virus Res. 2004 Oct;105(2):137-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15351487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 1995 Jun 15;308 ( Pt 3):801-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8948436</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 1961 May 27;176:647-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13692354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Epidemiol. 1969 Apr;89(4):422-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4305198</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1998 Sep;79 ( Pt 9):2221-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9747732</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1998 Oct;178(4):925-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9806017</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Rev. 2000 Jan;13(1):1-15, table of contents</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10627488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2004 Oct;74(2):344-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15332285</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1994 Sep;68(9):5448-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8057427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 1987 Jul;15(1):103-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2822808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2006 Sep;44(9):3055-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16954227</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Microbiol Infect Dis. 2000 May;19(5):336-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10898133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2001 Jan;82(Pt 1):103-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11125163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2008 Jan;80(1):159-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18041002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Dis Child. 1986 Jun;140(6):543-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3706232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2000 Jun;181(6):1891-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10837167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Med Virol. 2001 Mar-Apr;11(2):103-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11262529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2001 Sep;82(Pt 9):2117-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11514720</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1985 Apr;151(4):626-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2579169</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2005 May;43(5):2266-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15872254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2005;5:20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15801975</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Epidemiol. 1973 Aug;98(2):88-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4353439</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1978 Jul;138(1):24-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">355574</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1985 Oct;66 ( Pt 10):2111-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2413163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2002 Jul;45(1):10-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12217725</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2007 Sep;45(9):3022-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17609323</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pediatr. 2001 Sep;160(9):541-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11585076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Klin Padiatr. 2008 Sep-Oct;220(5):291-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18095251</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1985 Jun;82(12):4075-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3858865</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1991 Mar;72 ( Pt 3):669-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2005433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1991 Mar;163(3):464-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1995719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 May;78(9):4675-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15078950</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 May;69(5):2918-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7707517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Infect. 1997 Feb;3(6):640-646</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11864206</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1989 Nov;63(11):4767-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2677404</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2005 Oct;77(2):302-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16121371</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2005 Jan;43(1):36-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15634948</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br Med J. 1976 Nov 6;2(6044):1095-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">990783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Probl Pediatr. 1993 Feb;23(2):50-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7681743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 1991 Mar;29(3):653-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2064681</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1986 Feb;153(2):291-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2418126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2000 Apr;60(4):468-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10686032</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Comput Appl Biosci. 1996 Aug;12(4):357-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8902363</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Immunol. 1986 Jun;64(3):503-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3791688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1987 Aug;84(16):5625-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2441388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1991 Feb;72 ( Pt 2):349-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1993875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Infect Dis. 1990 Nov-Dec;12 Suppl 8:S870-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2270410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2004 Sep;74(1):156-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15258982</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mem Inst Oswaldo Cruz. 2005 May;100(3):221-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16113858</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Virol. 2003;47(2):97-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14524476</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 1986 Sep;3(5):418-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3444411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2003 Jul;27(2):180-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12829040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infection. 2002 Aug;30(4):186-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12236558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Epidemiol. 1973 Oct;98(4):289-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4355170</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1979 Mar 8;300(10):530-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">763253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1997 Oct;78 ( Pt 10):2411-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9349459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infection. 2003 Mar;31(2):75-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682811</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2003 Oct;71(2):305-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12938207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pediatr. 2007 Sep;166(9):957-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17569085</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=ExplorPubmed/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= *** parameter Area/wikiCode missing *** |area= ExplorPubmed |flux= Main |étape= Corpus |type= RBID |clé= pubmed:19386848 |texte= Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:19386848" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ExplorPubmed
![]() | This area was generated with Dilib version V0.6.35. | ![]() |