Influenza vaccination is associated with reduced severity of community-acquired pneumonia.
Identifieur interne : 000310 ( Main/Corpus ); précédent : 000309; suivant : 000311Influenza vaccination is associated with reduced severity of community-acquired pneumonia.
Auteurs : A. Tessmer ; T. Welte ; R. Schmidt-Ott ; S. Eberle ; G. Barten ; N. Suttorp ; T. SchabergSource :
- The European respiratory journal [ 1399-3003 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Cohort Studies, Community-Acquired Infections (mortality), Community-Acquired Infections (physiopathology), Female, Germany, Humans, Influenza Vaccines (therapeutic use), Influenza, Human (complications), Male, Middle Aged, Pneumonia (mortality), Pneumonia (physiopathology), Seasons, Treatment Outcome, Vaccination.
- MESH :
- chemical , therapeutic use : Influenza Vaccines.
- geographic : Germany.
- complications : Influenza, Human.
- mortality : Community-Acquired Infections, Pneumonia.
- physiopathology : Community-Acquired Infections, Pneumonia.
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Seasons, Treatment Outcome, Vaccination.
Abstract
Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.
DOI: 10.1183/09031936.00133510
PubMed: 21148226
Links to Exploration step
pubmed:21148226Le document en format XML
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<author><name sortKey="Tessmer, A" sort="Tessmer, A" uniqKey="Tessmer A" first="A" last="Tessmer">A. Tessmer</name>
<affiliation><nlm:affiliation>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin, Germany. antje.tessmer@charite.de</nlm:affiliation>
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<author><name sortKey="Welte, T" sort="Welte, T" uniqKey="Welte T" first="T" last="Welte">T. Welte</name>
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<author><name sortKey="Schmidt Ott, R" sort="Schmidt Ott, R" uniqKey="Schmidt Ott R" first="R" last="Schmidt-Ott">R. Schmidt-Ott</name>
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<front><div type="abstract" xml:lang="en">Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.</div>
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<Abstract><AbstractText>Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.</AbstractText>
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