[Pandemic influenza vaccines. How should they be designed?].
Identifieur interne : 000308 ( Main/Corpus ); précédent : 000307; suivant : 000309[Pandemic influenza vaccines. How should they be designed?].
Auteurs : J. LöwerSource :
- Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz [ 1437-1588 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Influenza Vaccines.
- geographic , epidemiology : Germany.
- chemical , therapeutic use : Influenza Vaccines.
- epidemiology : Influenza, Human.
- prevention & control : Influenza, Human, Pandemics.
- statistics & numerical data : Pandemics.
- Drug Design, Humans, Influenza A Virus, H1N1 Subtype.
Abstract
Pandemic influenza vaccines have to fulfill specific requirements. In contrast to seasonal influenza vaccines, they have to be effective even in an immunologically naïve population. In addition, they should be available in a relatively short period of time and should be produced at an unprecedented speed in huge amounts. For this reason, they need a specific design which has to be different from that of seasonal vaccines. With the given technological possibilities, antigen-sparing adjuvanted vaccines most closely fulfill the requirements of an ideal pandemic vaccine.
DOI: 10.1007/s00103-010-1159-z
PubMed: 21161473
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pubmed:21161473Le document en format XML
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How should they be designed?].</title><author><name sortKey="Lower, J" sort="Lower, J" uniqKey="Lower J" first="J" last="Löwer">J. Löwer</name><affiliation><nlm:affiliation>Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen (Hessen), Deutschland. 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In contrast to seasonal influenza vaccines, they have to be effective even in an immunologically naïve population. In addition, they should be available in a relatively short period of time and should be produced at an unprecedented speed in huge amounts. For this reason, they need a specific design which has to be different from that of seasonal vaccines. 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