Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.
Identifieur interne : 000289 ( Main/Corpus ); précédent : 000288; suivant : 000290Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.
Auteurs : Gernot Beutel ; Olaf Wiesner ; Matthias Eder ; Carsten Hafer ; Andrea S. Schneider ; Jan T. Kielstein ; Christian Kühn ; Albert Heim ; Tina Ganzenmüller ; Hans-Heinrich Kreipe ; Axel Haverich ; Andreas Tecklenburg ; Arnold Ganser ; Tobias Welte ; Marius M. HoeperSource :
- Critical care (London, England) [ 1466-609X ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Germany.
- mortality : Influenza, Human, Lymphohistiocytosis, Hemophagocytic.
- Adult, Critical Illness, Female, Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Prospective Studies, Severity of Illness Index.
Abstract
Virus-associated hemophagocytic syndrome (VAHS) is a severe complication of various viral infections often resulting in multiorgan failure and death. The purpose of this study was to describe baseline characteristics, development of VAHS, related treatments and associated mortality rate of consecutive critically ill patients with confirmed 2009 influenza A (H1N1) infection and respiratory failure.
DOI: 10.1186/cc10073
PubMed: 21366922
Links to Exploration step
pubmed:21366922Le document en format XML
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<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human (mortality)</term>
<term>Lymphohistiocytosis, Hemophagocytic (mortality)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Virus-associated hemophagocytic syndrome (VAHS) is a severe complication of various viral infections often resulting in multiorgan failure and death. The purpose of this study was to describe baseline characteristics, development of VAHS, related treatments and associated mortality rate of consecutive critically ill patients with confirmed 2009 influenza A (H1N1) infection and respiratory failure.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21366922</PMID>
<DateCompleted><Year>2011</Year>
<Month>12</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>2</Issue>
<PubDate><Year>2011</Year>
</PubDate>
</JournalIssue>
<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.</ArticleTitle>
<Pagination><MedlinePgn>R80</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/cc10073</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Virus-associated hemophagocytic syndrome (VAHS) is a severe complication of various viral infections often resulting in multiorgan failure and death. The purpose of this study was to describe baseline characteristics, development of VAHS, related treatments and associated mortality rate of consecutive critically ill patients with confirmed 2009 influenza A (H1N1) infection and respiratory failure.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a prospective observational study of 25 critically ill patients with 2009 influenza A (H1N1) infection at a single-center intensive care unit in Germany between 5 October 2009 and 4 January 2010. Demographic data, comorbidities, diagnosis of VAHS, illness progression, treatments and survival data were collected. The primary outcome measure was the development of VAHS and related mortality. Secondary outcome variables included duration of mechanical ventilation, support of extracorporeal membrane oxygenation and duration of viral shedding.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">VAHS developed in 9 (36%) of 25 critically ill patients with confirmed 2009 influenza A (H1N1) infection, and 8 (89%) of them died. In contrast, the mortality rate in the remaining 16 patients without VAHS was 25% (P = 0.004 for the survival difference in patients with or without VAHS by log-rank analysis). The patients were relatively young (median age, 45 years; interquartile range (IQR), 35 to 56 years of age); however, 18 patients (72%) presented with one or more risk factors for a severe course of illness. All 25 patients received mechanical ventilation for severe acute respiratory distress syndrome and refractory hypoxemia, with a median duration of mechanical ventilation of 19 days (IQR, 13 to 26 days). An additional 17 patients (68%) required extracorporeal membrane oxygenation for a median of 10 days (IQR, 6 to 19 days).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The findings of this study raise the possibility that VAHS may be a frequent complication of severe 2009 influenza A (H1N1) infection and represents an important contributor to multiorgan failure and death.</AbstractText>
</Abstract>
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<ForeName>Gernot</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Departments of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Beutel.Gernot@mh-hannover.de</Affiliation>
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<Author ValidYN="Y"><LastName>Wiesner</LastName>
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<Author ValidYN="Y"><LastName>Eder</LastName>
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<Author ValidYN="Y"><LastName>Hafer</LastName>
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<Author ValidYN="Y"><LastName>Schneider</LastName>
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<Author ValidYN="Y"><LastName>Kielstein</LastName>
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<Author ValidYN="Y"><LastName>Haverich</LastName>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2011;15(5):440</RefSource>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
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