An inception cohort study assessing the role of pneumococcal and other bacterial pathogens in children with influenza and ILI and a clinical decision model for stringent antibiotic use.
Identifieur interne : 000099 ( Main/Corpus ); précédent : 000098; suivant : 000100An inception cohort study assessing the role of pneumococcal and other bacterial pathogens in children with influenza and ILI and a clinical decision model for stringent antibiotic use.
Auteurs : Franziska Tief ; Christian Hoppe ; Lea Seeber ; Patrick Obermeier ; Xi Chen ; Katharina Karsch ; Susann Mühlhans ; Eleni Adamou ; Tim Conrad ; Ariel Beresniak ; Brunhilde Schweiger ; Thomas Adam ; Barbara RathSource :
- Antiviral therapy [ 2040-2058 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent, Anti-Bacterial Agents (therapeutic use), Bacterial Infections (complications), Bacterial Infections (diagnosis), Bacterial Infections (drug therapy), Child, Child, Preschool, Clinical Decision-Making, Cohort Studies, Coinfection (diagnosis), Coinfection (drug therapy), Decision Support Techniques, Female, Germany, Humans, Infant, Infant, Newborn, Influenza, Human (complications), Influenza, Human (diagnosis), Influenza, Human (drug therapy), Male, Pneumococcal Infections (complications), Pneumococcal Infections (diagnosis), Pneumococcal Infections (drug therapy).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents.
- complications : Bacterial Infections, Influenza, Human, Pneumococcal Infections.
- diagnosis : Bacterial Infections, Coinfection, Influenza, Human, Pneumococcal Infections.
- drug therapy : Bacterial Infections, Coinfection, Influenza, Human, Pneumococcal Infections.
- Adolescent, Child, Child, Preschool, Clinical Decision-Making, Cohort Studies, Decision Support Techniques, Female, Germany, Humans, Infant, Infant, Newborn, Male.
Abstract
Influenza-like illness (ILI) is a common reason for paediatric consultations. Viral causes predominate, but antibiotics are used frequently. With regard to influenza, pneumococcal coinfections are considered major contributors to morbidity/mortality.
DOI: 10.3851/IMP3034
PubMed: 26867096
Links to Exploration step
pubmed:26867096Le document en format XML
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<author><name sortKey="Tief, Franziska" sort="Tief, Franziska" uniqKey="Tief F" first="Franziska" last="Tief">Franziska Tief</name>
<affiliation><nlm:affiliation>Department of Paediatrics, Charité University Medical Centre Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Hoppe, Christian" sort="Hoppe, Christian" uniqKey="Hoppe C" first="Christian" last="Hoppe">Christian Hoppe</name>
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<author><name sortKey="Seeber, Lea" sort="Seeber, Lea" uniqKey="Seeber L" first="Lea" last="Seeber">Lea Seeber</name>
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<author><name sortKey="Obermeier, Patrick" sort="Obermeier, Patrick" uniqKey="Obermeier P" first="Patrick" last="Obermeier">Patrick Obermeier</name>
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<author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
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<author><name sortKey="Karsch, Katharina" sort="Karsch, Katharina" uniqKey="Karsch K" first="Katharina" last="Karsch">Katharina Karsch</name>
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<author><name sortKey="Muhlhans, Susann" sort="Muhlhans, Susann" uniqKey="Muhlhans S" first="Susann" last="Mühlhans">Susann Mühlhans</name>
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<author><name sortKey="Adamou, Eleni" sort="Adamou, Eleni" uniqKey="Adamou E" first="Eleni" last="Adamou">Eleni Adamou</name>
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<author><name sortKey="Conrad, Tim" sort="Conrad, Tim" uniqKey="Conrad T" first="Tim" last="Conrad">Tim Conrad</name>
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<author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name>
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<author><name sortKey="Adam, Thomas" sort="Adam, Thomas" uniqKey="Adam T" first="Thomas" last="Adam">Thomas Adam</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">An inception cohort study assessing the role of pneumococcal and other bacterial pathogens in children with influenza and ILI and a clinical decision model for stringent antibiotic use.</title>
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<affiliation><nlm:affiliation>Department of Paediatrics, Charité University Medical Centre Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Hoppe, Christian" sort="Hoppe, Christian" uniqKey="Hoppe C" first="Christian" last="Hoppe">Christian Hoppe</name>
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<author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
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<author><name sortKey="Karsch, Katharina" sort="Karsch, Katharina" uniqKey="Karsch K" first="Katharina" last="Karsch">Katharina Karsch</name>
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<author><name sortKey="Adamou, Eleni" sort="Adamou, Eleni" uniqKey="Adamou E" first="Eleni" last="Adamou">Eleni Adamou</name>
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<author><name sortKey="Conrad, Tim" sort="Conrad, Tim" uniqKey="Conrad T" first="Tim" last="Conrad">Tim Conrad</name>
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<author><name sortKey="Beresniak, Ariel" sort="Beresniak, Ariel" uniqKey="Beresniak A" first="Ariel" last="Beresniak">Ariel Beresniak</name>
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<author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name>
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<author><name sortKey="Adam, Thomas" sort="Adam, Thomas" uniqKey="Adam T" first="Thomas" last="Adam">Thomas Adam</name>
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<author><name sortKey="Rath, Barbara" sort="Rath, Barbara" uniqKey="Rath B" first="Barbara" last="Rath">Barbara Rath</name>
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<series><title level="j">Antiviral therapy</title>
<idno type="eISSN">2040-2058</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Bacterial Infections (complications)</term>
<term>Bacterial Infections (diagnosis)</term>
<term>Bacterial Infections (drug therapy)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Clinical Decision-Making</term>
<term>Cohort Studies</term>
<term>Coinfection (diagnosis)</term>
<term>Coinfection (drug therapy)</term>
<term>Decision Support Techniques</term>
<term>Female</term>
<term>Germany</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (diagnosis)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Male</term>
<term>Pneumococcal Infections (complications)</term>
<term>Pneumococcal Infections (diagnosis)</term>
<term>Pneumococcal Infections (drug therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bacterial Infections</term>
<term>Influenza, Human</term>
<term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Bacterial Infections</term>
<term>Coinfection</term>
<term>Influenza, Human</term>
<term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bacterial Infections</term>
<term>Coinfection</term>
<term>Influenza, Human</term>
<term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Clinical Decision-Making</term>
<term>Cohort Studies</term>
<term>Decision Support Techniques</term>
<term>Female</term>
<term>Germany</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">Influenza-like illness (ILI) is a common reason for paediatric consultations. Viral causes predominate, but antibiotics are used frequently. With regard to influenza, pneumococcal coinfections are considered major contributors to morbidity/mortality.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26867096</PMID>
<DateCompleted><Year>2018</Year>
<Month>01</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>05</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>5</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>Antiviral therapy</Title>
<ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation>
</Journal>
<ArticleTitle>An inception cohort study assessing the role of pneumococcal and other bacterial pathogens in children with influenza and ILI and a clinical decision model for stringent antibiotic use.</ArticleTitle>
<Pagination><MedlinePgn>413-24</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP3034</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Influenza-like illness (ILI) is a common reason for paediatric consultations. Viral causes predominate, but antibiotics are used frequently. With regard to influenza, pneumococcal coinfections are considered major contributors to morbidity/mortality.</AbstractText>
<AbstractText Label="METHODS">In the context of a perennial quality management (QM) programme at the Charité Departments of Paediatrics and Microbiology in collaboration with the Robert Koch Institute, children aged 0-18 years presenting with signs and symptoms of ILI were followed from the time of initial presentation until hospital discharge (Charité Influenza-Like Disease = ChILD Cohort). An independent QM team performed highly standardized clinical assessments using a disease severity score based on World Health Organization criteria for uncomplicated and complicated/progressive disease. Nasopharyngeal and pharyngeal samples were collected for viral reverse transcription polymerase chain reaction and bacterial culture/sensitivity and MaldiTOF analyses. The term 'detection' was used to denote any evidence of viral or bacterial pathogens in the (naso)pharyngeal cavity. With the ChILD Cohort data collected, a standard operating procedure (SOP) was created as a model system to reduce the inappropriate use of antibiotics in children with ILI. Monte Carlo simulations were performed to assess cost-effectiveness.</AbstractText>
<AbstractText Label="RESULTS">Among 2,569 ChILD Cohort patients enrolled from 12/2010 to 04/2013 (55% male, mean age 3.2 years, range 0-18, 19% >5 years), 411 patients showed laboratory-confirmed influenza, with bacterial co-detection in 35%. Influenza and pneumococcus were detected simultaneously in 12/2,569 patients, with disease severity clearly below average. Pneumococcal vaccination rates were close to 90%. Nonetheless, every fifth patient was already on antibiotics upon presentation; new antibiotic prescriptions were issued in an additional 20%. Simulation of the model SOP in the same dataset revealed that the proposed decision model could have reduced the inappropriate use of antibiotics significantly (P<0.01) with an incremental cost-effectiveness ratio of -99.55€.</AbstractText>
<AbstractText Label="CONCLUSIONS">Physicians should be made aware that in times of pneumococcal vaccination the prevalence and severity of influenza infections complicated by pneumococci may decline. Microbiological testing in combination with standardized disease severity assessments and review of vaccination records could be cost-effective, as well as promoting stringent use of antibiotics and a personalized approach to managing children with ILI.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tief</LastName>
<ForeName>Franziska</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Paediatrics, Charité University Medical Centre Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoppe</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Seeber</LastName>
<ForeName>Lea</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Obermeier</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xi</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Karsch</LastName>
<ForeName>Katharina</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mühlhans</LastName>
<ForeName>Susann</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Adamou</LastName>
<ForeName>Eleni</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Conrad</LastName>
<ForeName>Tim</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Beresniak</LastName>
<ForeName>Ariel</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schweiger</LastName>
<ForeName>Brunhilde</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Adam</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rath</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Antivir Ther</MedlineTA>
<NlmUniqueID>9815705</NlmUniqueID>
<ISSNLinking>1359-6535</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000066491" MajorTopicYN="N">Clinical Decision-Making</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003661" MajorTopicYN="N">Decision Support Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011008" MajorTopicYN="N">Pneumococcal Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>01</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>2</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>2</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>1</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26867096</ArticleId>
<ArticleId IdType="doi">10.3851/IMP3034</ArticleId>
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