Prevalence of nifedipine-induced gingival hyperplasia.
Identifieur interne : 004244 ( PubMed/Curation ); précédent : 004243; suivant : 004245Prevalence of nifedipine-induced gingival hyperplasia.
Auteurs : E B Nery [États-Unis] ; R G Edson ; K K Lee ; V K Pruthi ; J. WatsonSource :
- Journal of periodontology [ 0022-3492 ] ; 1995.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biopsie, Bouche édentée (physiopathologie), Collagène, Denture, Facteurs de l'âge, Femelle, Gingivectomie, Humains, Hyperplasie gingivale (), Hyperplasie gingivale (anatomopathologie), Indice d'hygiène buccodentaire, Inhibiteurs des canaux calciques (administration et posologie), Inhibiteurs des canaux calciques (effets indésirables), Mâle, Nifédipine (administration et posologie), Nifédipine (effets indésirables), Plasmocytes (anatomopathologie), Prévalence, Statistiques comme sujet, Tissu conjonctif (anatomopathologie), Épithélium (anatomopathologie).
- MESH :
- administration et posologie : Inhibiteurs des canaux calciques, Nifédipine.
- anatomopathologie : Hyperplasie gingivale, Plasmocytes, Tissu conjonctif, Épithélium.
- effets indésirables : Inhibiteurs des canaux calciques, Nifédipine.
- physiopathologie : Bouche édentée.
- Adulte d'âge moyen, Biopsie, Collagène, Denture, Facteurs de l'âge, Femelle, Gingivectomie, Humains, Hyperplasie gingivale, Indice d'hygiène buccodentaire, Mâle, Prévalence, Statistiques comme sujet.
English descriptors
- KwdEn :
- Age Factors, Biopsy, Calcium Channel Blockers (administration & dosage), Calcium Channel Blockers (adverse effects), Collagen, Connective Tissue (pathology), Dentition, Epithelium (pathology), Female, Gingival Hyperplasia (chemically induced), Gingival Hyperplasia (pathology), Gingival Hyperplasia (surgery), Gingivectomy, Humans, Male, Middle Aged, Mouth, Edentulous (physiopathology), Nifedipine (administration & dosage), Nifedipine (adverse effects), Oral Hygiene Index, Plasma Cells (pathology), Prevalence, Statistics as Topic.
- MESH :
- chemical , administration & dosage : Calcium Channel Blockers, Nifedipine.
- chemical , adverse effects : Calcium Channel Blockers, Nifedipine.
- chemically induced : Gingival Hyperplasia.
- pathology : Connective Tissue, Epithelium, Gingival Hyperplasia, Plasma Cells.
- physiopathology : Mouth, Edentulous.
- surgery : Gingival Hyperplasia.
- Age Factors, Biopsy, Collagen, Dentition, Female, Gingivectomy, Humans, Male, Middle Aged, Oral Hygiene Index, Prevalence, Statistics as Topic.
Abstract
This study investigated the prevalence of gingival hyperplasia in subjects who were undergoing treatment with a calcium channel blocker, nifedipine, in dentate and edentulous subjects. In addition, the relationship between gingival hyperplasia and 5 other variables (duration of nifedipine intake, dose, age, oral hygiene index, and number of teeth) was investigated. Results of statistical analyses showed overwhelming evidence that the percent of nifedipine subjects with gingival hyperplasia was greater than that of the control subjects (P < 0.05) and that, across treatment group, the percent of dentate subjects with hyperplasia was significantly higher than that for edentulous subjects (P < 0.05). The chi2 test showed a strong univariate relationship between gingival hyperplasia and, separately, oral hygiene and number of teeth. For 24% of the subjects with gingival hyperplasia index (GHI) values of 2 or 3, gingivectomy was performed, and the tissues were prepared for histological examination. Microscopic examination of the biopsy material showed findings similar to those from previously reported cases of nifedipine- or phenytoin-induced hyperplasia.
DOI: 10.1902/jop.1995.66.7.572
PubMed: 7562349
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Zablocki Medical Center Dental Research Section, Milwaukee, WI</wicri:regionArea></affiliation></author><author><name sortKey="Edson, R G" sort="Edson, R G" uniqKey="Edson R" first="R G" last="Edson">R G Edson</name></author><author><name sortKey="Lee, K K" sort="Lee, K K" uniqKey="Lee K" first="K K" last="Lee">K K Lee</name></author><author><name sortKey="Pruthi, V K" sort="Pruthi, V K" uniqKey="Pruthi V" first="V K" last="Pruthi">V K Pruthi</name></author><author><name sortKey="Watson, J" sort="Watson, J" uniqKey="Watson J" first="J" last="Watson">J. 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In addition, the relationship between gingival hyperplasia and 5 other variables (duration of nifedipine intake, dose, age, oral hygiene index, and number of teeth) was investigated. Results of statistical analyses showed overwhelming evidence that the percent of nifedipine subjects with gingival hyperplasia was greater than that of the control subjects (P < 0.05) and that, across treatment group, the percent of dentate subjects with hyperplasia was significantly higher than that for edentulous subjects (P < 0.05). The chi2 test showed a strong univariate relationship between gingival hyperplasia and, separately, oral hygiene and number of teeth. For 24% of the subjects with gingival hyperplasia index (GHI) values of 2 or 3, gingivectomy was performed, and the tissues were prepared for histological examination. Microscopic examination of the biopsy material showed findings similar to those from previously reported cases of nifedipine- or phenytoin-induced hyperplasia.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7562349</PMID><DateCompleted><Year>1995</Year><Month>11</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3492</ISSN><JournalIssue CitedMedium="Print"><Volume>66</Volume><Issue>7</Issue><PubDate><Year>1995</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of periodontology</Title><ISOAbbreviation>J. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Prevalence of nifedipine-induced gingival hyperplasia.</ArticleTitle><Pagination><MedlinePgn>572-8</MedlinePgn></Pagination><Abstract><AbstractText>This study investigated the prevalence of gingival hyperplasia in subjects who were undergoing treatment with a calcium channel blocker, nifedipine, in dentate and edentulous subjects. In addition, the relationship between gingival hyperplasia and 5 other variables (duration of nifedipine intake, dose, age, oral hygiene index, and number of teeth) was investigated. Results of statistical analyses showed overwhelming evidence that the percent of nifedipine subjects with gingival hyperplasia was greater than that of the control subjects (P < 0.05) and that, across treatment group, the percent of dentate subjects with hyperplasia was significantly higher than that for edentulous subjects (P < 0.05). The chi2 test showed a strong univariate relationship between gingival hyperplasia and, separately, oral hygiene and number of teeth. For 24% of the subjects with gingival hyperplasia index (GHI) values of 2 or 3, gingivectomy was performed, and the tissues were prepared for histological examination. Microscopic examination of the biopsy material showed findings similar to those from previously reported cases of nifedipine- or phenytoin-induced hyperplasia.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nery</LastName><ForeName>E B</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Department of Veterans Affairs, Clement J. Zablocki Medical Center Dental Research Section, Milwaukee, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edson</LastName><ForeName>R G</ForeName><Initials>RG</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>K K</ForeName><Initials>KK</Initials></Author><Author ValidYN="Y"><LastName>Pruthi</LastName><ForeName>V K</ForeName><Initials>VK</Initials></Author><Author ValidYN="Y"><LastName>Watson</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontol</MedlineTA><NlmUniqueID>8000345</NlmUniqueID><ISSNLinking>0022-3492</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002121">Calcium Channel Blockers</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>I9ZF7L6G2L</RegistryNumber><NameOfSubstance UI="D009543">Nifedipine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002121" MajorTopicYN="N">Calcium Channel Blockers</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003238" MajorTopicYN="N">Connective Tissue</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003817" MajorTopicYN="N">Dentition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005885" MajorTopicYN="N">Gingival Hyperplasia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005890" MajorTopicYN="N">Gingivectomy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009543" MajorTopicYN="N">Nifedipine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009911" MajorTopicYN="N">Oral Hygiene Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010950" MajorTopicYN="N">Plasma Cells</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013223" MajorTopicYN="N">Statistics as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7562349</ArticleId><ArticleId IdType="doi">10.1902/jop.1995.66.7.572</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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