Oral health status, C-reactive protein and mortality--a 10 year follow-up study.
Identifieur interne : 002E75 ( PubMed/Curation ); précédent : 002E74; suivant : 002E76Oral health status, C-reactive protein and mortality--a 10 year follow-up study.
Auteurs : S. Ajwani [Finlande] ; K J Mattila ; T O N Rhi ; R S Tilvis ; A. AinamoSource :
- Gerodontology [ 0734-0664 ] ; 2003.
Descripteurs français
- KwdFr :
- Analyse de survie, Analyse de variance, Appareils de prothèse dentaire (mortalité), Bouche édentée (mortalité), Bouche édentée (sang), Comorbidité, Enquêtes de santé dentaire, Femelle, Finlande (épidémiologie), Humains, Hygiène buccodentaire (mortalité), Loi du khi-deux, Maladie chronique, Maladies cardiovasculaires (mortalité), Maladies parodontales (mortalité), Maladies parodontales (sang), Modèles logistiques, Mâchoire partiellement édentée (mortalité), Mâchoire partiellement édentée (sang), Mâle, Parodontite (épidémiologie), Protéine C-réactive (analyse), Répartition par sexe, Répartition par âge, Santé buccodentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, État de santé, Études de suivi.
- MESH :
- analyse : Protéine C-réactive.
- mortalité : Appareils de prothèse dentaire, Bouche édentée, Hygiène buccodentaire, Maladies cardiovasculaires, Maladies parodontales, Mâchoire partiellement édentée.
- sang : Bouche édentée, Maladies parodontales, Mâchoire partiellement édentée.
- épidémiologie : Finlande, Parodontite.
- Analyse de survie, Analyse de variance, Comorbidité, Enquêtes de santé dentaire, Femelle, Humains, Loi du khi-deux, Maladie chronique, Modèles logistiques, Mâle, Répartition par sexe, Répartition par âge, Santé buccodentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, État de santé, Études de suivi.
- Wicri :
- geographic : Finlande.
English descriptors
- KwdEn :
- Age Distribution, Aged, Aged, 80 and over, Analysis of Variance, C-Reactive Protein (analysis), Cardiovascular Diseases (mortality), Chi-Square Distribution, Chronic Disease, Comorbidity, Dental Health Surveys, Dentures (mortality), Female, Finland (epidemiology), Follow-Up Studies, Health Status, Humans, Jaw, Edentulous, Partially (blood), Jaw, Edentulous, Partially (mortality), Logistic Models, Male, Mouth, Edentulous (blood), Mouth, Edentulous (mortality), Oral Health, Oral Hygiene (mortality), Periodontal Diseases (blood), Periodontal Diseases (mortality), Periodontitis (epidemiology), Sex Distribution, Survival Analysis.
- MESH :
- chemical , analysis : C-Reactive Protein.
- geographic , epidemiology : Finland.
- blood : Jaw, Edentulous, Partially, Mouth, Edentulous, Periodontal Diseases.
- epidemiology : Periodontitis.
- mortality : Cardiovascular Diseases, Dentures, Jaw, Edentulous, Partially, Mouth, Edentulous, Oral Hygiene, Periodontal Diseases.
- Age Distribution, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Chronic Disease, Comorbidity, Dental Health Surveys, Female, Follow-Up Studies, Health Status, Humans, Logistic Models, Male, Oral Health, Sex Distribution, Survival Analysis.
Abstract
Epidemiological studies have reported a strong association between C-reactive protein (CRP) and cardiovascular diseases (CVD). Elevated CRP levels have been observed both in dentate individuals with chronic dental infections like periodontal disease and in those edentulous. The mechanisms behind these observations, especially the reasons for the elevation of CRP in the edentulous, are poorly understood. The comparative data on the importance of these inflammatory conditions in the oral cavity as causes of elevated CRP levels and CVD risk factors are also limited.
PubMed: 12926749
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Ajwani</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Dentistry, University of Helsinki, Finland. shilpi.ajwani@stonebow.otago.ac.nz</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Mattila, K J" sort="Mattila, K J" uniqKey="Mattila K" first="K J" last="Mattila">K J Mattila</name></author><author><name sortKey="N Rhi, T O" sort="N Rhi, T O" uniqKey="N Rhi T" first="T O" last="N Rhi">T O N Rhi</name></author><author><name sortKey="Tilvis, R S" sort="Tilvis, R S" uniqKey="Tilvis R" first="R S" last="Tilvis">R S Tilvis</name></author><author><name sortKey="Ainamo, A" sort="Ainamo, A" uniqKey="Ainamo A" first="A" last="Ainamo">A. 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Ajwani</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Dentistry, University of Helsinki, Finland. shilpi.ajwani@stonebow.otago.ac.nz</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Mattila, K J" sort="Mattila, K J" uniqKey="Mattila K" first="K J" last="Mattila">K J Mattila</name></author><author><name sortKey="N Rhi, T O" sort="N Rhi, T O" uniqKey="N Rhi T" first="T O" last="N Rhi">T O N Rhi</name></author><author><name sortKey="Tilvis, R S" sort="Tilvis, R S" uniqKey="Tilvis R" first="R S" last="Tilvis">R S Tilvis</name></author><author><name sortKey="Ainamo, A" sort="Ainamo, A" uniqKey="Ainamo A" first="A" last="Ainamo">A. Ainamo</name></author></analytic><series><title level="j">Gerodontology</title><idno type="ISSN">0734-0664</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>C-Reactive Protein (analysis)</term><term>Cardiovascular Diseases (mortality)</term><term>Chi-Square Distribution</term><term>Chronic Disease</term><term>Comorbidity</term><term>Dental Health Surveys</term><term>Dentures (mortality)</term><term>Female</term><term>Finland (epidemiology)</term><term>Follow-Up Studies</term><term>Health Status</term><term>Humans</term><term>Jaw, Edentulous, Partially (blood)</term><term>Jaw, Edentulous, Partially (mortality)</term><term>Logistic Models</term><term>Male</term><term>Mouth, Edentulous (blood)</term><term>Mouth, Edentulous (mortality)</term><term>Oral Health</term><term>Oral Hygiene (mortality)</term><term>Periodontal Diseases (blood)</term><term>Periodontal Diseases (mortality)</term><term>Periodontitis (epidemiology)</term><term>Sex Distribution</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de survie</term><term>Analyse de variance</term><term>Appareils de prothèse dentaire (mortalité)</term><term>Bouche édentée (mortalité)</term><term>Bouche édentée (sang)</term><term>Comorbidité</term><term>Enquêtes de santé dentaire</term><term>Femelle</term><term>Finlande (épidémiologie)</term><term>Humains</term><term>Hygiène buccodentaire (mortalité)</term><term>Loi du khi-deux</term><term>Maladie chronique</term><term>Maladies cardiovasculaires (mortalité)</term><term>Maladies parodontales (mortalité)</term><term>Maladies parodontales (sang)</term><term>Modèles logistiques</term><term>Mâchoire partiellement édentée (mortalité)</term><term>Mâchoire partiellement édentée (sang)</term><term>Mâle</term><term>Parodontite (épidémiologie)</term><term>Protéine C-réactive (analyse)</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Santé buccodentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>État de santé</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Finland</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Jaw, Edentulous, Partially</term><term>Mouth, Edentulous</term><term>Periodontal Diseases</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cardiovascular Diseases</term><term>Dentures</term><term>Jaw, Edentulous, Partially</term><term>Mouth, Edentulous</term><term>Oral Hygiene</term><term>Periodontal Diseases</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Appareils de prothèse dentaire</term><term>Bouche édentée</term><term>Hygiène buccodentaire</term><term>Maladies cardiovasculaires</term><term>Maladies parodontales</term><term>Mâchoire partiellement édentée</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Bouche édentée</term><term>Maladies parodontales</term><term>Mâchoire partiellement édentée</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Finlande</term><term>Parodontite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Chi-Square Distribution</term><term>Chronic Disease</term><term>Comorbidity</term><term>Dental Health Surveys</term><term>Female</term><term>Follow-Up Studies</term><term>Health Status</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Oral Health</term><term>Sex Distribution</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term><term>Analyse de variance</term><term>Comorbidité</term><term>Enquêtes de santé dentaire</term><term>Femelle</term><term>Humains</term><term>Loi du khi-deux</term><term>Maladie chronique</term><term>Modèles logistiques</term><term>Mâle</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Santé buccodentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>État de santé</term><term>Études de suivi</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies have reported a strong association between C-reactive protein (CRP) and cardiovascular diseases (CVD). Elevated CRP levels have been observed both in dentate individuals with chronic dental infections like periodontal disease and in those edentulous. The mechanisms behind these observations, especially the reasons for the elevation of CRP in the edentulous, are poorly understood. The comparative data on the importance of these inflammatory conditions in the oral cavity as causes of elevated CRP levels and CVD risk factors are also limited.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12926749</PMID><DateCompleted><Year>2003</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0734-0664</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2003</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Gerodontology</Title><ISOAbbreviation>Gerodontology</ISOAbbreviation></Journal><ArticleTitle>Oral health status, C-reactive protein and mortality--a 10 year follow-up study.</ArticleTitle><Pagination><MedlinePgn>32-40</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Epidemiological studies have reported a strong association between C-reactive protein (CRP) and cardiovascular diseases (CVD). Elevated CRP levels have been observed both in dentate individuals with chronic dental infections like periodontal disease and in those edentulous. The mechanisms behind these observations, especially the reasons for the elevation of CRP in the edentulous, are poorly understood. The comparative data on the importance of these inflammatory conditions in the oral cavity as causes of elevated CRP levels and CVD risk factors are also limited.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine if edentulism is associated with increased levels of CRP and investigate the possible mechanism for this association; and to study the influence of periodontal disease and edentulism on 10-year mortality.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Of the 364 subjects aged 76, 81, and 86 years in 1990, 196 were dentate and 168 edentulous. By December 1999, 179 had died, almost half (n = 87) of them due to cardiovascular disease.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Significantly more of the edentulous subjects had elevated (> or = 3 mg/L) CRP levels as compared to those with at least 20 teeth (p < 0.01). They also had high salivary microbial counts (p < 0.05), and more mucosal lesions (p < 0.0001) than those with at least 20 teeth. In multivariate analysis, high microbial counts (OR 2.3, CI 1.06-5.05) and mucosal lesions (OR 2.18, CI 1.03-4.61) were significantly associated with elevated CRP levels. The risk for all-cause mortality was non-significantly elevated among the edentulous (RR 1.48, CI 0.95-2.31) and dentate with periodontal disease (RR 1.58, CI 0.96-2.61). CVD mortality was significantly higher among the dentate with periodontal disease (RR 1.97, CI 1.01-3.85) when compared with dentate without periodontal disease.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Among the edentulous, chronic infections like denture-related mucosal lesions are important determinants of elevated CRP, comparable to periodontal disease in the dentate. Elevated CRP per se and edentulism were not significantly associated with increased mortality. Periodontal disease was, however, still associated with a two-fold CVD mortality in this very old population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ajwani</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Dentistry, University of Helsinki, Finland. shilpi.ajwani@stonebow.otago.ac.nz</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattila</LastName><ForeName>K J</ForeName><Initials>KJ</Initials></Author><Author ValidYN="Y"><LastName>Närhi</LastName><ForeName>T O</ForeName><Initials>TO</Initials></Author><Author ValidYN="Y"><LastName>Tilvis</LastName><ForeName>R S</ForeName><Initials>RS</Initials></Author><Author ValidYN="Y"><LastName>Ainamo</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gerodontology</MedlineTA><NlmUniqueID>8215850</NlmUniqueID><ISSNLinking>0734-0664</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003753" MajorTopicYN="N">Dental Health Surveys</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003778" MajorTopicYN="N">Dentures</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005387" MajorTopicYN="N" Type="Geographic">Finland</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006304" MajorTopicYN="N">Health Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009909" MajorTopicYN="N">Oral Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009910" MajorTopicYN="N">Oral Hygiene</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>8</Month><Day>21</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>10</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>8</Month><Day>21</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12926749</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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