An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects.
Identifieur interne : 002901 ( PubMed/Curation ); précédent : 002900; suivant : 002902An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects.
Auteurs : V J Kingsmill [Royaume-Uni] ; B K B. Berkovitz ; A W BarrettSource :
- Archives of oral biology [ 0003-9969 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Bouche édentée (anatomopathologie), Cellules de Merkel (cytologie), Cellules épithéliales (anatomopathologie), Femelle, Gencive (anatomopathologie), Humains, Immunohistochimie (), Kératine-20, Kératines (analyse), Mâle, Numération cellulaire, Perte dentaire (anatomopathologie), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- analyse : Kératines.
- anatomopathologie : Bouche édentée, Cellules épithéliales, Gencive, Perte dentaire.
- cytologie : Cellules de Merkel.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Immunohistochimie, Kératine-20, Mâle, Numération cellulaire, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Keratins.
- chemical : Keratin-20.
- cytology : Merkel Cells.
- methods : Immunohistochemistry.
- pathology : Epithelial Cells, Gingiva, Mouth, Edentulous, Tooth Loss.
- Adult, Aged, Aged, 80 and over, Cell Count, Female, Humans, Male, Middle Aged.
Abstract
To investigate whether there is a difference in the density of Merkel cells between the gingiva of dentate and edentate subjects.
DOI: 10.1016/j.archoralbio.2005.02.004
PubMed: 16137497
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Berkovitz</name></author><author><name sortKey="Barrett, A W" sort="Barrett, A W" uniqKey="Barrett A" first="A W" last="Barrett">A W Barrett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16137497</idno><idno type="pmid">16137497</idno><idno type="doi">10.1016/j.archoralbio.2005.02.004</idno><idno type="wicri:Area/PubMed/Corpus">002901</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002901</idno><idno type="wicri:Area/PubMed/Curation">002901</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002901</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects.</title><author><name sortKey="Kingsmill, V J" sort="Kingsmill, V J" uniqKey="Kingsmill V" first="V J" last="Kingsmill">V J Kingsmill</name><affiliation wicri:level="1"><nlm:affiliation>Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD</wicri:regionArea></affiliation></author><author><name sortKey="Berkovitz, B K B" sort="Berkovitz, B K B" uniqKey="Berkovitz B" first="B K B" last="Berkovitz">B K B. Berkovitz</name></author><author><name sortKey="Barrett, A W" sort="Barrett, A W" uniqKey="Barrett A" first="A W" last="Barrett">A W Barrett</name></author></analytic><series><title level="j">Archives of oral biology</title><idno type="ISSN">0003-9969</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Epithelial Cells (pathology)</term><term>Female</term><term>Gingiva (pathology)</term><term>Humans</term><term>Immunohistochemistry (methods)</term><term>Keratin-20</term><term>Keratins (analysis)</term><term>Male</term><term>Merkel Cells (cytology)</term><term>Middle Aged</term><term>Mouth, Edentulous (pathology)</term><term>Tooth Loss (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bouche édentée (anatomopathologie)</term><term>Cellules de Merkel (cytologie)</term><term>Cellules épithéliales (anatomopathologie)</term><term>Femelle</term><term>Gencive (anatomopathologie)</term><term>Humains</term><term>Immunohistochimie ()</term><term>Kératine-20</term><term>Kératines (analyse)</term><term>Mâle</term><term>Numération cellulaire</term><term>Perte dentaire (anatomopathologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Keratins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Keratin-20</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Kératines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bouche édentée</term><term>Cellules épithéliales</term><term>Gencive</term><term>Perte dentaire</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules de Merkel</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Merkel Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelial Cells</term><term>Gingiva</term><term>Mouth, Edentulous</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Kératine-20</term><term>Mâle</term><term>Numération cellulaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate whether there is a difference in the density of Merkel cells between the gingiva of dentate and edentate subjects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16137497</PMID><DateCompleted><Year>2006</Year><Month>03</Month><Day>09</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0003-9969</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>10</Issue><PubDate><Year>2005</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Archives of oral biology</Title><ISOAbbreviation>Arch. Oral Biol.</ISOAbbreviation></Journal><ArticleTitle>An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects.</ArticleTitle><Pagination><MedlinePgn>883-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate whether there is a difference in the density of Merkel cells between the gingiva of dentate and edentate subjects.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One hundred and two blocks of human mandibular (n=55) and maxillary (n=47) gingiva from 69 white skinned individuals (44 males, 25 females, mean age 70.1 years, range 42--92 years) were analysed. Twenty-six individuals had teeth remaining in at least one jaw (mean age of dentate 64.5 years, edentate 72.1 years), of which 15 were dentate in both jaws. Overall, 24/55 mandibles and 17/47 maxillae were dentate. Five micrometer sections were stained with a monoclonal antibody to cytokeratin 20 (CK 20) using standard immunoperoxidase or immunoalkaline phosphatase methods. Positive cells were counted in 20 consecutive high power fields using the x 40 objective in three sections from each biopsy, and the results analysed for differences related to age, sex, site and presence of teeth.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">CK 20-positive Merkel cells were present either singly or in clusters in the basal epithelial layers, particularly at the tips of rete ridges. Numbers of gingival Merkel cells were significantly higher (p<0.005, Mann-Whitney) in edentate (cells per field mean, median, standard deviation, respectively: 1.39, 0.64, and 1.85) when compared to dentate (0.67, 0.20, and 1.21) specimens. The differences were not statistically significant for any other variable.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The data raise the possibility that reduced perception following loss of teeth may be compensated for by an increase in the local Merkel cell population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kingsmill</LastName><ForeName>V J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berkovitz</LastName><ForeName>B K B</ForeName><Initials>BK</Initials></Author><Author ValidYN="Y"><LastName>Barrett</LastName><ForeName>A W</ForeName><Initials>AW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>03</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Arch Oral Biol</MedlineTA><NlmUniqueID>0116711</NlmUniqueID><ISSNLinking>0003-9969</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C507499">KRT20 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053554">Keratin-20</NameOfSubstance></Chemical><Chemical><RegistryNumber>68238-35-7</RegistryNumber><NameOfSubstance UI="D007633">Keratins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053554" MajorTopicYN="N">Keratin-20</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007633" MajorTopicYN="N">Keratins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018862" MajorTopicYN="N">Merkel Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016388" MajorTopicYN="N">Tooth Loss</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2004</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>02</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>3</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16137497</ArticleId><ArticleId IdType="pii">S0003-9969(05)00071-3</ArticleId><ArticleId IdType="doi">10.1016/j.archoralbio.2005.02.004</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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