Cyclosporin-A inhibits the expression of cyclooxygenase-2 in gingiva.
Identifieur interne : 002369 ( PubMed/Curation ); précédent : 002368; suivant : 002370Cyclosporin-A inhibits the expression of cyclooxygenase-2 in gingiva.
Auteurs : C-Y Chiang [République populaire de Chine] ; Y-T Chen ; F-M Hung ; H-P Tu ; M M-J Fu ; E. FuSource :
- Journal of periodontal research [ 0022-3484 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Antienzymes (pharmacologie), Cellules cultivées, Cellules stromales (), Cellules stromales (enzymologie), Cellules épithéliales (), Cellules épithéliales (enzymologie), Ciclosporine (pharmacologie), Cyclooxygenase 2 (analyse), Dinoprostone (analyse), Facteur de nécrose tumorale alpha (analyse), Femelle, Fibroblastes (), Fibroblastes (enzymologie), Gencive (), Gencive (enzymologie), Humains, Inhibiteurs de la cyclooxygénase 2 (pharmacologie), Interleukine-1 bêta (analyse), Interleukine-6 (analyse), Mâchoire édentée (anatomopathologie), RT-PCR, Rat Sprague-Dawley, Rats, Technique de Western.
- MESH :
- analyse : Cyclooxygenase 2, Dinoprostone, Facteur de nécrose tumorale alpha, Interleukine-1 bêta, Interleukine-6.
- anatomopathologie : Mâchoire édentée.
- enzymologie : Cellules stromales, Cellules épithéliales, Fibroblastes, Gencive.
- pharmacologie : Antienzymes, Ciclosporine, Inhibiteurs de la cyclooxygénase 2.
- Adulte, Animaux, Cellules cultivées, Cellules stromales, Cellules épithéliales, Femelle, Fibroblastes, Gencive, Humains, RT-PCR, Rat Sprague-Dawley, Rats, Technique de Western.
English descriptors
- KwdEn :
- Adult, Animals, Blotting, Western, Cells, Cultured, Cyclooxygenase 2 (analysis), Cyclooxygenase 2 Inhibitors (pharmacology), Cyclosporine (pharmacology), Dinoprostone (analysis), Enzyme Inhibitors (pharmacology), Epithelial Cells (drug effects), Epithelial Cells (enzymology), Female, Fibroblasts (drug effects), Fibroblasts (enzymology), Gingiva (drug effects), Gingiva (enzymology), Humans, Interleukin-1beta (analysis), Interleukin-6 (analysis), Jaw, Edentulous (pathology), Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Stromal Cells (drug effects), Stromal Cells (enzymology), Tumor Necrosis Factor-alpha (analysis).
- MESH :
- chemical , analysis : Cyclooxygenase 2, Dinoprostone, Interleukin-1beta, Interleukin-6, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Cyclooxygenase 2 Inhibitors, Cyclosporine, Enzyme Inhibitors.
- drug effects : Epithelial Cells, Fibroblasts, Gingiva, Stromal Cells.
- enzymology : Epithelial Cells, Fibroblasts, Gingiva, Stromal Cells.
- pathology : Jaw, Edentulous.
- Adult, Animals, Blotting, Western, Cells, Cultured, Female, Humans, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Various inflammatory mediators are involved in the development of cyclosporine A-induced gingival overgrowth. In this study, the gingival expression of cyclooxygenase-2 after cyclosporine A therapy was examined in vivo and in vitro.
DOI: 10.1111/j.1600-0765.2006.00967.x
PubMed: 17760822
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Fu</name></author></analytic><series><title level="j">Journal of periodontal research</title><idno type="ISSN">0022-3484</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>Cells, Cultured</term><term>Cyclooxygenase 2 (analysis)</term><term>Cyclooxygenase 2 Inhibitors (pharmacology)</term><term>Cyclosporine (pharmacology)</term><term>Dinoprostone (analysis)</term><term>Enzyme Inhibitors (pharmacology)</term><term>Epithelial Cells (drug effects)</term><term>Epithelial Cells (enzymology)</term><term>Female</term><term>Fibroblasts (drug effects)</term><term>Fibroblasts (enzymology)</term><term>Gingiva (drug effects)</term><term>Gingiva (enzymology)</term><term>Humans</term><term>Interleukin-1beta (analysis)</term><term>Interleukin-6 (analysis)</term><term>Jaw, Edentulous (pathology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Stromal Cells (drug effects)</term><term>Stromal Cells (enzymology)</term><term>Tumor Necrosis Factor-alpha (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Antienzymes (pharmacologie)</term><term>Cellules cultivées</term><term>Cellules stromales ()</term><term>Cellules stromales (enzymologie)</term><term>Cellules épithéliales ()</term><term>Cellules épithéliales (enzymologie)</term><term>Ciclosporine (pharmacologie)</term><term>Cyclooxygenase 2 (analyse)</term><term>Dinoprostone (analyse)</term><term>Facteur de nécrose tumorale alpha (analyse)</term><term>Femelle</term><term>Fibroblastes ()</term><term>Fibroblastes (enzymologie)</term><term>Gencive ()</term><term>Gencive (enzymologie)</term><term>Humains</term><term>Inhibiteurs de la cyclooxygénase 2 (pharmacologie)</term><term>Interleukine-1 bêta (analyse)</term><term>Interleukine-6 (analyse)</term><term>Mâchoire édentée (anatomopathologie)</term><term>RT-PCR</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Technique de Western</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Cyclooxygenase 2</term><term>Dinoprostone</term><term>Interleukin-1beta</term><term>Interleukin-6</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclooxygenase 2 Inhibitors</term><term>Cyclosporine</term><term>Enzyme Inhibitors</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Cyclooxygenase 2</term><term>Dinoprostone</term><term>Facteur de nécrose tumorale alpha</term><term>Interleukine-1 bêta</term><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mâchoire édentée</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epithelial Cells</term><term>Fibroblasts</term><term>Gingiva</term><term>Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules stromales</term><term>Cellules épithéliales</term><term>Fibroblastes</term><term>Gencive</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Epithelial Cells</term><term>Fibroblasts</term><term>Gingiva</term><term>Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antienzymes</term><term>Ciclosporine</term><term>Inhibiteurs de la cyclooxygénase 2</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Cellules cultivées</term><term>Cellules stromales</term><term>Cellules épithéliales</term><term>Femelle</term><term>Fibroblastes</term><term>Gencive</term><term>Humains</term><term>RT-PCR</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Technique de Western</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Various inflammatory mediators are involved in the development of cyclosporine A-induced gingival overgrowth. In this study, the gingival expression of cyclooxygenase-2 after cyclosporine A therapy was examined in vivo and in vitro.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17760822</PMID><DateCompleted><Year>2007</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3484</ISSN><JournalIssue CitedMedium="Print"><Volume>42</Volume><Issue>5</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of periodontal research</Title><ISOAbbreviation>J. Periodont. Res.</ISOAbbreviation></Journal><ArticleTitle>Cyclosporin-A inhibits the expression of cyclooxygenase-2 in gingiva.</ArticleTitle><Pagination><MedlinePgn>443-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Various inflammatory mediators are involved in the development of cyclosporine A-induced gingival overgrowth. In this study, the gingival expression of cyclooxygenase-2 after cyclosporine A therapy was examined in vivo and in vitro.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">After edentulous ridges on maxilla were established, 21 Sprague-Dawley rats received cyclosporine A daily for 4 wk, and a further 21 rats received solvent. After the rats were killed, the expression of cyclooxygenase-2 mRNA, interleukin-1beta mRNA, tumor necrosis factor-alpha mRNA, and interleukin-6 mRNA was examined in the edentulous gingiva. The expression of cyclooxygenase-2 protein and the production of prostaglandin E2 were also evaluated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In cultured human gingival fibroblasts and epithelial cells, the expression of cyclooxygenase-2 mRNA was measured after treatment with cyclosporine A. Significantly lower expression of cyclooxygenase-2 and interleukin-1beta mRNA, but higher interleukin-6 expression, were observed in gingiva from cyclosporine A-treated rats than in those from the control rats. Significantly less prostaglandin E2 production was observed in cyclosporine A-treated rats. Immunohistochemistry revealed that fewer gingival stromal cells were positively stained for cyclooxygenase-2 in cyclosporine A-treated rats. In cultured cells, significantly less cyclooxygenase-2 mRNA was detected after treatment with cyclosporine A.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The expression of cyclooxygenase-2 was lower in the plaque nonretentive gingivae and the in vitro gingival cells upon treatment with cyclosporine A. Thus, we propose that cyclosporine A inhibits the expression of gingival cyclooxygenase-2.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chiang</LastName><ForeName>C-Y</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Y-T</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Hung</LastName><ForeName>F-M</ForeName><Initials>FM</Initials></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>H-P</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>M M-J</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontal Res</MedlineTA><NlmUniqueID>0055107</NlmUniqueID><ISSNLinking>0022-3484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052246">Cyclooxygenase 2 Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>K7Q1JQR04M</RegistryNumber><NameOfSubstance UI="D015232">Dinoprostone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052246" MajorTopicYN="N">Cyclooxygenase 2 Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015232" MajorTopicYN="N">Dinoprostone</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017154" MajorTopicYN="N">Stromal Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>9</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>10</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>9</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17760822</ArticleId><ArticleId IdType="pii">JRE967</ArticleId><ArticleId IdType="doi">10.1111/j.1600-0765.2006.00967.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document 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