Single nucleotide polymorphisms in HIF-1α gene and residual ridge resorption (RRR) of mandible in Korean population.
Identifieur interne : 000573 ( PubMed/Curation ); précédent : 000572; suivant : 000574Single nucleotide polymorphisms in HIF-1α gene and residual ridge resorption (RRR) of mandible in Korean population.
Auteurs : J. Paek [Corée du Sud] ; Y. Oh ; J. Kim ; J-H LeeSource :
- Gene expression [ 1052-2166 ] ; 2015.
Descripteurs français
- KwdFr :
- Femelle, Humains, Mandibule (anatomopathologie), Mâchoire édentée (anatomopathologie), Mâchoire édentée (génétique), Mâle, Population d'origine asiatique, Remodelage osseux (génétique), Résorption alvéolaire (anatomopathologie), Résorption alvéolaire (génétique), Résorption osseuse (anatomopathologie), Résorption osseuse (génétique), Sous-unité alpha du facteur-1 induit par l'hypoxie (biosynthèse), Sous-unité alpha du facteur-1 induit par l'hypoxie (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Études d'associations génétiques.
- MESH :
- anatomopathologie : Mandibule, Mâchoire édentée, Résorption alvéolaire, Résorption osseuse.
- biosynthèse : Sous-unité alpha du facteur-1 induit par l'hypoxie.
- génétique : Mâchoire édentée, Remodelage osseux, Résorption alvéolaire, Résorption osseuse, Sous-unité alpha du facteur-1 induit par l'hypoxie.
- Femelle, Humains, Mâle, Population d'origine asiatique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études d'associations génétiques.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alveolar Bone Loss (genetics), Alveolar Bone Loss (pathology), Asian Continental Ancestry Group, Bone Remodeling (genetics), Bone Resorption (genetics), Bone Resorption (pathology), Female, Genetic Association Studies, Humans, Hypoxia-Inducible Factor 1, alpha Subunit (biosynthesis), Hypoxia-Inducible Factor 1, alpha Subunit (genetics), Jaw, Edentulous (genetics), Jaw, Edentulous (pathology), Male, Mandible (pathology).
- MESH :
- chemical , biosynthesis : Hypoxia-Inducible Factor 1, alpha Subunit.
- genetics : Alveolar Bone Loss, Bone Remodeling, Bone Resorption, Hypoxia-Inducible Factor 1, alpha Subunit, Jaw, Edentulous.
- pathology : Alveolar Bone Loss, Bone Resorption, Jaw, Edentulous, Mandible.
- Aged, Aged, 80 and over, Asian Continental Ancestry Group, Female, Genetic Association Studies, Humans, Male.
Abstract
Tooth extraction is a routine surgical procedure in dental treatment. As a wound healing process after tooth extraction, a saddle-shaped residual ridge forms due to bone formation in the extraction socket and localized bone resorption on the external surface of the jawbone. The residual ridge is subjected to continuous bone resorption with substantial differences among individuals. In some cases, it results in excessive bone atrophy, which complicates dental restorative treatment. This unique oral wound healing process may be influenced by factors that are specific to oral tissue. HIF expression is different in oral wound healing compared to that of skin wounds. The objective of this study was to examine a genetic association between SNP of the HIF-1α gene, which is known to have high genetic diversity, and the residual ridge resorption (RRR). Two hundred and two Korean subjects (70.80 ± 9.40 years) with partially or completely edentulous mandible were recruited, and edentulous mandibular bone height was measured following the protocol of the American College of Prosthodontists. The HIF-1α allele was directly sequenced in 24 subjects resulting in the variants over 5% frequency in 95% likelihood, whereas tag-SNPs were selected to perform analysis for the remaining population. Student's t-test and ANOVA were used for statistical analysis to examine the association between the SNPs and the RRR. Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1α transactivity, enhancing angiogenesis and increasing new vessel formation. Thus, rs11549467 may play an important role in the disturbed bone remodeling balance resulting in RRR. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction. Most importantly, early screening using genetic information will rescue susceptible patients from the vulnerable situation of excessive jawbone atrophy where no effective prosthetic treatment is available.
DOI: 10.3727/105221615X14181440065490
PubMed: 25700369
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Kim</name></author><author><name sortKey="Lee, J H" sort="Lee, J H" uniqKey="Lee J" first="J-H" last="Lee">J-H Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25700369</idno><idno type="pmid">25700369</idno><idno type="doi">10.3727/105221615X14181440065490</idno><idno type="wicri:Area/PubMed/Corpus">000573</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000573</idno><idno type="wicri:Area/PubMed/Curation">000573</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000573</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Single nucleotide polymorphisms in HIF-1α gene and residual ridge resorption (RRR) of mandible in Korean population.</title><author><name sortKey="Paek, J" sort="Paek, J" uniqKey="Paek J" first="J" last="Paek">J. Paek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Prosthodontics, Kyung Hee University Dental Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Kyung Hee University Dental Hospital, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Y" sort="Oh, Y" uniqKey="Oh Y" first="Y" last="Oh">Y. Oh</name></author><author><name sortKey="Kim, J" sort="Kim, J" uniqKey="Kim J" first="J" last="Kim">J. Kim</name></author><author><name sortKey="Lee, J H" sort="Lee, J H" uniqKey="Lee J" first="J-H" last="Lee">J-H Lee</name></author></analytic><series><title level="j">Gene expression</title><idno type="ISSN">1052-2166</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alveolar Bone Loss (genetics)</term><term>Alveolar Bone Loss (pathology)</term><term>Asian Continental Ancestry Group</term><term>Bone Remodeling (genetics)</term><term>Bone Resorption (genetics)</term><term>Bone Resorption (pathology)</term><term>Female</term><term>Genetic Association Studies</term><term>Humans</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (biosynthesis)</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (genetics)</term><term>Jaw, Edentulous (genetics)</term><term>Jaw, Edentulous (pathology)</term><term>Male</term><term>Mandible (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mandibule (anatomopathologie)</term><term>Mâchoire édentée (anatomopathologie)</term><term>Mâchoire édentée (génétique)</term><term>Mâle</term><term>Population d'origine asiatique</term><term>Remodelage osseux (génétique)</term><term>Résorption alvéolaire (anatomopathologie)</term><term>Résorption alvéolaire (génétique)</term><term>Résorption osseuse (anatomopathologie)</term><term>Résorption osseuse (génétique)</term><term>Sous-unité alpha du facteur-1 induit par l'hypoxie (biosynthèse)</term><term>Sous-unité alpha du facteur-1 induit par l'hypoxie (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Hypoxia-Inducible Factor 1, alpha Subunit</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mandibule</term><term>Mâchoire édentée</term><term>Résorption alvéolaire</term><term>Résorption osseuse</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Sous-unité alpha du facteur-1 induit par l'hypoxie</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alveolar Bone Loss</term><term>Bone Remodeling</term><term>Bone Resorption</term><term>Hypoxia-Inducible Factor 1, alpha Subunit</term><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mâchoire édentée</term><term>Remodelage osseux</term><term>Résorption alvéolaire</term><term>Résorption osseuse</term><term>Sous-unité alpha du facteur-1 induit par l'hypoxie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Bone Loss</term><term>Bone Resorption</term><term>Jaw, Edentulous</term><term>Mandible</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Asian Continental Ancestry Group</term><term>Female</term><term>Genetic Association Studies</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Population d'origine asiatique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tooth extraction is a routine surgical procedure in dental treatment. As a wound healing process after tooth extraction, a saddle-shaped residual ridge forms due to bone formation in the extraction socket and localized bone resorption on the external surface of the jawbone. The residual ridge is subjected to continuous bone resorption with substantial differences among individuals. In some cases, it results in excessive bone atrophy, which complicates dental restorative treatment. This unique oral wound healing process may be influenced by factors that are specific to oral tissue. HIF expression is different in oral wound healing compared to that of skin wounds. The objective of this study was to examine a genetic association between SNP of the HIF-1α gene, which is known to have high genetic diversity, and the residual ridge resorption (RRR). Two hundred and two Korean subjects (70.80 ± 9.40 years) with partially or completely edentulous mandible were recruited, and edentulous mandibular bone height was measured following the protocol of the American College of Prosthodontists. The HIF-1α allele was directly sequenced in 24 subjects resulting in the variants over 5% frequency in 95% likelihood, whereas tag-SNPs were selected to perform analysis for the remaining population. Student's t-test and ANOVA were used for statistical analysis to examine the association between the SNPs and the RRR. Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1α transactivity, enhancing angiogenesis and increasing new vessel formation. Thus, rs11549467 may play an important role in the disturbed bone remodeling balance resulting in RRR. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction. Most importantly, early screening using genetic information will rescue susceptible patients from the vulnerable situation of excessive jawbone atrophy where no effective prosthetic treatment is available.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25700369</PMID><DateCompleted><Year>2015</Year><Month>04</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1052-2166</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>3</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Gene expression</Title><ISOAbbreviation>Gene Expr.</ISOAbbreviation></Journal><ArticleTitle>Single nucleotide polymorphisms in HIF-1α gene and residual ridge resorption (RRR) of mandible in Korean population.</ArticleTitle><Pagination><MedlinePgn>137-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3727/105221615X14181440065490</ELocationID><Abstract><AbstractText>Tooth extraction is a routine surgical procedure in dental treatment. As a wound healing process after tooth extraction, a saddle-shaped residual ridge forms due to bone formation in the extraction socket and localized bone resorption on the external surface of the jawbone. The residual ridge is subjected to continuous bone resorption with substantial differences among individuals. In some cases, it results in excessive bone atrophy, which complicates dental restorative treatment. This unique oral wound healing process may be influenced by factors that are specific to oral tissue. HIF expression is different in oral wound healing compared to that of skin wounds. The objective of this study was to examine a genetic association between SNP of the HIF-1α gene, which is known to have high genetic diversity, and the residual ridge resorption (RRR). Two hundred and two Korean subjects (70.80 ± 9.40 years) with partially or completely edentulous mandible were recruited, and edentulous mandibular bone height was measured following the protocol of the American College of Prosthodontists. The HIF-1α allele was directly sequenced in 24 subjects resulting in the variants over 5% frequency in 95% likelihood, whereas tag-SNPs were selected to perform analysis for the remaining population. Student's t-test and ANOVA were used for statistical analysis to examine the association between the SNPs and the RRR. Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1α transactivity, enhancing angiogenesis and increasing new vessel formation. Thus, rs11549467 may play an important role in the disturbed bone remodeling balance resulting in RRR. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction. Most importantly, early screening using genetic information will rescue susceptible patients from the vulnerable situation of excessive jawbone atrophy where no effective prosthetic treatment is available.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Paek</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Prosthodontics, Kyung Hee University Dental Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>J-H</ForeName><Initials>JH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gene Expr</MedlineTA><NlmUniqueID>9200651</NlmUniqueID><ISSNLinking>1052-2166</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497442">HIF1A protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051795">Hypoxia-Inducible Factor 1, alpha Subunit</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044466" MajorTopicYN="N">Asian Continental Ancestry Group</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016723" MajorTopicYN="N">Bone Remodeling</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001862" MajorTopicYN="N">Bone Resorption</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056726" MajorTopicYN="N">Genetic Association Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051795" MajorTopicYN="N">Hypoxia-Inducible Factor 1, alpha Subunit</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25700369</ArticleId><ArticleId IdType="doi">10.3727/105221615X14181440065490</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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