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Deficiency of salivary PAF in edentulous individuals.

Identifieur interne : 004A47 ( PubMed/Corpus ); précédent : 004A46; suivant : 004A48

Deficiency of salivary PAF in edentulous individuals.

Auteurs : L M Mcmanus ; B T Marze ; A V Schiess

Source :

Journal of periodontal research [ 0022-3484 ] ; 1990.

RBID : pubmed:2148947

English descriptors

KwdEn :
- Adult, Aged, Biological Assay, Chromatography, Thin Layer, Female, Humans, Male, Middle Aged, Mouth, Edentulous (metabolism), Neutrophils (chemistry), Periodontitis (physiopathology), Periodontium (chemistry), Platelet Activating Factor (analysis), Platelet Activating Factor (deficiency), Platelet Activating Factor (physiology), Saliva (chemistry).
MESH :
- chemical , analysis : Platelet Activating Factor.
- chemistry : Neutrophils, Periodontium, Saliva.
- chemical , deficiency : Platelet Activating Factor.
- metabolism : Mouth, Edentulous.
- chemical , physiology : Platelet Activating Factor.
- physiopathology : Periodontitis.
- Adult, Aged, Biological Assay, Chromatography, Thin Layer, Female, Humans, Male, Middle Aged.

Abstract

PAF, a potent phospholipid mediator of inflammation, is present in normal human, mixed saliva. However, the anatomic origin of PAF is not known. In this study, PAF levels in mixed saliva of edentulous subjects were estimated in comparison to that of dentate individuals. PAF activity was assessed in bioassay and expressed relative to the activity of known amounts of authentic PAF, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC). PAF was not detected in the saliva of 60% of the edentulous subjects; moreover, when present, the PAF levels were significantly less (635 +/- 82 AGEPC fmole equivalents/ml saliva, mean +/- SEM, n = 6) than in dentate subjects (5568 +/- 1135 AGEPC fmole equivalents/ml saliva, n = 27). Of relevance, the numbers of polymorphonuclear leukocytes in the mixed saliva samples of edentulous subjects were markedly reduced when compared to those of normal subjects. These findings suggest that salivary PAF most likely originates from the crevicular space, and derives from inflammatory cells within the gingival and/or periodontal tissues.

PubMed: 2148947

Links to Exploration step

pubmed:2148947

Le document en format XML

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<author><name sortKey="Mcmanus, L M" sort="Mcmanus, L M" uniqKey="Mcmanus L" first="L M" last="Mcmanus">L M Mcmanus</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Texas Health Science Center, San Antonio.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marze, B T" sort="Marze, B T" uniqKey="Marze B" first="B T" last="Marze">B T Marze</name>
</author>
<author><name sortKey="Schiess, A V" sort="Schiess, A V" uniqKey="Schiess A" first="A V" last="Schiess">A V Schiess</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Deficiency of salivary PAF in edentulous individuals.</title>
<author><name sortKey="Mcmanus, L M" sort="Mcmanus, L M" uniqKey="Mcmanus L" first="L M" last="Mcmanus">L M Mcmanus</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Texas Health Science Center, San Antonio.</nlm:affiliation>
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<author><name sortKey="Marze, B T" sort="Marze, B T" uniqKey="Marze B" first="B T" last="Marze">B T Marze</name>
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<author><name sortKey="Schiess, A V" sort="Schiess, A V" uniqKey="Schiess A" first="A V" last="Schiess">A V Schiess</name>
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<series><title level="j">Journal of periodontal research</title>
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<term>Aged</term>
<term>Biological Assay</term>
<term>Chromatography, Thin Layer</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mouth, Edentulous (metabolism)</term>
<term>Neutrophils (chemistry)</term>
<term>Periodontitis (physiopathology)</term>
<term>Periodontium (chemistry)</term>
<term>Platelet Activating Factor (analysis)</term>
<term>Platelet Activating Factor (deficiency)</term>
<term>Platelet Activating Factor (physiology)</term>
<term>Saliva (chemistry)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Platelet Activating Factor</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Neutrophils</term>
<term>Periodontium</term>
<term>Saliva</term>
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<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Platelet Activating Factor</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mouth, Edentulous</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Platelet Activating Factor</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Biological Assay</term>
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<front><div type="abstract" xml:lang="en">PAF, a potent phospholipid mediator of inflammation, is present in normal human, mixed saliva. However, the anatomic origin of PAF is not known. In this study, PAF levels in mixed saliva of edentulous subjects were estimated in comparison to that of dentate individuals. PAF activity was assessed in bioassay and expressed relative to the activity of known amounts of authentic PAF, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC). PAF was not detected in the saliva of 60% of the edentulous subjects; moreover, when present, the PAF levels were significantly less (635 +/- 82 AGEPC fmole equivalents/ml saliva, mean +/- SEM, n = 6) than in dentate subjects (5568 +/- 1135 AGEPC fmole equivalents/ml saliva, n = 27). Of relevance, the numbers of polymorphonuclear leukocytes in the mixed saliva samples of edentulous subjects were markedly reduced when compared to those of normal subjects. These findings suggest that salivary PAF most likely originates from the crevicular space, and derives from inflammatory cells within the gingival and/or periodontal tissues.</div>
</front>
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<DateCompleted><Year>1991</Year>
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<DateRevised><Year>2007</Year>
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<Title>Journal of periodontal research</Title>
<ISOAbbreviation>J. Periodont. Res.</ISOAbbreviation>
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<ArticleTitle>Deficiency of salivary PAF in edentulous individuals.</ArticleTitle>
<Pagination><MedlinePgn>347-51</MedlinePgn>
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<Abstract><AbstractText>PAF, a potent phospholipid mediator of inflammation, is present in normal human, mixed saliva. However, the anatomic origin of PAF is not known. In this study, PAF levels in mixed saliva of edentulous subjects were estimated in comparison to that of dentate individuals. PAF activity was assessed in bioassay and expressed relative to the activity of known amounts of authentic PAF, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC). PAF was not detected in the saliva of 60% of the edentulous subjects; moreover, when present, the PAF levels were significantly less (635 +/- 82 AGEPC fmole equivalents/ml saliva, mean +/- SEM, n = 6) than in dentate subjects (5568 +/- 1135 AGEPC fmole equivalents/ml saliva, n = 27). Of relevance, the numbers of polymorphonuclear leukocytes in the mixed saliva samples of edentulous subjects were markedly reduced when compared to those of normal subjects. These findings suggest that salivary PAF most likely originates from the crevicular space, and derives from inflammatory cells within the gingival and/or periodontal tissues.</AbstractText>
</Abstract>
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<ForeName>L M</ForeName>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
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<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
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<MeshHeading><DescriptorName UI="D010519" MajorTopicYN="N">Periodontium</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
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<MeshHeading><DescriptorName UI="D010972" MajorTopicYN="N">Platelet Activating Factor</DescriptorName>
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<QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
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Deficiency of salivary PAF in edentulous individuals.

Deficiency of salivary PAF in edentulous individuals.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki