Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study.
Identifieur interne : 003653 ( PubMed/Corpus ); précédent : 003652; suivant : 003654Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study.
Auteurs : J P Van Den Bergh ; C M Ten Bruggenkate ; H H Groeneveld ; E H Burger ; D B TuinzingSource :
- Journal of clinical periodontology [ 0303-6979 ] ; 2000.
English descriptors
- KwdEn :
- Biopsy, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins (therapeutic use), Bone Transplantation (methods), Dental Implantation, Endosseous, Female, Humans, Jaw, Edentulous, Partially (pathology), Jaw, Edentulous, Partially (surgery), Male, Maxilla, Maxillary Sinus (diagnostic imaging), Maxillary Sinus (pathology), Maxillary Sinus (surgery), Middle Aged, Pilot Projects, Prospective Studies, Radiography, Recombinant Proteins (therapeutic use), Transforming Growth Factor beta (therapeutic use), Transplantation, Autologous.
- MESH :
- chemical , therapeutic use : Bone Morphogenetic Proteins, Recombinant Proteins, Transforming Growth Factor beta.
- chemical : Bone Morphogenetic Protein 7.
- diagnostic imaging : Maxillary Sinus.
- methods : Bone Transplantation.
- pathology : Jaw, Edentulous, Partially, Maxillary Sinus.
- surgery : Jaw, Edentulous, Partially, Maxillary Sinus.
- Biopsy, Dental Implantation, Endosseous, Female, Humans, Male, Maxilla, Middle Aged, Pilot Projects, Prospective Studies, Radiography, Transplantation, Autologous.
Abstract
This pilot study was designed to determine the clinical bone formation ability of a human recombinant DNA bone morphogenetic protein-7, also referred to as Osteogenic Protein-1 [OP-1] combined with a collagen carrier, implanted in the maxillary sinus of 3 patients. The results were compared with a group of 3 patients treated with sinus floor elevation and autogenous bone grafts.
PubMed: 10983596
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study.</title><author><name sortKey="Van Den Bergh, J P" sort="Van Den Bergh, J P" uniqKey="Van Den Bergh J" first="J P" last="Van Den Bergh">J P Van Den Bergh</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, ACTA, Vrije Universiteit, Amsterdam, The Netherlands. kaakchirurgie@antonius.net</nlm:affiliation></affiliation></author><author><name sortKey="Ten Bruggenkate, C M" sort="Ten Bruggenkate, C M" uniqKey="Ten Bruggenkate C" first="C M" last="Ten Bruggenkate">C M Ten Bruggenkate</name></author><author><name sortKey="Groeneveld, H H" sort="Groeneveld, H H" uniqKey="Groeneveld H" first="H H" last="Groeneveld">H H Groeneveld</name></author><author><name sortKey="Burger, E H" sort="Burger, E H" uniqKey="Burger E" first="E H" last="Burger">E H Burger</name></author><author><name sortKey="Tuinzing, D B" sort="Tuinzing, D B" uniqKey="Tuinzing D" first="D B" last="Tuinzing">D B Tuinzing</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10983596</idno><idno type="pmid">10983596</idno><idno type="wicri:Area/PubMed/Corpus">003653</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study.</title><author><name sortKey="Van Den Bergh, J P" sort="Van Den Bergh, J P" uniqKey="Van Den Bergh J" first="J P" last="Van Den Bergh">J P Van Den Bergh</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, ACTA, Vrije Universiteit, Amsterdam, The Netherlands. kaakchirurgie@antonius.net</nlm:affiliation></affiliation></author><author><name sortKey="Ten Bruggenkate, C M" sort="Ten Bruggenkate, C M" uniqKey="Ten Bruggenkate C" first="C M" last="Ten Bruggenkate">C M Ten Bruggenkate</name></author><author><name sortKey="Groeneveld, H H" sort="Groeneveld, H H" uniqKey="Groeneveld H" first="H H" last="Groeneveld">H H Groeneveld</name></author><author><name sortKey="Burger, E H" sort="Burger, E H" uniqKey="Burger E" first="E H" last="Burger">E H Burger</name></author><author><name sortKey="Tuinzing, D B" sort="Tuinzing, D B" uniqKey="Tuinzing D" first="D B" last="Tuinzing">D B Tuinzing</name></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="ISSN">0303-6979</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biopsy</term><term>Bone Morphogenetic Protein 7</term><term>Bone Morphogenetic Proteins (therapeutic use)</term><term>Bone Transplantation (methods)</term><term>Dental Implantation, Endosseous</term><term>Female</term><term>Humans</term><term>Jaw, Edentulous, Partially (pathology)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Male</term><term>Maxilla</term><term>Maxillary Sinus (diagnostic imaging)</term><term>Maxillary Sinus (pathology)</term><term>Maxillary Sinus (surgery)</term><term>Middle Aged</term><term>Pilot Projects</term><term>Prospective Studies</term><term>Radiography</term><term>Recombinant Proteins (therapeutic use)</term><term>Transforming Growth Factor beta (therapeutic use)</term><term>Transplantation, Autologous</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Morphogenetic Proteins</term><term>Recombinant Proteins</term><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bone Morphogenetic Protein 7</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Maxillary Sinus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Bone Transplantation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous, Partially</term><term>Maxillary Sinus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term><term>Maxillary Sinus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Dental Implantation, Endosseous</term><term>Female</term><term>Humans</term><term>Male</term><term>Maxilla</term><term>Middle Aged</term><term>Pilot Projects</term><term>Prospective Studies</term><term>Radiography</term><term>Transplantation, Autologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This pilot study was designed to determine the clinical bone formation ability of a human recombinant DNA bone morphogenetic protein-7, also referred to as Osteogenic Protein-1 [OP-1] combined with a collagen carrier, implanted in the maxillary sinus of 3 patients. The results were compared with a group of 3 patients treated with sinus floor elevation and autogenous bone grafts.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10983596</PMID><DateCompleted><Year>2001</Year><Month>01</Month><Day>03</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0303-6979</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>9</Issue><PubDate><Year>2000</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of clinical periodontology</Title><ISOAbbreviation>J. Clin. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study.</ArticleTitle><Pagination><MedlinePgn>627-36</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">This pilot study was designed to determine the clinical bone formation ability of a human recombinant DNA bone morphogenetic protein-7, also referred to as Osteogenic Protein-1 [OP-1] combined with a collagen carrier, implanted in the maxillary sinus of 3 patients. The results were compared with a group of 3 patients treated with sinus floor elevation and autogenous bone grafts.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">6 consecutive patients, 4 female and 2 male, between 48 and 57 years of age were treated by means of sinus floor elevation for insufficient bone height in the posterior maxilla for implant surgery. 3 patients, 2 female and 1 male, were treated with OP-1 attached to a collagen device. In these patients, 4 maxillary sinus grafting procedures according to Tatum's method were carried out. 1 g of collagen carrier containing 2.5 mg rhOP-1 mixed with 3 ml of saline was placed between the bony floor and the elevated mucosal lining of the most caudal part of the maxillary sinus, in order to increase the vertical bone dimension to place dental implants of a sufficient length. The 3 other patients, also 2 female and 1 male, with a total of 5 sinus sites, were treated with sinus floor elevation and autogenous iliac crest bone grafts. After 6 months, during dental implant preparation, bone cores were taken for histology. Thus, clinical, radiological and histological results of the 2 groups of 3 patients were compared.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">6 months after sinus grafting with OP-1, in 1 male, well-vascularized bone-like tissue of good quality was observed clinically. This could be confirmed by histology. In the second, female, patient no bone formation was observed at all. A cyst-like granular tissue mass, without purulent content, was removed. In the 3rd, female, patient, who received bilateral sinus grafts, some bone-like formation was seen, however it showed flexible tissue which led to the decision that at 6 months after the sinus grafting, the implant placement had to be postponed. In all 5 autogenous grafted sinuses a bone appearance similar to normal maxillary bone was observed clinically as well as histologically and dental implants could be placed six months after sinus floor elevation surgery.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings indicate that the OP-1 device has the potential for initiating bone formation in the human maxillary sinus within 6 months after a sinus floor elevation operation. However, the various findings in these 3 patients indicate that the behaviour of the material is at this moment insufficiently predictable, in this indication area. Further investigation is indicated before OP-1 can be successfully used instead of the "gold standard" autogenous bone graft.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van den Bergh</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, ACTA, Vrije Universiteit, Amsterdam, The Netherlands. kaakchirurgie@antonius.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>ten Bruggenkate</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Groeneveld</LastName><ForeName>H H</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Burger</LastName><ForeName>E H</ForeName><Initials>EH</Initials></Author><Author ValidYN="Y"><LastName>Tuinzing</LastName><ForeName>D B</ForeName><Initials>DB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Periodontol</MedlineTA><NlmUniqueID>0425123</NlmUniqueID><ISSNLinking>0303-6979</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C525819">BMP7 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055419">Bone Morphogenetic Protein 7</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019485">Bone Morphogenetic Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016212">Transforming Growth Factor beta</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055419" MajorTopicYN="N">Bone Morphogenetic Protein 7</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019485" MajorTopicYN="N">Bone Morphogenetic Proteins</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016025" MajorTopicYN="N">Bone Transplantation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008437" MajorTopicYN="N">Maxilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008443" MajorTopicYN="N">Maxillary Sinus</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016212" MajorTopicYN="N">Transforming Growth Factor beta</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014182" MajorTopicYN="N">Transplantation, Autologous</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>9</Month><Day>13</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>2</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>9</Month><Day>13</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10983596</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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