Cyclosporin-induced gingival overgrowth at the newly formed edentulous ridge in rats: a morphological and histometric evaluation.
Identifieur interne : 003443 ( PubMed/Corpus ); précédent : 003442; suivant : 003444Cyclosporin-induced gingival overgrowth at the newly formed edentulous ridge in rats: a morphological and histometric evaluation.
Auteurs : E. Fu ; Y D Hsieh ; E C Shen ; S. Nieh ; T K Mao ; C Y ChiangSource :
- Journal of periodontology [ 0022-3492 ] ; 2001.
English descriptors
- KwdEn :
- Alveolar Process (drug effects), Alveolar Process (pathology), Analysis of Variance, Animals, Bone Matrix (drug effects), Bone Matrix (pathology), Coloring Agents, Connective Tissue (drug effects), Connective Tissue (pathology), Cyclosporine (adverse effects), Dental Models, Epithelium (drug effects), Epithelium (pathology), Gingiva (drug effects), Gingiva (pathology), Gingival Overgrowth (chemically induced), Gingival Overgrowth (pathology), Image Processing, Computer-Assisted, Immunosuppressive Agents (adverse effects), Jaw, Edentulous (pathology), Jaw, Edentulous (physiopathology), Male, Rats, Rats, Sprague-Dawley, Tolonium Chloride.
- MESH :
- chemical , adverse effects : Cyclosporine, Immunosuppressive Agents.
- chemical : Coloring Agents, Tolonium Chloride.
- chemically induced : Gingival Overgrowth.
- drug effects : Alveolar Process, Bone Matrix, Connective Tissue, Epithelium, Gingiva.
- pathology : Alveolar Process, Bone Matrix, Connective Tissue, Epithelium, Gingiva, Gingival Overgrowth, Jaw, Edentulous.
- physiopathology : Jaw, Edentulous.
- Analysis of Variance, Animals, Dental Models, Image Processing, Computer-Assisted, Male, Rats, Rats, Sprague-Dawley.
Abstract
Since cyclosporin A (CsA)-induced overgrowth seldom occurs at sites distant from teeth, the periodontal ligament has been considered significant. The aim of this study was to examine overgrowth occurrence at the edentulous ridge--the sites without the ligament--after CsA therapy in rats.
DOI: 10.1902/jop.2001.72.7.889
PubMed: 11495137
Links to Exploration step
pubmed:11495137Le document en format XML
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Nieh</name></author><author><name sortKey="Mao, T K" sort="Mao, T K" uniqKey="Mao T" first="T K" last="Mao">T K Mao</name></author><author><name sortKey="Chiang, C Y" sort="Chiang, C Y" uniqKey="Chiang C" first="C Y" last="Chiang">C Y Chiang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11495137</idno><idno type="pmid">11495137</idno><idno type="doi">10.1902/jop.2001.72.7.889</idno><idno type="wicri:Area/PubMed/Corpus">003443</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003443</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cyclosporin-induced gingival overgrowth at the newly formed edentulous ridge in rats: a morphological and histometric evaluation.</title><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name><affiliation><nlm:affiliation>Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC. dentalab@tpts5.seed.net.tw</nlm:affiliation></affiliation></author><author><name sortKey="Hsieh, Y D" sort="Hsieh, Y D" uniqKey="Hsieh Y" first="Y D" last="Hsieh">Y D Hsieh</name></author><author><name sortKey="Shen, E C" sort="Shen, E C" uniqKey="Shen E" first="E C" last="Shen">E C Shen</name></author><author><name sortKey="Nieh, S" sort="Nieh, S" uniqKey="Nieh S" first="S" last="Nieh">S. Nieh</name></author><author><name sortKey="Mao, T K" sort="Mao, T K" uniqKey="Mao T" first="T K" last="Mao">T K Mao</name></author><author><name sortKey="Chiang, C Y" sort="Chiang, C Y" uniqKey="Chiang C" first="C Y" last="Chiang">C Y Chiang</name></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Process (drug effects)</term><term>Alveolar Process (pathology)</term><term>Analysis of Variance</term><term>Animals</term><term>Bone Matrix (drug effects)</term><term>Bone Matrix (pathology)</term><term>Coloring Agents</term><term>Connective Tissue (drug effects)</term><term>Connective Tissue (pathology)</term><term>Cyclosporine (adverse effects)</term><term>Dental Models</term><term>Epithelium (drug effects)</term><term>Epithelium (pathology)</term><term>Gingiva (drug effects)</term><term>Gingiva (pathology)</term><term>Gingival Overgrowth (chemically induced)</term><term>Gingival Overgrowth (pathology)</term><term>Image Processing, Computer-Assisted</term><term>Immunosuppressive Agents (adverse effects)</term><term>Jaw, Edentulous (pathology)</term><term>Jaw, Edentulous (physiopathology)</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Tolonium Chloride</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cyclosporine</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Coloring Agents</term><term>Tolonium Chloride</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Gingival Overgrowth</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Alveolar Process</term><term>Bone Matrix</term><term>Connective Tissue</term><term>Epithelium</term><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term><term>Bone Matrix</term><term>Connective Tissue</term><term>Epithelium</term><term>Gingiva</term><term>Gingival Overgrowth</term><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Dental Models</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since cyclosporin A (CsA)-induced overgrowth seldom occurs at sites distant from teeth, the periodontal ligament has been considered significant. The aim of this study was to examine overgrowth occurrence at the edentulous ridge--the sites without the ligament--after CsA therapy in rats.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11495137</PMID><DateCompleted><Year>2001</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3492</ISSN><JournalIssue CitedMedium="Print"><Volume>72</Volume><Issue>7</Issue><PubDate><Year>2001</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of periodontology</Title><ISOAbbreviation>J. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Cyclosporin-induced gingival overgrowth at the newly formed edentulous ridge in rats: a morphological and histometric evaluation.</ArticleTitle><Pagination><MedlinePgn>889-94</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since cyclosporin A (CsA)-induced overgrowth seldom occurs at sites distant from teeth, the periodontal ligament has been considered significant. The aim of this study was to examine overgrowth occurrence at the edentulous ridge--the sites without the ligament--after CsA therapy in rats.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">After extracting all right maxillary molars, 16 Sprague-Dawley rats underwent a 2-week healing period. The animals were separated into CsA and control groups. CsA rats received 15 mg/kg of CsA by gastric feeding for 4 weeks, while the control group received only mineral oil. At the end of study, all animals were sacrificed and stone models were immediately obtained by rubber-based impressions. The edentulous ridge morphology, including the bucco-lingual width and the vertical height, was measured on the models. For histometry, 10 sections were selected from the edentulous ridge of each animal after undecalcified tissue preparation. The soft tissue areas of the edentulous ridge and the trabecular bone morphology of the dental alveolus were measured.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">CsA therapy produced a significant increase of the ridge width and height, measured from the stone models, when compared to the control group. Under histometry, CsA resulted in a significant increase of the epithelium, connective tissue, and total soft tissue areas. The measured trabecular bone volume was affected by both examining factors: the drug therapy and the location of the dental alveolus. CsA therapy produced a significant loss of bone volume but a significant increase of the bone-specific surface area. Although the mean osteoid volume was similar between CsA and control groups, a significant decrease of the fractional formation surface in the CsA group was revealed.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">An enlarged edentulous ridge and an altered dental alveolar bone morphology were observed in CsA-treated animals at the end of the study; therefore, we suggest that CsA may induce not only a soft tissue overgrowth but also an alveolar bone alteration at the edentulous ridge. The hypothesis that tooth or periodontal ligament is an essential component for the overgrowth development is questioned.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC. dentalab@tpts5.seed.net.tw</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsieh</LastName><ForeName>Y D</ForeName><Initials>YD</Initials></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>E C</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Nieh</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>T K</ForeName><Initials>TK</Initials></Author><Author ValidYN="Y"><LastName>Chiang</LastName><ForeName>C Y</ForeName><Initials>CY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontol</MedlineTA><NlmUniqueID>8000345</NlmUniqueID><ISSNLinking>0022-3492</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004396">Coloring Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>15XUH0X66N</RegistryNumber><NameOfSubstance UI="D014048">Tolonium Chloride</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000539" MajorTopicYN="N">Alveolar Process</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001857" MajorTopicYN="N">Bone Matrix</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004396" MajorTopicYN="N">Coloring Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003238" MajorTopicYN="N">Connective Tissue</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003765" MajorTopicYN="N">Dental Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019214" MajorTopicYN="N">Gingival Overgrowth</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014048" MajorTopicYN="N">Tolonium Chloride</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>8</Month><Day>10</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>10</Month><Day>26</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>8</Month><Day>10</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11495137</ArticleId><ArticleId 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