Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans.
Identifieur interne : 002D46 ( PubMed/Corpus ); précédent : 002D45; suivant : 002D47Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans.
Auteurs : Marco Degidi ; Maurizio Piattelli ; Antonio Scarano ; Giovanna Iezzi ; Adriano PiattelliSource :
- The Journal of oral implantology [ 0160-6972 ] ; 2004.
English descriptors
- KwdEn :
- Aged, Alveolar Ridge Augmentation (methods), Animals, Bone Marrow (pathology), Bone Matrix (transplantation), Bone Substitutes (therapeutic use), Bone Transplantation (pathology), Cattle, Dental Implants, Female, Follow-Up Studies, Humans, Jaw, Edentulous (surgery), Jaw, Edentulous, Partially (surgery), Male, Maxilla (pathology), Maxilla (surgery), Maxillary Sinus (pathology), Maxillary Sinus (surgery), Middle Aged, Minerals (therapeutic use), Osteogenesis (physiology).
- MESH :
- chemical , therapeutic use : Bone Substitutes, Minerals.
- methods : Alveolar Ridge Augmentation.
- pathology : Bone Marrow, Bone Transplantation, Maxilla, Maxillary Sinus.
- physiology : Osteogenesis.
- surgery : Jaw, Edentulous, Jaw, Edentulous, Partially, Maxilla, Maxillary Sinus.
- transplantation : Bone Matrix.
- Aged, Animals, Cattle, Dental Implants, Female, Follow-Up Studies, Humans, Male, Middle Aged.
Abstract
Bone substitutes should be used when sufficient amounts of autologous bone cannot be harvested from intraoral donor sites. P-15 is a highly conserved linear peptide with a 15 amino acid sequence identical to the sequence contained in the residues 766 to 780 of the alpha-chain of type I collagen. PepGen P-15 (Dentsply Friadent, Mannheim, Germany) is a combination of the mineral component of bovine bone (Osteograf/N 300) with P-15. Bio-Oss (Geistlich, Mannheim, Germany) is a deproteinized sterilized bovine bone with 75% to 80% porosity and a crystal size of approximately 10 microm in the form of cortical granules. The purpose of the present histological and histomorphometrical study was to compare maxillary sinus augmentation procedures in humans performed with PepGen P-15 with procedures associated with Bio-Oss and autologous bone. Seven patients participated in this study (3 men and 4 women; ages between 48 and 69 years, mean of 58 years) and were categorized into 3 groups. In group 1, a mixture of 50% autologous bone from an intraoral source and 50% Bio-Oss was used. In group 2, the graft materials used were 50% Bio-Oss and 50% PepGen P-15. In group 3, 50% autologous bone and 50% PepGen P-15 were used. Group 1 histomorphometry showed that the percentage of newly formed bone was 38.7% +/- 3.2%, marrow spaces represented 45.6% +/- 5%, and residual graft particles constituted the remaining 14.4% +/- 2.1%. Group 2 histomorphometry showed that newly formed bone represented 36.7% +/- 3.3%, marrow spaces represented 39.7% +/- 3.4%, and residual graft particles represented 19.6% +/- 2.1%. In group 3, newly formed bone represented 32.2% +/- 3.2%, marrow spaces represented 38% +/- 2.5%, and residual graft particles represented 28.8% +/- 1.1%. Non-statistically significant differences were found in the percentage of newly formed bone in the different groups (P = .360). Statistically significant differences were found in the percentage of residual graft materials among the different groups (group 1 vs groups 2 and 3) (P = .0001). These data demonstrate that the use of bone-replacement materials, without the addition of autologous bone, could be an alternative in sinus augmentation procedures. Such treatment would increase patient satisfaction, decrease surgical complications, and save the clinician substantial operating time.
DOI: 10.1563/0720.1
PubMed: 15641457
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans.</title><author><name sortKey="Degidi, Marco" sort="Degidi, Marco" uniqKey="Degidi M" first="Marco" last="Degidi">Marco Degidi</name><affiliation><nlm:affiliation>Dental School, University of Chieti, Chieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Piattelli, Maurizio" sort="Piattelli, Maurizio" uniqKey="Piattelli M" first="Maurizio" last="Piattelli">Maurizio Piattelli</name></author><author><name sortKey="Scarano, Antonio" sort="Scarano, Antonio" uniqKey="Scarano A" first="Antonio" last="Scarano">Antonio Scarano</name></author><author><name sortKey="Iezzi, Giovanna" sort="Iezzi, Giovanna" uniqKey="Iezzi G" first="Giovanna" last="Iezzi">Giovanna Iezzi</name></author><author><name sortKey="Piattelli, Adriano" sort="Piattelli, Adriano" uniqKey="Piattelli A" first="Adriano" last="Piattelli">Adriano Piattelli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15641457</idno><idno type="pmid">15641457</idno><idno type="doi">10.1563/0720.1</idno><idno type="wicri:Area/PubMed/Corpus">002D46</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans.</title><author><name sortKey="Degidi, Marco" sort="Degidi, Marco" uniqKey="Degidi M" first="Marco" last="Degidi">Marco Degidi</name><affiliation><nlm:affiliation>Dental School, University of Chieti, Chieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Piattelli, Maurizio" sort="Piattelli, Maurizio" uniqKey="Piattelli M" first="Maurizio" last="Piattelli">Maurizio Piattelli</name></author><author><name sortKey="Scarano, Antonio" sort="Scarano, Antonio" uniqKey="Scarano A" first="Antonio" last="Scarano">Antonio Scarano</name></author><author><name sortKey="Iezzi, Giovanna" sort="Iezzi, Giovanna" uniqKey="Iezzi G" first="Giovanna" last="Iezzi">Giovanna Iezzi</name></author><author><name sortKey="Piattelli, Adriano" sort="Piattelli, Adriano" uniqKey="Piattelli A" first="Adriano" last="Piattelli">Adriano Piattelli</name></author></analytic><series><title level="j">The Journal of oral implantology</title><idno type="ISSN">0160-6972</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alveolar Ridge Augmentation (methods)</term><term>Animals</term><term>Bone Marrow (pathology)</term><term>Bone Matrix (transplantation)</term><term>Bone Substitutes (therapeutic use)</term><term>Bone Transplantation (pathology)</term><term>Cattle</term><term>Dental Implants</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Jaw, Edentulous (surgery)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Male</term><term>Maxilla (pathology)</term><term>Maxilla (surgery)</term><term>Maxillary Sinus (pathology)</term><term>Maxillary Sinus (surgery)</term><term>Middle Aged</term><term>Minerals (therapeutic use)</term><term>Osteogenesis (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Substitutes</term><term>Minerals</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone Marrow</term><term>Bone Transplantation</term><term>Maxilla</term><term>Maxillary Sinus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous</term><term>Jaw, Edentulous, Partially</term><term>Maxilla</term><term>Maxillary Sinus</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Bone Matrix</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Animals</term><term>Cattle</term><term>Dental Implants</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone substitutes should be used when sufficient amounts of autologous bone cannot be harvested from intraoral donor sites. P-15 is a highly conserved linear peptide with a 15 amino acid sequence identical to the sequence contained in the residues 766 to 780 of the alpha-chain of type I collagen. PepGen P-15 (Dentsply Friadent, Mannheim, Germany) is a combination of the mineral component of bovine bone (Osteograf/N 300) with P-15. Bio-Oss (Geistlich, Mannheim, Germany) is a deproteinized sterilized bovine bone with 75% to 80% porosity and a crystal size of approximately 10 microm in the form of cortical granules. The purpose of the present histological and histomorphometrical study was to compare maxillary sinus augmentation procedures in humans performed with PepGen P-15 with procedures associated with Bio-Oss and autologous bone. Seven patients participated in this study (3 men and 4 women; ages between 48 and 69 years, mean of 58 years) and were categorized into 3 groups. In group 1, a mixture of 50% autologous bone from an intraoral source and 50% Bio-Oss was used. In group 2, the graft materials used were 50% Bio-Oss and 50% PepGen P-15. In group 3, 50% autologous bone and 50% PepGen P-15 were used. Group 1 histomorphometry showed that the percentage of newly formed bone was 38.7% +/- 3.2%, marrow spaces represented 45.6% +/- 5%, and residual graft particles constituted the remaining 14.4% +/- 2.1%. Group 2 histomorphometry showed that newly formed bone represented 36.7% +/- 3.3%, marrow spaces represented 39.7% +/- 3.4%, and residual graft particles represented 19.6% +/- 2.1%. In group 3, newly formed bone represented 32.2% +/- 3.2%, marrow spaces represented 38% +/- 2.5%, and residual graft particles represented 28.8% +/- 1.1%. Non-statistically significant differences were found in the percentage of newly formed bone in the different groups (P = .360). Statistically significant differences were found in the percentage of residual graft materials among the different groups (group 1 vs groups 2 and 3) (P = .0001). These data demonstrate that the use of bone-replacement materials, without the addition of autologous bone, could be an alternative in sinus augmentation procedures. Such treatment would increase patient satisfaction, decrease surgical complications, and save the clinician substantial operating time.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15641457</PMID><DateCompleted><Year>2005</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0160-6972</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2004</Year></PubDate></JournalIssue><Title>The Journal of oral implantology</Title><ISOAbbreviation>J Oral Implantol</ISOAbbreviation></Journal><ArticleTitle>Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans.</ArticleTitle><Pagination><MedlinePgn>376-83</MedlinePgn></Pagination><Abstract><AbstractText>Bone substitutes should be used when sufficient amounts of autologous bone cannot be harvested from intraoral donor sites. P-15 is a highly conserved linear peptide with a 15 amino acid sequence identical to the sequence contained in the residues 766 to 780 of the alpha-chain of type I collagen. PepGen P-15 (Dentsply Friadent, Mannheim, Germany) is a combination of the mineral component of bovine bone (Osteograf/N 300) with P-15. Bio-Oss (Geistlich, Mannheim, Germany) is a deproteinized sterilized bovine bone with 75% to 80% porosity and a crystal size of approximately 10 microm in the form of cortical granules. The purpose of the present histological and histomorphometrical study was to compare maxillary sinus augmentation procedures in humans performed with PepGen P-15 with procedures associated with Bio-Oss and autologous bone. Seven patients participated in this study (3 men and 4 women; ages between 48 and 69 years, mean of 58 years) and were categorized into 3 groups. In group 1, a mixture of 50% autologous bone from an intraoral source and 50% Bio-Oss was used. In group 2, the graft materials used were 50% Bio-Oss and 50% PepGen P-15. In group 3, 50% autologous bone and 50% PepGen P-15 were used. Group 1 histomorphometry showed that the percentage of newly formed bone was 38.7% +/- 3.2%, marrow spaces represented 45.6% +/- 5%, and residual graft particles constituted the remaining 14.4% +/- 2.1%. Group 2 histomorphometry showed that newly formed bone represented 36.7% +/- 3.3%, marrow spaces represented 39.7% +/- 3.4%, and residual graft particles represented 19.6% +/- 2.1%. In group 3, newly formed bone represented 32.2% +/- 3.2%, marrow spaces represented 38% +/- 2.5%, and residual graft particles represented 28.8% +/- 1.1%. Non-statistically significant differences were found in the percentage of newly formed bone in the different groups (P = .360). Statistically significant differences were found in the percentage of residual graft materials among the different groups (group 1 vs groups 2 and 3) (P = .0001). These data demonstrate that the use of bone-replacement materials, without the addition of autologous bone, could be an alternative in sinus augmentation procedures. Such treatment would increase patient satisfaction, decrease surgical complications, and save the clinician substantial operating time.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Degidi</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dental School, University of Chieti, Chieti, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piattelli</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Scarano</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Iezzi</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Piattelli</LastName><ForeName>Adriano</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Oral Implantol</MedlineTA><NlmUniqueID>7801086</NlmUniqueID><ISSNLinking>0160-6972</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C077540">Bio-Oss</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008903">Minerals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C403137">PepGen P-15</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000540" MajorTopicYN="N">Alveolar Ridge Augmentation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001853" MajorTopicYN="N">Bone Marrow</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001857" MajorTopicYN="N">Bone Matrix</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018786" MajorTopicYN="N">Bone Substitutes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016025" MajorTopicYN="N">Bone Transplantation</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008437" MajorTopicYN="N">Maxilla</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008443" MajorTopicYN="N">Maxillary Sinus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008903" MajorTopicYN="N">Minerals</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>1</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>2</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>1</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15641457</ArticleId><ArticleId IdType="doi">10.1563/0720.1</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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