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Ultrasound to stimulate early bone formation in a distraction gap: a double blind randomised clinical pilot trial in the edentulous mandible.

Identifieur interne : 002A01 ( PubMed/Corpus ); précédent : 002A00; suivant : 002A02

Ultrasound to stimulate early bone formation in a distraction gap: a double blind randomised clinical pilot trial in the edentulous mandible.

Auteurs : Jurjen Schortinghuis ; Antonius L J J. Bronckers ; Boudewijn Stegenga ; Gerry M. Raghoebar ; Lambert G M. De Bont

Source :

RBID : pubmed:15748694

English descriptors

Abstract

In a double blind randomised clinical pilot trial, it was investigated whether low intensity pulsed ultrasound therapy stimulates early bone formation in a distraction gap created in a severely resorbed mandible.

DOI: 10.1016/j.archoralbio.2004.09.005
PubMed: 15748694

Links to Exploration step

pubmed:15748694

Le document en format XML

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<title xml:lang="en">Ultrasound to stimulate early bone formation in a distraction gap: a double blind randomised clinical pilot trial in the edentulous mandible.</title>
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<name sortKey="Schortinghuis, Jurjen" sort="Schortinghuis, Jurjen" uniqKey="Schortinghuis J" first="Jurjen" last="Schortinghuis">Jurjen Schortinghuis</name>
<affiliation>
<nlm:affiliation>Department of Oral and Maxillofacial Surgery, Research Institute of Biomedical Engineering, Materials Science and Application, Groningen University Medical Centre, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. j.schortinghuis@kchir.azg.nl</nlm:affiliation>
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<name sortKey="Bronckers, Antonius L J J" sort="Bronckers, Antonius L J J" uniqKey="Bronckers A" first="Antonius L J J" last="Bronckers">Antonius L J J. Bronckers</name>
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<name sortKey="Stegenga, Boudewijn" sort="Stegenga, Boudewijn" uniqKey="Stegenga B" first="Boudewijn" last="Stegenga">Boudewijn Stegenga</name>
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<name sortKey="Raghoebar, Gerry M" sort="Raghoebar, Gerry M" uniqKey="Raghoebar G" first="Gerry M" last="Raghoebar">Gerry M. Raghoebar</name>
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<name sortKey="De Bont, Lambert G M" sort="De Bont, Lambert G M" uniqKey="De Bont L" first="Lambert G M" last="De Bont">Lambert G M. De Bont</name>
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<term>Aged</term>
<term>Bone Remodeling</term>
<term>Dental Implantation, Endosseous</term>
<term>Denture, Complete, Lower</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Jaw, Edentulous (pathology)</term>
<term>Jaw, Edentulous (surgery)</term>
<term>Male</term>
<term>Mandible (pathology)</term>
<term>Middle Aged</term>
<term>Osteogenesis, Distraction (methods)</term>
<term>Pilot Projects</term>
<term>Time Factors</term>
<term>Ultrasonic Therapy</term>
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<term>Jaw, Edentulous</term>
<term>Mandible</term>
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<term>Bone Remodeling</term>
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<term>Denture, Complete, Lower</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
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<div type="abstract" xml:lang="en">In a double blind randomised clinical pilot trial, it was investigated whether low intensity pulsed ultrasound therapy stimulates early bone formation in a distraction gap created in a severely resorbed mandible.</div>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In a double blind randomised clinical pilot trial, it was investigated whether low intensity pulsed ultrasound therapy stimulates early bone formation in a distraction gap created in a severely resorbed mandible.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Eight patients underwent a mandibular vertical distraction over an average distance of 6.6+/-1.1mm. Ultrasound self-therapy or placebo therapy was started on the first day of distraction and continued daily until the implants were inserted. After 31+/-3.8 days of consolidation, the distraction device was removed, a transmandibular biopsy was taken, and two endosseous implants were inserted.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All patients complied well with ultrasound therapy. During an average of 30.1+/-4.1 months follow-up, no complications did occur. Microradiographic examination of the biopsies revealed a comparable mean area of mineralised tissue in the distraction gap of 1.9+/-1.7mm(2) in the ultrasound treatment group and 1.9+/-1.3mm(2) in the placebo treatment group. Histological examination indicated that active woven bone was present within the distraction gap just adjacent to the osteotomy plane, with no apparent differences between the treatment groups. The lamellar bone formation outside the distraction gap appeared to have started as well.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">During a 31-day consolidation period, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible and it seems that this period is too short to evaluate properly if there is an effect. Therefore, a longer consolidation period has to be studied.</AbstractText>
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