The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible: a double-blind trial.
Identifieur interne : 001F41 ( PubMed/Corpus ); précédent : 001F40; suivant : 001F42The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible: a double-blind trial.
Auteurs : J. Schortinghuis ; A L J J. Bronckers ; J. Gravendeel ; B. Stegenga ; G M RaghoebarSource :
- International journal of oral and maxillofacial surgery [ 0901-5027 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Alveolar Bone Loss (rehabilitation), Alveolar Bone Loss (surgery), Bone Regeneration (physiology), Bony Callus (cytology), Bony Callus (physiology), Dental Implantation, Endosseous, Dental Implants, Double-Blind Method, Humans, Jaw, Edentulous (rehabilitation), Longitudinal Studies, Mandible (cytology), Mandible (physiology), Mandibular Advancement (methods), Middle Aged, Osteogenesis, Distraction (methods), Ultrasonic Therapy (methods).
- MESH :
- chemical : Dental Implants.
- cytology : Bony Callus, Mandible.
- methods : Mandibular Advancement, Osteogenesis, Distraction, Ultrasonic Therapy.
- physiology : Bone Regeneration, Bony Callus, Mandible.
- rehabilitation : Alveolar Bone Loss, Jaw, Edentulous.
- surgery : Alveolar Bone Loss.
- Aged, Dental Implantation, Endosseous, Double-Blind Method, Humans, Longitudinal Studies, Middle Aged.
Abstract
Whether low intensity pulsed ultrasound therapy stimulates osteogenesis in mandibular distraction was investigated in a double-blind trial. Nine patients underwent a vertical mandibular distraction over a distance of 5.1+/-1.2mm. Ultrasound or placebo therapy was started daily from the first day of distraction. After 46+/-8.1 days consolidation, two endosseous implants were inserted and a transmandibular biopsy was taken. Ultrasonographs were taken regularly to follow osteogenesis inside the gap. There were no complications during the 44+/-7.1 months of follow-up. Microradiographic measurements of the biopsies revealed no differences in the area of mineralized tissue in the distraction gap. The cranially distracted bone segment appeared significantly more radiolucent than the caudal bone. Histological examination showed large lacunae inside the cranially distracted bone segment, filled with clusters of osteoclasts and surrounded by clear tetracycline double labels. Within the distraction gap, woven bone was present, with no apparent differences between the treatment groups. Ultrasonographic follow-up revealed that osteogenesis inside the distraction gap progresses from 4 to 20 weeks post distraction, with no differences between the ultrasound and the placebo groups. In summary, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible.
DOI: 10.1016/j.ijom.2008.07.004
PubMed: 18757179
Links to Exploration step
pubmed:18757179Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible: a double-blind trial.</title><author><name sortKey="Schortinghuis, J" sort="Schortinghuis, J" uniqKey="Schortinghuis J" first="J" last="Schortinghuis">J. Schortinghuis</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG), The Netherlands. j.schortinghuis@kchir.umcg.nl</nlm:affiliation></affiliation></author><author><name sortKey="Bronckers, A L J J" sort="Bronckers, A L J J" uniqKey="Bronckers A" first="A L J J" last="Bronckers">A L J J. Bronckers</name></author><author><name sortKey="Gravendeel, J" sort="Gravendeel, J" uniqKey="Gravendeel J" first="J" last="Gravendeel">J. Gravendeel</name></author><author><name sortKey="Stegenga, B" sort="Stegenga, B" uniqKey="Stegenga B" first="B" last="Stegenga">B. Stegenga</name></author><author><name sortKey="Raghoebar, G M" sort="Raghoebar, G M" uniqKey="Raghoebar G" first="G M" last="Raghoebar">G M Raghoebar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18757179</idno><idno type="pmid">18757179</idno><idno type="doi">10.1016/j.ijom.2008.07.004</idno><idno type="wicri:Area/PubMed/Corpus">001F41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible: a double-blind trial.</title><author><name sortKey="Schortinghuis, J" sort="Schortinghuis, J" uniqKey="Schortinghuis J" first="J" last="Schortinghuis">J. Schortinghuis</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG), The Netherlands. j.schortinghuis@kchir.umcg.nl</nlm:affiliation></affiliation></author><author><name sortKey="Bronckers, A L J J" sort="Bronckers, A L J J" uniqKey="Bronckers A" first="A L J J" last="Bronckers">A L J J. Bronckers</name></author><author><name sortKey="Gravendeel, J" sort="Gravendeel, J" uniqKey="Gravendeel J" first="J" last="Gravendeel">J. Gravendeel</name></author><author><name sortKey="Stegenga, B" sort="Stegenga, B" uniqKey="Stegenga B" first="B" last="Stegenga">B. Stegenga</name></author><author><name sortKey="Raghoebar, G M" sort="Raghoebar, G M" uniqKey="Raghoebar G" first="G M" last="Raghoebar">G M Raghoebar</name></author></analytic><series><title level="j">International journal of oral and maxillofacial surgery</title><idno type="ISSN">0901-5027</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alveolar Bone Loss (rehabilitation)</term><term>Alveolar Bone Loss (surgery)</term><term>Bone Regeneration (physiology)</term><term>Bony Callus (cytology)</term><term>Bony Callus (physiology)</term><term>Dental Implantation, Endosseous</term><term>Dental Implants</term><term>Double-Blind Method</term><term>Humans</term><term>Jaw, Edentulous (rehabilitation)</term><term>Longitudinal Studies</term><term>Mandible (cytology)</term><term>Mandible (physiology)</term><term>Mandibular Advancement (methods)</term><term>Middle Aged</term><term>Osteogenesis, Distraction (methods)</term><term>Ultrasonic Therapy (methods)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bony Callus</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mandibular Advancement</term><term>Osteogenesis, Distraction</term><term>Ultrasonic Therapy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Regeneration</term><term>Bony Callus</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Alveolar Bone Loss</term><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Alveolar Bone Loss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dental Implantation, Endosseous</term><term>Double-Blind Method</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Whether low intensity pulsed ultrasound therapy stimulates osteogenesis in mandibular distraction was investigated in a double-blind trial. Nine patients underwent a vertical mandibular distraction over a distance of 5.1+/-1.2mm. Ultrasound or placebo therapy was started daily from the first day of distraction. After 46+/-8.1 days consolidation, two endosseous implants were inserted and a transmandibular biopsy was taken. Ultrasonographs were taken regularly to follow osteogenesis inside the gap. There were no complications during the 44+/-7.1 months of follow-up. Microradiographic measurements of the biopsies revealed no differences in the area of mineralized tissue in the distraction gap. The cranially distracted bone segment appeared significantly more radiolucent than the caudal bone. Histological examination showed large lacunae inside the cranially distracted bone segment, filled with clusters of osteoclasts and surrounded by clear tetracycline double labels. Within the distraction gap, woven bone was present, with no apparent differences between the treatment groups. Ultrasonographic follow-up revealed that osteogenesis inside the distraction gap progresses from 4 to 20 weeks post distraction, with no differences between the ultrasound and the placebo groups. In summary, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18757179</PMID><DateCompleted><Year>2009</Year><Month>02</Month><Day>19</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0901-5027</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><Issue>11</Issue><PubDate><Year>2008</Year><Month>Nov</Month></PubDate></JournalIssue><Title>International journal of oral and maxillofacial surgery</Title><ISOAbbreviation>Int J Oral Maxillofac Surg</ISOAbbreviation></Journal><ArticleTitle>The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible: a double-blind trial.</ArticleTitle><Pagination><MedlinePgn>1014-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijom.2008.07.004</ELocationID><Abstract><AbstractText>Whether low intensity pulsed ultrasound therapy stimulates osteogenesis in mandibular distraction was investigated in a double-blind trial. Nine patients underwent a vertical mandibular distraction over a distance of 5.1+/-1.2mm. Ultrasound or placebo therapy was started daily from the first day of distraction. After 46+/-8.1 days consolidation, two endosseous implants were inserted and a transmandibular biopsy was taken. Ultrasonographs were taken regularly to follow osteogenesis inside the gap. There were no complications during the 44+/-7.1 months of follow-up. Microradiographic measurements of the biopsies revealed no differences in the area of mineralized tissue in the distraction gap. The cranially distracted bone segment appeared significantly more radiolucent than the caudal bone. Histological examination showed large lacunae inside the cranially distracted bone segment, filled with clusters of osteoclasts and surrounded by clear tetracycline double labels. Within the distraction gap, woven bone was present, with no apparent differences between the treatment groups. Ultrasonographic follow-up revealed that osteogenesis inside the distraction gap progresses from 4 to 20 weeks post distraction, with no differences between the ultrasound and the placebo groups. In summary, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schortinghuis</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG), The Netherlands. j.schortinghuis@kchir.umcg.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bronckers</LastName><ForeName>A L J J</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Gravendeel</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Stegenga</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Raghoebar</LastName><ForeName>G M</ForeName><Initials>GM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>08</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Int J Oral Maxillofac Surg</MedlineTA><NlmUniqueID>8605826</NlmUniqueID><ISSNLinking>0901-5027</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName><QualifierName UI="Q000534" MajorTopicYN="Y">rehabilitation</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001861" MajorTopicYN="N">Bone Regeneration</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002146" MajorTopicYN="N">Bony Callus</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019186" MajorTopicYN="N">Mandibular Advancement</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019857" MajorTopicYN="N">Osteogenesis, Distraction</DescriptorName><QualifierName UI="Q000379" 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