Biocompatibility and manageability of a new fixable bone graft for the treatment of localized bone defects: preliminary study in a dog model.
Identifieur interne : 001F22 ( PubMed/Corpus ); précédent : 001F21; suivant : 001F23Biocompatibility and manageability of a new fixable bone graft for the treatment of localized bone defects: preliminary study in a dog model.
Auteurs : Filippo Fontana ; Isabella Rocchietta ; Claudia Dellavia ; Myron Nevins ; Massimo SimionSource :
- The International journal of periodontics & restorative dentistry [ 0198-7569 ] ; 2008.
English descriptors
- KwdEn :
- Alveolar Ridge Augmentation (instrumentation), Alveolar Ridge Augmentation (methods), Animals, Bicuspid, Biocompatible Materials (therapeutic use), Bone Matrix (transplantation), Bone Remodeling (physiology), Bone Screws, Bone Substitutes (therapeutic use), Cattle, Collagen (therapeutic use), Dogs, Durapatite (therapeutic use), Horses, Internal Fixators, Jaw, Edentulous, Partially (pathology), Jaw, Edentulous, Partially (surgery), Male, Mandible (pathology), Mandible (surgery), Minerals (therapeutic use), Models, Animal, Random Allocation, Safety, Surgical Wound Dehiscence (etiology), Time Factors.
- MESH :
- chemical , therapeutic use : Biocompatible Materials, Bone Substitutes, Collagen, Durapatite, Minerals.
- etiology : Surgical Wound Dehiscence.
- instrumentation : Alveolar Ridge Augmentation.
- methods : Alveolar Ridge Augmentation.
- pathology : Jaw, Edentulous, Partially, Mandible.
- physiology : Bone Remodeling.
- surgery : Jaw, Edentulous, Partially, Mandible.
- transplantation : Bone Matrix.
- Animals, Bicuspid, Bone Screws, Cattle, Dogs, Horses, Internal Fixators, Male, Models, Animal, Random Allocation, Safety, Time Factors.
Abstract
The present investigation was performed to compare the biocompatibility, safety, and manageability of a newly developed bone block and a deproteinized bovine bone block (Bio-Oss) for the treatment of localized bone defects in a dog model. Two male beagle dogs were used for this study. The mandibular premolars were extracted and two saddle-type defects were created bilaterally in the edentulous area. The defects were filled according to a randomized design with Bio-Oss bone block or with an equine hydroxyapatite plus collagen bone block (eHAC). Most control and test sites developed dehiscences during healing. After 4 weeks, the animals were euthanized and each hemimandible was prepared for histologic examination. No significant difference in terms of local tolerance was observed between test and control sites, and test and control sites showed similar histologic findings. However, a significant difference was noticed between the Bio-Oss block and the new bone block in terms of manageability.
PubMed: 19146056
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sortKey="Simion, Massimo" sort="Simion, Massimo" uniqKey="Simion M" first="Massimo" last="Simion">Massimo Simion</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:19146056</idno><idno type="pmid">19146056</idno><idno type="wicri:Area/PubMed/Corpus">001F22</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biocompatibility and manageability of a new fixable bone graft for the treatment of localized bone defects: preliminary study in a dog model.</title><author><name sortKey="Fontana, Filippo" sort="Fontana, Filippo" uniqKey="Fontana F" first="Filippo" last="Fontana">Filippo Fontana</name><affiliation><nlm:affiliation>Department of Implantology, School of Dentistry, University of Milano, Italy. filofontana@libero.it</nlm:affiliation></affiliation></author><author><name sortKey="Rocchietta, Isabella" sort="Rocchietta, Isabella" uniqKey="Rocchietta I" first="Isabella" last="Rocchietta">Isabella Rocchietta</name></author><author><name sortKey="Dellavia, Claudia" sort="Dellavia, Claudia" uniqKey="Dellavia C" first="Claudia" last="Dellavia">Claudia Dellavia</name></author><author><name sortKey="Nevins, Myron" sort="Nevins, Myron" uniqKey="Nevins M" first="Myron" last="Nevins">Myron Nevins</name></author><author><name sortKey="Simion, Massimo" sort="Simion, Massimo" uniqKey="Simion M" first="Massimo" last="Simion">Massimo Simion</name></author></analytic><series><title level="j">The International journal of periodontics & restorative dentistry</title><idno type="ISSN">0198-7569</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Ridge Augmentation (instrumentation)</term><term>Alveolar Ridge Augmentation (methods)</term><term>Animals</term><term>Bicuspid</term><term>Biocompatible Materials (therapeutic use)</term><term>Bone Matrix (transplantation)</term><term>Bone Remodeling (physiology)</term><term>Bone Screws</term><term>Bone Substitutes (therapeutic use)</term><term>Cattle</term><term>Collagen (therapeutic use)</term><term>Dogs</term><term>Durapatite (therapeutic use)</term><term>Horses</term><term>Internal Fixators</term><term>Jaw, Edentulous, Partially (pathology)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Male</term><term>Mandible (pathology)</term><term>Mandible (surgery)</term><term>Minerals (therapeutic use)</term><term>Models, Animal</term><term>Random Allocation</term><term>Safety</term><term>Surgical Wound Dehiscence (etiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Biocompatible Materials</term><term>Bone Substitutes</term><term>Collagen</term><term>Durapatite</term><term>Minerals</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Surgical Wound Dehiscence</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Alveolar Ridge Augmentation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous, Partially</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Remodeling</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Bone Matrix</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bicuspid</term><term>Bone 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Two male beagle dogs were used for this study. The mandibular premolars were extracted and two saddle-type defects were created bilaterally in the edentulous area. The defects were filled according to a randomized design with Bio-Oss bone block or with an equine hydroxyapatite plus collagen bone block (eHAC). Most control and test sites developed dehiscences during healing. After 4 weeks, the animals were euthanized and each hemimandible was prepared for histologic examination. No significant difference in terms of local tolerance was observed between test and control sites, and test and control sites showed similar histologic findings. However, a significant difference was noticed between the Bio-Oss block and the new bone block in terms of manageability.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19146056</PMID><DateCompleted><Year>2009</Year><Month>03</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0198-7569</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The International journal of periodontics & restorative dentistry</Title><ISOAbbreviation>Int J Periodontics Restorative Dent</ISOAbbreviation></Journal><ArticleTitle>Biocompatibility and manageability of a new fixable bone graft for the treatment of localized bone defects: preliminary study in a dog model.</ArticleTitle><Pagination><MedlinePgn>601-7</MedlinePgn></Pagination><Abstract><AbstractText>The present investigation was performed to compare the biocompatibility, safety, and manageability of a newly developed bone block and a deproteinized bovine bone block (Bio-Oss) for the treatment of localized bone defects in a dog model. Two male beagle dogs were used for this study. The mandibular premolars were extracted and two saddle-type defects were created bilaterally in the edentulous area. The defects were filled according to a randomized design with Bio-Oss bone block or with an equine hydroxyapatite plus collagen bone block (eHAC). Most control and test sites developed dehiscences during healing. After 4 weeks, the animals were euthanized and each hemimandible was prepared for histologic examination. No significant difference in terms of local tolerance was observed between test and control sites, and test and control sites showed similar histologic findings. 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Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Periodontics Restorative Dent</MedlineTA><NlmUniqueID>8200894</NlmUniqueID><ISSNLinking>0198-7569</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C077540">Bio-Oss</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008903">Minerals</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>91D9GV0Z28</RegistryNumber><NameOfSubstance UI="D017886">Durapatite</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000540" MajorTopicYN="N">Alveolar Ridge Augmentation</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001641" MajorTopicYN="N">Bicuspid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001672" MajorTopicYN="N">Biocompatible Materials</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001857" MajorTopicYN="N">Bone Matrix</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016723" 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