Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment.
Identifieur interne : 001E29 ( PubMed/Corpus ); précédent : 001E28; suivant : 001E30Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment.
Auteurs : Y-T Chin ; H-P Tu ; Y-T Chen ; N-T Dai ; E-C Shen ; C-Y Chiang ; M M-J Fu ; E. FuSource :
- Journal of periodontal research [ 1600-0765 ] ; 2009.
English descriptors
- KwdEn :
- Animals, Cell Proliferation (drug effects), Cells, Cultured, Cyclosporine (pharmacology), Endothelin A Receptor Antagonists, Endothelin B Receptor Antagonists, Endothelin-1 (analysis), Endothelin-1 (metabolism), Fibroblasts (drug effects), Fibroblasts (pathology), Gingiva (drug effects), Gingiva (pathology), Humans, Immunosuppressive Agents (pharmacology), Male, Mouth, Edentulous (pathology), Nitric Oxide Synthase Type II (analysis), Proliferating Cell Nuclear Antigen (analysis), Rats, Receptor, Endothelin A (analysis), Receptor, Endothelin B (analysis), Up-Regulation.
- MESH :
- chemical , analysis : Endothelin-1, Nitric Oxide Synthase Type II, Proliferating Cell Nuclear Antigen, Receptor, Endothelin A, Receptor, Endothelin B.
- chemical , metabolism : Endothelin-1.
- chemical , pharmacology : Cyclosporine, Immunosuppressive Agents.
- drug effects : Cell Proliferation, Fibroblasts, Gingiva.
- pathology : Fibroblasts, Gingiva, Mouth, Edentulous.
- Animals, Cells, Cultured, Endothelin A Receptor Antagonists, Endothelin B Receptor Antagonists, Humans, Male, Rats, Up-Regulation.
Abstract
This study aimed to evaluate the expression and bioactivities of endothelin-1 (ET-1) in gingiva during cyclosporine A (CsA) treatment.
DOI: 10.1111/j.1600-0765.2007.01058.x
PubMed: 18973526
Links to Exploration step
pubmed:18973526Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment.</title><author><name sortKey="Chin, Y T" sort="Chin, Y T" uniqKey="Chin Y" first="Y-T" last="Chin">Y-T Chin</name><affiliation><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, H P" sort="Tu, H P" uniqKey="Tu H" first="H-P" last="Tu">H-P Tu</name></author><author><name sortKey="Chen, Y T" sort="Chen, Y T" uniqKey="Chen Y" first="Y-T" last="Chen">Y-T Chen</name></author><author><name sortKey="Dai, N T" sort="Dai, N T" uniqKey="Dai N" first="N-T" last="Dai">N-T Dai</name></author><author><name sortKey="Shen, E C" sort="Shen, E C" uniqKey="Shen E" first="E-C" last="Shen">E-C Shen</name></author><author><name sortKey="Chiang, C Y" sort="Chiang, C Y" uniqKey="Chiang C" first="C-Y" last="Chiang">C-Y Chiang</name></author><author><name sortKey="Fu, M M J" sort="Fu, M M J" uniqKey="Fu M" first="M M-J" last="Fu">M M-J Fu</name></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:18973526</idno><idno type="pmid">18973526</idno><idno type="doi">10.1111/j.1600-0765.2007.01058.x</idno><idno type="wicri:Area/PubMed/Corpus">001E29</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment.</title><author><name sortKey="Chin, Y T" sort="Chin, Y T" uniqKey="Chin Y" first="Y-T" last="Chin">Y-T Chin</name><affiliation><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, H P" sort="Tu, H P" uniqKey="Tu H" first="H-P" last="Tu">H-P Tu</name></author><author><name sortKey="Chen, Y T" sort="Chen, Y T" uniqKey="Chen Y" first="Y-T" last="Chen">Y-T Chen</name></author><author><name sortKey="Dai, N T" sort="Dai, N T" uniqKey="Dai N" first="N-T" last="Dai">N-T Dai</name></author><author><name sortKey="Shen, E C" sort="Shen, E C" uniqKey="Shen E" first="E-C" last="Shen">E-C Shen</name></author><author><name sortKey="Chiang, C Y" sort="Chiang, C Y" uniqKey="Chiang C" first="C-Y" last="Chiang">C-Y Chiang</name></author><author><name sortKey="Fu, M M J" sort="Fu, M M J" uniqKey="Fu M" first="M M-J" last="Fu">M M-J Fu</name></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name></author></analytic><series><title level="j">Journal of periodontal research</title><idno type="eISSN">1600-0765</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Proliferation (drug effects)</term><term>Cells, Cultured</term><term>Cyclosporine (pharmacology)</term><term>Endothelin A Receptor Antagonists</term><term>Endothelin B Receptor Antagonists</term><term>Endothelin-1 (analysis)</term><term>Endothelin-1 (metabolism)</term><term>Fibroblasts (drug effects)</term><term>Fibroblasts (pathology)</term><term>Gingiva (drug effects)</term><term>Gingiva (pathology)</term><term>Humans</term><term>Immunosuppressive Agents (pharmacology)</term><term>Male</term><term>Mouth, Edentulous (pathology)</term><term>Nitric Oxide Synthase Type II (analysis)</term><term>Proliferating Cell Nuclear Antigen (analysis)</term><term>Rats</term><term>Receptor, Endothelin A (analysis)</term><term>Receptor, Endothelin B (analysis)</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Endothelin-1</term><term>Nitric Oxide Synthase Type II</term><term>Proliferating Cell Nuclear Antigen</term><term>Receptor, Endothelin A</term><term>Receptor, Endothelin B</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Endothelin-1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclosporine</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Fibroblasts</term><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibroblasts</term><term>Gingiva</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Endothelin A Receptor Antagonists</term><term>Endothelin B Receptor Antagonists</term><term>Humans</term><term>Male</term><term>Rats</term><term>Up-Regulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aimed to evaluate the expression and bioactivities of endothelin-1 (ET-1) in gingiva during cyclosporine A (CsA) treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18973526</PMID><DateCompleted><Year>2009</Year><Month>09</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0765</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of periodontal research</Title><ISOAbbreviation>J. Periodont. Res.</ISOAbbreviation></Journal><ArticleTitle>Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment.</ArticleTitle><Pagination><MedlinePgn>35-42</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0765.2007.01058.x</ELocationID><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">This study aimed to evaluate the expression and bioactivities of endothelin-1 (ET-1) in gingiva during cyclosporine A (CsA) treatment.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">After establishing edentulous ridges, experimental rats were fed 30 mg/kg/day CsA while control animals received mineral oil for 4 weeks, after which a reverse transcription-polymerase chain reaction (RT-PCR) and/or immunohistochemistry was used to examine the expression of ET-1, its receptors, proliferating cell nuclear antigen (PCNA) and inducible nitric oxide synthase (iNOS) in gingivae. The roles of the endothelin receptors A and B (ET(A) and ET(B)) in CsA-enhanced expression of PCNA and iNOS were examined in cultured human gingival fibroblasts pretreated with receptor antagonists, by immunocytochemistry and RT-PCR, respectively.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The mRNA expression of ET-1, ET(A) and ET(B), as well as of PCNA and iNOS, was significantly greater in edentulous gingiva that received CsA compared with control gingiva. Immunohistochemistry revealed more cells positively stained for ET-1 and its receptors in the tissues of CsA-treated rats than in those of control rats. In fibroblast cultures, enhanced mRNA expression of ET-1, ET(A) and ET(B) was observed after CsA treatment at the concentrations of 10 and 100 ng/mL. Cyclosporine A-enhanced PCNA expression was somewhat reduced by blockade of ET(A), but not ET(B), whereas iNOS expression was somewhat reduced by blockade of ET(B).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Based on the present findings, we suggest that: (1) CsA upregulates the gingival expression of ET-1 and its receptors; and (2) ET(A) and ET(B) have different bioactivities, ET(A) being involved in cell proliferation and ET(B) being associated with iNOS expression.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Y-T</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>H-P</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Y-T</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>N-T</ForeName><Initials>NT</Initials></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>E-C</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Chiang</LastName><ForeName>C-Y</ForeName><Initials>CY</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>M M-J</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>10</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontal Res</MedlineTA><NlmUniqueID>0055107</NlmUniqueID><ISSNLinking>0022-3484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065130">Endothelin A Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065131">Endothelin B Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019332">Endothelin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018809">Proliferating Cell Nuclear Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044022">Receptor, Endothelin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044023">Receptor, Endothelin B</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="C496319">NOS2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="D052247">Nitric Oxide Synthase Type II</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="C496318">Nos2 protein, rat</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065130" MajorTopicYN="N">Endothelin A Receptor Antagonists</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065131" MajorTopicYN="N">Endothelin B Receptor Antagonists</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019332" MajorTopicYN="N">Endothelin-1</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052247" MajorTopicYN="N">Nitric Oxide Synthase Type II</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018809" MajorTopicYN="N">Proliferating Cell Nuclear Antigen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044022" MajorTopicYN="N">Receptor, Endothelin A</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044023" MajorTopicYN="N">Receptor, Endothelin B</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>11</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>11</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18973526</ArticleId><ArticleId IdType="pii">JRE1058</ArticleId><ArticleId IdType="doi">10.1111/j.1600-0765.2007.01058.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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