Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.
Identifieur interne : 001E15 ( PubMed/Corpus ); précédent : 001E14; suivant : 001E16Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.
Auteurs : Claudia Cristina Montes ; Fabiano Alvim-Pereira ; Bruno Borges De Castilhos ; Marcos Luciano Lopes Sakurai ; Marcia Olandoski ; Paula Cristina TrevilattoSource :
- Clinical oral implants research [ 1600-0501 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Brazil, Case-Control Studies, Cytosine, Dental Implants, Dental Restoration Failure, Dentition, Female, Gene Frequency, Genetic Predisposition to Disease (genetics), Genotype, Humans, Interleukin 1 Receptor Antagonist Protein (genetics), Interleukin-1beta (genetics), Introns (genetics), Jaw, Edentulous (classification), Male, Middle Aged, Periodontal Index, Polymerase Chain Reaction, Polymorphism, Genetic (genetics), Polymorphism, Restriction Fragment Length, Smoking, Thymine.
- MESH :
- chemical , genetics : Interleukin 1 Receptor Antagonist Protein, Interleukin-1beta.
- chemical : Cytosine, Dental Implants, Thymine.
- geographic : Brazil.
- classification : Jaw, Edentulous.
- genetics : Genetic Predisposition to Disease, Introns, Polymorphism, Genetic.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Dental Restoration Failure, Dentition, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Periodontal Index, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Smoking.
Abstract
Although dental implants have a high success rate, failures occur, in spite of adequate clinical conditions. Together with the observation that multiple implant losses occur in certain groups of individuals (clusterization phenomenon), this suggests that host response may influence implant failure. Little is known about the influence of genetic susceptibility on implant loss. Interleukin (IL)-1 beta and IL-1 ra are believed to play a key role in the immune-inflammatory response, and polymorphisms IL1B (C+3954T) and IL1RN (intron 2) are shown to alter the coding proteins expression.
DOI: 10.1111/j.1600-0501.2008.01629.x
PubMed: 19191798
Links to Exploration step
pubmed:19191798Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.</title><author><name sortKey="Montes, Claudia Cristina" sort="Montes, Claudia Cristina" uniqKey="Montes C" first="Claudia Cristina" last="Montes">Claudia Cristina Montes</name><affiliation><nlm:affiliation>Graduate Program at Centro de Ensino Superior dos Campos Gerais (CESCAGE), Ponta Grossa, PR, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Alvim Pereira, Fabiano" sort="Alvim Pereira, Fabiano" uniqKey="Alvim Pereira F" first="Fabiano" last="Alvim-Pereira">Fabiano Alvim-Pereira</name></author><author><name sortKey="De Castilhos, Bruno Borges" sort="De Castilhos, Bruno Borges" uniqKey="De Castilhos B" first="Bruno Borges" last="De Castilhos">Bruno Borges De Castilhos</name></author><author><name sortKey="Sakurai, Marcos Luciano Lopes" sort="Sakurai, Marcos Luciano Lopes" uniqKey="Sakurai M" first="Marcos Luciano Lopes" last="Sakurai">Marcos Luciano Lopes Sakurai</name></author><author><name sortKey="Olandoski, Marcia" sort="Olandoski, Marcia" uniqKey="Olandoski M" first="Marcia" last="Olandoski">Marcia Olandoski</name></author><author><name sortKey="Trevilatto, Paula Cristina" sort="Trevilatto, Paula Cristina" uniqKey="Trevilatto P" first="Paula Cristina" last="Trevilatto">Paula Cristina Trevilatto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19191798</idno><idno type="pmid">19191798</idno><idno type="doi">10.1111/j.1600-0501.2008.01629.x</idno><idno type="wicri:Area/PubMed/Corpus">001E15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.</title><author><name sortKey="Montes, Claudia Cristina" sort="Montes, Claudia Cristina" uniqKey="Montes C" first="Claudia Cristina" last="Montes">Claudia Cristina Montes</name><affiliation><nlm:affiliation>Graduate Program at Centro de Ensino Superior dos Campos Gerais (CESCAGE), Ponta Grossa, PR, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Alvim Pereira, Fabiano" sort="Alvim Pereira, Fabiano" uniqKey="Alvim Pereira F" first="Fabiano" last="Alvim-Pereira">Fabiano Alvim-Pereira</name></author><author><name sortKey="De Castilhos, Bruno Borges" sort="De Castilhos, Bruno Borges" uniqKey="De Castilhos B" first="Bruno Borges" last="De Castilhos">Bruno Borges De Castilhos</name></author><author><name sortKey="Sakurai, Marcos Luciano Lopes" sort="Sakurai, Marcos Luciano Lopes" uniqKey="Sakurai M" first="Marcos Luciano Lopes" last="Sakurai">Marcos Luciano Lopes Sakurai</name></author><author><name sortKey="Olandoski, Marcia" sort="Olandoski, Marcia" uniqKey="Olandoski M" first="Marcia" last="Olandoski">Marcia Olandoski</name></author><author><name sortKey="Trevilatto, Paula Cristina" sort="Trevilatto, Paula Cristina" uniqKey="Trevilatto P" first="Paula Cristina" last="Trevilatto">Paula Cristina Trevilatto</name></author></analytic><series><title level="j">Clinical oral implants research</title><idno type="eISSN">1600-0501</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brazil</term><term>Case-Control Studies</term><term>Cytosine</term><term>Dental Implants</term><term>Dental Restoration Failure</term><term>Dentition</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genotype</term><term>Humans</term><term>Interleukin 1 Receptor Antagonist Protein (genetics)</term><term>Interleukin-1beta (genetics)</term><term>Introns (genetics)</term><term>Jaw, Edentulous (classification)</term><term>Male</term><term>Middle Aged</term><term>Periodontal Index</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic (genetics)</term><term>Polymorphism, Restriction Fragment Length</term><term>Smoking</term><term>Thymine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interleukin 1 Receptor Antagonist Protein</term><term>Interleukin-1beta</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cytosine</term><term>Dental Implants</term><term>Thymine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Introns</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Dental Restoration Failure</term><term>Dentition</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Periodontal Index</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Restriction Fragment Length</term><term>Smoking</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although dental implants have a high success rate, failures occur, in spite of adequate clinical conditions. Together with the observation that multiple implant losses occur in certain groups of individuals (clusterization phenomenon), this suggests that host response may influence implant failure. Little is known about the influence of genetic susceptibility on implant loss. Interleukin (IL)-1 beta and IL-1 ra are believed to play a key role in the immune-inflammatory response, and polymorphisms IL1B (C+3954T) and IL1RN (intron 2) are shown to alter the coding proteins expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19191798</PMID><DateCompleted><Year>2009</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1600-0501</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>2</Issue><PubDate><Year>2009</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Clinical oral implants research</Title><ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation></Journal><ArticleTitle>Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.</ArticleTitle><Pagination><MedlinePgn>208-17</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0501.2008.01629.x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although dental implants have a high success rate, failures occur, in spite of adequate clinical conditions. Together with the observation that multiple implant losses occur in certain groups of individuals (clusterization phenomenon), this suggests that host response may influence implant failure. Little is known about the influence of genetic susceptibility on implant loss. Interleukin (IL)-1 beta and IL-1 ra are believed to play a key role in the immune-inflammatory response, and polymorphisms IL1B (C+3954T) and IL1RN (intron 2) are shown to alter the coding proteins expression.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this study was to investigate the association between dental implant loss and polymorphisms IL1B (+3954) and IL1RN (intron 2).</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">The study population (n=266) was divided into Test group (T)- 90 subjects with implant loss, and Control group (C)- 176 subjects without any implant failure. Genotyping was performed by PCR-RFLP.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The number of present teeth was observed to influence implant loss. No differences in genotype and allele frequencies between C and T were found for IL1B (+3954) and IL1RN (intron 2) polymorphisms. However, the analysis of the whole study population (control and test groups) showed that genotype 2/2 was significantly more frequent in individuals with multiple implant losses (n=35) than in individuals that lost up to a single implant (n=231) (OR: 3.07, IC: 1.13-8.34, P=0.027).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">It was observed that number of teeth and edentulism were associated with implant loss. Genotype 2/2 of IL1RN polymorphism was significantly more frequent in patients who presented multiple losses, which suggests that the clusterization phenomenon has a genetic basis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Montes</LastName><ForeName>Claudia Cristina</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Graduate Program at Centro de Ensino Superior dos Campos Gerais (CESCAGE), Ponta Grossa, PR, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alvim-Pereira</LastName><ForeName>Fabiano</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>de Castilhos</LastName><ForeName>Bruno Borges</ForeName><Initials>BB</Initials></Author><Author ValidYN="Y"><LastName>Sakurai</LastName><ForeName>Marcos Luciano Lopes</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Olandoski</LastName><ForeName>Marcia</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Trevilatto</LastName><ForeName>Paula Cristina</ForeName><Initials>PC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Clin Oral Implants Res</MedlineTA><NlmUniqueID>9105713</NlmUniqueID><ISSNLinking>0905-7161</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C507763">IL1RN protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053590">Interleukin 1 Receptor Antagonist Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>8J337D1HZY</RegistryNumber><NameOfSubstance UI="D003596">Cytosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>QR26YLT7LT</RegistryNumber><NameOfSubstance UI="D013941">Thymine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003596" MajorTopicYN="Y">Cytosine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019232" MajorTopicYN="Y">Dental Restoration Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003817" MajorTopicYN="N">Dentition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053590" MajorTopicYN="N">Interleukin 1 Receptor Antagonist Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007438" MajorTopicYN="N">Introns</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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PubStatus="pubmed"><Year>2009</Year><Month>2</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>5</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19191798</ArticleId><ArticleId IdType="pii">CLR1629</ArticleId><ArticleId IdType="doi">10.1111/j.1600-0501.2008.01629.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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