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Histopathologic findings in bone from edentulous alveolar ridges: a role in osteonecrosis of the jaws?

Identifieur interne : 001885 ( PubMed/Corpus ); précédent : 001884; suivant : 001886

Histopathologic findings in bone from edentulous alveolar ridges: a role in osteonecrosis of the jaws?

Auteurs : James D. Kassolis ; Mark Scheper ; Bruno Jham ; Mark A. Reynolds

Source :

Bone [ 1873-2763 ] ; 2010.

RBID : pubmed:20399289

English descriptors

KwdEn :
- Alveolar Process (pathology), Bone and Bones (microbiology), Bone and Bones (pathology), Colony Count, Microbial, Female, Humans, Inflammation (pathology), Jaw Diseases (pathology), Jaw, Edentulous (pathology), Male, Osteocytes (pathology), Osteonecrosis (pathology), Tissue Survival.
MESH :
- microbiology : Bone and Bones.
- pathology : Alveolar Process, Bone and Bones, Inflammation, Jaw Diseases, Jaw, Edentulous, Osteocytes, Osteonecrosis.
- Colony Count, Microbial, Female, Humans, Male, Tissue Survival.

Abstract

Bisphosphonate-related osteonecrosis of the jaws (BONJ) is characterized by a breach in the oral mucosa with exposure of necrotic bone. Although bisphosphonates impact multiple biologic processes, including bone turnover and vascularity, factors contributing to the pathogenesis of BONJ remain poorly understood. In this retrospective analysis, the histopathologic findings from 154 alveolar bone specimens obtained during osteotomy preparation for dental implant placement were reviewed from 147 consecutively treated patients [male (79); female (68); Caucasian (141); African-American (6)]. The alveolar ridge sites had been edentulous for 1 year or longer. None of the patients in this study had a history of bisphosphonate therapy or clinical evidence of BONJ. Two pathologists, masked, using predetermined criteria, reviewed and substantiated the pathology reports provided by the licensed pathology service. In selected cases, special stains had been conducted to help establish the presence of bacteria. The histopathologic findings for the core specimens were as follows: 76 viable bone (49.4%); 54 nonviable bone (35.0%); and 24 osteomyelitis (15.6%). These histopathologic findings indicate that the edentulous jaw can contain regions of nonviable bone and microbial biofilm formation for 1 year or more after tooth extraction and mucosal healing. Regions of necrotic bone and subclinical infection may contribute to the development of untoward clinical events, such BONJ and early implant failure.

DOI: 10.1016/j.bone.2010.04.588
PubMed: 20399289

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pubmed:20399289

Le document en format XML

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<author><name sortKey="Kassolis, James D" sort="Kassolis, James D" uniqKey="Kassolis J" first="James D" last="Kassolis">James D. Kassolis</name>
<affiliation><nlm:affiliation>Department of Periodontics, University of Maryland, Dental School, Baltimore, MD, USA. jdkass@comcast.net</nlm:affiliation>
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<author><name sortKey="Scheper, Mark" sort="Scheper, Mark" uniqKey="Scheper M" first="Mark" last="Scheper">Mark Scheper</name>
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<author><name sortKey="Jham, Bruno" sort="Jham, Bruno" uniqKey="Jham B" first="Bruno" last="Jham">Bruno Jham</name>
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<author><name sortKey="Reynolds, Mark A" sort="Reynolds, Mark A" uniqKey="Reynolds M" first="Mark A" last="Reynolds">Mark A. Reynolds</name>
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<front><div type="abstract" xml:lang="en">Bisphosphonate-related osteonecrosis of the jaws (BONJ) is characterized by a breach in the oral mucosa with exposure of necrotic bone. Although bisphosphonates impact multiple biologic processes, including bone turnover and vascularity, factors contributing to the pathogenesis of BONJ remain poorly understood. In this retrospective analysis, the histopathologic findings from 154 alveolar bone specimens obtained during osteotomy preparation for dental implant placement were reviewed from 147 consecutively treated patients [male (79); female (68); Caucasian (141); African-American (6)]. The alveolar ridge sites had been edentulous for 1 year or longer. None of the patients in this study had a history of bisphosphonate therapy or clinical evidence of BONJ. Two pathologists, masked, using predetermined criteria, reviewed and substantiated the pathology reports provided by the licensed pathology service. In selected cases, special stains had been conducted to help establish the presence of bacteria. The histopathologic findings for the core specimens were as follows: 76 viable bone (49.4%); 54 nonviable bone (35.0%); and 24 osteomyelitis (15.6%). These histopathologic findings indicate that the edentulous jaw can contain regions of nonviable bone and microbial biofilm formation for 1 year or more after tooth extraction and mucosal healing. Regions of necrotic bone and subclinical infection may contribute to the development of untoward clinical events, such BONJ and early implant failure.</div>
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<Abstract><AbstractText>Bisphosphonate-related osteonecrosis of the jaws (BONJ) is characterized by a breach in the oral mucosa with exposure of necrotic bone. Although bisphosphonates impact multiple biologic processes, including bone turnover and vascularity, factors contributing to the pathogenesis of BONJ remain poorly understood. In this retrospective analysis, the histopathologic findings from 154 alveolar bone specimens obtained during osteotomy preparation for dental implant placement were reviewed from 147 consecutively treated patients [male (79); female (68); Caucasian (141); African-American (6)]. The alveolar ridge sites had been edentulous for 1 year or longer. None of the patients in this study had a history of bisphosphonate therapy or clinical evidence of BONJ. Two pathologists, masked, using predetermined criteria, reviewed and substantiated the pathology reports provided by the licensed pathology service. In selected cases, special stains had been conducted to help establish the presence of bacteria. The histopathologic findings for the core specimens were as follows: 76 viable bone (49.4%); 54 nonviable bone (35.0%); and 24 osteomyelitis (15.6%). These histopathologic findings indicate that the edentulous jaw can contain regions of nonviable bone and microbial biofilm formation for 1 year or more after tooth extraction and mucosal healing. Regions of necrotic bone and subclinical infection may contribute to the development of untoward clinical events, such BONJ and early implant failure.</AbstractText>
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Histopathologic findings in bone from edentulous alveolar ridges: a role in osteonecrosis of the jaws?

Histopathologic findings in bone from edentulous alveolar ridges: a role in osteonecrosis of the jaws?

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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