Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans.
Identifieur interne : 001277 ( PubMed/Corpus ); précédent : 001276; suivant : 001278Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans.
Auteurs : Giovanni E. Salvi ; Marco Aglietta ; Sigrun Eick ; Anton Sculean ; Niklaus P. Lang ; Christoph A. RamseierSource :
- Clinical oral implants research [ 1600-0501 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Biofilms, Biomarkers (analysis), Dental Implants, Dental Plaque (complications), Dental Plaque (microbiology), Dental Plaque Index, Female, Gingival Crevicular Fluid (chemistry), Gingivitis (etiology), Gingivitis (microbiology), Humans, Interleukin-1beta (analysis), Jaw, Edentulous, Partially (rehabilitation), Male, Mandible (surgery), Matrix Metalloproteinase 8 (analysis), Middle Aged, Mucositis (etiology), Mucositis (microbiology), Periodontal Index, Titanium.
- MESH :
- chemical , analysis : Biomarkers, Interleukin-1beta, Matrix Metalloproteinase 8.
- chemistry : Gingival Crevicular Fluid.
- complications : Dental Plaque.
- etiology : Gingivitis, Mucositis.
- microbiology : Dental Plaque, Gingivitis, Mucositis.
- rehabilitation : Jaw, Edentulous, Partially.
- surgery : Mandible.
- Adult, Aged, Biofilms, Dental Implants, Dental Plaque Index, Female, Humans, Male, Middle Aged, Periodontal Index, Titanium.
Abstract
To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans.
DOI: 10.1111/j.1600-0501.2011.02220.x
PubMed: 21806683
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pubmed:21806683Le document en format XML
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Salvi</name><affiliation><nlm:affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. giovanni.salvi@zmk.unibe.ch</nlm:affiliation></affiliation></author><author><name sortKey="Aglietta, Marco" sort="Aglietta, Marco" uniqKey="Aglietta M" first="Marco" last="Aglietta">Marco Aglietta</name></author><author><name sortKey="Eick, Sigrun" sort="Eick, Sigrun" uniqKey="Eick S" first="Sigrun" last="Eick">Sigrun Eick</name></author><author><name sortKey="Sculean, Anton" sort="Sculean, Anton" uniqKey="Sculean A" first="Anton" last="Sculean">Anton Sculean</name></author><author><name sortKey="Lang, Niklaus P" sort="Lang, Niklaus P" uniqKey="Lang N" first="Niklaus P" last="Lang">Niklaus P. Lang</name></author><author><name sortKey="Ramseier, Christoph A" sort="Ramseier, Christoph A" uniqKey="Ramseier C" first="Christoph A" last="Ramseier">Christoph A. Ramseier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21806683</idno><idno type="pmid">21806683</idno><idno type="doi">10.1111/j.1600-0501.2011.02220.x</idno><idno type="wicri:Area/PubMed/Corpus">001277</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001277</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans.</title><author><name sortKey="Salvi, Giovanni E" sort="Salvi, Giovanni E" uniqKey="Salvi G" first="Giovanni E" last="Salvi">Giovanni E. Salvi</name><affiliation><nlm:affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. giovanni.salvi@zmk.unibe.ch</nlm:affiliation></affiliation></author><author><name sortKey="Aglietta, Marco" sort="Aglietta, Marco" uniqKey="Aglietta M" first="Marco" last="Aglietta">Marco Aglietta</name></author><author><name sortKey="Eick, Sigrun" sort="Eick, Sigrun" uniqKey="Eick S" first="Sigrun" last="Eick">Sigrun Eick</name></author><author><name sortKey="Sculean, Anton" sort="Sculean, Anton" uniqKey="Sculean A" first="Anton" last="Sculean">Anton Sculean</name></author><author><name sortKey="Lang, Niklaus P" sort="Lang, Niklaus P" uniqKey="Lang N" first="Niklaus P" last="Lang">Niklaus P. Lang</name></author><author><name sortKey="Ramseier, Christoph A" sort="Ramseier, Christoph A" uniqKey="Ramseier C" first="Christoph A" last="Ramseier">Christoph A. Ramseier</name></author></analytic><series><title level="j">Clinical oral implants research</title><idno type="eISSN">1600-0501</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biofilms</term><term>Biomarkers (analysis)</term><term>Dental Implants</term><term>Dental Plaque (complications)</term><term>Dental Plaque (microbiology)</term><term>Dental Plaque Index</term><term>Female</term><term>Gingival Crevicular Fluid (chemistry)</term><term>Gingivitis (etiology)</term><term>Gingivitis (microbiology)</term><term>Humans</term><term>Interleukin-1beta (analysis)</term><term>Jaw, Edentulous, Partially (rehabilitation)</term><term>Male</term><term>Mandible (surgery)</term><term>Matrix Metalloproteinase 8 (analysis)</term><term>Middle Aged</term><term>Mucositis (etiology)</term><term>Mucositis (microbiology)</term><term>Periodontal Index</term><term>Titanium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Interleukin-1beta</term><term>Matrix Metalloproteinase 8</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Gingival Crevicular Fluid</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dental Plaque</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gingivitis</term><term>Mucositis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Dental Plaque</term><term>Gingivitis</term><term>Mucositis</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Mandible</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biofilms</term><term>Dental Implants</term><term>Dental Plaque Index</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Periodontal Index</term><term>Titanium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21806683</PMID><DateCompleted><Year>2012</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0501</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>2</Issue><PubDate><Year>2012</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Clinical oral implants research</Title><ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation></Journal><ArticleTitle>Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans.</ArticleTitle><Pagination><MedlinePgn>182-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0501.2011.02220.x</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1β). Microbial samples were analyzed using DNA-DNA hybridization for 40 species.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL-1β levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.</AbstractText><CopyrightInformation>© 2011 John Wiley & Sons A/S.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Salvi</LastName><ForeName>Giovanni E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. giovanni.salvi@zmk.unibe.ch</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aglietta</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Eick</LastName><ForeName>Sigrun</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sculean</LastName><ForeName>Anton</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Niklaus P</ForeName><Initials>NP</Initials></Author><Author ValidYN="Y"><LastName>Ramseier</LastName><ForeName>Christoph A</ForeName><Initials>CA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Clin Oral Implants Res</MedlineTA><NlmUniqueID>9105713</NlmUniqueID><ISSNLinking>0905-7161</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.34</RegistryNumber><NameOfSubstance UI="D020784">Matrix Metalloproteinase 8</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003773" MajorTopicYN="N">Dental Plaque</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003774" MajorTopicYN="N">Dental Plaque Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005883" MajorTopicYN="N">Gingival Crevicular Fluid</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005891" MajorTopicYN="N">Gingivitis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000534" MajorTopicYN="Y">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020784" MajorTopicYN="N">Matrix Metalloproteinase 8</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052016" MajorTopicYN="N">Mucositis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010512" MajorTopicYN="N">Periodontal Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21806683</ArticleId><ArticleId 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