Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.
Identifieur interne : 000C12 ( PubMed/Corpus ); précédent : 000C11; suivant : 000C13Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.
Auteurs : Marco Esposito ; Maria Gabriella Grusovin ; Helen V. WorthingtonSource :
- The Cochrane database of systematic reviews [ 1469-493X ] ; 2013.
English descriptors
- KwdEn :
- Amoxicillin (administration & dosage), Anti-Bacterial Agents (administration & dosage), Antibiotic Prophylaxis (adverse effects), Bacterial Infections (prevention & control), Dental Implants (adverse effects), Dental Restoration Failure, Drug Administration Schedule, Humans, Jaw, Edentulous, Partially (surgery), Randomized Controlled Trials as Topic.
- MESH :
- chemical , administration & dosage : Amoxicillin, Anti-Bacterial Agents.
- adverse effects : Antibiotic Prophylaxis, Dental Implants.
- prevention & control : Bacterial Infections.
- surgery : Jaw, Edentulous, Partially.
- Dental Restoration Failure, Drug Administration Schedule, Humans, Randomized Controlled Trials as Topic.
Abstract
Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat, and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis; with reduced host-response; when surgery is performed in infected sites; in cases of extensive and prolonged surgical interventions; and when large foreign materials are implanted. A variety of prophylactic systemic antibiotic regimens have been suggested to minimise infections after dental implant placement. More recent protocols recommended short-term prophylaxis, if antibiotics have to be used. Adverse events may occur with the administration of antibiotics, and can range from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.
DOI: 10.1002/14651858.CD004152.pub4
PubMed: 23904048
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pubmed:23904048Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</title><author><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name><affiliation><nlm:affiliation>Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK. espositomarco@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Grusovin, Maria Gabriella" sort="Grusovin, Maria Gabriella" uniqKey="Grusovin M" first="Maria Gabriella" last="Grusovin">Maria Gabriella Grusovin</name></author><author><name sortKey="Worthington, Helen V" sort="Worthington, Helen V" uniqKey="Worthington H" first="Helen V" last="Worthington">Helen V. Worthington</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23904048</idno><idno type="pmid">23904048</idno><idno type="doi">10.1002/14651858.CD004152.pub4</idno><idno type="wicri:Area/PubMed/Corpus">000C12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</title><author><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name><affiliation><nlm:affiliation>Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK. espositomarco@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Grusovin, Maria Gabriella" sort="Grusovin, Maria Gabriella" uniqKey="Grusovin M" first="Maria Gabriella" last="Grusovin">Maria Gabriella Grusovin</name></author><author><name sortKey="Worthington, Helen V" sort="Worthington, Helen V" uniqKey="Worthington H" first="Helen V" last="Worthington">Helen V. Worthington</name></author></analytic><series><title level="j">The Cochrane database of systematic reviews</title><idno type="eISSN">1469-493X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amoxicillin (administration & dosage)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Antibiotic Prophylaxis (adverse effects)</term><term>Bacterial Infections (prevention & control)</term><term>Dental Implants (adverse effects)</term><term>Dental Restoration Failure</term><term>Drug Administration Schedule</term><term>Humans</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Amoxicillin</term><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antibiotic Prophylaxis</term><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dental Restoration Failure</term><term>Drug Administration Schedule</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat, and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis; with reduced host-response; when surgery is performed in infected sites; in cases of extensive and prolonged surgical interventions; and when large foreign materials are implanted. A variety of prophylactic systemic antibiotic regimens have been suggested to minimise infections after dental implant placement. More recent protocols recommended short-term prophylaxis, if antibiotics have to be used. Adverse events may occur with the administration of antibiotics, and can range from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23904048</PMID><DateCompleted><Year>2013</Year><Month>12</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>06</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1469-493X</ISSN><JournalIssue CitedMedium="Internet"><Issue>7</Issue><PubDate><Year>2013</Year><Month>Jul</Month><Day>31</Day></PubDate></JournalIssue><Title>The Cochrane database of systematic reviews</Title><ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation></Journal><ArticleTitle>Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</ArticleTitle><Pagination><MedlinePgn>CD004152</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/14651858.CD004152.pub4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat, and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis; with reduced host-response; when surgery is performed in infected sites; in cases of extensive and prolonged surgical interventions; and when large foreign materials are implanted. A variety of prophylactic systemic antibiotic regimens have been suggested to minimise infections after dental implant placement. More recent protocols recommended short-term prophylaxis, if antibiotics have to be used. Adverse events may occur with the administration of antibiotics, and can range from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess the beneficial or harmful effects of systemic prophylactic antibiotics at dental implant placement versus no antibiotic or placebo administration and, if antibiotics are beneficial, to determine which type, dosage and duration is the most effective.</AbstractText><AbstractText Label="SEARCH METHODS" NlmCategory="METHODS">We searched the Cochrane Oral Health Group's Trials Register (to 17 June 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 5), MEDLINE via OVID (1946 to 17 June 2013) and EMBASE via OVID (1980 to 17 June 2013). There were no language or date restrictions placed on the searches of the electronic databases.</AbstractText><AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Randomised controlled clinical trials (RCTs) with a follow-up of at least three months, that compared the administration of various prophylactic antibiotic regimens versus no antibiotics to people undergoing dental implant placement. Outcome measures included prosthesis failures, implant failures, postoperative infections and adverse events (gastrointestinal, hypersensitivity, etc).</AbstractText><AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">Screening of eligible studies, assessment of the risk of bias of the trials and data extraction were conducted in duplicate and independently by two review authors. Results were expressed as risk ratios (RRs) using a random-effects model for dichotomous outcomes with 95% confidence intervals (CIs). Heterogeneity, including both clinical and methodological factors, was to be investigated.</AbstractText><AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">Six RCTs with 1162 participants were included: three trials compared 2 g of preoperative amoxicillin versus placebo (927 participants), one compared 3 g of preoperative amoxicillin versus placebo (55 participants), one compared 1 g of preoperative amoxicillin plus 500 mg four times a day for two days versus no antibiotics (80 participants), and one compared four groups: (1) 2 g of preoperative amoxicillin; (2) 2 g of preoperative amoxicillin plus 1 g twice a day for seven days; (3) 1 g of postoperative amoxicillin twice a day for seven days, and (4) no antibiotics (100 participants). The overall body of evidence was considered to be of moderate quality. The meta-analyses of the six trials showed a statistically significant higher number of participants experiencing implant failures in the group not receiving antibiotics (RR 0.33; 95% CI 0.16 to 0.67, P value 0.002, heterogeneity: Tau(2) 0.00; Chi(2) 2.87, df = 5 (P value 0.57); I(2) 0%). The number needed to treat for one additional beneficial outcome (NNTB) to prevent one person having an implant failure is 25 (95% CI 14 to 100), based on an implant failure rate of 6% in participants not receiving antibiotics. There was borderline statistical significance for prosthesis failures (RR 0.44; 95% CI 0.19 to 1.00), with no statistically significant differences for infections (RR 0.69; 95% CI 0.36 to 1.35), or adverse events (RR 1; 95% CI 0.06 to 15.85) (only two minor adverse events were recorded, one in the placebo group). No conclusive information can be derived from the only trial that compared three different durations of antibiotic prophylaxis since no event (implant/prosthesis failures, infections or adverse events) occurred in any of the 25 participants included in each study group. There were no trials that evaluated different antibiotics or different antibiotic dosages.</AbstractText><AbstractText Label="AUTHORS' CONCLUSIONS" NlmCategory="CONCLUSIONS">Scientific evidence suggests that, in general, antibiotics are beneficial for reducing failure of dental implants placed in ordinary conditions. Specifically 2 g or 3 g of amoxicillin given orally, as a single administration, one hour preoperatively significantly reduces failure of dental implants. No significant adverse events were reported. It might be sensible to suggest the use of a single dose of 2 g prophylactic amoxicillin prior to dental implant placement. It is still unknown whether postoperative antibiotics are beneficial, and which antibiotic is the most effective.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Esposito</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK. espositomarco@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grusovin</LastName><ForeName>Maria Gabriella</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Worthington</LastName><ForeName>Helen V</ForeName><Initials>HV</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cochrane Database Syst Rev</MedlineTA><NlmUniqueID>100909747</NlmUniqueID><ISSNLinking>1361-6137</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>804826J2HU</RegistryNumber><NameOfSubstance UI="D000658">Amoxicillin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Evid Based Dent. 2015 Jun;16(2):50-1</RefSource><PMID Version="1">26114789</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Am Dent Assoc. 2014 Oct;145(10):1068-70</RefSource><PMID Version="1">25270707</PMID></CommentsCorrections><CommentsCorrections RefType="UpdateOf"><RefSource>Cochrane Database Syst Rev. 2010;(7):CD004152</RefSource><PMID Version="1">20614437</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000658" MajorTopicYN="N">Amoxicillin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019072" MajorTopicYN="N">Antibiotic Prophylaxis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019232" MajorTopicYN="Y">Dental Restoration Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23904048</ArticleId><ArticleId IdType="doi">10.1002/14651858.CD004152.pub4</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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