Bone formation at porous titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 cDNA plasmid in the posterior mandible in dogs.
Identifieur interne : 000A94 ( PubMed/Corpus ); précédent : 000A93; suivant : 000A95Bone formation at porous titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 cDNA plasmid in the posterior mandible in dogs.
Auteurs : Fu-Ming He ; Hai-Qin Shan ; Jian-Wei Shen ; Qiao-Hong JiangSource :
- The International journal of oral & maxillofacial implants [ 1942-4434 ]
English descriptors
- KwdEn :
- Adult, Animals, Bone Morphogenetic Protein 2 (administration & dosage), Coated Materials, Biocompatible, Dental Implants, Dogs, Humans, Jaw, Edentulous (rehabilitation), Mandible, Osseointegration (drug effects), Osseointegration (physiology), Osteogenesis (drug effects), Osteogenesis (physiology), Plasmids (administration & dosage), Porosity, Random Allocation, Recombinant Proteins (administration & dosage), Surface Properties, Titanium (chemistry), Transforming Growth Factor beta (administration & dosage).
- MESH :
- chemical , administration & dosage : Bone Morphogenetic Protein 2, Recombinant Proteins, Transforming Growth Factor beta.
- administration & dosage : Plasmids.
- chemical , chemistry : Titanium.
- drug effects : Osseointegration, Osteogenesis.
- physiology : Osseointegration, Osteogenesis.
- rehabilitation : Jaw, Edentulous.
- Adult, Animals, Coated Materials, Biocompatible, Dental Implants, Dogs, Humans, Mandible, Porosity, Random Allocation, Surface Properties.
Abstract
The objective of this study was to evaluate peri-implant bone formation and osseointegration at titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 (rhBMP-2) cDNA placed into canine mandibles.
PubMed: 24278934
Links to Exploration step
pubmed:24278934Le document en format XML
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type="pmid">24278934</idno><idno type="wicri:Area/PubMed/Corpus">000A94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bone formation at porous titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 cDNA plasmid in the posterior mandible in dogs.</title><author><name sortKey="He, Fu Ming" sort="He, Fu Ming" uniqKey="He F" first="Fu-Ming" last="He">Fu-Ming He</name></author><author><name sortKey="Shan, Hai Qin" sort="Shan, Hai Qin" uniqKey="Shan H" first="Hai-Qin" last="Shan">Hai-Qin Shan</name></author><author><name sortKey="Shen, Jian Wei" sort="Shen, Jian Wei" uniqKey="Shen J" first="Jian-Wei" last="Shen">Jian-Wei Shen</name></author><author><name sortKey="Jiang, Qiao Hong" sort="Jiang, Qiao Hong" uniqKey="Jiang Q" first="Qiao-Hong" last="Jiang">Qiao-Hong Jiang</name></author></analytic><series><title level="j">The International journal of oral & maxillofacial implants</title><idno type="eISSN">1942-4434</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Bone Morphogenetic Protein 2 (administration & dosage)</term><term>Coated Materials, Biocompatible</term><term>Dental Implants</term><term>Dogs</term><term>Humans</term><term>Jaw, Edentulous (rehabilitation)</term><term>Mandible</term><term>Osseointegration (drug effects)</term><term>Osseointegration (physiology)</term><term>Osteogenesis (drug effects)</term><term>Osteogenesis (physiology)</term><term>Plasmids (administration & dosage)</term><term>Porosity</term><term>Random Allocation</term><term>Recombinant Proteins (administration & dosage)</term><term>Surface Properties</term><term>Titanium (chemistry)</term><term>Transforming Growth Factor beta (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bone Morphogenetic Protein 2</term><term>Recombinant Proteins</term><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Plasmids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Titanium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Osseointegration</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Osseointegration</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Coated Materials, Biocompatible</term><term>Dental Implants</term><term>Dogs</term><term>Humans</term><term>Mandible</term><term>Porosity</term><term>Random Allocation</term><term>Surface Properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to evaluate peri-implant bone formation and osseointegration at titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 (rhBMP-2) cDNA placed into canine mandibles.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24278934</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>30</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1942-4434</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>6</Issue><PubDate><MedlineDate>2013 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>The International journal of oral & maxillofacial implants</Title><ISOAbbreviation>Int J Oral Maxillofac Implants</ISOAbbreviation></Journal><ArticleTitle>Bone formation at porous titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 cDNA plasmid in the posterior mandible in dogs.</ArticleTitle><Pagination><MedlinePgn>1648-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.11607/jomi.3132</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The objective of this study was to evaluate peri-implant bone formation and osseointegration at titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 (rhBMP-2) cDNA placed into canine mandibles.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The rhBMP-2 plasmid was assembled on sandblasted/dual-acid-etched pure titanium implant surfaces using layer-by-layer assembly. The rhBMP-2 plasmid-coated implants were placed into the edentulous posterior mandibles of 12 adult beagle dogs. Implants without the rhBMP-2 plasmid coating served as controls. Treatments were randomized between jaw quadrants, and four implants were placed in each mandibular quadrant. After 4, 8, and 12 weeks in situ, mandibles were retrieved and prepared for removal torque testing and histomorphometric evaluation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eight layers of rhBMP-2 plasmid were assembled onto the implant surfaces. Histomorphometric analysis showed that, after 4 and 8 weeks of healing, the intrathread bone area (BA) was slightly higher for test implants (54.21% and 59.56%) than for control implants (38.48% and 54.98%), respectively, but no statistically significant differences were seen at any time points. Mechanical tests showed that the mean removal torque values of the rhBMP-2 cDNA-coated implants were greater than those of the control implants after 8 weeks of healing (91 Ncm versus 61 Ncm; P = .31).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Coating implants with multiple layers of an rhBMP-2 plasmid did not promote peri-implant bone formation and osseointegration in this model.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Fu-ming</ForeName><Initials>FM</Initials></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Hai-qin</ForeName><Initials>HQ</Initials></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Jian-wei</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Qiao-hong</ForeName><Initials>QH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Oral Maxillofac Implants</MedlineTA><NlmUniqueID>8611905</NlmUniqueID><ISSNLinking>0882-2786</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055396">Bone Morphogenetic Protein 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020099">Coated Materials, Biocompatible</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016212">Transforming Growth Factor beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C499469">recombinant human bone morphogenetic protein-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055396" MajorTopicYN="N">Bone Morphogenetic Protein 2</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020099" MajorTopicYN="Y">Coated Materials, Biocompatible</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016348" MajorTopicYN="N">Osseointegration</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010957" MajorTopicYN="N">Plasmids</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016062" MajorTopicYN="N">Porosity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="Y">Titanium</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016212" MajorTopicYN="N">Transforming Growth Factor beta</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>5</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24278934</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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