Evaluation of a topical herbal patch for soft tissue wound healing: an animal study.
Identifieur interne : 000508 ( PubMed/Corpus ); précédent : 000507; suivant : 000509Evaluation of a topical herbal patch for soft tissue wound healing: an animal study.
Auteurs : Liat Chaushu ; Miron Weinreb ; Ilan Beitlitum ; Ofer Moses ; Carlos E. NemcovskySource :
- Journal of clinical periodontology [ 1600-051X ] ; 2015.
English descriptors
- KwdEn :
- Animals, Cell Count, Cell Proliferation (drug effects), Collagen (analysis), Drug Evaluation, Preclinical, Echinacea, Epithelium (drug effects), Epithelium (pathology), Gingiva (drug effects), Gingiva (pathology), Gingiva (surgery), Jaw, Edentulous (surgery), Macrophages (drug effects), Macrophages (pathology), Maxilla (surgery), Microvessels (drug effects), Microvessels (pathology), Models, Animal, Phytotherapy (methods), Placebos, Plant Extracts (therapeutic use), Rats, Rats, Wistar, Re-Epithelialization (drug effects), Sambucus nigra, Surgical Flaps (pathology), Surgical Flaps (surgery), Time Factors, Triterpenes (therapeutic use), Wound Healing (drug effects).
- MESH :
- chemical , analysis : Collagen.
- drug effects : Cell Proliferation, Epithelium, Gingiva, Macrophages, Microvessels, Re-Epithelialization, Wound Healing.
- methods : Phytotherapy.
- pathology : Epithelium, Gingiva, Macrophages, Microvessels, Surgical Flaps.
- surgery : Gingiva, Jaw, Edentulous, Maxilla, Surgical Flaps.
- chemical , therapeutic use : Plant Extracts, Triterpenes.
- Animals, Cell Count, Drug Evaluation, Preclinical, Echinacea, Models, Animal, Placebos, Rats, Rats, Wistar, Sambucus nigra, Time Factors.
Abstract
This study evaluated the effects of a topical herbal patch (PerioPatch®) for gingival wound healing in a rat model.
DOI: 10.1111/jcpe.12372
PubMed: 25640329
Links to Exploration step
pubmed:25640329Le document en format XML
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Nemcovsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25640329</idno><idno type="pmid">25640329</idno><idno type="doi">10.1111/jcpe.12372</idno><idno type="wicri:Area/PubMed/Corpus">000508</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000508</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of a topical herbal patch for soft tissue wound healing: an animal study.</title><author><name sortKey="Chaushu, Liat" sort="Chaushu, Liat" uniqKey="Chaushu L" first="Liat" last="Chaushu">Liat Chaushu</name><affiliation><nlm:affiliation>Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Weinreb, Miron" sort="Weinreb, Miron" uniqKey="Weinreb M" first="Miron" last="Weinreb">Miron Weinreb</name></author><author><name sortKey="Beitlitum, Ilan" sort="Beitlitum, Ilan" uniqKey="Beitlitum I" first="Ilan" last="Beitlitum">Ilan Beitlitum</name></author><author><name sortKey="Moses, Ofer" sort="Moses, Ofer" uniqKey="Moses O" first="Ofer" last="Moses">Ofer Moses</name></author><author><name sortKey="Nemcovsky, Carlos E" sort="Nemcovsky, Carlos E" uniqKey="Nemcovsky C" first="Carlos E" last="Nemcovsky">Carlos E. Nemcovsky</name></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="eISSN">1600-051X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Cell Proliferation (drug effects)</term><term>Collagen (analysis)</term><term>Drug Evaluation, Preclinical</term><term>Echinacea</term><term>Epithelium (drug effects)</term><term>Epithelium (pathology)</term><term>Gingiva (drug effects)</term><term>Gingiva (pathology)</term><term>Gingiva (surgery)</term><term>Jaw, Edentulous (surgery)</term><term>Macrophages (drug effects)</term><term>Macrophages (pathology)</term><term>Maxilla (surgery)</term><term>Microvessels (drug effects)</term><term>Microvessels (pathology)</term><term>Models, Animal</term><term>Phytotherapy (methods)</term><term>Placebos</term><term>Plant Extracts (therapeutic use)</term><term>Rats</term><term>Rats, Wistar</term><term>Re-Epithelialization (drug effects)</term><term>Sambucus nigra</term><term>Surgical Flaps (pathology)</term><term>Surgical Flaps (surgery)</term><term>Time Factors</term><term>Triterpenes (therapeutic use)</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Epithelium</term><term>Gingiva</term><term>Macrophages</term><term>Microvessels</term><term>Re-Epithelialization</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Phytotherapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Gingiva</term><term>Macrophages</term><term>Microvessels</term><term>Surgical Flaps</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Gingiva</term><term>Jaw, Edentulous</term><term>Maxilla</term><term>Surgical Flaps</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Extracts</term><term>Triterpenes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Drug Evaluation, Preclinical</term><term>Echinacea</term><term>Models, Animal</term><term>Placebos</term><term>Rats</term><term>Rats, Wistar</term><term>Sambucus nigra</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study evaluated the effects of a topical herbal patch (PerioPatch®) for gingival wound healing in a rat model.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25640329</PMID><DateCompleted><Year>2016</Year><Month>06</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-051X</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of clinical periodontology</Title><ISOAbbreviation>J. Clin. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Evaluation of a topical herbal patch for soft tissue wound healing: an animal study.</ArticleTitle><Pagination><MedlinePgn>288-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jcpe.12372</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">This study evaluated the effects of a topical herbal patch (PerioPatch®) for gingival wound healing in a rat model.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">A mid-crestal incision was performed on each side of the edentulous anterior maxilla in 48, 6-month-old, Wistar rats. Full-thickness flaps were raised, repositioned and sutured. Four experimental groups were established: herbal patch, placebo patch, no patch and no patch and no surgery. Patches were placed immediately after surgery and replaced every 12 h for the following 3 days. Half of the animals were killed after 5 and the remaining ones after 12 days. Tissue blocks were retrieved and processed for histological and immunohistochemical evaluation. Epithelial gap, collagen contents, amount of macrophages, cellular proliferation and vascular contents were evaluated in the central incision area. Statistical analysis consisted of two-way anova.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The herbal patch group presented the smallest epithelial gap at 12 days, the highest collagen content both at 5 and 12 days, a larger number of proliferating cells at day 5 and more numerous blood vessels at day 12. Macrophage number was similar in all groups.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Herbal patch improved wound healing in this animal model.</AbstractText><CopyrightInformation>© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chaushu</LastName><ForeName>Liat</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinreb</LastName><ForeName>Miron</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Beitlitum</LastName><ForeName>Ilan</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Moses</LastName><ForeName>Ofer</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Nemcovsky</LastName><ForeName>Carlos E</ForeName><Initials>CE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Periodontol</MedlineTA><NlmUniqueID>0425123</NlmUniqueID><ISSNLinking>0303-6979</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C526146">Centella asiatica extract</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010919">Placebos</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014315">Triterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Clin Periodontol. 2004 Sep;31(9):730-5</RefSource><PMID Version="1">15312094</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Oral Maxillofac Surg. 2004 Sep;62(9):1103-7</RefSource><PMID Version="1">15346361</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Periodontol. 2004 Oct;31(10):840-4</RefSource><PMID Version="1">15367186</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Immunopharmacol. 2014 Jun;20(2):322-30</RefSource><PMID Version="1">24675438</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Histol. 2013 Feb;44(1):83-90</RefSource><PMID Version="1">23054142</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Biochem 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MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020900" MajorTopicYN="N">Echinacea</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008437" MajorTopicYN="N">Maxilla</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055806" MajorTopicYN="N">Microvessels</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug 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effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027924" MajorTopicYN="N">Sambucus nigra</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013524" MajorTopicYN="N">Surgical Flaps</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014315" MajorTopicYN="N">Triterpenes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC5024077</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">animal study</Keyword><Keyword MajorTopicYN="N">collagen</Keyword><Keyword MajorTopicYN="N">epithelium</Keyword><Keyword MajorTopicYN="N">herbal</Keyword><Keyword MajorTopicYN="N">histology</Keyword><Keyword MajorTopicYN="N">immunohistochemistry</Keyword><Keyword MajorTopicYN="N">inflammation</Keyword><Keyword MajorTopicYN="N">topical</Keyword><Keyword MajorTopicYN="N">wound healing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>01</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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