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Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.

Identifieur interne : 000121 ( PubMed/Corpus ); précédent : 000120; suivant : 000122

Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.

Auteurs : Juan Jose Toro ; Francisca Cecilia Gushiken ; Deanna Schneider ; Shuko Lee ; David Johannes Haile ; Cesar Ovidio Freytes

Source :

RBID : pubmed:26984247

English descriptors

Abstract

Patients undergoing autologous hematopoietic stem cell transplantation (HSCT) are at risk for oral complications which may cause significant morbidity. The aim of this study was to compare the incidence of toxicities and complications in edentulous and dentate patients undergoing autologous HSCT for multiple myeloma.

DOI: 10.1007/s00520-016-3168-4
PubMed: 26984247

Links to Exploration step

pubmed:26984247

Le document en format XML

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<title level="j">Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</title>
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<term>Female</term>
<term>Hematopoietic Stem Cell Transplantation (adverse effects)</term>
<term>Hematopoietic Stem Cell Transplantation (methods)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mouth Diseases (etiology)</term>
<term>Mouth, Edentulous (etiology)</term>
<term>Multiple Myeloma (drug therapy)</term>
<term>Multiple Myeloma (therapy)</term>
<term>Retrospective Studies</term>
<term>Transplantation Conditioning (adverse effects)</term>
<term>Transplantation Conditioning (methods)</term>
<term>Transplantation, Autologous (adverse effects)</term>
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<term>Hematopoietic Stem Cell Transplantation</term>
<term>Transplantation Conditioning</term>
<term>Transplantation, Autologous</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Mouth Diseases</term>
<term>Mouth, Edentulous</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Transplantation Conditioning</term>
</keywords>
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<term>Multiple Myeloma</term>
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<term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Female</term>
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<div type="abstract" xml:lang="en">Patients undergoing autologous hematopoietic stem cell transplantation (HSCT) are at risk for oral complications which may cause significant morbidity. The aim of this study was to compare the incidence of toxicities and complications in edentulous and dentate patients undergoing autologous HSCT for multiple myeloma.</div>
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<DateCompleted>
<Year>2017</Year>
<Month>10</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1433-7339</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>24</Volume>
<Issue>8</Issue>
<PubDate>
<Year>2016</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</Title>
<ISOAbbreviation>Support Care Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.</ArticleTitle>
<Pagination>
<MedlinePgn>3411-5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00520-016-3168-4</ELocationID>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Patients undergoing autologous hematopoietic stem cell transplantation (HSCT) are at risk for oral complications which may cause significant morbidity. The aim of this study was to compare the incidence of toxicities and complications in edentulous and dentate patients undergoing autologous HSCT for multiple myeloma.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a retrospective case-control study to analyze the incidence of bacteremia, fever, and oral mucositis, between edentulous and dentate patients. All patients underwent dental evaluation, received dental treatment if indicated, and were cleared before transplantation. The two groups were matched for age, gender, ethnicity, disease stage, time from diagnosis to transplant, performance status, and conditioning regimen.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 45 edentulous and 90 dentate patients were enrolled. All patients were male with a median age of 60 years and a mean performance status by Karnofsky score of 90 %. Two thirds had stage III MM with a median time from diagnosis to transplantation of 12 months, and all received melphalan as part of the conditioning regimen. The incidence of bacteremia (p = 0.553), fever (p = 0.245), severity of oral mucositis (p = 0.465), and other post-transplant toxicities were similar between both groups.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">There were no significant differences in the incidence of bacteremia, fever, severity of oral mucositis, or other complications between edentulous and dentate patients with multiple myeloma after autologous HSCT.</AbstractText>
</Abstract>
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<CommentsCorrectionsList>
<CommentsCorrections RefType="Cites">
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