Acute-phase inflammatory response to periodontal disease in the US population.
Identifieur interne : 002D75 ( PubMed/Checkpoint ); précédent : 002D74; suivant : 002D76Acute-phase inflammatory response to periodontal disease in the US population.
Auteurs : G D Slade [États-Unis] ; S. Offenbacher ; J D Beck ; G. Heiss ; J S PankowSource :
- Journal of dental research [ 0022-0345 ] ; 2000.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Bouche édentée (sang), Bouche édentée (épidémiologie), Facteurs de risque, Femelle, Humains, Maladies parodontales (sang), Maladies parodontales (épidémiologie), Mâle, Perte dentaire (sang), Perte dentaire (épidémiologie), Protéine C-réactive (analyse), Prévalence, Réaction inflammatoire aigüe (sang), Réaction inflammatoire aigüe (épidémiologie), Sujet âgé, États-Unis d'Amérique (épidémiologie), Études transversales.
- MESH :
- analyse : Protéine C-réactive.
- sang : Bouche édentée, Maladies parodontales, Perte dentaire, Réaction inflammatoire aigüe.
- épidémiologie : Bouche édentée, Maladies parodontales, Perte dentaire, Réaction inflammatoire aigüe, États-Unis d'Amérique.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Prévalence, Sujet âgé, Études transversales.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Acute-Phase Reaction (blood), Acute-Phase Reaction (epidemiology), Adolescent, Adult, Aged, C-Reactive Protein (analysis), Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Mouth, Edentulous (blood), Mouth, Edentulous (epidemiology), Periodontal Diseases (blood), Periodontal Diseases (epidemiology), Prevalence, Risk Factors, Tooth Loss (blood), Tooth Loss (epidemiology), United States (epidemiology).
- MESH :
- chemical , analysis : C-Reactive Protein.
- geographic , epidemiology : United States.
- blood : Acute-Phase Reaction, Mouth, Edentulous, Periodontal Diseases, Tooth Loss.
- epidemiology : Acute-Phase Reaction, Mouth, Edentulous, Periodontal Diseases, Tooth Loss.
- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors.
Abstract
Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal disease, established risk factors for elevated CRP, and CRP levels within the US population; and (2) determine whether total tooth loss is associated with reduced CRP. Data were obtained from the third National Health and Nutrition Examination Survey. A random sample of the US population was interviewed in their homes and examined at mobile examination centers. CRP was quantified from peripheral blood samples and analyzed as a continuous variable and as the prevalence of elevated CRP (> or = 10 mg/L). Some 12,949 people aged 18+ years who had periodontal examinations and an additional 1,817 edentulous people aged 18+ years were included in the analysis. Dentate people with extensive periodontal disease (> 10% of sites with periodontal pockets 4+ mm) had an increase of approximately one-third in mean CRP and a doubling in prevalence of elevated CRP compared with periodontally healthy people. Raised CRP levels among people with extensive periodontal disease persisted in multivariate analyses (P < 0.01), with established risk factors for elevated CRP (diabetes, arthritis, emphysema, smoking, and anti-inflammatory medications) and sociodemographic factors controlled for. However, CRP levels were similarly raised in edentulous people. Furthermore, the established risk factors for elevated CRP modified relationships between oral status and CRP levels. Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP.
DOI: 10.1177/00220345000790010701
PubMed: 10690660
Affiliations:
- États-Unis
- Caroline du Nord
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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pubmed:10690660Le document en format XML
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This study aimed to: (1) evaluate associations among periodontal disease, established risk factors for elevated CRP, and CRP levels within the US population; and (2) determine whether total tooth loss is associated with reduced CRP. Data were obtained from the third National Health and Nutrition Examination Survey. A random sample of the US population was interviewed in their homes and examined at mobile examination centers. CRP was quantified from peripheral blood samples and analyzed as a continuous variable and as the prevalence of elevated CRP (> or = 10 mg/L). Some 12,949 people aged 18+ years who had periodontal examinations and an additional 1,817 edentulous people aged 18+ years were included in the analysis. Dentate people with extensive periodontal disease (> 10% of sites with periodontal pockets 4+ mm) had an increase of approximately one-third in mean CRP and a doubling in prevalence of elevated CRP compared with periodontally healthy people. Raised CRP levels among people with extensive periodontal disease persisted in multivariate analyses (P < 0.01), with established risk factors for elevated CRP (diabetes, arthritis, emphysema, smoking, and anti-inflammatory medications) and sociodemographic factors controlled for. However, CRP levels were similarly raised in edentulous people. Furthermore, the established risk factors for elevated CRP modified relationships between oral status and CRP levels. Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10690660</PMID><DateCompleted><Year>2000</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-0345</ISSN><JournalIssue CitedMedium="Print"><Volume>79</Volume><Issue>1</Issue><PubDate><Year>2000</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of dental research</Title><ISOAbbreviation>J. Dent. Res.</ISOAbbreviation></Journal><ArticleTitle>Acute-phase inflammatory response to periodontal disease in the US population.</ArticleTitle><Pagination><MedlinePgn>49-57</MedlinePgn></Pagination><Abstract><AbstractText>Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal disease, established risk factors for elevated CRP, and CRP levels within the US population; and (2) determine whether total tooth loss is associated with reduced CRP. Data were obtained from the third National Health and Nutrition Examination Survey. A random sample of the US population was interviewed in their homes and examined at mobile examination centers. CRP was quantified from peripheral blood samples and analyzed as a continuous variable and as the prevalence of elevated CRP (> or = 10 mg/L). Some 12,949 people aged 18+ years who had periodontal examinations and an additional 1,817 edentulous people aged 18+ years were included in the analysis. Dentate people with extensive periodontal disease (> 10% of sites with periodontal pockets 4+ mm) had an increase of approximately one-third in mean CRP and a doubling in prevalence of elevated CRP compared with periodontally healthy people. Raised CRP levels among people with extensive periodontal disease persisted in multivariate analyses (P < 0.01), with established risk factors for elevated CRP (diabetes, arthritis, emphysema, smoking, and anti-inflammatory medications) and sociodemographic factors controlled for. However, CRP levels were similarly raised in edentulous people. Furthermore, the established risk factors for elevated CRP modified relationships between oral status and CRP levels. Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Slade</LastName><ForeName>G D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Department of Dental Ecology, University of North Carolina at Chapel Hill, 27599-7450, USA. gary_slade@dentistry.unc.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Offenbacher</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Beck</LastName><ForeName>J D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Heiss</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Pankow</LastName><ForeName>J S</ForeName><Initials>JS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P20 DE12374</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Dent Res</MedlineTA><NlmUniqueID>0354343</NlmUniqueID><ISSNLinking>0022-0345</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000210" MajorTopicYN="N">Acute-Phase Reaction</DescriptorName><QualifierName UI="Q000097" 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MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016388" MajorTopicYN="N">Tooth Loss</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>2</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>2</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10690660</ArticleId><ArticleId IdType="doi">10.1177/00220345000790010701</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><noCountry><name sortKey="Beck, J D" sort="Beck, J D" uniqKey="Beck J" first="J D" last="Beck">J D Beck</name><name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name><name sortKey="Offenbacher, S" sort="Offenbacher, S" uniqKey="Offenbacher S" first="S" last="Offenbacher">S. Offenbacher</name><name sortKey="Pankow, J S" sort="Pankow, J S" uniqKey="Pankow J" first="J S" last="Pankow">J S Pankow</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Slade, G D" sort="Slade, G D" uniqKey="Slade G" first="G D" last="Slade">G D Slade</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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