Antibodies to periodontal pathogens are associated with coronary heart disease.
Identifieur interne : 002744 ( PubMed/Checkpoint ); précédent : 002743; suivant : 002745Antibodies to periodontal pathogens are associated with coronary heart disease.
Auteurs : Pirkko J. Pussinen [Finlande] ; Pekka Jousilahti ; Georg Alfthan ; Timo Palosuo ; Sirkka Asikainen ; Veikko SalomaaSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Aggregatibacter actinomycetemcomitans (immunologie), Analyse de régression, Anticorps antibactériens (sang), Cholestérol HDL (sang), Humains, Immunoglobuline G (sang), Maladie coronarienne (immunologie), Maladie coronarienne (microbiologie), Mâchoire partiellement édentée (immunologie), Mâle, Odds ratio, Parodontite (immunologie), Parodontite (microbiologie), Porphyromonas gingivalis (immunologie), Sujet âgé, Études transversales.
- MESH :
- immunologie : Aggregatibacter actinomycetemcomitans, Maladie coronarienne, Mâchoire partiellement édentée, Parodontite, Porphyromonas gingivalis.
- microbiologie : Maladie coronarienne, Parodontite.
- sang : Anticorps antibactériens, Cholestérol HDL, Immunoglobuline G.
- Adulte d'âge moyen, Analyse de régression, Humains, Mâle, Odds ratio, Sujet âgé, Études transversales.
English descriptors
- KwdEn :
- Aged, Aggregatibacter actinomycetemcomitans (immunology), Antibodies, Bacterial (blood), Cholesterol, HDL (blood), Coronary Disease (immunology), Coronary Disease (microbiology), Cross-Sectional Studies, Humans, Immunoglobulin G (blood), Jaw, Edentulous, Partially (immunology), Male, Middle Aged, Odds Ratio, Periodontitis (immunology), Periodontitis (microbiology), Porphyromonas gingivalis (immunology), Regression Analysis.
- MESH :
- chemical , blood : Antibodies, Bacterial, Cholesterol, HDL, Immunoglobulin G.
- immunology : Aggregatibacter actinomycetemcomitans, Coronary Disease, Jaw, Edentulous, Partially, Periodontitis, Porphyromonas gingivalis.
- microbiology : Coronary Disease, Periodontitis.
- Aged, Cross-Sectional Studies, Humans, Male, Middle Aged, Odds Ratio, Regression Analysis.
Abstract
We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
DOI: 10.1161/01.ATV.0000072969.71452.87
PubMed: 12714435
Affiliations:
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Pussinen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland. pirkko.pussinen@helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name></author><author><name sortKey="Alfthan, Georg" sort="Alfthan, Georg" uniqKey="Alfthan G" first="Georg" last="Alfthan">Georg Alfthan</name></author><author><name sortKey="Palosuo, Timo" sort="Palosuo, Timo" uniqKey="Palosuo T" first="Timo" last="Palosuo">Timo Palosuo</name></author><author><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12714435</idno><idno type="pmid">12714435</idno><idno type="doi">10.1161/01.ATV.0000072969.71452.87</idno><idno type="wicri:Area/PubMed/Corpus">002E72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E72</idno><idno type="wicri:Area/PubMed/Curation">002E72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002E72</idno><idno type="wicri:Area/PubMed/Checkpoint">002E72</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antibodies to periodontal pathogens are associated with coronary heart disease.</title><author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J" last="Pussinen">Pirkko J. Pussinen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland. pirkko.pussinen@helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name></author><author><name sortKey="Alfthan, Georg" sort="Alfthan, Georg" uniqKey="Alfthan G" first="Georg" last="Alfthan">Georg Alfthan</name></author><author><name sortKey="Palosuo, Timo" sort="Palosuo, Timo" uniqKey="Palosuo T" first="Timo" last="Palosuo">Timo Palosuo</name></author><author><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="eISSN">1524-4636</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aggregatibacter actinomycetemcomitans (immunology)</term><term>Antibodies, Bacterial (blood)</term><term>Cholesterol, HDL (blood)</term><term>Coronary Disease (immunology)</term><term>Coronary Disease (microbiology)</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Jaw, Edentulous, Partially (immunology)</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Periodontitis (immunology)</term><term>Periodontitis (microbiology)</term><term>Porphyromonas gingivalis (immunology)</term><term>Regression Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aggregatibacter actinomycetemcomitans (immunologie)</term><term>Analyse de régression</term><term>Anticorps antibactériens (sang)</term><term>Cholestérol HDL (sang)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Maladie coronarienne (immunologie)</term><term>Maladie coronarienne (microbiologie)</term><term>Mâchoire partiellement édentée (immunologie)</term><term>Mâle</term><term>Odds ratio</term><term>Parodontite (immunologie)</term><term>Parodontite (microbiologie)</term><term>Porphyromonas gingivalis (immunologie)</term><term>Sujet âgé</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Bacterial</term><term>Cholesterol, HDL</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Aggregatibacter actinomycetemcomitans</term><term>Maladie coronarienne</term><term>Mâchoire partiellement édentée</term><term>Parodontite</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans</term><term>Coronary Disease</term><term>Jaw, Edentulous, Partially</term><term>Periodontitis</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladie coronarienne</term><term>Parodontite</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coronary Disease</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antibactériens</term><term>Cholestérol HDL</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Regression Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de régression</term><term>Humains</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12714435</PMID><DateCompleted><Year>2004</Year><Month>02</Month><Day>05</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>7</Issue><PubDate><Year>2003</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Arteriosclerosis, thrombosis, and vascular biology</Title><ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation></Journal><ArticleTitle>Antibodies to periodontal pathogens are associated with coronary heart disease.</ArticleTitle><Pagination><MedlinePgn>1250-4</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pussinen</LastName><ForeName>Pirkko J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland. pirkko.pussinen@helsinki.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jousilahti</LastName><ForeName>Pekka</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Alfthan</LastName><ForeName>Georg</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Palosuo</LastName><ForeName>Timo</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Asikainen</LastName><ForeName>Sirkka</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Salomaa</LastName><ForeName>Veikko</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2003</Year><Month>04</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA><NlmUniqueID>9505803</NlmUniqueID><ISSNLinking>1079-5642</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008076">Cholesterol, HDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1309-11</RefSource><PMID Version="1">12909566</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016976" MajorTopicYN="N">Aggregatibacter actinomycetemcomitans</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000907" MajorTopicYN="N">Antibodies, Bacterial</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008076" MajorTopicYN="N">Cholesterol, HDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003327" MajorTopicYN="N">Coronary Disease</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>2</Month><Day>6</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12714435</ArticleId><ArticleId IdType="doi">10.1161/01.ATV.0000072969.71452.87</ArticleId><ArticleId IdType="pii">01.ATV.0000072969.71452.87</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Alfthan, Georg" sort="Alfthan, Georg" uniqKey="Alfthan G" first="Georg" last="Alfthan">Georg Alfthan</name><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><name sortKey="Palosuo, Timo" sort="Palosuo, Timo" uniqKey="Palosuo T" first="Timo" last="Palosuo">Timo Palosuo</name><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name></noCountry><country name="Finlande"><noRegion><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J" last="Pussinen">Pirkko J. 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