Difference in apolipoprotein E type 4 allele (APOE epsilon 4) among dentate and edentulous subjects.
Identifieur interne : 001B74 ( PubMed/Checkpoint ); précédent : 001B73; suivant : 001B75Difference in apolipoprotein E type 4 allele (APOE epsilon 4) among dentate and edentulous subjects.
Auteurs : Maud Bergdahl [Norvège] ; Jan Bergdahl ; Lars Nyberg ; Lars-Göran NilssonSource :
- Gerodontology [ 0734-0664 ] ; 2008.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Allèles, Analyse multivariée, Apolipoprotéine E4 (génétique), Bouche édentée (génétique), Femelle, Fréquence d'allèle, Humains, Isoformes de protéines, Loi du khi-deux, Modèles logistiques, Mâle, Perte dentaire (génétique), Polymorphisme génétique, Réaction de polymérisation en chaîne, Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- génétique : Apolipoprotéine E4, Bouche édentée, Perte dentaire.
- Adulte, Adulte d'âge moyen, Allèles, Analyse multivariée, Femelle, Fréquence d'allèle, Humains, Isoformes de protéines, Loi du khi-deux, Modèles logistiques, Mâle, Polymorphisme génétique, Réaction de polymérisation en chaîne, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alleles, Apolipoprotein E4 (genetics), Chi-Square Distribution, Female, Gene Frequency, Humans, Logistic Models, Male, Middle Aged, Mouth, Edentulous (genetics), Multivariate Analysis, Polymerase Chain Reaction, Polymorphism, Genetic, Protein Isoforms, Tooth Loss (genetics).
- MESH :
- chemical , genetics : Apolipoprotein E4.
- genetics : Mouth, Edentulous, Tooth Loss.
- Adult, Aged, Aged, 80 and over, Alleles, Chi-Square Distribution, Female, Gene Frequency, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Polymerase Chain Reaction, Polymorphism, Genetic, Protein Isoforms.
Abstract
To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (epsilon 4) was associated with edentulousness even when certain factors were controlled.
DOI: 10.1111/j.1741-2358.2008.00225.x
PubMed: 18318702
Affiliations:
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Goran" uniqKey="Nilsson L" first="Lars-Göran" last="Nilsson">Lars-Göran Nilsson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18318702</idno><idno type="pmid">18318702</idno><idno type="doi">10.1111/j.1741-2358.2008.00225.x</idno><idno type="wicri:Area/PubMed/Corpus">002009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002009</idno><idno type="wicri:Area/PubMed/Curation">002009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002009</idno><idno type="wicri:Area/PubMed/Checkpoint">002009</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Difference in apolipoprotein E type 4 allele (APOE epsilon 4) among dentate and edentulous subjects.</title><author><name sortKey="Bergdahl, Maud" sort="Bergdahl, Maud" uniqKey="Bergdahl M" first="Maud" last="Bergdahl">Maud Bergdahl</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Dentistry, University of Tromsø, Tromsø, Norway. maud.bergdahl@fagmed.uit.no</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Dentistry, University of Tromsø, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Bergdahl, Jan" sort="Bergdahl, Jan" uniqKey="Bergdahl J" first="Jan" last="Bergdahl">Jan Bergdahl</name></author><author><name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name></author><author><name sortKey="Nilsson, Lars Goran" sort="Nilsson, Lars Goran" uniqKey="Nilsson L" first="Lars-Göran" last="Nilsson">Lars-Göran Nilsson</name></author></analytic><series><title level="j">Gerodontology</title><idno type="ISSN">0734-0664</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Apolipoprotein E4 (genetics)</term><term>Chi-Square Distribution</term><term>Female</term><term>Gene Frequency</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Mouth, Edentulous (genetics)</term><term>Multivariate Analysis</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic</term><term>Protein Isoforms</term><term>Tooth Loss (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Analyse multivariée</term><term>Apolipoprotéine E4 (génétique)</term><term>Bouche édentée (génétique)</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Humains</term><term>Isoformes de protéines</term><term>Loi du khi-deux</term><term>Modèles logistiques</term><term>Mâle</term><term>Perte dentaire (génétique)</term><term>Polymorphisme génétique</term><term>Réaction de polymérisation en chaîne</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mouth, Edentulous</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term><term>Bouche édentée</term><term>Perte dentaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Chi-Square Distribution</term><term>Female</term><term>Gene Frequency</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic</term><term>Protein Isoforms</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Analyse multivariée</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Humains</term><term>Isoformes de protéines</term><term>Loi du khi-deux</term><term>Modèles logistiques</term><term>Mâle</term><term>Polymorphisme génétique</term><term>Réaction de polymérisation en chaîne</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (epsilon 4) was associated with edentulousness even when certain factors were controlled.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18318702</PMID><DateCompleted><Year>2008</Year><Month>11</Month><Day>10</Day></DateCompleted><DateRevised><Year>2008</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0734-0664</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Gerodontology</Title><ISOAbbreviation>Gerodontology</ISOAbbreviation></Journal><ArticleTitle>Difference in apolipoprotein E type 4 allele (APOE epsilon 4) among dentate and edentulous subjects.</ArticleTitle><Pagination><MedlinePgn>179-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1741-2358.2008.00225.x</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (epsilon 4) was associated with edentulousness even when certain factors were controlled.</AbstractText><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The APOE are important in lipid homeostasis, and APOE epsilon 4 has been found in many diseases and to have a negative impact on longevity. Tooth loss is more common in ill aged subjects with low income and education.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">In a population-based study involving 1860 subjects between 35 and 85 years 1321 dentate (mean age = 54; 54% women, 46% men) and 539 edentulous (mean age = 72; 62% women, 38% men) subjects were studied. Logistic regression was performed with dentate/edentulous as dependent variables and years of education, socio-economic status, social network, stress level, handicap from birth, 23 various diseases and APOE epsilon 4 as covariates. Thereafter, APOE epsilon 4 frequencies were studied in 342 dentate and 336 edentulous subjects 50-85 years of age. The subjects were matched with regard to age, gender, years of education, living condition, stress level, handicap from birth and 23 various diseases.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">APOE allele frequency in the total group was epsilon 2 = 7.8%, epsilon 3 = 76.4% and epsilon 4 = 15.8%. Age, living condition, years of education and APOE epsilon 4 were significant covariates in edentulous subjects (p </AbstractText> <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Despite matching both groups with regard to different background factors, the edentulous group had a higher frequency of APOE epsilon 4 than the dentate group. Thus, genetic factors might contribute to greater risk in developing complex oral diseases leading to tooth loss or just be an indication that the subjects in our study carrying APOE epsilon 4 are more fragile.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bergdahl</LastName><ForeName>Maud</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Clinical Dentistry, University of Tromsø, Tromsø, Norway. maud.bergdahl@fagmed.uit.no</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergdahl</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Nyberg</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Nilsson</LastName><ForeName>Lars-Göran</ForeName><Initials>LG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>03</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gerodontology</MedlineTA><NlmUniqueID>8215850</NlmUniqueID><ISSNLinking>0734-0664</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053327">Apolipoprotein E4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020033">Protein Isoforms</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053327" MajorTopicYN="N">Apolipoprotein E4</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020033" MajorTopicYN="N">Protein Isoforms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016388" MajorTopicYN="N">Tooth Loss</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>11</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18318702</ArticleId><ArticleId IdType="pii">GER225</ArticleId><ArticleId IdType="doi">10.1111/j.1741-2358.2008.00225.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Norvège</li></country></list><tree><noCountry><name sortKey="Bergdahl, Jan" sort="Bergdahl, Jan" uniqKey="Bergdahl J" first="Jan" last="Bergdahl">Jan Bergdahl</name><name sortKey="Nilsson, Lars Goran" sort="Nilsson, Lars Goran" uniqKey="Nilsson L" first="Lars-Göran" last="Nilsson">Lars-Göran Nilsson</name><name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name></noCountry><country name="Norvège"><noRegion><name sortKey="Bergdahl, Maud" sort="Bergdahl, Maud" uniqKey="Bergdahl M" first="Maud" last="Bergdahl">Maud Bergdahl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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