Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.
Identifieur interne : 000621 ( PubMed/Checkpoint ); précédent : 000620; suivant : 000622Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.
Auteurs : Rudolf M. Gruber [Allemagne] ; Sebastian Krohn ; Corinna Mauth ; Michel Dard ; Aart Molenberg ; Katharina Lange ; Christina Perske ; Henning SchliephakeSource :
- Journal of clinical periodontology [ 1600-051X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Attribution aléatoire, Densité osseuse (), Facteur de croissance transformant bêta (usage thérapeutique), Femelle, Maladies mandibulaires (), Mandibule (), Mandibule (anatomopathologie), Matériaux biocompatibles (usage thérapeutique), Mâchoire partiellement édentée (), Ostéogenèse (), Phosphates de calcium (usage thérapeutique), Porc miniature, Processus alvéolaire (), Processus alvéolaire (anatomopathologie), Protéine morphogénétique osseuse de type 2 (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Reconstruction mandibulaire (), Résorption alvéolaire (), Substituts osseux (usage thérapeutique), Suidae, Vecteurs de médicaments.
- MESH :
- anatomopathologie : Mandibule, Processus alvéolaire.
- usage thérapeutique : Facteur de croissance transformant bêta, Matériaux biocompatibles, Phosphates de calcium, Protéine morphogénétique osseuse de type 2, Protéines recombinantes, Substituts osseux.
- Animaux, Attribution aléatoire, Densité osseuse, Femelle, Maladies mandibulaires, Mandibule, Mâchoire partiellement édentée, Ostéogenèse, Porc miniature, Processus alvéolaire, Reconstruction mandibulaire, Résorption alvéolaire, Suidae, Vecteurs de médicaments.
English descriptors
- KwdEn :
- Alveolar Bone Loss (surgery), Alveolar Process (drug effects), Alveolar Process (pathology), Animals, Biocompatible Materials (therapeutic use), Bone Density (drug effects), Bone Morphogenetic Protein 2 (therapeutic use), Bone Substitutes (therapeutic use), Calcium Phosphates (therapeutic use), Drug Carriers, Female, Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use), Jaw, Edentulous, Partially (surgery), Mandible (drug effects), Mandible (pathology), Mandibular Diseases (surgery), Mandibular Reconstruction (methods), Osteogenesis (drug effects), Random Allocation, Recombinant Proteins (therapeutic use), Swine, Swine, Miniature, Transforming Growth Factor beta (therapeutic use).
- MESH :
- chemical , therapeutic use : Biocompatible Materials, Bone Morphogenetic Protein 2, Bone Substitutes, Calcium Phosphates, Hydrogel, Polyethylene Glycol Dimethacrylate, Recombinant Proteins, Transforming Growth Factor beta.
- drug effects : Alveolar Process, Bone Density, Mandible, Osteogenesis.
- methods : Mandibular Reconstruction.
- pathology : Alveolar Process, Mandible.
- surgery : Alveolar Bone Loss, Jaw, Edentulous, Partially, Mandibular Diseases.
- Animals, Drug Carriers, Female, Random Allocation, Swine, Swine, Miniature.
Abstract
To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.
DOI: 10.1111/jcpe.12264
PubMed: 24738890
Affiliations:
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use)</term><term>Bone Density (drug effects)</term><term>Bone Morphogenetic Protein 2 (therapeutic use)</term><term>Bone Substitutes (therapeutic use)</term><term>Calcium Phosphates (therapeutic use)</term><term>Drug Carriers</term><term>Female</term><term>Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Mandible (drug effects)</term><term>Mandible (pathology)</term><term>Mandibular Diseases (surgery)</term><term>Mandibular Reconstruction (methods)</term><term>Osteogenesis (drug effects)</term><term>Random Allocation</term><term>Recombinant Proteins (therapeutic use)</term><term>Swine</term><term>Swine, Miniature</term><term>Transforming Growth Factor beta (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Densité osseuse ()</term><term>Facteur de croissance transformant bêta (usage thérapeutique)</term><term>Femelle</term><term>Maladies mandibulaires ()</term><term>Mandibule ()</term><term>Mandibule (anatomopathologie)</term><term>Matériaux biocompatibles (usage thérapeutique)</term><term>Mâchoire partiellement édentée ()</term><term>Ostéogenèse ()</term><term>Phosphates de calcium (usage thérapeutique)</term><term>Porc miniature</term><term>Processus alvéolaire ()</term><term>Processus alvéolaire (anatomopathologie)</term><term>Protéine morphogénétique osseuse de type 2 (usage thérapeutique)</term><term>Protéines recombinantes (usage thérapeutique)</term><term>Reconstruction mandibulaire ()</term><term>Résorption alvéolaire ()</term><term>Substituts osseux (usage thérapeutique)</term><term>Suidae</term><term>Vecteurs de médicaments</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Biocompatible Materials</term><term>Bone Morphogenetic Protein 2</term><term>Bone Substitutes</term><term>Calcium Phosphates</term><term>Hydrogel, Polyethylene Glycol Dimethacrylate</term><term>Recombinant Proteins</term><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mandibule</term><term>Processus alvéolaire</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Alveolar Process</term><term>Bone Density</term><term>Mandible</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mandibular Reconstruction</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Alveolar Bone Loss</term><term>Jaw, Edentulous, Partially</term><term>Mandibular Diseases</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance transformant bêta</term><term>Matériaux biocompatibles</term><term>Phosphates de calcium</term><term>Protéine morphogénétique osseuse de type 2</term><term>Protéines recombinantes</term><term>Substituts osseux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Carriers</term><term>Female</term><term>Random Allocation</term><term>Swine</term><term>Swine, Miniature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Densité osseuse</term><term>Femelle</term><term>Maladies mandibulaires</term><term>Mandibule</term><term>Mâchoire partiellement édentée</term><term>Ostéogenèse</term><term>Porc miniature</term><term>Processus alvéolaire</term><term>Reconstruction mandibulaire</term><term>Résorption alvéolaire</term><term>Suidae</term><term>Vecteurs de médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24738890</PMID><DateCompleted><Year>2015</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-051X</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of clinical periodontology</Title><ISOAbbreviation>J. Clin. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.</ArticleTitle><Pagination><MedlinePgn>820-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jcpe.12264</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Bilateral mandibular partial thickness 20 × 8 × 8 mm (L × W × H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP-2 (105 μg/defect) in contra-lateral sites using a split-mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4-week healing interval when the animals were killed for histometric analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Bone morphogenetic proteins-2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP-2 induced bone formation.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Polyethylene glycol compromises the osteogenic effect of BMP-2.</AbstractText><CopyrightInformation>© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gruber</LastName><ForeName>Rudolf M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Georgia Augusta University, Goettingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krohn</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Mauth</LastName><ForeName>Corinna</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Dard</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Molenberg</LastName><ForeName>Aart</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Katharina</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Perske</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Schliephake</LastName><ForeName>Henning</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Periodontol</MedlineTA><NlmUniqueID>0425123</NlmUniqueID><ISSNLinking>0303-6979</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055396">Bone Morphogenetic Protein 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002130">Calcium Phosphates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016212">Transforming Growth Factor beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C485817">beta-tricalcium phosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C499469">recombinant human bone morphogenetic protein-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>25852-47-5</RegistryNumber><NameOfSubstance UI="D020136">Hydrogel, Polyethylene Glycol Dimethacrylate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000539" MajorTopicYN="N">Alveolar Process</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001672" MajorTopicYN="N">Biocompatible Materials</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015519" MajorTopicYN="N">Bone Density</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055396" MajorTopicYN="N">Bone Morphogenetic Protein 2</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018786" MajorTopicYN="N">Bone Substitutes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002130" MajorTopicYN="N">Calcium Phosphates</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004337" MajorTopicYN="N">Drug Carriers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020136" MajorTopicYN="N">Hydrogel, Polyethylene Glycol Dimethacrylate</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008336" MajorTopicYN="N">Mandibular Diseases</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D063175" MajorTopicYN="N">Mandibular Reconstruction</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013556" MajorTopicYN="N">Swine, Miniature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016212" MajorTopicYN="N">Transforming Growth Factor beta</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bone morphogenetic protein 2</Keyword><Keyword MajorTopicYN="N">jawbone defects</Keyword><Keyword MajorTopicYN="N">maxillomandibular reconstruction</Keyword><Keyword MajorTopicYN="N">polyethylene glycol hydrogel</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24738890</ArticleId><ArticleId IdType="doi">10.1111/jcpe.12264</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name><name sortKey="Krohn, Sebastian" sort="Krohn, Sebastian" uniqKey="Krohn S" first="Sebastian" last="Krohn">Sebastian Krohn</name><name sortKey="Lange, Katharina" sort="Lange, Katharina" uniqKey="Lange K" first="Katharina" last="Lange">Katharina Lange</name><name sortKey="Mauth, Corinna" sort="Mauth, Corinna" uniqKey="Mauth C" first="Corinna" last="Mauth">Corinna Mauth</name><name sortKey="Molenberg, Aart" sort="Molenberg, Aart" uniqKey="Molenberg A" first="Aart" last="Molenberg">Aart Molenberg</name><name sortKey="Perske, Christina" sort="Perske, Christina" uniqKey="Perske C" first="Christina" last="Perske">Christina Perske</name><name sortKey="Schliephake, Henning" sort="Schliephake, Henning" uniqKey="Schliephake H" first="Henning" last="Schliephake">Henning Schliephake</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Gruber, Rudolf M" sort="Gruber, Rudolf M" uniqKey="Gruber R" first="Rudolf M" last="Gruber">Rudolf M. 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