Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser
Identifieur interne : 002F87 ( Pmc/Curation ); précédent : 002F86; suivant : 002F88Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser
Auteurs : Maurício Malheiros Badar [Brésil] ; Marcela Moreira Salles [Brésil] ; Vanessa Maria Fagundes Leite [Brésil] ; Carolina Noronha Ferraz De Arruda [Brésil] ; Viviane De Cássia Oliveira [Brésil] ; Cássio Do Nascimento [Brésil] ; Raphael Freitas De Souza [Brésil] ; Helena De Freitas De Oliveira Paranhos [Brésil] ; Cláudia Helena Silva-Lovato [Brésil]Source :
- Journal of Applied Oral Science [ 1678-7757 ] ; 2017.
Abstract
The development of opportunistic infections due to poor denture hygiene conditions justified the search for effective hygiene protocols for controlling denture biofilm.
This study evaluated
It was conducted a controlled clinical trial, randomized, double-blind, and crossover. Sixty-four denture wearers with (n=24) and without candidiasis (n=40) were instructed to brush (3 times/day) and immerse their dentures (20 min/day) in different storage solutions (S1 / S2: 0.25% / 0.5% sodium hypochlorite; S3: 10%
S1 (4.41±7.98%) and S2 (2.93±5.23%) were more effective then S3 (6.95±10.93%) in biofilm remotion(P<0.0001). All solutions were different from the control (11.07±11.99%). S3 was the most effective solution in remission of candidiasis (50%), followed by S1 (46%). Concerning antimicrobial action, S1/S2 were similar and resulted in the lowest microorganism mean count (P=0.04), followed by S3. No significant differences were found with patient’s satisfaction.
10%
Url:
DOI: 10.1590/1678-7757-2016-0222
PubMed: 28678952
PubMed Central: 5482256
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<author><name sortKey="Oliveira, Viviane De Cassia" sort="Oliveira, Viviane De Cassia" uniqKey="Oliveira V" first="Viviane De Cássia" last="Oliveira">Viviane De Cássia Oliveira</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical trial for evaluation of <italic>Ricinus communis</italic>
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<author><name sortKey="Badar, Mauricio Malheiros" sort="Badar, Mauricio Malheiros" uniqKey="Badar M" first="Maurício Malheiros" last="Badar">Maurício Malheiros Badar</name>
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<country xml:lang="fr">Brésil</country>
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<author><name sortKey="Salles, Marcela Moreira" sort="Salles, Marcela Moreira" uniqKey="Salles M" first="Marcela Moreira" last="Salles">Marcela Moreira Salles</name>
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<country xml:lang="fr">Brésil</country>
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<author><name sortKey="Leite, Vanessa Maria Fagundes" sort="Leite, Vanessa Maria Fagundes" uniqKey="Leite V" first="Vanessa Maria Fagundes" last="Leite">Vanessa Maria Fagundes Leite</name>
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<country xml:lang="fr">Brésil</country>
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<author><name sortKey="De Arruda, Carolina Noronha Ferraz" sort="De Arruda, Carolina Noronha Ferraz" uniqKey="De Arruda C" first="Carolina Noronha Ferraz" last="De Arruda">Carolina Noronha Ferraz De Arruda</name>
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<author><name sortKey="Oliveira, Viviane De Cassia" sort="Oliveira, Viviane De Cassia" uniqKey="Oliveira V" first="Viviane De Cássia" last="Oliveira">Viviane De Cássia Oliveira</name>
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<author><name sortKey="Do Nascimento, Cassio" sort="Do Nascimento, Cassio" uniqKey="Do Nascimento C" first="Cássio" last="Do Nascimento">Cássio Do Nascimento</name>
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<country xml:lang="fr">Brésil</country>
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<author><name sortKey="De Souza, Raphael Freitas" sort="De Souza, Raphael Freitas" uniqKey="De Souza R" first="Raphael Freitas" last="De Souza">Raphael Freitas De Souza</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
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<author><name sortKey="Paranhos, Helena De Freitas De Oliveira" sort="Paranhos, Helena De Freitas De Oliveira" uniqKey="Paranhos H" first="Helena De Freitas De Oliveira" last="Paranhos">Helena De Freitas De Oliveira Paranhos</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silva Lovato, Claudia Helena" sort="Silva Lovato, Claudia Helena" uniqKey="Silva Lovato C" first="Cláudia Helena" last="Silva-Lovato">Cláudia Helena Silva-Lovato</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP</wicri:regionArea>
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<series><title level="j">Journal of Applied Oral Science</title>
<idno type="ISSN">1678-7757</idno>
<idno type="eISSN">1678-7765</idno>
<imprint><date when="2017">2017</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The development of opportunistic infections due to poor denture hygiene conditions justified the search for effective hygiene protocols for controlling denture biofilm. </p>
<sec><title>Objective</title>
<p> This study evaluated <italic>Ricinus communis</italic>
and sodium hypochlorite solutions in terms of biofilm removal ability, remission of candidiasis, antimicrobial activity, and participant satisfaction.</p>
</sec>
<sec><title>Material and Methods</title>
<p> It was conducted a controlled clinical trial, randomized, double-blind, and crossover. Sixty-four denture wearers with (n=24) and without candidiasis (n=40) were instructed to brush (3 times/day) and immerse their dentures (20 min/day) in different storage solutions (S1 / S2: 0.25% / 0.5% sodium hypochlorite; S3: 10% <italic>R. communis</italic>
; S4: Saline).The trial period for each solution was seven days and a washout period of seven days was used before starting the use of another solution. The variables were analyzed at baseline and after each trial period. The biofilm of inner surfaces of maxillary dentures was disclosed, photographed, and total and dyed areas were measured (Image Tool software). The percentage of biofilm was calculated. Remission of candidiasis was assessed by visual scale and score were attributed. Antimicrobial activity was assessed by the DNA-Checkerboard hybridization method. Patient satisfaction was measured using a questionnaire.</p>
</sec>
<sec><title>Results</title>
<p> S1 (4.41±7.98%) and S2 (2.93±5.23%) were more effective then S3 (6.95±10.93%) in biofilm remotion(P<0.0001). All solutions were different from the control (11.07±11.99%). S3 was the most effective solution in remission of candidiasis (50%), followed by S1 (46%). Concerning antimicrobial action, S1/S2 were similar and resulted in the lowest microorganism mean count (P=0.04), followed by S3. No significant differences were found with patient’s satisfaction.</p>
</sec>
<sec><title>Conclusions</title>
<p> 10% <italic>R. communis</italic>
and 0.25% sodium hypochlorite were effective in biofilm removal, causing remission of candidiasis and reducing the formation of microbial colonies in denture surfaces. All solutions were approved by patients.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Appl Oral Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">J Appl Oral Sci</journal-id>
<journal-id journal-id-type="publisher-id">jaos</journal-id>
<journal-title-group><journal-title>Journal of Applied Oral Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">1678-7757</issn>
<issn pub-type="epub">1678-7765</issn>
<publisher><publisher-name>Faculdade De Odontologia De Bauru - USP</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28678952</article-id>
<article-id pub-id-type="pmc">5482256</article-id>
<article-id pub-id-type="publisher-id">1678-7757-2016-0222</article-id>
<article-id pub-id-type="doi">10.1590/1678-7757-2016-0222</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Clinical trial for evaluation of <italic>Ricinus communis</italic>
and sodium hypochlorite as denture cleanser</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>BADARÓ</surname>
<given-names>Maurício Malheiros</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>SALLES</surname>
<given-names>Marcela Moreira</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>LEITE</surname>
<given-names>Vanessa Maria Fagundes</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de ARRUDA</surname>
<given-names>Carolina Noronha Ferraz</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>OLIVEIRA</surname>
<given-names>Viviane de Cássia</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>do NASCIMENTO</surname>
<given-names>Cássio</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de SOUZA</surname>
<given-names>Raphael Freitas</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>PARANHOS</surname>
<given-names>Helena de Freitas de Oliveira</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>SILVA-LOVATO</surname>
<given-names>Cláudia Helena</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Ribeirão Preto, SP, Brazil</aff>
<author-notes><corresp> Corresponding address: Prof. Drª. Cláudia Helena Lovato da Silva. Departamento de Materiais Dentários e Prótese - Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo - Avenida do Café s/n. 14040-904 - Ribeirão Preto - SP - Brazil. Phone: +55(16)3315-4006. e-mail: <email>chl@forp.usp.br</email>
</corresp>
</author-notes>
<pub-date pub-type="epub-ppub"><season>May-Jun</season>
<year>2017</year>
</pub-date>
<pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><season>May-Jun</season>
<year>2017</year>
</pub-date>
<volume>25</volume>
<issue>3</issue>
<fpage>324</fpage>
<lpage>334</lpage>
<history><date date-type="received"><day>02</day>
<month>5</month>
<year>2016</year>
</date>
<date date-type="rev-recd"><day>04</day>
<month>11</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>27</day>
<month>11</month>
<year>2016</year>
</date>
</history>
<permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p> This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. </license-p>
</license>
</permissions>
<abstract><title>Abstract</title>
<p>The development of opportunistic infections due to poor denture hygiene conditions justified the search for effective hygiene protocols for controlling denture biofilm. </p>
<sec><title>Objective</title>
<p> This study evaluated <italic>Ricinus communis</italic>
and sodium hypochlorite solutions in terms of biofilm removal ability, remission of candidiasis, antimicrobial activity, and participant satisfaction.</p>
</sec>
<sec><title>Material and Methods</title>
<p> It was conducted a controlled clinical trial, randomized, double-blind, and crossover. Sixty-four denture wearers with (n=24) and without candidiasis (n=40) were instructed to brush (3 times/day) and immerse their dentures (20 min/day) in different storage solutions (S1 / S2: 0.25% / 0.5% sodium hypochlorite; S3: 10% <italic>R. communis</italic>
; S4: Saline).The trial period for each solution was seven days and a washout period of seven days was used before starting the use of another solution. The variables were analyzed at baseline and after each trial period. The biofilm of inner surfaces of maxillary dentures was disclosed, photographed, and total and dyed areas were measured (Image Tool software). The percentage of biofilm was calculated. Remission of candidiasis was assessed by visual scale and score were attributed. Antimicrobial activity was assessed by the DNA-Checkerboard hybridization method. Patient satisfaction was measured using a questionnaire.</p>
</sec>
<sec><title>Results</title>
<p> S1 (4.41±7.98%) and S2 (2.93±5.23%) were more effective then S3 (6.95±10.93%) in biofilm remotion(P<0.0001). All solutions were different from the control (11.07±11.99%). S3 was the most effective solution in remission of candidiasis (50%), followed by S1 (46%). Concerning antimicrobial action, S1/S2 were similar and resulted in the lowest microorganism mean count (P=0.04), followed by S3. No significant differences were found with patient’s satisfaction.</p>
</sec>
<sec><title>Conclusions</title>
<p> 10% <italic>R. communis</italic>
and 0.25% sodium hypochlorite were effective in biofilm removal, causing remission of candidiasis and reducing the formation of microbial colonies in denture surfaces. All solutions were approved by patients.</p>
</sec>
</abstract>
<kwd-group><kwd>Denture</kwd>
<kwd>Biofilms</kwd>
<kwd>Candidiasis</kwd>
<kwd>Disinfection</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
<table-count count="5"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="30"></ref-count>
<page-count count="11"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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