Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects
Identifieur interne : 002F06 ( Pmc/Curation ); précédent : 002F05; suivant : 002F07Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects
Auteurs : Jwa-Young Kim [Corée du Sud] ; Byoung-Eun Yang [Corée du Sud] ; Jin-Hee Ahn [Corée du Sud] ; Sang O. Park [Corée du Sud] ; Hye-Won Shim [Corée du Sud]Source :
- The Journal of Advanced Prosthodontics [ 2005-7806 ] ; 2014.
Abstract
Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-Gide®) using a rat calvarial defect model.
Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-Gide®). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination.
Bone regeneration was observed in the SF and Bio-Gide®-treated groups to a greater extent than in the control group (mean volume of new bone was 5.49 ± 1.48 mm3 at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-Gide® samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks (8.75 ± 0.80 vs. 8.47 ± 0.75 mm3, respectively,
SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.
Url:
DOI: 10.4047/jap.2014.6.6.539
PubMed: 25551015
PubMed Central: 4279054
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F06
Links to Exploration step
PMC:4279054Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects</title><author><name sortKey="Kim, Jwa Young" sort="Kim, Jwa Young" uniqKey="Kim J" first="Jwa-Young" last="Kim">Jwa-Young Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Byoung Eun" sort="Yang, Byoung Eun" uniqKey="Yang B" first="Byoung-Eun" last="Yang">Byoung-Eun Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Ahn, Jin Hee" sort="Ahn, Jin Hee" uniqKey="Ahn J" first="Jin-Hee" last="Ahn">Jin-Hee Ahn</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sang O" sort="Park, Sang O" uniqKey="Park S" first="Sang O" last="Park">Sang O. Park</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, Hye Won" sort="Shim, Hye Won" uniqKey="Shim H" first="Hye-Won" last="Shim">Hye-Won Shim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25551015</idno><idno type="pmc">4279054</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279054</idno><idno type="RBID">PMC:4279054</idno><idno type="doi">10.4047/jap.2014.6.6.539</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002F06</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F06</idno><idno type="wicri:Area/Pmc/Curation">002F06</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects</title><author><name sortKey="Kim, Jwa Young" sort="Kim, Jwa Young" uniqKey="Kim J" first="Jwa-Young" last="Kim">Jwa-Young Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Byoung Eun" sort="Yang, Byoung Eun" uniqKey="Yang B" first="Byoung-Eun" last="Yang">Byoung-Eun Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Ahn, Jin Hee" sort="Ahn, Jin Hee" uniqKey="Ahn J" first="Jin-Hee" last="Ahn">Jin-Hee Ahn</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sang O" sort="Park, Sang O" uniqKey="Park S" first="Sang O" last="Park">Sang O. Park</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, Hye Won" sort="Shim, Hye Won" uniqKey="Shim H" first="Hye-Won" last="Shim">Hye-Won Shim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Advanced Prosthodontics</title><idno type="ISSN">2005-7806</idno><idno type="eISSN">2005-7814</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title><p>Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-Gide®) using a rat calvarial defect model.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-Gide®). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination.</p></sec><sec><title>RESULTS</title><p>Bone regeneration was observed in the SF and Bio-Gide®-treated groups to a greater extent than in the control group (mean volume of new bone was 5.49 ± 1.48 mm<sup>3</sup> at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-Gide® samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks (8.75 ± 0.80 vs. 8.47 ± 0.75 mm<sup>3</sup>, respectively, <italic>P</italic>=.592).</p></sec><sec><title>CONCLUSION</title><p>SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Becker, Be" uniqKey="Becker B">BE Becker</name></author><author><name sortKey="Becker, W" uniqKey="Becker W">W Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karring, T" uniqKey="Karring T">T Karring</name></author><author><name sortKey="Nyman, S" uniqKey="Nyman S">S Nyman</name></author><author><name sortKey="Gottlow, J" uniqKey="Gottlow J">J Gottlow</name></author><author><name sortKey="Laurell, L" uniqKey="Laurell L">L Laurell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="H Mmerle, Ch" uniqKey="H Mmerle C">CH Hämmerle</name></author><author><name sortKey="Jung, Re" uniqKey="Jung R">RE Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahlin, C" uniqKey="Dahlin C">C Dahlin</name></author><author><name sortKey="Linde, A" uniqKey="Linde A">A Linde</name></author><author><name sortKey="Gottlow, J" uniqKey="Gottlow J">J Gottlow</name></author><author><name sortKey="Nyman, S" uniqKey="Nyman S">S Nyman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linde, A" uniqKey="Linde A">A Linde</name></author><author><name sortKey="Thoren, C" uniqKey="Thoren C">C Thorén</name></author><author><name sortKey="Dahlin, C" uniqKey="Dahlin C">C Dahlin</name></author><author><name sortKey="Sandberg, E" uniqKey="Sandberg E">E Sandberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="H Mmerle, Ch" uniqKey="H Mmerle C">CH Hämmerle</name></author><author><name sortKey="Jung, Re" uniqKey="Jung R">RE Jung</name></author><author><name sortKey="Feloutzis, A" uniqKey="Feloutzis A">A Feloutzis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Re" uniqKey="Jung R">RE Jung</name></author><author><name sortKey="Fenner, N" uniqKey="Fenner N">N Fenner</name></author><author><name sortKey="H Mmerle, Ch" uniqKey="H Mmerle C">CH Hämmerle</name></author><author><name sortKey="Zitzmann, Nu" uniqKey="Zitzmann N">NU Zitzmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahlin, C" uniqKey="Dahlin C">C Dahlin</name></author><author><name sortKey="Sennerby, L" uniqKey="Sennerby L">L Sennerby</name></author><author><name sortKey="Lekholm, U" uniqKey="Lekholm U">U Lekholm</name></author><author><name sortKey="Linde, A" uniqKey="Linde A">A Linde</name></author><author><name sortKey="Nyman, S" uniqKey="Nyman S">S Nyman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davarpanah, M" uniqKey="Davarpanah M">M Davarpanah</name></author><author><name sortKey="Tecucianu, Jf" uniqKey="Tecucianu J">JF Tecucianu</name></author><author><name sortKey="Slama, M" uniqKey="Slama M">M Slama</name></author><author><name sortKey="Celletti, R" uniqKey="Celletti R">R Celletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machtei, Ee" uniqKey="Machtei E">EE Machtei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simion, M" uniqKey="Simion M">M Simion</name></author><author><name sortKey="Baldoni, M" uniqKey="Baldoni M">M Baldoni</name></author><author><name sortKey="Rossi, P" uniqKey="Rossi P">P Rossi</name></author><author><name sortKey="Zaffe, D" uniqKey="Zaffe D">D Zaffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidmaier, G" uniqKey="Schmidmaier G">G Schmidmaier</name></author><author><name sortKey="Baehr, K" uniqKey="Baehr K">K Baehr</name></author><author><name sortKey="Mohr, S" uniqKey="Mohr S">S Mohr</name></author><author><name sortKey="Kretschmar, M" uniqKey="Kretschmar M">M Kretschmar</name></author><author><name sortKey="Beck, S" uniqKey="Beck S">S Beck</name></author><author><name sortKey="Wildemann, B" uniqKey="Wildemann B">B Wildemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warrer, K" uniqKey="Warrer K">K Warrer</name></author><author><name sortKey="Karring, T" uniqKey="Karring T">T Karring</name></author><author><name sortKey="Nyman, S" uniqKey="Nyman S">S Nyman</name></author><author><name sortKey="Gogolewski, S" uniqKey="Gogolewski S">S Gogolewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sevor, Jj" uniqKey="Sevor J">JJ Sevor</name></author><author><name sortKey="Meffert, Rm" uniqKey="Meffert R">RM Meffert</name></author><author><name sortKey="Cassingham, Rj" uniqKey="Cassingham R">RJ Cassingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tams, J" uniqKey="Tams J">J Tams</name></author><author><name sortKey="Rozema, Fr" uniqKey="Rozema F">FR Rozema</name></author><author><name sortKey="Bos, Rr" uniqKey="Bos R">RR Bos</name></author><author><name sortKey="Roodenburg, Jl" uniqKey="Roodenburg J">JL Roodenburg</name></author><author><name sortKey="Nikkels, Pg" uniqKey="Nikkels P">PG Nikkels</name></author><author><name sortKey="Vermey, A" uniqKey="Vermey A">A Vermey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, L" uniqKey="Wu L">L Wu</name></author><author><name sortKey="Ding, J" uniqKey="Ding J">J Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Ms" uniqKey="Taylor M">MS Taylor</name></author><author><name sortKey="Daniels, Au" uniqKey="Daniels A">AU Daniels</name></author><author><name sortKey="Andriano, Kp" uniqKey="Andriano K">KP Andriano</name></author><author><name sortKey="Heller, J" uniqKey="Heller J">J Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zitzmann, Nu" uniqKey="Zitzmann N">NU Zitzmann</name></author><author><name sortKey="Sch Rer, P" uniqKey="Sch Rer P">P Schärer</name></author><author><name sortKey="Marinello, Cp" uniqKey="Marinello C">CP Marinello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fishman, Ja" uniqKey="Fishman J">JA Fishman</name></author><author><name sortKey="Scobie, L" uniqKey="Scobie L">L Scobie</name></author><author><name sortKey="Takeuchi, Y" uniqKey="Takeuchi Y">Y Takeuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauli, G" uniqKey="Pauli G">G Pauli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Leeuwen, Ac" uniqKey="Van Leeuwen A">AC van Leeuwen</name></author><author><name sortKey="Huddleston Slater, Jj" uniqKey="Huddleston Slater J">JJ Huddleston Slater</name></author><author><name sortKey="Gielkens, Pf" uniqKey="Gielkens P">PF Gielkens</name></author><author><name sortKey="De Jong, Jr" uniqKey="De Jong J">JR de Jong</name></author><author><name sortKey="Grijpma, Dw" uniqKey="Grijpma D">DW Grijpma</name></author><author><name sortKey="Bos, Rr" uniqKey="Bos R">RR Bos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altman, Gh" uniqKey="Altman G">GH Altman</name></author><author><name sortKey="Diaz, F" uniqKey="Diaz F">F Diaz</name></author><author><name sortKey="Jakuba, C" uniqKey="Jakuba C">C Jakuba</name></author><author><name sortKey="Calabro, T" uniqKey="Calabro T">T Calabro</name></author><author><name sortKey="Horan, Rl" uniqKey="Horan R">RL Horan</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Richmond, J" uniqKey="Richmond J">J Richmond</name></author><author><name sortKey="Kaplan, Dl" uniqKey="Kaplan D">DL Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, Bm" uniqKey="Min B">BM Min</name></author><author><name sortKey="Lee, G" uniqKey="Lee G">G Lee</name></author><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name></author><author><name sortKey="Nam, Ys" uniqKey="Nam Y">YS Nam</name></author><author><name sortKey="Lee, Ts" uniqKey="Lee T">TS Lee</name></author><author><name sortKey="Park, Wh" uniqKey="Park W">WH Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sofia, S" uniqKey="Sofia S">S Sofia</name></author><author><name sortKey="Mccarthy, Mb" uniqKey="Mccarthy M">MB McCarthy</name></author><author><name sortKey="Gronowicz, G" uniqKey="Gronowicz G">G Gronowicz</name></author><author><name sortKey="Kaplan, Dl" uniqKey="Kaplan D">DL Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Jeong, L" uniqKey="Jeong L">L Jeong</name></author><author><name sortKey="Park, Hn" uniqKey="Park H">HN Park</name></author><author><name sortKey="Shin, Sy" uniqKey="Shin S">SY Shin</name></author><author><name sortKey="Park, Wh" uniqKey="Park W">WH Park</name></author><author><name sortKey="Lee, Sc" uniqKey="Lee S">SC Lee</name></author><author><name sortKey="Kim, Ti" uniqKey="Kim T">TI Kim</name></author><author><name sortKey="Park, Yj" uniqKey="Park Y">YJ Park</name></author><author><name sortKey="Seol, Yj" uniqKey="Seol Y">YJ Seol</name></author><author><name sortKey="Lee, Ym" uniqKey="Lee Y">YM Lee</name></author><author><name sortKey="Ku, Y" uniqKey="Ku Y">Y Ku</name></author><author><name sortKey="Rhyu, Ic" uniqKey="Rhyu I">IC Rhyu</name></author><author><name sortKey="Han, Sb" uniqKey="Han S">SB Han</name></author><author><name sortKey="Chung, Cp" uniqKey="Chung C">CP Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, C" uniqKey="Bosch C">C Bosch</name></author><author><name sortKey="Melsen, B" uniqKey="Melsen B">B Melsen</name></author><author><name sortKey="Vargervik, K" uniqKey="Vargervik K">K Vargervik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gielkens, Pf" uniqKey="Gielkens P">PF Gielkens</name></author><author><name sortKey="Schortinghuis, J" uniqKey="Schortinghuis J">J Schortinghuis</name></author><author><name sortKey="De Jong, Jr" uniqKey="De Jong J">JR de Jong</name></author><author><name sortKey="Raghoebar, Gm" uniqKey="Raghoebar G">GM Raghoebar</name></author><author><name sortKey="Stegenga, B" uniqKey="Stegenga B">B Stegenga</name></author><author><name sortKey="Bos, Rr" uniqKey="Bos R">RR Bos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruegsegger, P" uniqKey="Ruegsegger P">P Rüegsegger</name></author><author><name sortKey="Koller, B" uniqKey="Koller B">B Koller</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalstra, M" uniqKey="Dalstra M">M Dalstra</name></author><author><name sortKey="Verna, C" uniqKey="Verna C">C Verna</name></author><author><name sortKey="Cacciafesta, V" uniqKey="Cacciafesta V">V Cacciafesta</name></author><author><name sortKey="Andreassen, Tt" uniqKey="Andreassen T">TT Andreassen</name></author><author><name sortKey="Melsen, B" uniqKey="Melsen B">B Melsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verna, C" uniqKey="Verna C">C Verna</name></author><author><name sortKey="Dalstra, M" uniqKey="Dalstra M">M Dalstra</name></author><author><name sortKey="Wikesjo, Um" uniqKey="Wikesjo U">UM Wikesjö</name></author><author><name sortKey="Trombelli, L" uniqKey="Trombelli L">L Trombelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coelho, Pg" uniqKey="Coelho P">PG Coelho</name></author><author><name sortKey="Giro, G" uniqKey="Giro G">G Giro</name></author><author><name sortKey="Kim, W" uniqKey="Kim W">W Kim</name></author><author><name sortKey="Granato, R" uniqKey="Granato R">R Granato</name></author><author><name sortKey="Marin, C" uniqKey="Marin C">C Marin</name></author><author><name sortKey="Bonfante, Ea" uniqKey="Bonfante E">EA Bonfante</name></author><author><name sortKey="Bonfante, S" uniqKey="Bonfante S">S Bonfante</name></author><author><name sortKey="Lilin, T" uniqKey="Lilin T">T Lilin</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gielkens, Pf" uniqKey="Gielkens P">PF Gielkens</name></author><author><name sortKey="Schortinghuis, J" uniqKey="Schortinghuis J">J Schortinghuis</name></author><author><name sortKey="De Jong, Jr" uniqKey="De Jong J">JR de Jong</name></author><author><name sortKey="Huysmans, Mc" uniqKey="Huysmans M">MC Huysmans</name></author><author><name sortKey="Leeuwen, Mb" uniqKey="Leeuwen M">MB Leeuwen</name></author><author><name sortKey="Raghoebar, Gm" uniqKey="Raghoebar G">GM Raghoebar</name></author><author><name sortKey="Bos, Rr" uniqKey="Bos R">RR Bos</name></author><author><name sortKey="Stegenga, B" uniqKey="Stegenga B">B Stegenga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahlin, C" uniqKey="Dahlin C">C Dahlin</name></author><author><name sortKey="Andersson, L" uniqKey="Andersson L">L Andersson</name></author><author><name sortKey="Linde, A" uniqKey="Linde A">A Linde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uebersax, L" uniqKey="Uebersax L">L Uebersax</name></author><author><name sortKey="Hagenmuller, H" uniqKey="Hagenmuller H">H Hagenmüller</name></author><author><name sortKey="Hofmann, S" uniqKey="Hofmann S">S Hofmann</name></author><author><name sortKey="Gruenblatt, E" uniqKey="Gruenblatt E">E Gruenblatt</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Müller</name></author><author><name sortKey="Vunjak Novakovic, G" uniqKey="Vunjak Novakovic G">G Vunjak-Novakovic</name></author><author><name sortKey="Kaplan, Dl" uniqKey="Kaplan D">DL Kaplan</name></author><author><name sortKey="Merkle, Hp" uniqKey="Merkle H">HP Merkle</name></author><author><name sortKey="Meinel, L" uniqKey="Meinel L">L Meinel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id><journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id><journal-id journal-id-type="publisher-id">JAP</journal-id><journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title></journal-title-group><issn pub-type="ppub">2005-7806</issn><issn pub-type="epub">2005-7814</issn><publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25551015</article-id><article-id pub-id-type="pmc">4279054</article-id><article-id pub-id-type="doi">10.4047/jap.2014.6.6.539</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jwa-Young</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Byoung-Eun</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Jin-Hee</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sang O</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Shim</surname><given-names>Hye-Won</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</aff><aff id="A2"><label>2</label>Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.</aff><aff id="A3"><label>3</label>Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul, Republic of Korea.</aff><author-notes><corresp>Corresponding author: Hye-Won Shim. Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro, 170-gil, Dongan-gu, Anyang 431-796, Republic of Korea. Tel. 82 31 380 5974: <email>hyewonshim@hallym.or.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2014</year></pub-date><volume>6</volume><issue>6</issue><fpage>539</fpage><lpage>546</lpage><history><date date-type="received"><day>12</day><month>5</month><year>2014</year></date><date date-type="rev-recd"><day>04</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>18</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Korean Academy of Prosthodontics</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>PURPOSE</title><p>Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-Gide®) using a rat calvarial defect model.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-Gide®). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination.</p></sec><sec><title>RESULTS</title><p>Bone regeneration was observed in the SF and Bio-Gide®-treated groups to a greater extent than in the control group (mean volume of new bone was 5.49 ± 1.48 mm<sup>3</sup> at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-Gide® samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks (8.75 ± 0.80 vs. 8.47 ± 0.75 mm<sup>3</sup>, respectively, <italic>P</italic>=.592).</p></sec><sec><title>CONCLUSION</title><p>SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.</p></sec></abstract><kwd-group><kwd>Silk</kwd><kwd>Bone regeneration</kwd><kwd>Membranes</kwd><kwd>Dental implants</kwd><kwd>Collagen</kwd><kwd>Guided tissue regeneration</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><p>Rat calvarium showing (A) the bilateral 5 mm-sized bony defects and (B) calvarial defects covered by a silk fibroin membrane.</p></caption><graphic xlink:href="jap-6-539-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><p>Histological view of calvarial defects at 2, 4, and 8 weeks (original magnification ×40, hematoxylin and eosin stain). (A) photograph of Bio-Gide® membrane treated group at 2 weeks; (B) photograph of silk fibroin membrane treated group at 2 weeks; (C) photograph of control group at 2 weeks; (D) photograph of Bio-Gide® membrane treated group at 4 weeks; (E) photograph of silk fibroin membrane treated group at 4 weeks; (F) photograph of control group at 4 weeks; (G) photograph of Bio-Gide® membrane treated group at 8 weeks; (H) photograph of silk fibroin membrane treated group at 8 weeks; (I) photograph of control group at 8 weeks. BGM: Bio-Gide® membrane, SFM: silk fibroin membrane, OB: old bone, NB: new generating bone, IG: infiltrating growth of fibrotic and epithelial cells.</p></caption><graphic xlink:href="jap-6-539-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><p>Microcomputerized tomographic
image of the region of interest (ROI) in the
calvarial defect in the control, silk fibroin
membrane-, and Bio-Gide® membrane-treated
groups at 2, 4, and 8 weeks. The ROI is
denoted by the circled area in each image,
which shows the amount of new bone
generated.</p></caption><graphic xlink:href="jap-6-539-g003"></graphic></fig><fig id="F4" orientation="portrait" position="float"><label>Fig. 4</label><caption><p>Graph of the mean volume (and SD) of new bone formation (in mm<sup>3</sup>) (y-axis) for the control, Bio-Gide®
membrane, and silk fibroin (SF) membrane-treated groups
at 2, 4, and 8 weeks after surgery.</p></caption><graphic xlink:href="jap-6-539-g004"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Absolute volume of new bone (in mm<sup>3</sup>) in the original defect as measured using micro-CT. The number of bony
defects in the control group was six at 2 weeks, seven in the Bio-Gide® group and the silk fibroin group at 2 and 4 weeks,
and eight in the other four groups</p></caption><graphic xlink:href="jap-6-539-i001"></graphic></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002F06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4279054
|texte= Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25551015" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |