Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
Identifieur interne : 002E50 ( Pmc/Curation ); précédent : 002E49; suivant : 002E51Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium
Auteurs : Yicheng Cheng [République populaire de Chine] ; Jiang Wu [République populaire de Chine] ; Bo Gao [République populaire de Chine] ; Xianghui Zhao [République populaire de Chine] ; Junyan Yao [République populaire de Chine] ; Shenglin Mei [République populaire de Chine] ; Liang Zhang [République populaire de Chine] ; Huifang Ren [République populaire de Chine]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2012.
Abstract
Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro.
BBF-loaded PLLA nanoparticles were prepared using the emulsion solvent-evaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium.
The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours.
The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.
Url:
DOI: 10.2147/IJN.S37022
PubMed: 23152682
PubMed Central: 3496405
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<series><title level="j">International Journal of Nanomedicine</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro.</p>
</sec>
<sec><title>Methods</title>
<p>BBF-loaded PLLA nanoparticles were prepared using the emulsion solvent-evaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium.</p>
</sec>
<sec><title>Results</title>
<p>The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours.</p>
</sec>
<sec><title>Conclusion</title>
<p>The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id>
<journal-title-group><journal-title>International Journal of Nanomedicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1176-9114</issn>
<issn pub-type="epub">1178-2013</issn>
<publisher><publisher-name>Dove Medical Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23152682</article-id>
<article-id pub-id-type="pmc">3496405</article-id>
<article-id pub-id-type="doi">10.2147/IJN.S37022</article-id>
<article-id pub-id-type="publisher-id">ijn-7-5641</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Yicheng</given-names>
</name>
<xref ref-type="aff" rid="af1-ijn-7-5641">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Jiang</given-names>
</name>
<xref ref-type="aff" rid="af1-ijn-7-5641">1</xref>
<xref ref-type="corresp" rid="c1-ijn-7-5641"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Bo</given-names>
</name>
<xref ref-type="aff" rid="af1-ijn-7-5641">1</xref>
<xref ref-type="corresp" rid="c1-ijn-7-5641"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Xianghui</given-names>
</name>
<xref ref-type="aff" rid="af2-ijn-7-5641">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yao</surname>
<given-names>Junyan</given-names>
</name>
<xref ref-type="aff" rid="af3-ijn-7-5641">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mei</surname>
<given-names>Shenglin</given-names>
</name>
<xref ref-type="aff" rid="af1-ijn-7-5641">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Liang</given-names>
</name>
<xref ref-type="aff" rid="af4-ijn-7-5641">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ren</surname>
<given-names>Huifang</given-names>
</name>
<xref ref-type="aff" rid="af1-ijn-7-5641">1</xref>
</contrib>
</contrib-group>
<aff id="af1-ijn-7-5641"><label>1</label>
Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi’an, China</aff>
<aff id="af2-ijn-7-5641"><label>2</label>
Institute of Neuroscience, School of Basic Medicine, Fourth Military Medical University, Xi’an, China</aff>
<aff id="af3-ijn-7-5641"><label>3</label>
Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi’an, China</aff>
<aff id="af4-ijn-7-5641"><label>4</label>
Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi’an, China</aff>
<author-notes><corresp id="c1-ijn-7-5641">Correspondence: Jiang Wu, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 145, West Changle Road, Xi’an 710032, People’s Republic of China, Tel +86 29 8477 6469, Fax +86 29 8477 6469, Email <email>wujiang@fmmu.edu.cn</email>
. Bo Gao, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, No. 145, West Changle Road, Xi’an 710032, People’s Republic of China, Tel +86 29 8477 6469, Fax +86 29 8477 6469, Email <email>gaobo@fmmu.edu.cn</email>
</corresp>
<fn id="fn1-ijn-7-5641"><p>Yicheng Cheng and Jiang Wu contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>11</month>
<year>2012</year>
</pub-date>
<volume>7</volume>
<fpage>5641</fpage>
<lpage>5652</lpage>
<permissions><copyright-statement>© 2012 Cheng et al, publisher and licensee Dove Medical Press Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro.</p>
</sec>
<sec><title>Methods</title>
<p>BBF-loaded PLLA nanoparticles were prepared using the emulsion solvent-evaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium.</p>
</sec>
<sec><title>Results</title>
<p>The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours.</p>
</sec>
<sec><title>Conclusion</title>
<p>The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.</p>
</sec>
</abstract>
<kwd-group><kwd>antibacterial</kwd>
<kwd>coating</kwd>
<kwd>halogenated furanone</kwd>
<kwd>nanoparticles</kwd>
<kwd>microarc oxidation</kwd>
<kwd>sustained release</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-ijn-7-5641" position="float"><label>Figure 1</label>
<caption><p>Chemical structure of (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone.</p>
</caption>
<graphic xlink:href="ijn-7-5641f1"></graphic>
</fig>
<fig id="f2-ijn-7-5641" position="float"><label>Figure 2</label>
<caption><p>Schematic presentation of the preparation of BBF-loaded PLLA nanoparticles and the fabrication of antibacterial coating containing BBF-loaded PLLA nanoparticles on MAO-Ti. (<bold>A</bold>
) Preparation of BBF-loaded PLLA nanoparticles. (<bold>B</bold>
) Fabrication of antibacterial coating containing BBF-loaded PLLA nanoparticles on MAO-Ti.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; DCM, dichloroethane; PLLA, poly(L-lactic acid); NPs, nanoparticles; MAO-Ti, microarc-oxidized titanium; PVA, poly (vinyl alcohol); O/W, oil/water.</p>
</caption>
<graphic xlink:href="ijn-7-5641f2"></graphic>
</fig>
<fig id="f3-ijn-7-5641" position="float"><label>Figure 3</label>
<caption><p>Size distribution of BBF-loaded PLLA nanoparticles.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid).</p>
</caption>
<graphic xlink:href="ijn-7-5641f3"></graphic>
</fig>
<fig id="f4-ijn-7-5641" position="float"><label>Figure 4</label>
<caption><p>Scanning electron microscopic images of BBF-loaded PLLA nanoparticles. (<bold>A</bold>
) BBF-loaded PLLA nanoparticles at low magnification. (<bold>B</bold>
) BBF-loaded PLLA nanoparticles at high magnification.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid).</p>
</caption>
<graphic xlink:href="ijn-7-5641f4"></graphic>
</fig>
<fig id="f5-ijn-7-5641" position="float"><label>Figure 5</label>
<caption><p>In vitro release curves for BBF from BBF-loaded PLLA nanoparticles and BBF powder in phosphate-buffered saline. (<bold>A</bold>
) Experimental points over the complete time assay. (<bold>B</bold>
) First 24 hours of the release study (n = 3).</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid); NPs, nanoparticles.</p>
</caption>
<graphic xlink:href="ijn-7-5641f5"></graphic>
</fig>
<fig id="f6-ijn-7-5641" position="float"><label>Figure 6</label>
<caption><p>Scanning electron microscopic images of the degradation process of BBF-loaded PLLA nanoparticles in phosphate-buffered saline. (<bold>A</bold>
) 10 days. (<bold>B</bold>
) 20 days. (<bold>C</bold>
) 30 days. (<bold>D</bold>
) 45 days.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid).</p>
</caption>
<graphic xlink:href="ijn-7-5641f6"></graphic>
</fig>
<fig id="f7-ijn-7-5641" position="float"><label>Figure 7</label>
<caption><p>Scanning electron microscopic images of the surface morphology of commercially pure titanium (<bold>A</bold>
) before and (<bold>B</bold>
) after microarc oxidation.</p>
</caption>
<graphic xlink:href="ijn-7-5641f7"></graphic>
</fig>
<fig id="f8-ijn-7-5641" position="float"><label>Figure 8</label>
<caption><p>X-ray diffraction spectra of the surface phase composition of the microarc oxidation coatings.</p>
</caption>
<graphic xlink:href="ijn-7-5641f8"></graphic>
</fig>
<fig id="f9-ijn-7-5641" position="float"><label>Figure 9</label>
<caption><p>Scanning electron microscopic images of the antibacterial coating containing BBF-loaded PLLA nanoparticles on microarc-oxidized titanium. Antibacterial coating at low (<bold>A</bold>
) and high (<bold>B</bold>
) magnification.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid).</p>
</caption>
<graphic xlink:href="ijn-7-5641f9"></graphic>
</fig>
<fig id="f10-ijn-7-5641" position="float"><label>Figure 10</label>
<caption><p>In vitro release curves for BBF from antibacterial coating containing BBF-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium. (<bold>A</bold>
) Experimental points over the complete time assay. (<bold>B</bold>
) First 24 hours for the release study (n = 3).</p>
<p><bold>Abbreviation:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone.</p>
</caption>
<graphic xlink:href="ijn-7-5641f10"></graphic>
</fig>
<fig id="f11-ijn-7-5641" position="float"><label>Figure 11</label>
<caption><p>Scanning electron microscopic images of the degradation process for antibacterial coating containing BBF-loaded PLLA nanoparticles on microarc oxidation-treated titanium in phosphate-buffered saline. (<bold>A</bold>
) 15 days. (<bold>B</bold>
) 30 days. (<bold>C</bold>
) 45 days. (<bold>D</bold>
) 60 days.</p>
<p><bold>Abbreviations:</bold>
BBF, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone; PLLA, poly(L-lactic acid).</p>
</caption>
<graphic xlink:href="ijn-7-5641f11"></graphic>
</fig>
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