Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction
Identifieur interne : 002C63 ( Pmc/Curation ); précédent : 002C62; suivant : 002C64Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction
Auteurs : Vicky Ehlers [Allemagne] ; Ines Willershausen [Allemagne] ; Joachim Kraft [Allemagne] ; Thomas Münzel [Allemagne] ; Brita Willershausen [Allemagne]Source :
- Head & Face Medicine [ 1746-160X ] ; 2011.
Abstract
The aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI).
A total of 48 GCF samples from 20 AMI patients, hospitalized at the Department of Cardiology and Angiology of the Johannes Gutenberg University Mainz, were investigated. Besides the myocardial infarction all patients suffered from chronic periodontal disease. Fifty-one GCF samples from 20 healthy age matched individuals with similar periodontal conditions served as controls. The dental examination included the assessment of oral hygiene, gingival inflammation, probing pocket depth, clinical attachment level and X-ray examination. The study was only carried out after the positive consent of the regional ethic commission. A quantitative assessment of aMMP-8 levels in the gingival crevicular fluid was performed with the help of the DentoAnalyzer (Dentognostics GmbH, Jena, Germany), utilising an immunological procedure.
The aMMP-8 concentrations found in the gingival crevicular fluid of the AMI patients significantly differed (p = 0.001; mean value 30.33 ± 41.99 ng/ml aMMP-8) from the control group (mean value 10.0 ± 10.7 ng/ml aMMP-8). These findings suggest that periodontal inflammation in AMI patients might be associated with higher MMP-8-values compared to the healthy controls.
The acute myocardial infarction seems to influence the degree of periodontal inflammation, thus the measurement of the gingival crevicular fluid MMP8 levels seems to be a helpful biochemical test to obtain information about the severity of the periodontal disease.
Url:
DOI: 10.1186/1746-160X-7-1
PubMed: 21219642
PubMed Central: 3022744
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction</title><author><name sortKey="Ehlers, Vicky" sort="Ehlers, Vicky" uniqKey="Ehlers V" first="Vicky" last="Ehlers">Vicky Ehlers</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Willershausen, Ines" sort="Willershausen, Ines" uniqKey="Willershausen I" first="Ines" last="Willershausen">Ines Willershausen</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Joachim" sort="Kraft, Joachim" uniqKey="Kraft J" first="Joachim" last="Kraft">Joachim Kraft</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Munzel, Thomas" sort="Munzel, Thomas" uniqKey="Munzel T" first="Thomas" last="Münzel">Thomas Münzel</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Cardiology and Angiology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology and Angiology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Willershausen, Brita" sort="Willershausen, Brita" uniqKey="Willershausen B" first="Brita" last="Willershausen">Brita Willershausen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21219642</idno><idno type="pmc">3022744</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022744</idno><idno type="RBID">PMC:3022744</idno><idno type="doi">10.1186/1746-160X-7-1</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C63</idno><idno type="wicri:Area/Pmc/Curation">002C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction</title><author><name sortKey="Ehlers, Vicky" sort="Ehlers, Vicky" uniqKey="Ehlers V" first="Vicky" last="Ehlers">Vicky Ehlers</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Willershausen, Ines" sort="Willershausen, Ines" uniqKey="Willershausen I" first="Ines" last="Willershausen">Ines Willershausen</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Joachim" sort="Kraft, Joachim" uniqKey="Kraft J" first="Joachim" last="Kraft">Joachim Kraft</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Munzel, Thomas" sort="Munzel, Thomas" uniqKey="Munzel T" first="Thomas" last="Münzel">Thomas Münzel</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Cardiology and Angiology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology and Angiology, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Willershausen, Brita" sort="Willershausen, Brita" uniqKey="Willershausen B" first="Brita" last="Willershausen">Brita Willershausen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz</wicri:regionArea></affiliation></author></analytic><series><title level="j">Head & Face Medicine</title><idno type="eISSN">1746-160X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI).</p></sec><sec><title>Methods</title><p>A total of 48 GCF samples from 20 AMI patients, hospitalized at the Department of Cardiology and Angiology of the Johannes Gutenberg University Mainz, were investigated. Besides the myocardial infarction all patients suffered from chronic periodontal disease. Fifty-one GCF samples from 20 healthy age matched individuals with similar periodontal conditions served as controls. The dental examination included the assessment of oral hygiene, gingival inflammation, probing pocket depth, clinical attachment level and X-ray examination. The study was only carried out after the positive consent of the regional ethic commission. A quantitative assessment of aMMP-8 levels in the gingival crevicular fluid was performed with the help of the DentoAnalyzer (Dentognostics GmbH, Jena, Germany), utilising an immunological procedure.</p></sec><sec><title>Results</title><p>The aMMP-8 concentrations found in the gingival crevicular fluid of the AMI patients significantly differed (p = 0.001; mean value 30.33 ± 41.99 ng/ml aMMP-8) from the control group (mean value 10.0 ± 10.7 ng/ml aMMP-8). These findings suggest that periodontal inflammation in AMI patients might be associated with higher MMP-8-values compared to the healthy controls.</p></sec><sec><title>Conclusions</title><p>The acute myocardial infarction seems to influence the degree of periodontal inflammation, thus the measurement of the gingival crevicular fluid MMP8 levels seems to be a helpful biochemical test to obtain information about the severity of the periodontal disease.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="M Ntyl, P" uniqKey="M Ntyl P">P Mäntylä</name></author><author><name sortKey="Stenman, M" uniqKey="Stenman M">M Stenman</name></author><author><name sortKey="Kinane, Df" uniqKey="Kinane D">DF Kinane</name></author><author><name sortKey="Tikanoja, S" uniqKey="Tikanoja S">S Tikanoja</name></author><author><name sortKey="Luoto, H" uniqKey="Luoto H">H Luoto</name></author><author><name sortKey="Salo, T" uniqKey="Salo T">T Salo</name></author><author><name sortKey="Sosa, T" uniqKey="Sosa T">T Sosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Yy" uniqKey="Li Y">YY Li</name></author><author><name sortKey="Reldmann, Am" uniqKey="Reldmann A">AM Reldmann</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Mc Tiermann, Cf" uniqKey="Mc Tiermann C">CF MC Tiermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagase, H" uniqKey="Nagase H">H Nagase</name></author><author><name sortKey="Woessner, Jrjf" uniqKey="Woessner J">JRJF Woessner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynods, Jj" uniqKey="Reynods J">JJ Reynods</name></author><author><name sortKey="Hembry, Rm" uniqKey="Hembry R">RM Hembry</name></author><author><name sortKey="Meikle, Mc" uniqKey="Meikle M">MC Meikle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinane, Df" uniqKey="Kinane D">DF Kinane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mann, Dl" uniqKey="Mann D">DL Mann</name></author><author><name sortKey="Spinale, Fg" uniqKey="Spinale F">FG Spinale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyagi, Sc" uniqKey="Tyagi S">SC Tyagi</name></author><author><name sortKey="Kumar, Sg" uniqKey="Kumar S">SG Kumar</name></author><author><name sortKey="Haas, Sj" uniqKey="Haas S">SJ Haas</name></author><author><name sortKey="Reddy, Hk" uniqKey="Reddy H">HK Reddy</name></author><author><name sortKey="Voelker, Dj" uniqKey="Voelker D">DJ Voelker</name></author><author><name sortKey="Hayden, Mr" uniqKey="Hayden M">MR Hayden</name></author><author><name sortKey="Demmy, Tl" uniqKey="Demmy T">TL Demmy</name></author><author><name sortKey="Schmaltz, Ra" uniqKey="Schmaltz R">RA Schmaltz</name></author><author><name sortKey="Curtis, Jj" uniqKey="Curtis J">JJ Curtis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birkedal Hansen, H" uniqKey="Birkedal Hansen H">H Birkedal-Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mc Culloch, Ca" uniqKey="Mc Culloch C">CA Mc Culloch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Tj Derhane, L" uniqKey="Tj Derhane L">L Tjäderhane</name></author><author><name sortKey="Salo, T" uniqKey="Salo T">T Salo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Tj Derhane, L" uniqKey="Tj Derhane L">L Tjäderhane</name></author><author><name sortKey="Konttinen, Yt" uniqKey="Konttinen Y">YT Konttinen</name></author><author><name sortKey="Lauhio, A" uniqKey="Lauhio A">A Lauhio</name></author><author><name sortKey="Salo, T" uniqKey="Salo T">T Salo</name></author><author><name sortKey="Lee, Hm" uniqKey="Lee H">HM Lee</name></author><author><name sortKey="Golub, Lm" uniqKey="Golub L">LM Golub</name></author><author><name sortKey="Brown, Dl" uniqKey="Brown D">DL Brown</name></author><author><name sortKey="M Ntyl, P" uniqKey="M Ntyl P">P Mäntylä</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Ntyl, P" uniqKey="M Ntyl P">P Mäntylä</name></author><author><name sortKey="Stenman, M" uniqKey="Stenman M">M Stenman</name></author><author><name sortKey="Kinane, D" uniqKey="Kinane D">D Kinane</name></author><author><name sortKey="Salo, T" uniqKey="Salo T">T Salo</name></author><author><name sortKey="Suomalainen, K" uniqKey="Suomalainen K">K Suomalainen</name></author><author><name sortKey="Tikanoja, S" uniqKey="Tikanoja S">S Tikanoja</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mattila, Kj" uniqKey="Mattila K">KJ Mattila</name></author><author><name sortKey="Nieminen, Ms" uniqKey="Nieminen M">MS Nieminen</name></author><author><name sortKey="Valtonen, Vv" uniqKey="Valtonen V">VV Valtonen</name></author><author><name sortKey="Rasi, Vp" uniqKey="Rasi V">VP Rasi</name></author><author><name sortKey="Kes Niemi, Ya" uniqKey="Kes Niemi Y">YA Kesäniemi</name></author><author><name sortKey="Syrj L, Sl" uniqKey="Syrj L S">SL Syrjälä</name></author><author><name sortKey="Jungell, Ps" uniqKey="Jungell P">PS Jungell</name></author><author><name sortKey="Isoluoma, M" uniqKey="Isoluoma M">M Isoluoma</name></author><author><name sortKey="Hietaniemi, K" uniqKey="Hietaniemi K">K Hietaniemi</name></author><author><name sortKey="Jokinen, Mj" uniqKey="Jokinen M">MJ Jokinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattila, Kj" uniqKey="Mattila K">KJ Mattila</name></author><author><name sortKey="Valtonen, Vv" uniqKey="Valtonen V">VV Valtonen</name></author><author><name sortKey="Nieminen, M" uniqKey="Nieminen M">M Nieminen</name></author><author><name sortKey="Huttunen, Jk" uniqKey="Huttunen J">JK Huttunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beck, Jd" uniqKey="Beck J">JD Beck</name></author><author><name sortKey="Slade, G" uniqKey="Slade G">G Slade</name></author><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Page, Rc" uniqKey="Page R">RC Page</name></author><author><name sortKey="Kornman, Ks" uniqKey="Kornman K">KS Kornman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quigley, Ga" uniqKey="Quigley G">GA Quigley</name></author><author><name sortKey="Hein, Jw" uniqKey="Hein J">JW Hein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saxer, Up" uniqKey="Saxer U">UP Saxer</name></author><author><name sortKey="Muhlemann, Hr" uniqKey="Muhlemann H">HR Mühlemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munjal, S" uniqKey="Munjal S">S Munjal</name></author><author><name sortKey="Miethe, P" uniqKey="Miethe P">P Miethe</name></author><author><name sortKey="Netuschil, L" uniqKey="Netuschil L">L Netuschil</name></author><author><name sortKey="Struck, F" uniqKey="Struck F">F Struck</name></author><author><name sortKey="Maier, K" uniqKey="Maier K">K Maier</name></author><author><name sortKey="Bauermeister, C" uniqKey="Bauermeister C">C Bauermeister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munjal, Sk" uniqKey="Munjal S">SK Munjal</name></author><author><name sortKey="Prescher, N" uniqKey="Prescher N">N Prescher</name></author><author><name sortKey="Struck, F" uniqKey="Struck F">F Struck</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Maier, K" uniqKey="Maier K">K Maier</name></author><author><name sortKey="Netuschil, L" uniqKey="Netuschil L">L Netuschil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartmann, H" uniqKey="Hartmann H">H Hartmann</name></author><author><name sortKey="Lubbers, B" uniqKey="Lubbers B">B Lubbers</name></author><author><name sortKey="Casaretto, M" uniqKey="Casaretto M">M Casaretto</name></author><author><name sortKey="Bautsch, W" uniqKey="Bautsch W">W Bautsch</name></author><author><name sortKey="Klos, A" uniqKey="Klos A">A Klos</name></author><author><name sortKey="Kohl, J" uniqKey="Kohl J">J Kohl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavuslu, S" uniqKey="Cavuslu S">S Cavuslu</name></author><author><name sortKey="Oncul, O" uniqKey="Oncul O">O Oncul</name></author><author><name sortKey="Altunay, H" uniqKey="Altunay H">H Altunay</name></author><author><name sortKey="Ozsoy, Mf" uniqKey="Ozsoy M">MF Ozsoy</name></author><author><name sortKey="Kocak, N" uniqKey="Kocak N">N Kocak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stove, S" uniqKey="Stove S">S Stove</name></author><author><name sortKey="Klos, A" uniqKey="Klos A">A Klos</name></author><author><name sortKey="Bautsch, W" uniqKey="Bautsch W">W Bautsch</name></author><author><name sortKey="Kohl, J" uniqKey="Kohl J">J Kohl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Mh" uniqKey="Meyer M">MH Meyer</name></author><author><name sortKey="Stehr, M" uniqKey="Stehr M">M Stehr</name></author><author><name sortKey="Bhuju, S" uniqKey="Bhuju S">S Bhuju</name></author><author><name sortKey="Krause, Hj" uniqKey="Krause H">HJ Krause</name></author><author><name sortKey="Hartmann, M" uniqKey="Hartmann M">M Hartmann</name></author><author><name sortKey="Miethe, P" uniqKey="Miethe P">P Miethe</name></author><author><name sortKey="Singh, M" uniqKey="Singh M">M Singh</name></author><author><name sortKey="Keusgen, M" uniqKey="Keusgen M">M Keusgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Golub, Lm" uniqKey="Golub L">LM Golub</name></author><author><name sortKey="Lee, Hm" uniqKey="Lee H">HM Lee</name></author><author><name sortKey="Stoner, Ja" uniqKey="Stoner J">JA Stoner</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Reinhardt, Ra" uniqKey="Reinhardt R">RA Reinhardt</name></author><author><name sortKey="Wolff, Ms" uniqKey="Wolff M">MS Wolff</name></author><author><name sortKey="Ryan, Me" uniqKey="Ryan M">ME Ryan</name></author><author><name sortKey="Nummikoski, Pv" uniqKey="Nummikoski P">PV Nummikoski</name></author><author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beck, J" uniqKey="Beck J">J Beck</name></author><author><name sortKey="Garcia, R" uniqKey="Garcia R">R Garcia</name></author><author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name></author><author><name sortKey="Vokonas, Ps" uniqKey="Vokonas P">PS Vokonas</name></author><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willershausen, B" uniqKey="Willershausen B">B Willershausen</name></author><author><name sortKey="Kasaj, A" uniqKey="Kasaj A">A Kasaj</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Zahorka, D" uniqKey="Zahorka D">D Zahorka</name></author><author><name sortKey="Brise O, B" uniqKey="Brise O B">B Briseño</name></author><author><name sortKey="Blettner, M" uniqKey="Blettner M">M Blettner</name></author><author><name sortKey="Genth Zotz, S" uniqKey="Genth Zotz S">S Genth-Zotz</name></author><author><name sortKey="Munzel, T" uniqKey="Munzel T">T Münzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Humphrey, Ll" uniqKey="Humphrey L">LL Humphrey</name></author><author><name sortKey="Fu, R" uniqKey="Fu R">R Fu</name></author><author><name sortKey="Buckley, Di" uniqKey="Buckley D">DI Buckley</name></author><author><name sortKey="Freeman, M" uniqKey="Freeman M">M Freeman</name></author><author><name sortKey="Helfand, M" uniqKey="Helfand M">M Helfand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rose, Lf" uniqKey="Rose L">LF Rose</name></author><author><name sortKey="Mealey, B" uniqKey="Mealey B">B Mealey</name></author><author><name sortKey="Minsk, L" uniqKey="Minsk L">L Minsk</name></author><author><name sortKey="Cohen, Dw" uniqKey="Cohen D">DW Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuholm, J" uniqKey="Furuholm J">J Furuholm</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Qvarnstrom, M" uniqKey="Qvarnstrom M">M Qvarnström</name></author><author><name sortKey="Janket, St" uniqKey="Janket S">ST Janket</name></author><author><name sortKey="Tervahartiala, T" uniqKey="Tervahartiala T">T Tervahartiala</name></author><author><name sortKey="Nuutinen, P" uniqKey="Nuutinen P">P Nuutinen</name></author><author><name sortKey="Meurman, Jh" uniqKey="Meurman J">JH Meurman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinane, D" uniqKey="Kinane D">D Kinane</name></author><author><name sortKey="Bouchard, P" uniqKey="Bouchard P">P Bouchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joshipura, Kj" uniqKey="Joshipura K">KJ Joshipura</name></author><author><name sortKey="Pitihat, W" uniqKey="Pitihat W">W Pitihat</name></author><author><name sortKey="Hung, Hc" uniqKey="Hung H">HC Hung</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Golditz, Ga" uniqKey="Golditz G">GA Golditz</name></author><author><name sortKey="Douglass, Cw" uniqKey="Douglass C">CW Douglass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinane, Df" uniqKey="Kinane D">DF Kinane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larkin, M" uniqKey="Larkin M">M Larkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slade, Gd" uniqKey="Slade G">GD Slade</name></author><author><name sortKey="Ghezzi, Em" uniqKey="Ghezzi E">EM Ghezzi</name></author><author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name></author><author><name sortKey="Beck, Jd" uniqKey="Beck J">JD Beck</name></author><author><name sortKey="Riche, E" uniqKey="Riche E">E Riche</name></author><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grau, Aj" uniqKey="Grau A">AJ Grau</name></author><author><name sortKey="Becher, H" uniqKey="Becher H">H Becher</name></author><author><name sortKey="Ziegler, Cm" uniqKey="Ziegler C">CM Ziegler</name></author><author><name sortKey="Lichy, C" uniqKey="Lichy C">C Lichy</name></author><author><name sortKey="Buggle, F" uniqKey="Buggle F">F Buggle</name></author><author><name sortKey="Kaiser, C" uniqKey="Kaiser C">C Kaiser</name></author><author><name sortKey="Lutz, R" uniqKey="Lutz R">R Lutz</name></author><author><name sortKey="Bultmann, S" uniqKey="Bultmann S">S Bültmann</name></author><author><name sortKey="Preusch, M" uniqKey="Preusch M">M Preusch</name></author><author><name sortKey="Dorfer, Ce" uniqKey="Dorfer C">CE Dörfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattila, Kj" uniqKey="Mattila K">KJ Mattila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattila, Kj" uniqKey="Mattila K">KJ Mattila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuomainen, Am" uniqKey="Tuomainen A">AM Tuomainen</name></author><author><name sortKey="Nyyssonen, K" uniqKey="Nyyssonen K">K Nyyssönen</name></author><author><name sortKey="Laukkanen, Ja" uniqKey="Laukkanen J">JA Laukkanen</name></author><author><name sortKey="Tervahartiala, T" uniqKey="Tervahartiala T">T Tervahartiala</name></author><author><name sortKey="Tuomainen, Tp" uniqKey="Tuomainen T">TP Tuomainen</name></author><author><name sortKey="Salonen, Jt" uniqKey="Salonen J">JT Salonen</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Pussinen, Pj" uniqKey="Pussinen P">PJ Pussinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Stefano, F" uniqKey="De Stefano F">F De Stefano</name></author><author><name sortKey="Anda, Rf" uniqKey="Anda R">RF Anda</name></author><author><name sortKey="Kahn, Hs" uniqKey="Kahn H">HS Kahn</name></author><author><name sortKey="Williamson, Df" uniqKey="Williamson D">DF Williamson</name></author><author><name sortKey="Russel, Cm" uniqKey="Russel C">CM Russel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanic, Am" uniqKey="Romanic A">AM Romanic</name></author><author><name sortKey="Harrison, Sm" uniqKey="Harrison S">SM Harrison</name></author><author><name sortKey="Bao, W" uniqKey="Bao W">W Bao</name></author><author><name sortKey="Burns Kurtis, Cl" uniqKey="Burns Kurtis C">CL Burns-Kurtis</name></author><author><name sortKey="Pickering, S" uniqKey="Pickering S">S Pickering</name></author><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Grau, E" uniqKey="Grau E">E Grau</name></author><author><name sortKey="Mao, J" uniqKey="Mao J">J Mao</name></author><author><name sortKey="Sathe, Gm" uniqKey="Sathe G">GM Sathe</name></author><author><name sortKey="Ohlstein, Eh" uniqKey="Ohlstein E">EH Ohlstein</name></author><author><name sortKey="Yue, Eh" uniqKey="Yue E">EH Yue</name></author><author><name sortKey="Yue, Tl" uniqKey="Yue T">TL Yue</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Face Med</journal-id><journal-title-group><journal-title>Head & Face Medicine</journal-title></journal-title-group><issn pub-type="epub">1746-160X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21219642</article-id><article-id pub-id-type="pmc">3022744</article-id><article-id pub-id-type="publisher-id">1746-160X-7-1</article-id><article-id pub-id-type="doi">10.1186/1746-160X-7-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes" id="A1"><name><surname>Ehlers</surname><given-names>Vicky</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>vicky.ehlers@unimedizin-mainz.de</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A2"><name><surname>Willershausen</surname><given-names>Ines</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>ines.willershausen@unimedizin-mainz.de</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Kraft</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>gruner@uni-mainz.de</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Münzel</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>thomas.muenzel@unimedizin-mainz.de</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Willershausen</surname><given-names>Brita</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>brita.willershausen@unimedizin-mainz.de</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</aff><aff id="I2"><label>2</label>Institute for Dental Material Sciences and Technology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</aff><aff id="I3"><label>3</label>Department of Cardiology and Angiology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany</aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>10</day><month>1</month><year>2011</year></pub-date><volume>7</volume><fpage>1</fpage><lpage>1</lpage><history><date date-type="received"><day>12</day><month>4</month><year>2010</year></date><date date-type="accepted"><day>10</day><month>1</month><year>2011</year></date></history><permissions><copyright-statement>Copyright ©2011 Ehlers et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>Ehlers et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.head-face-med.com/content/7/1/1"></self-uri><abstract><sec><title>Background</title><p>The aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI).</p></sec><sec><title>Methods</title><p>A total of 48 GCF samples from 20 AMI patients, hospitalized at the Department of Cardiology and Angiology of the Johannes Gutenberg University Mainz, were investigated. Besides the myocardial infarction all patients suffered from chronic periodontal disease. Fifty-one GCF samples from 20 healthy age matched individuals with similar periodontal conditions served as controls. The dental examination included the assessment of oral hygiene, gingival inflammation, probing pocket depth, clinical attachment level and X-ray examination. The study was only carried out after the positive consent of the regional ethic commission. A quantitative assessment of aMMP-8 levels in the gingival crevicular fluid was performed with the help of the DentoAnalyzer (Dentognostics GmbH, Jena, Germany), utilising an immunological procedure.</p></sec><sec><title>Results</title><p>The aMMP-8 concentrations found in the gingival crevicular fluid of the AMI patients significantly differed (p = 0.001; mean value 30.33 ± 41.99 ng/ml aMMP-8) from the control group (mean value 10.0 ± 10.7 ng/ml aMMP-8). These findings suggest that periodontal inflammation in AMI patients might be associated with higher MMP-8-values compared to the healthy controls.</p></sec><sec><title>Conclusions</title><p>The acute myocardial infarction seems to influence the degree of periodontal inflammation, thus the measurement of the gingival crevicular fluid MMP8 levels seems to be a helpful biochemical test to obtain information about the severity of the periodontal disease.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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