α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus
Identifieur interne : 002C14 ( Pmc/Curation ); précédent : 002C13; suivant : 002C15α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus
Auteurs : Juan Pablo Aitken [Chili] ; Carolina Ortiz [Chili] ; Irene Morales-Bozo [Chili] ; Gonzalo Rojas-Alcayaga [Chili] ; Mauricio Baeza [Chili] ; Caroll Beltran [Chili] ; Alejandro Escobar [Chili]Source :
- Disease Markers [ 0278-0240 ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/128653
PubMed: 25821337
PubMed Central: 4363888
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>α</italic>-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus</title><author><name sortKey="Aitken, Juan Pablo" sort="Aitken, Juan Pablo" uniqKey="Aitken J" first="Juan Pablo" last="Aitken">Juan Pablo Aitken</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Ortiz, Carolina" sort="Ortiz, Carolina" uniqKey="Ortiz C" first="Carolina" last="Ortiz">Carolina Ortiz</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Morales Bozo, Irene" sort="Morales Bozo, Irene" uniqKey="Morales Bozo I" first="Irene" last="Morales-Bozo">Irene Morales-Bozo</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Rojas Alcayaga, Gonzalo" sort="Rojas Alcayaga, Gonzalo" uniqKey="Rojas Alcayaga G" first="Gonzalo" last="Rojas-Alcayaga">Gonzalo Rojas-Alcayaga</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Baeza, Mauricio" sort="Baeza, Mauricio" uniqKey="Baeza M" first="Mauricio" last="Baeza">Mauricio Baeza</name><affiliation wicri:level="1"><nlm:aff id="I3">Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Beltran, Caroll" sort="Beltran, Caroll" uniqKey="Beltran C" first="Caroll" last="Beltran">Caroll Beltran</name><affiliation wicri:level="1"><nlm:aff id="I4">Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Escobar, Alejandro" sort="Escobar, Alejandro" uniqKey="Escobar A" first="Alejandro" last="Escobar">Alejandro Escobar</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25821337</idno><idno type="pmc">4363888</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363888</idno><idno type="RBID">PMC:4363888</idno><idno type="doi">10.1155/2015/128653</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002C14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C14</idno><idno type="wicri:Area/Pmc/Curation">002C14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>α</italic>-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus</title><author><name sortKey="Aitken, Juan Pablo" sort="Aitken, Juan Pablo" uniqKey="Aitken J" first="Juan Pablo" last="Aitken">Juan Pablo Aitken</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Ortiz, Carolina" sort="Ortiz, Carolina" uniqKey="Ortiz C" first="Carolina" last="Ortiz">Carolina Ortiz</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Morales Bozo, Irene" sort="Morales Bozo, Irene" uniqKey="Morales Bozo I" first="Irene" last="Morales-Bozo">Irene Morales-Bozo</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Rojas Alcayaga, Gonzalo" sort="Rojas Alcayaga, Gonzalo" uniqKey="Rojas Alcayaga G" first="Gonzalo" last="Rojas-Alcayaga">Gonzalo Rojas-Alcayaga</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Baeza, Mauricio" sort="Baeza, Mauricio" uniqKey="Baeza M" first="Mauricio" last="Baeza">Mauricio Baeza</name><affiliation wicri:level="1"><nlm:aff id="I3">Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Beltran, Caroll" sort="Beltran, Caroll" uniqKey="Beltran C" first="Caroll" last="Beltran">Caroll Beltran</name><affiliation wicri:level="1"><nlm:aff id="I4">Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Escobar, Alejandro" sort="Escobar, Alejandro" uniqKey="Escobar A" first="Alejandro" last="Escobar">Alejandro Escobar</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea></affiliation></author></analytic><series><title level="j">Disease Markers</title><idno type="ISSN">0278-0240</idno><idno type="eISSN">1875-8630</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that <italic>α</italic>-2-macroglobulin levels are elevated in diabetic patients. <italic>Methods</italic>. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between <italic>α</italic>-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated. <italic>Results</italic>. We found a positive correlation between <italic>α</italic>-2-macroglobulin and HbA1c (<italic>r</italic> = 0.778 and <italic>P</italic> < 0.0001). Area under the receivers operating characteristic (ROC) curve of <italic>α</italic>-2-macroglobulin indicated a positive discrimination threshold of <italic>α</italic>-2-macroglobulin (AUC = 0.903, CI 95%: 0.847–0.959, <italic>P</italic> < 0.0001) to diagnose glycemic control. <italic>Conclusions</italic>. Our data strongly suggest that the level of saliva <italic>α</italic>-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hu, F B" uniqKey="Hu F">F. B. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmer, H K" uniqKey="Holmer H">H. K. Holmer</name></author><author><name sortKey="Ogden, L A" uniqKey="Ogden L">L. A. Ogden</name></author><author><name sortKey="Burda, B U" uniqKey="Burda B">B. U. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Dis Markers</journal-id><journal-id journal-id-type="iso-abbrev">Dis. Markers</journal-id><journal-id journal-id-type="publisher-id">DM</journal-id><journal-title-group><journal-title>Disease Markers</journal-title></journal-title-group><issn pub-type="ppub">0278-0240</issn><issn pub-type="epub">1875-8630</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25821337</article-id><article-id pub-id-type="pmc">4363888</article-id><article-id pub-id-type="doi">10.1155/2015/128653</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title><italic>α</italic>-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Aitken</surname><given-names>Juan Pablo</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ortiz</surname><given-names>Carolina</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Morales-Bozo</surname><given-names>Irene</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rojas-Alcayaga</surname><given-names>Gonzalo</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baeza</surname><given-names>Mauricio</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beltran</surname><given-names>Caroll</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1587-4179</contrib-id><name><surname>Escobar</surname><given-names>Alejandro</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</aff><aff id="I2"><sup>2</sup>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</aff><aff id="I3"><sup>3</sup>Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</aff><aff id="I4"><sup>4</sup>Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile</aff><author-notes><corresp id="cor1">*Alejandro Escobar: <email>janodvm@gmail.com</email></corresp><fn fn-type="other"><p>Academic Editor: Donald H. Chace</p></fn></author-notes><pub-date pub-type="ppub"><year>2015</year></pub-date><pub-date pub-type="epub"><day>3</day><month>3</month><year>2015</year></pub-date><volume>2015</volume><elocation-id>128653</elocation-id><history><date date-type="received"><day>9</day><month>12</month><year>2014</year></date><date date-type="rev-recd"><day>9</day><month>2</month><year>2015</year></date><date date-type="accepted"><day>9</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Juan Pablo Aitken et al.</copyright-statement><copyright-year>2015</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Background</italic>. Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that <italic>α</italic>-2-macroglobulin levels are elevated in diabetic patients. <italic>Methods</italic>. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between <italic>α</italic>-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated. <italic>Results</italic>. We found a positive correlation between <italic>α</italic>-2-macroglobulin and HbA1c (<italic>r</italic> = 0.778 and <italic>P</italic> < 0.0001). Area under the receivers operating characteristic (ROC) curve of <italic>α</italic>-2-macroglobulin indicated a positive discrimination threshold of <italic>α</italic>-2-macroglobulin (AUC = 0.903, CI 95%: 0.847–0.959, <italic>P</italic> < 0.0001) to diagnose glycemic control. <italic>Conclusions</italic>. Our data strongly suggest that the level of saliva <italic>α</italic>-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Box-plot showing the comparison of saliva levels of A2MG between patients with adequate and inadequate glycemic control (HbA1c percentages <7% and >7%).</p></caption><graphic xlink:href="DM2015-128653.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Scatter diagram showing the association between HbA1 percentage and saliva levels of A2MG based on Pearson's correlation analysis.</p></caption><graphic xlink:href="DM2015-128653.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>ROC curve of saliva levels of A2MG in DM2 patients with inadequate glycemic control. Receiver operating characteristic (ROC) curves displayed a positive discrimination threshold of A2MG in saliva to diagnose inadequate glycemic control in subjects with DM2.</p></caption><graphic xlink:href="DM2015-128653.003"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Baseline demographic and clinical characteristics based on the percentage of glycosylated hemoglobin.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th><th align="center" rowspan="1" colspan="1">HbA1c <7%<break></break>(<italic>n</italic> = 45/37.5%)</th><th align="center" rowspan="1" colspan="1">HbA1c >7%<break></break>(<italic>n</italic> = 75/62.5%)</th><th align="center" rowspan="1" colspan="1">Total<break></break>(<italic>n</italic> = 120/100%)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Male </td><td align="center" rowspan="1" colspan="1">12 (26.6%)</td><td align="center" rowspan="1" colspan="1">27 (36%)</td><td align="center" rowspan="1" colspan="1">39 (32.5%)</td></tr><tr><td align="left" rowspan="1" colspan="1">Age (years)</td><td align="center" rowspan="1" colspan="1">60.2 (10.2)</td><td align="center" rowspan="1" colspan="1">62.4 (10.1)</td><td align="center" rowspan="1" colspan="1">61.6 (10.1)</td></tr><tr><td align="left" rowspan="1" colspan="1">BMI</td><td align="center" rowspan="1" colspan="1">29.0 (4.2)</td><td align="center" rowspan="1" colspan="1">28.8 (4.5)</td><td align="center" rowspan="1" colspan="1">28.9 (4.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">HT</td><td align="center" rowspan="1" colspan="1">29 (64)</td><td align="center" rowspan="1" colspan="1">45 (60)</td><td align="center" rowspan="1" colspan="1">74 (61.6)</td></tr></tbody></table><table-wrap-foot><fn><p>BMI: body mass index; HT: hypertension; HbA1c: glycosylated hemoglobin. There were no statistically significant differences in any parameters.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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