Identification of oral bacterial DNA in synovial fluid of arthritis patients with native and failed prosthetic joints
Identifieur interne : 002791 ( Pmc/Curation ); précédent : 002790; suivant : 002792Identification of oral bacterial DNA in synovial fluid of arthritis patients with native and failed prosthetic joints
Auteurs : Stéphanie Témoin [États-Unis] ; Alia Chakaki [États-Unis] ; Ali Askari [États-Unis] ; Ahmed El-Halaby [États-Unis] ; Steven Fitzgerald [États-Unis] ; Randall E. Marcus [États-Unis] ; Yiping W. Han [États-Unis] ; Nabil F. Bissada [États-Unis]Source :
- Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [ 1076-1608 ] ; 2012.
Abstract
We examined the presence of bacterial DNA in synovial fluids of native or aseptically failed prosthetic joints from patients having periodontal disease and arthritis to determine if there is bacterial spread from the oral cavity to the joints.
A total of 36 subjects were enrolled in the study. Among these, 11 were diagnosed with rheumatoid arthritis (RA), and 25 with osteoarthritis (OA). Eight patients with OA and are with RA had failed prostheses. Synovial fluid was aspirated from the affected hip or knee joint. Pooled subgingival plaque samples were collected followed by clinical periodontal examination. Bacterial DNA was extracted from the collected synovial fluid and dental plaque samples followed by polymerase chain reactions (PCR) and DNA sequence analysis of the 16S-23S rRNA genes.
Of the 36 subjects, bacterial DNA was detected in the synovial fluid samples from five patients (13.9%), two with rheumatoid arthritis (one native and one failed prosthetic joints) and three with osteoarthritis (one native and two failed prosthetic joints). Of these five patients, two were diagnosed with periodontitis and had identical bacterial clones (
The present findings of this bacterial DNA in synovial fluid suggest the possibility of infection translocating from the periodontal tissue to the synovium. We suggest that patients with arthritis or failed prosthetic joints be examined for the presence of periodontal diseases and that be treated accordingly.
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DOI: 10.1097/RHU.0b013e3182500c95
PubMed: 22426587
PubMed Central: 3888235
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Steven Fitzgerald<affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation><affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of oral bacterial DNA in synovial fluid of arthritis patients with native and failed prosthetic joints</title><author><name sortKey="Temoin, Stephanie" sort="Temoin, Stephanie" uniqKey="Temoin S" first="Stéphanie" last="Témoin">Stéphanie Témoin</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Chakaki, Alia" sort="Chakaki, Alia" uniqKey="Chakaki A" first="Alia" last="Chakaki">Alia Chakaki</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Askari, Ali" sort="Askari, Ali" uniqKey="Askari A" first="Ali" last="Askari">Ali Askari</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Rheumatology, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Rheumatology, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="El Halaby, Ahmed" sort="El Halaby, Ahmed" uniqKey="El Halaby A" first="Ahmed" last="El-Halaby">Ahmed El-Halaby</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, Steven" sort="Fitzgerald, Steven" uniqKey="Fitzgerald S" first="Steven" last="Fitzgerald">Steven Fitzgerald</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Orthopaedics, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Marcus, Randall E" sort="Marcus, Randall E" uniqKey="Marcus R" first="Randall E." last="Marcus">Randall E. Marcus</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Orthopaedics, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Han, Yiping W" sort="Han, Yiping W" uniqKey="Han Y" first="Yiping W." last="Han">Yiping W. Han</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Bissada, Nabil F" sort="Bissada, Nabil F" uniqKey="Bissada N" first="Nabil F." last="Bissada">Nabil F. Bissada</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22426587</idno><idno type="pmc">3888235</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888235</idno><idno type="RBID">PMC:3888235</idno><idno type="doi">10.1097/RHU.0b013e3182500c95</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002791</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002791</idno><idno type="wicri:Area/Pmc/Curation">002791</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002791</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of oral bacterial DNA in synovial fluid of arthritis patients with native and failed prosthetic joints</title><author><name sortKey="Temoin, Stephanie" sort="Temoin, Stephanie" uniqKey="Temoin S" first="Stéphanie" last="Témoin">Stéphanie Témoin</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Chakaki, Alia" sort="Chakaki, Alia" uniqKey="Chakaki A" first="Alia" last="Chakaki">Alia Chakaki</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Askari, Ali" sort="Askari, Ali" uniqKey="Askari A" first="Ali" last="Askari">Ali Askari</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Rheumatology, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Rheumatology, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="El Halaby, Ahmed" sort="El Halaby, Ahmed" uniqKey="El Halaby A" first="Ahmed" last="El-Halaby">Ahmed El-Halaby</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, Steven" sort="Fitzgerald, Steven" uniqKey="Fitzgerald S" first="Steven" last="Fitzgerald">Steven Fitzgerald</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Orthopaedics, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Marcus, Randall E" sort="Marcus, Randall E" uniqKey="Marcus R" first="Randall E." last="Marcus">Randall E. Marcus</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Orthopaedics, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A6">Department of Orthopedic Surgery, University Hospitals Case Medical Center</nlm:aff><wicri:noCountry code="subfield">University Hospitals Case Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Han, Yiping W" sort="Han, Yiping W" uniqKey="Han Y" first="Yiping W." last="Han">Yiping W. Han</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Bissada, Nabil F" sort="Bissada, Nabil F" uniqKey="Bissada N" first="Nabil F." last="Bissada">Nabil F. Bissada</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases</title><idno type="ISSN">1076-1608</idno><idno type="eISSN">1536-7355</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">We examined the presence of bacterial DNA in synovial fluids of native or aseptically failed prosthetic joints from patients having periodontal disease and arthritis to determine if there is bacterial spread from the oral cavity to the joints.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A total of 36 subjects were enrolled in the study. Among these, 11 were diagnosed with rheumatoid arthritis (RA), and 25 with osteoarthritis (OA). Eight patients with OA and are with RA had failed prostheses. Synovial fluid was aspirated from the affected hip or knee joint. Pooled subgingival plaque samples were collected followed by clinical periodontal examination. Bacterial DNA was extracted from the collected synovial fluid and dental plaque samples followed by polymerase chain reactions (PCR) and DNA sequence analysis of the 16S-23S rRNA genes.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of the 36 subjects, bacterial DNA was detected in the synovial fluid samples from five patients (13.9%), two with rheumatoid arthritis (one native and one failed prosthetic joints) and three with osteoarthritis (one native and two failed prosthetic joints). Of these five patients, two were diagnosed with periodontitis and had identical bacterial clones (<italic>Fusobacterium nucleatum</italic> and <italic>Serratia proteamaculans</italic>, respectively) detected in both the synovial fluid and dental plaque samples.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The present findings of this bacterial DNA in synovial fluid suggest the possibility of infection translocating from the periodontal tissue to the synovium. We suggest that patients with arthritis or failed prosthetic joints be examined for the presence of periodontal diseases and that be treated accordingly.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9518034</journal-id><journal-id journal-id-type="pubmed-jr-id">32619</journal-id><journal-id journal-id-type="nlm-ta">J Clin Rheumatol</journal-id><journal-id journal-id-type="iso-abbrev">J Clin Rheumatol</journal-id><journal-title-group><journal-title>Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases</journal-title></journal-title-group><issn pub-type="ppub">1076-1608</issn><issn pub-type="epub">1536-7355</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22426587</article-id><article-id pub-id-type="pmc">3888235</article-id><article-id pub-id-type="doi">10.1097/RHU.0b013e3182500c95</article-id><article-id pub-id-type="manuscript">NIHMS525122</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Identification of oral bacterial DNA in synovial fluid of arthritis patients with native and failed prosthetic joints</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Témoin</surname><given-names>Stéphanie</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chakaki</surname><given-names>Alia</given-names></name><degrees>DDS, MSD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Askari</surname><given-names>Ali</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>El-Halaby</surname><given-names>Ahmed</given-names></name><degrees>DDS, MSD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Fitzgerald</surname><given-names>Steven</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">‡</xref><xref ref-type="aff" rid="A6">¶</xref></contrib><contrib contrib-type="author"><name><surname>Marcus</surname><given-names>Randall E.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">‡</xref><xref ref-type="aff" rid="A6">¶</xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Yiping W.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A4">§</xref><xref ref-type="aff" rid="A5">∥</xref></contrib><contrib contrib-type="author"><name><surname>Bissada</surname><given-names>Nabil F.</given-names></name><degrees>DDS, MSD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib></contrib-group><aff id="A1"><label>*</label>Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A2"><label>†</label>Department of Rheumatology, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A3"><label>‡</label>Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A4"><label>§</label>Department of Pathology, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A5"><label>∥</label>Department of Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A6"><label>¶</label>Department of Orthopedic Surgery, University Hospitals Case Medical Center</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author: Nabil Bissada, DDS, MSD. Mailing address: Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4905. Phone: (216) 368-6757. Fax: (216) 368-3204. <email>nabil.bissada@case.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>1</month><year>2014</year></pub-date><volume>18</volume><issue>3</issue><fpage>117</fpage><lpage>121</lpage><pmc-comment>elocation-id from pubmed: 10.1097/RHU.0b013e3182500c95</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">We examined the presence of bacterial DNA in synovial fluids of native or aseptically failed prosthetic joints from patients having periodontal disease and arthritis to determine if there is bacterial spread from the oral cavity to the joints.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A total of 36 subjects were enrolled in the study. Among these, 11 were diagnosed with rheumatoid arthritis (RA), and 25 with osteoarthritis (OA). Eight patients with OA and are with RA had failed prostheses. Synovial fluid was aspirated from the affected hip or knee joint. Pooled subgingival plaque samples were collected followed by clinical periodontal examination. Bacterial DNA was extracted from the collected synovial fluid and dental plaque samples followed by polymerase chain reactions (PCR) and DNA sequence analysis of the 16S-23S rRNA genes.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of the 36 subjects, bacterial DNA was detected in the synovial fluid samples from five patients (13.9%), two with rheumatoid arthritis (one native and one failed prosthetic joints) and three with osteoarthritis (one native and two failed prosthetic joints). Of these five patients, two were diagnosed with periodontitis and had identical bacterial clones (<italic>Fusobacterium nucleatum</italic> and <italic>Serratia proteamaculans</italic>, respectively) detected in both the synovial fluid and dental plaque samples.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The present findings of this bacterial DNA in synovial fluid suggest the possibility of infection translocating from the periodontal tissue to the synovium. We suggest that patients with arthritis or failed prosthetic joints be examined for the presence of periodontal diseases and that be treated accordingly.</p></sec></abstract><kwd-group><kwd>Oral bacteria</kwd><kwd>Synovial fluid</kwd><kwd>Rheumatoid arthritis</kwd><kwd>Osteoarthritis</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R21 DE017165 || DE</award-id></award-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R01 DE014924 || DE</award-id></award-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>K02 DE016102 || DE</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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