Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging
Identifieur interne : 002708 ( Pmc/Curation ); précédent : 002707; suivant : 002709Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging
Auteurs : M S Gomes [Brésil] ; F N Hugo [Brésil] ; J B Hilgert [Brésil] ; M. Sant'Ana Filho [Brésil] ; D M P. Padilha [Brésil] ; E M Simonsick [États-Unis] ; L. Ferrucci [États-Unis] ; M A Reynolds [États-Unis]Source :
- International endodontic journal [ 0143-2885 ] ; 2015.
Abstract
To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Aging (BLSA).
This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations. Periodontal disease (PD) and missing teeth were recorded. Total number of AP and RCT sites was determined from panoramic radiographs. EB was calculated as the sum of AP and RCT sites. Oral inflammatory burden (OIB) was calculated combining PD and EB. The main outcome was, incident CVE including angina, myocardial infarction and cardiovascular-related death. Participants were monitored for up to 44 years (mean=17.4±11.1 years) following dental examination. Relative Risks (RR) were calculated through Poisson regression models, estimating the relationship between AP, RCT, EB, PD, OIB and incident CVE.
Mean age at baseline was 55.0±16.8 years and 51.4% were men. Sixty two participants (22.3%) developed CVE. Bivariate analysis showed that PD, EB, number of teeth and OIB were associated with incident CVE. Multivariate models, adjusted for socio-demographic and medical variables, showed that age≥60 years (RR=3.07, 95%CI=1.68-5.62), hypertension (RR=2.0, 95%CI=1.16-3.46) and EB≥3 (RR=1.77, 95%CI=1.04-3.02) were independently associated with incident CVE. The association between OIB and incident CVE was reduced to non-significance after adjustments (RR=1.97, 95%CI=0.83-4.70).
EB in mid-life was an independent predictor of CVE among community-dwelling participants in the BLSA. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP.
Url:
DOI: 10.1111/iej.12468
PubMed: 26011008
PubMed Central: 5134837
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging</title><author><name sortKey="Gomes, M S" sort="Gomes, M S" uniqKey="Gomes M" first="M S" last="Gomes">M S Gomes</name><affiliation wicri:level="1"><nlm:aff id="A1">Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre</wicri:regionArea></affiliation></author><author><name sortKey="Hugo, F N" sort="Hugo, F N" uniqKey="Hugo F" first="F N" last="Hugo">F N Hugo</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Hilgert, J B" sort="Hilgert, J B" uniqKey="Hilgert J" first="J B" last="Hilgert">J B Hilgert</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Sant Ana Filho, M" sort="Sant Ana Filho, M" uniqKey="Sant Ana Filho M" first="M" last="Sant'Ana Filho">M. Sant'Ana Filho</name><affiliation wicri:level="1"><nlm:aff id="A3">Postgraduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Padilha, D M P" sort="Padilha, D M P" uniqKey="Padilha D" first="D M P" last="Padilha">D M P. Padilha</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Simonsick, E M" sort="Simonsick, E M" uniqKey="Simonsick E" first="E M" last="Simonsick">E M Simonsick</name><affiliation wicri:level="1"><nlm:aff id="A4">National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A4">National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Reynolds, M A" sort="Reynolds, M A" uniqKey="Reynolds M" first="M A" last="Reynolds">M A Reynolds</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26011008</idno><idno type="pmc">5134837</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134837</idno><idno type="RBID">PMC:5134837</idno><idno type="doi">10.1111/iej.12468</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002708</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002708</idno><idno type="wicri:Area/Pmc/Curation">002708</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002708</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging</title><author><name sortKey="Gomes, M S" sort="Gomes, M S" uniqKey="Gomes M" first="M S" last="Gomes">M S Gomes</name><affiliation wicri:level="1"><nlm:aff id="A1">Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre</wicri:regionArea></affiliation></author><author><name sortKey="Hugo, F N" sort="Hugo, F N" uniqKey="Hugo F" first="F N" last="Hugo">F N Hugo</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Hilgert, J B" sort="Hilgert, J B" uniqKey="Hilgert J" first="J B" last="Hilgert">J B Hilgert</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Sant Ana Filho, M" sort="Sant Ana Filho, M" uniqKey="Sant Ana Filho M" first="M" last="Sant'Ana Filho">M. Sant'Ana Filho</name><affiliation wicri:level="1"><nlm:aff id="A3">Postgraduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Padilha, D M P" sort="Padilha, D M P" uniqKey="Padilha D" first="D M P" last="Padilha">D M P. Padilha</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea></affiliation></author><author><name sortKey="Simonsick, E M" sort="Simonsick, E M" uniqKey="Simonsick E" first="E M" last="Simonsick">E M Simonsick</name><affiliation wicri:level="1"><nlm:aff id="A4">National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A4">National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Reynolds, M A" sort="Reynolds, M A" uniqKey="Reynolds M" first="M A" last="Reynolds">M A Reynolds</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD</wicri:regionArea></affiliation></author></analytic><series><title level="j">International endodontic journal</title><idno type="ISSN">0143-2885</idno><idno type="eISSN">1365-2591</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim</title><p id="P1">To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Aging (BLSA).</p></sec><sec id="S2"><title>Methodology</title><p id="P2">This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations. Periodontal disease (PD) and missing teeth were recorded. Total number of AP and RCT sites was determined from panoramic radiographs. EB was calculated as the sum of AP and RCT sites. Oral inflammatory burden (OIB) was calculated combining PD and EB. The main outcome was, incident CVE including angina, myocardial infarction and cardiovascular-related death. Participants were monitored for up to 44 years (mean=17.4±11.1 years) following dental examination. Relative Risks (RR) were calculated through Poisson regression models, estimating the relationship between AP, RCT, EB, PD, OIB and incident CVE.</p></sec><sec id="S3"><title>Results</title><p id="P3">Mean age at baseline was 55.0±16.8 years and 51.4% were men. Sixty two participants (22.3%) developed CVE. Bivariate analysis showed that PD, EB, number of teeth and OIB were associated with incident CVE. Multivariate models, adjusted for socio-demographic and medical variables, showed that age≥60 years (RR=3.07, 95%CI=1.68-5.62), hypertension (RR=2.0, 95%CI=1.16-3.46) and EB≥3 (RR=1.77, 95%CI=1.04-3.02) were independently associated with incident CVE. The association between OIB and incident CVE was reduced to non-significance after adjustments (RR=1.97, 95%CI=0.83-4.70).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">EB in mid-life was an independent predictor of CVE among community-dwelling participants in the BLSA. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8004996</journal-id><journal-id journal-id-type="pubmed-jr-id">4259</journal-id><journal-id journal-id-type="nlm-ta">Int Endod J</journal-id><journal-id journal-id-type="iso-abbrev">Int Endod J</journal-id><journal-title-group><journal-title>International endodontic journal</journal-title></journal-title-group><issn pub-type="ppub">0143-2885</issn><issn pub-type="epub">1365-2591</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26011008</article-id><article-id pub-id-type="pmc">5134837</article-id><article-id pub-id-type="doi">10.1111/iej.12468</article-id><article-id pub-id-type="manuscript">NIHMS693697</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gomes</surname><given-names>M S</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hugo</surname><given-names>F N</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hilgert</surname><given-names>J B</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sant'Ana Filho</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Padilha</surname><given-names>D M P</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Simonsick</surname><given-names>E M</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ferrucci</surname><given-names>L</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Reynolds</surname><given-names>M A</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre, Brazil</aff><aff id="A2"><label>2</label>Department of Community Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</aff><aff id="A3"><label>3</label>Postgraduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</aff><aff id="A4"><label>4</label>National Institute on Aging, Translational Gerontology Branch, Intramural Research Program, Baltimore, MD, USA</aff><aff id="A5"><label>5</label>Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD, USA.</aff><author-notes><corresp id="CR1"><bold>Corresponding author:</bold> Maximiliano Schünke Gomes, Medical and Dental Center of the Military Police of Rio Grande do Sul, Rua Sete de Setembro, 372, Porto Alegre, Brazil. CEP 90000-190, Phone:+55 051 99569626, Fax:+55 051 32882966, <email>endomax@gmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>11</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2017</year></pub-date><volume>49</volume><issue>4</issue><fpage>334</fpage><lpage>342</lpage><pmc-comment>elocation-id from pubmed: 10.1111/iej.12468</pmc-comment>
<abstract><sec id="S1"><title>Aim</title><p id="P1">To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Aging (BLSA).</p></sec><sec id="S2"><title>Methodology</title><p id="P2">This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations. Periodontal disease (PD) and missing teeth were recorded. Total number of AP and RCT sites was determined from panoramic radiographs. EB was calculated as the sum of AP and RCT sites. Oral inflammatory burden (OIB) was calculated combining PD and EB. The main outcome was, incident CVE including angina, myocardial infarction and cardiovascular-related death. Participants were monitored for up to 44 years (mean=17.4±11.1 years) following dental examination. Relative Risks (RR) were calculated through Poisson regression models, estimating the relationship between AP, RCT, EB, PD, OIB and incident CVE.</p></sec><sec id="S3"><title>Results</title><p id="P3">Mean age at baseline was 55.0±16.8 years and 51.4% were men. Sixty two participants (22.3%) developed CVE. Bivariate analysis showed that PD, EB, number of teeth and OIB were associated with incident CVE. Multivariate models, adjusted for socio-demographic and medical variables, showed that age≥60 years (RR=3.07, 95%CI=1.68-5.62), hypertension (RR=2.0, 95%CI=1.16-3.46) and EB≥3 (RR=1.77, 95%CI=1.04-3.02) were independently associated with incident CVE. The association between OIB and incident CVE was reduced to non-significance after adjustments (RR=1.97, 95%CI=0.83-4.70).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">EB in mid-life was an independent predictor of CVE among community-dwelling participants in the BLSA. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP.</p></sec></abstract><kwd-group><kwd>atherosclerosis</kwd><kwd>cardiovascular diseases</kwd><kwd>inflammation</kwd><kwd>oral-systemic diseases</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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