The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system
Identifieur interne : 002637 ( Pmc/Curation ); précédent : 002636; suivant : 002638The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system
Auteurs : Seunghee Cha [États-Unis] ; Hong-Kyun Kim [Corée du Sud] ; Hong-Seop Kho ; Young-Seok Park [Corée du Sud]Source :
- Current drug delivery [ 1567-2018 ] ; 2017.
Abstract
Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS). The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration. All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively. When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.
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DOI: 10.2174/1567201813666161013150648
PubMed: 27739377
PubMed Central: 5561526
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Hong-Seop Kho<affiliation><nlm:aff id="A3">Department of Oral Medicine and Oral Diagnosis, Seoul National Univerist, Seoul, Repubpic of Korea</nlm:aff>
<wicri:noCountry code="subfield">Repubpic of Korea</wicri:noCountry>
</affiliation>
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<series><title level="j">Current drug delivery</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS). The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration. All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively. When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.</p>
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101208455</journal-id>
<journal-id journal-id-type="pubmed-jr-id">32341</journal-id>
<journal-id journal-id-type="nlm-ta">Curr Drug Deliv</journal-id>
<journal-id journal-id-type="iso-abbrev">Curr Drug Deliv</journal-id>
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<title-group><article-title>The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Cha</surname>
<given-names>Seunghee</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">†</xref>
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<given-names>Hong-Kyun</given-names>
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<degrees>PhD</degrees>
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<xref rid="FN2" ref-type="author-notes">†</xref>
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<contrib contrib-type="author"><name><surname>Kho</surname>
<given-names>Hong-Seop</given-names>
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<degrees>DDS, MSD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
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<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Young-Seok</given-names>
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<degrees>DDS, MSD, PhD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1"><label>1</label>
Oral and Mxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, U.S.A</aff>
<aff id="A2"><label>2</label>
Departmentof Oral Anatomy,School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea</aff>
<aff id="A3"><label>3</label>
Department of Oral Medicine and Oral Diagnosis, Seoul National Univerist, Seoul, Repubpic of Korea</aff>
<aff id="A4"><label>4</label>
Department of Oral Anatomy, Seoul National Univeristy School of Dentistry, P.O. Box: 03080, Seoul, South Korea</aff>
<author-notes><corresp id="FN1"><label>*</label>
Address correspondence to this author at the Tel/Fax: +82-2-740-8669, +82-2-765-1925; <email>ayoayo7@snu.ac.kr</email>
</corresp>
<fn id="FN2" fn-type="equal"><label>†</label>
<p>contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>26</day>
<month>7</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="ppub"><year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>8</month>
<year>2017</year>
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<volume>14</volume>
<issue>4</issue>
<fpage>581</fpage>
<lpage>586</lpage>
<pmc-comment>elocation-id from pubmed: 10.2174/1567201813666161013150648</pmc-comment>
<abstract><p id="P1">Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS). The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration. All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively. When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.</p>
</abstract>
<kwd-group><kwd>implant-mediated drug delivery system</kwd>
<kwd>pilocarpine hydrochloride</kwd>
<kwd>dry eye</kwd>
<kwd>sustained release</kwd>
<kwd>osseogate</kwd>
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