Refining exposure definitions for studies of periodontal disease and systemic disease associations
Identifieur interne : 002605 ( Pmc/Curation ); précédent : 002604; suivant : 002606Refining exposure definitions for studies of periodontal disease and systemic disease associations
Auteurs : Ryan T. Demmer [États-Unis] ; Thomas Kocher ; Christian Schwahn ; Henry Völzke [Allemagne] ; David R. Jacobs [Norvège] ; Moïse Desvarieux [États-Unis, France]Source :
- Community dentistry and oral epidemiology [ 0301-5661 ] ; 2008.
Abstract
Substantial variation exists in reported associations between periodontal infections and cardiovascular disease. Imprecise periodontal exposure definitions are possible contributors to this variability. We studied appropriate exposure definitions for studying associations between clinical periodontal disease (PD) and systemic disease.
Data originate from men and women aged 20–79 enrolled in the Study of Health in Pomerania (SHIP) from 1997–2001. Age and sex-adjusted correlation analysis identified PD definitions with the highest cross-sectional associations with three subclinical markers of systemic disease: plasma fibrinogen (
In men and women, percent of sites with attachment loss (AL) ≥6 mm and tooth loss both revealed the highest correlation with HbA1c (
A range of near optimal definitions varied according to gender and whether the systemic disease marker reflected an acute or chronic situation. Pocket depth was more strongly correlated with the acute marker fibrinogen while attachment and tooth loss tended to be more strongly correlated with the chronic markers, HbA1c, and c-IMT. These findings can be useful in designing future studies investigating the association between PD and systemic disease.
Url:
DOI: 10.1111/j.1600-0528.2008.00435.x
PubMed: 18422705
PubMed Central: 5651676
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Thomas Kocher<affiliation><nlm:aff id="A2">Abteilung Parodontologie, Zentrum ZMK</nlm:aff>
<wicri:noCountry code="subfield">Zentrum ZMK</wicri:noCountry>
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<affiliation><nlm:aff id="A2">Abteilung Parodontologie, Zentrum ZMK</nlm:aff>
<wicri:noCountry code="subfield">Zentrum ZMK</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Substantial variation exists in reported associations between periodontal infections and cardiovascular disease. Imprecise periodontal exposure definitions are possible contributors to this variability. We studied appropriate exposure definitions for studying associations between clinical periodontal disease (PD) and systemic disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data originate from men and women aged 20–79 enrolled in the Study of Health in Pomerania (SHIP) from 1997–2001. Age and sex-adjusted correlation analysis identified PD definitions with the highest cross-sectional associations with three subclinical markers of systemic disease: plasma fibrinogen (<italic>n</italic>
= 3481), serum hemoglobin A1c (HbA1c) (<italic>n</italic>
= 3480), and common carotid artery intima-media thickness (c-IMT) (<italic>n</italic>
= 1745, age ≥ 45).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">In men and women, percent of sites with attachment loss (AL) ≥6 mm and tooth loss both revealed the highest correlation with HbA1c (<italic>ρ</italic>
= 0.11; several other definitions related similarly), while the strongest fibrinogen correlation was observed with percent of sites with pocket depth ≥3 mm (<italic>ρ</italic>
= 0.19). Findings for c-IMT among men were strongest for percent of sites with AL ≥6 mm (<italic>ρ</italic>
= 0.14; several other definitions related similarly) while among women, percent of sites with pocket depth ≥5 or 6 mm had the highest observed correlation (<italic>ρ</italic>
= 0.13).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">A range of near optimal definitions varied according to gender and whether the systemic disease marker reflected an acute or chronic situation. Pocket depth was more strongly correlated with the acute marker fibrinogen while attachment and tooth loss tended to be more strongly correlated with the chronic markers, HbA1c, and c-IMT. These findings can be useful in designing future studies investigating the association between PD and systemic disease.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410263</journal-id>
<journal-id journal-id-type="pubmed-jr-id">3109</journal-id>
<journal-id journal-id-type="nlm-ta">Community Dent Oral Epidemiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Community Dent Oral Epidemiol</journal-id>
<journal-title-group><journal-title>Community dentistry and oral epidemiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0301-5661</issn>
<issn pub-type="epub">1600-0528</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18422705</article-id>
<article-id pub-id-type="pmc">5651676</article-id>
<article-id pub-id-type="doi">10.1111/j.1600-0528.2008.00435.x</article-id>
<article-id pub-id-type="manuscript">NIHMS908999</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Refining exposure definitions for studies of periodontal disease and systemic disease associations</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Demmer</surname>
<given-names>Ryan T.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kocher</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwahn</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Völzke</surname>
<given-names>Henry</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacobs</surname>
<given-names>David R</given-names>
<suffix>Jr</suffix>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Desvarieux</surname>
<given-names>Moïse</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</aff>
<aff id="A2"><label>2</label>
Abteilung Parodontologie, Zentrum ZMK</aff>
<aff id="A3"><label>3</label>
Institut für Epidemiologie und Sozialmedizin, University of Greifswald, Greifswald, Germany</aff>
<aff id="A4"><label>4</label>
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota Minneapolis, MN, USA and Department of Nutrition, University of Oslo, Oslo, Norway</aff>
<aff id="A5"><label>5</label>
INSERM, Paris, and Universite Pierre et Marie Curie-Paris6, Paris</aff>
<author-notes><corresp id="FN1">Ryan T. Demmer, PhD MPH, Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA, Tel: 212-305-9339, Fax: 212-342-2756, <email>rtd2106@columbia.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>9</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>14</day>
<month>4</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>10</month>
<year>2017</year>
</pub-date>
<volume>36</volume>
<issue>6</issue>
<fpage>493</fpage>
<lpage>502</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/j.1600-0528.2008.00435.x</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Substantial variation exists in reported associations between periodontal infections and cardiovascular disease. Imprecise periodontal exposure definitions are possible contributors to this variability. We studied appropriate exposure definitions for studying associations between clinical periodontal disease (PD) and systemic disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data originate from men and women aged 20–79 enrolled in the Study of Health in Pomerania (SHIP) from 1997–2001. Age and sex-adjusted correlation analysis identified PD definitions with the highest cross-sectional associations with three subclinical markers of systemic disease: plasma fibrinogen (<italic>n</italic>
= 3481), serum hemoglobin A1c (HbA1c) (<italic>n</italic>
= 3480), and common carotid artery intima-media thickness (c-IMT) (<italic>n</italic>
= 1745, age ≥ 45).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">In men and women, percent of sites with attachment loss (AL) ≥6 mm and tooth loss both revealed the highest correlation with HbA1c (<italic>ρ</italic>
= 0.11; several other definitions related similarly), while the strongest fibrinogen correlation was observed with percent of sites with pocket depth ≥3 mm (<italic>ρ</italic>
= 0.19). Findings for c-IMT among men were strongest for percent of sites with AL ≥6 mm (<italic>ρ</italic>
= 0.14; several other definitions related similarly) while among women, percent of sites with pocket depth ≥5 or 6 mm had the highest observed correlation (<italic>ρ</italic>
= 0.13).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">A range of near optimal definitions varied according to gender and whether the systemic disease marker reflected an acute or chronic situation. Pocket depth was more strongly correlated with the acute marker fibrinogen while attachment and tooth loss tended to be more strongly correlated with the chronic markers, HbA1c, and c-IMT. These findings can be useful in designing future studies investigating the association between PD and systemic disease.</p>
</sec>
</abstract>
<kwd-group><kwd>atherosclerosis</kwd>
<kwd>cardiovascular</kwd>
<kwd>epidemiology</kwd>
<kwd>hemoglobin Alc</kwd>
<kwd>inflammation</kwd>
<kwd>periodontal</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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