Ligature-Induced Peri-Implantitis in Mice
Identifieur interne : 002584 ( Pmc/Curation ); précédent : 002583; suivant : 002585Ligature-Induced Peri-Implantitis in Mice
Auteurs : Flavia Q. Pirih [États-Unis] ; Sarah Hiyari [États-Unis] ; Ana Dv Barroso [Brésil] ; Adrian Ca Jorge [Brésil] ; Jeniffer Perussolo [Brésil] ; Elisa Atti [États-Unis] ; Sotirios Tetradis [États-Unis] ; Paulo M. Camargo [États-Unis]Source :
- Journal of periodontal research [ 0022-3484 ] ; 2014.
Abstract
Peri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone, and may lead to implant loss. A detailed understanding of the pathogenesis of peri-implantitis is lacking. The objective of this study was to develop a murine model of experimental peri-implantitis.
Machined, smooth surface screw-shaped titanium implants were placed in the healed alveolar bone of the left maxillary molars of C57BL/6J male mice, eight weeks after tooth extraction. Peri-implantitis was induced by securing silk ligatures around the head of the implant fixtures. Implant survival and peri-implant bone levels were analyzed by micro-computerized tomography (micro-CT) scans and histology twelve weeks after ligature placement.
Implant survival was 60% (6/10) for implants with ligatures and 100% (8/8) for controls. Micro-CT revealed significantly greater bone loss around the implants that received ligatures and that survived as compared to controls. The radiographic findings were confirmed via histology and toluidine blue staining.
This study describes a murine model of experimental peri-implantitis around screw-shaped titanium implants placed in the edentulous alveolar bone. This model should be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate potential treatment interventions.
Url:
DOI: 10.1111/jre.12234
PubMed: 25244403
PubMed Central: 4368501
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Pirih</name><affiliation wicri:level="1"><nlm:aff id="A1">DDS, PhD, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>DDS, PhD, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Hiyari, Sarah" sort="Hiyari, Sarah" uniqKey="Hiyari S" first="Sarah" last="Hiyari">Sarah Hiyari</name><affiliation wicri:level="1"><nlm:aff id="A2">MS, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MS, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Barroso, Ana Dv" sort="Barroso, Ana Dv" uniqKey="Barroso A" first="Ana Dv" last="Barroso">Ana Dv Barroso</name><affiliation wicri:level="1"><nlm:aff id="A3">DDS, Universidade Federal do Espirito Santo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Federal do Espirito Santo</wicri:regionArea></affiliation></author><author><name sortKey="Jorge, Adrian Ca" sort="Jorge, Adrian Ca" uniqKey="Jorge A" first="Adrian Ca" last="Jorge">Adrian Ca Jorge</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS, Universidade Estadual de Ponta Grossa, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Estadual de Ponta Grossa</wicri:regionArea></affiliation></author><author><name sortKey="Perussolo, Jeniffer" sort="Perussolo, Jeniffer" uniqKey="Perussolo J" first="Jeniffer" last="Perussolo">Jeniffer Perussolo</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS, Universidade Estadual de Ponta Grossa, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Estadual de Ponta Grossa</wicri:regionArea></affiliation></author><author><name sortKey="Atti, Elisa" sort="Atti, Elisa" uniqKey="Atti E" first="Elisa" last="Atti">Elisa Atti</name><affiliation wicri:level="1"><nlm:aff id="A2">MS, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MS, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Tetradis, Sotirios" sort="Tetradis, Sotirios" uniqKey="Tetradis S" first="Sotirios" last="Tetradis">Sotirios Tetradis</name><affiliation wicri:level="1"><nlm:aff id="A5">DDS, PhD, University of California, Los Angeles, Section of Oral Radiology, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>DDS, PhD, University of California, Los Angeles, Section of Oral Radiology</wicri:regionArea></affiliation></author><author><name sortKey="Camargo, Paulo M" sort="Camargo, Paulo M" uniqKey="Camargo P" first="Paulo M" last="Camargo">Paulo M. 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Pirih</name><affiliation wicri:level="1"><nlm:aff id="A1">DDS, PhD, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>DDS, PhD, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Hiyari, Sarah" sort="Hiyari, Sarah" uniqKey="Hiyari S" first="Sarah" last="Hiyari">Sarah Hiyari</name><affiliation wicri:level="1"><nlm:aff id="A2">MS, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MS, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Barroso, Ana Dv" sort="Barroso, Ana Dv" uniqKey="Barroso A" first="Ana Dv" last="Barroso">Ana Dv Barroso</name><affiliation wicri:level="1"><nlm:aff id="A3">DDS, Universidade Federal do Espirito Santo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Federal do Espirito Santo</wicri:regionArea></affiliation></author><author><name sortKey="Jorge, Adrian Ca" sort="Jorge, Adrian Ca" uniqKey="Jorge A" first="Adrian Ca" last="Jorge">Adrian Ca Jorge</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS, Universidade Estadual de Ponta Grossa, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Estadual de Ponta Grossa</wicri:regionArea></affiliation></author><author><name sortKey="Perussolo, Jeniffer" sort="Perussolo, Jeniffer" uniqKey="Perussolo J" first="Jeniffer" last="Perussolo">Jeniffer Perussolo</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS, Universidade Estadual de Ponta Grossa, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>DDS, Universidade Estadual de Ponta Grossa</wicri:regionArea></affiliation></author><author><name sortKey="Atti, Elisa" sort="Atti, Elisa" uniqKey="Atti E" first="Elisa" last="Atti">Elisa Atti</name><affiliation wicri:level="1"><nlm:aff id="A2">MS, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MS, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author><author><name sortKey="Tetradis, Sotirios" sort="Tetradis, Sotirios" uniqKey="Tetradis S" first="Sotirios" last="Tetradis">Sotirios Tetradis</name><affiliation wicri:level="1"><nlm:aff id="A5">DDS, PhD, University of California, Los Angeles, Section of Oral Radiology, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>DDS, PhD, University of California, Los Angeles, Section of Oral Radiology</wicri:regionArea></affiliation></author><author><name sortKey="Camargo, Paulo M" sort="Camargo, Paulo M" uniqKey="Camargo P" first="Paulo M" last="Camargo">Paulo M. Camargo</name><affiliation wicri:level="1"><nlm:aff id="A6">DDS, MS, MBA, University of California, Los Angeles, Section of Periodontics, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>DDS, MS, MBA, University of California, Los Angeles, Section of Periodontics</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of periodontal research</title><idno type="ISSN">0022-3484</idno><idno type="eISSN">1600-0765</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title><p id="P1">Peri-implantitis has a prevalence of 11-47%, involves destruction of
peri-implant bone, and may lead to implant loss. A detailed understanding of the
pathogenesis of peri-implantitis is lacking. The objective of this study was to develop
a murine model of experimental peri-implantitis.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">Machined, smooth surface screw-shaped titanium implants were placed in the
healed alveolar bone of the left maxillary molars of C57BL/6J male mice, eight weeks
after tooth extraction. Peri-implantitis was induced by securing silk ligatures around
the head of the implant fixtures. Implant survival and peri-implant bone levels were
analyzed by micro-computerized tomography (micro-CT) scans and histology twelve weeks
after ligature placement.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implant survival was 60% (6/10) for implants with ligatures and
100% (8/8) for controls. Micro-CT revealed significantly greater bone loss
around the implants that received ligatures and that survived as compared to controls.
The radiographic findings were confirmed via histology and toluidine blue staining.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This study describes a murine model of experimental peri-implantitis around
screw-shaped titanium implants placed in the edentulous alveolar bone. This model should
be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate
potential treatment interventions.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0055107</journal-id><journal-id journal-id-type="pubmed-jr-id">5143</journal-id><journal-id journal-id-type="nlm-ta">J Periodontal Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Periodont. Res.</journal-id><journal-title-group><journal-title>Journal of periodontal research</journal-title></journal-title-group><issn pub-type="ppub">0022-3484</issn><issn pub-type="epub">1600-0765</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25244403</article-id><article-id pub-id-type="pmc">4368501</article-id><article-id pub-id-type="doi">10.1111/jre.12234</article-id><article-id pub-id-type="manuscript">NIHMS625872</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Ligature-Induced Peri-Implantitis in Mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pirih</surname><given-names>Flavia Q</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hiyari</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Ana DV</given-names></name><xref ref-type="aff" rid="A3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Jorge</surname><given-names>Adrian CA</given-names></name><xref ref-type="aff" rid="A4">§</xref></contrib><contrib contrib-type="author"><name><surname>Perussolo</surname><given-names>Jeniffer</given-names></name><xref ref-type="aff" rid="A4">§</xref></contrib><contrib contrib-type="author"><name><surname>Atti</surname><given-names>Elisa</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Tetradis</surname><given-names>Sotirios</given-names></name><xref ref-type="aff" rid="A5">¶</xref></contrib><contrib contrib-type="author"><name><surname>Camargo</surname><given-names>Paulo M</given-names></name><xref ref-type="aff" rid="A6">#</xref></contrib></contrib-group><aff id="A1"><label>*</label>DDS, PhD, University of California, Los Angeles, Section of Periodontics, United States</aff><aff id="A2"><label>†</label>MS, University of California, Los Angeles, Section of Periodontics, United States</aff><aff id="A3"><label>‡</label>DDS, Universidade Federal do Espirito Santo, Brazil</aff><aff id="A4"><label>§</label>DDS, Universidade Estadual de Ponta Grossa, Brazil</aff><aff id="A5"><label>¶</label>DDS, PhD, University of California, Los Angeles, Section of Oral Radiology, United States</aff><aff id="A6"><label>#</label>DDS, MS, MBA, University of California, Los Angeles, Section of Periodontics, United States</aff><author-notes><corresp id="FN1">Corresponding author: Dr. Paulo M. Camargo,
<email>pcamargo@dentistry.ucla.edu</email>, Phone (310) 825-0928, Fax: (310) 206-3282,
UCLA School of Dentistry, Periodontics - CHS 63048, 10833 Le Conte Ave. Los Angeles, CA
90095</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>20</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2016</year></pub-date><volume>50</volume><issue>4</issue><fpage>519</fpage><lpage>524</lpage><pmc-comment>elocation-id from pubmed: 10.1111/jre.12234</pmc-comment>
<abstract><sec id="S1"><title>Introduction</title><p id="P1">Peri-implantitis has a prevalence of 11-47%, involves destruction of
peri-implant bone, and may lead to implant loss. A detailed understanding of the
pathogenesis of peri-implantitis is lacking. The objective of this study was to develop
a murine model of experimental peri-implantitis.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">Machined, smooth surface screw-shaped titanium implants were placed in the
healed alveolar bone of the left maxillary molars of C57BL/6J male mice, eight weeks
after tooth extraction. Peri-implantitis was induced by securing silk ligatures around
the head of the implant fixtures. Implant survival and peri-implant bone levels were
analyzed by micro-computerized tomography (micro-CT) scans and histology twelve weeks
after ligature placement.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implant survival was 60% (6/10) for implants with ligatures and
100% (8/8) for controls. Micro-CT revealed significantly greater bone loss
around the implants that received ligatures and that survived as compared to controls.
The radiographic findings were confirmed via histology and toluidine blue staining.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This study describes a murine model of experimental peri-implantitis around
screw-shaped titanium implants placed in the edentulous alveolar bone. This model should
be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate
potential treatment interventions.</p></sec></abstract><kwd-group><kwd>peri-implantitis</kwd><kwd>dental implant</kwd><kwd>animal model</kwd><kwd>bone loss</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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