Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue
Identifieur interne : 002501 ( Pmc/Curation ); précédent : 002500; suivant : 002502Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue
Auteurs : Lisa Marie Schlecht [Allemagne, États-Unis] ; Brian M. Peters [États-Unis] ; Bastiaan P. Krom [Pays-Bas] ; Jeffrey A. Freiberg [États-Unis] ; Gertrud M. H Nsch [Allemagne] ; Scott G. Filler [États-Unis] ; Mary Ann Jabra-Rizk [États-Unis] ; Mark E. Shirtliff [États-Unis]Source :
- Microbiology [ 1350-0872 ] ; 2015.
Abstract
Url:
DOI: 10.1099/mic.0.083485-0
PubMed: 25332378
PubMed Central: 4274785
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Systemic <italic>Staphylococcus aureus</italic>
infection mediated by <italic>Candida albicans</italic>
hyphal invasion of mucosal tissue</title>
<author><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, Germany</nlm:aff>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502</wicri:regionArea>
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<author><name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Systemic <italic>Staphylococcus aureus</italic>
infection mediated by <italic>Candida albicans</italic>
hyphal invasion of mucosal tissue</title>
<author><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
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<author><name sortKey="Peters, Brian M" sort="Peters, Brian M" uniqKey="Peters B" first="Brian M." last="Peters">Brian M. Peters</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krom, Bastiaan P" sort="Krom, Bastiaan P" uniqKey="Krom B" first="Bastiaan P." last="Krom">Bastiaan P. Krom</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freiberg, Jeffrey A" sort="Freiberg, Jeffrey A" uniqKey="Freiberg J" first="Jeffrey A." last="Freiberg">Jeffrey A. Freiberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="H Nsch, Gertrud M" sort="H Nsch, Gertrud M" uniqKey="H Nsch G" first="Gertrud M." last="H Nsch">Gertrud M. H Nsch</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Filler, Scott G" sort="Filler, Scott G" uniqKey="Filler S" first="Scott G." last="Filler">Scott G. Filler</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shirtliff, Mark E" sort="Shirtliff, Mark E" uniqKey="Shirtliff M" first="Mark E." last="Shirtliff">Mark E. Shirtliff</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbiology</title>
<idno type="ISSN">1350-0872</idno>
<idno type="eISSN">1465-2080</idno>
<imprint><date when="2015">2015</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><italic>Candida albicans</italic>
and <italic>Staphylococcus aureus</italic>
are often co-isolated in cases of biofilm-associated infections. <italic>C. albicans</italic>
can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic <italic>S. aureus</italic>
infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which <italic>S. aureus</italic>
is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of <italic>Candida albicans. In vitro</italic>
and <italic>ex vivo</italic>
findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The <italic>C. albicans</italic>
cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for <italic>C. albicans</italic>
to transport <italic>S. aureus</italic>
into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that <italic>C. albicans</italic>
can facilitate the invasion of <italic>S. aureus</italic>
across mucosal barriers, leading to systemic infection in co-colonized patients.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbiology</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbiology (Reading, Engl.)</journal-id>
<journal-id journal-id-type="publisher-id">Micro</journal-id>
<journal-id journal-id-type="hwp">mic</journal-id>
<journal-title-group><journal-title>Microbiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1350-0872</issn>
<issn pub-type="epub">1465-2080</issn>
<publisher><publisher-name>Society for General Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25332378</article-id>
<article-id pub-id-type="pmc">4274785</article-id>
<article-id pub-id-type="publisher-id">083485</article-id>
<article-id pub-id-type="doi">10.1099/mic.0.083485-0</article-id>
<article-categories><subj-group subj-group-type="article-type"><subject>Standard</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Microbial Pathogenicity</subject>
</subj-group>
</article-categories>
<title-group><article-title>Systemic <italic>Staphylococcus aureus</italic>
infection mediated by <italic>Candida albicans</italic>
hyphal invasion of mucosal tissue</article-title>
<alt-title alt-title-type="recto-page-foot"><ext-link ext-link-type="uri" xlink:href="http://mic.sgmjournals.org">http://mic.sgmjournals.org</ext-link>
</alt-title>
<alt-title alt-title-type="verso-running-head">L. M. Schlecht and others</alt-title>
<alt-title alt-title-type="recto-running-head">Systemic <italic>S. aureus</italic>
infection mediated through <italic>C. albicans</italic>
hyphal invasion</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Schlecht</surname>
<given-names>Lisa Marie</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>Brian M.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krom</surname>
<given-names>Bastiaan P.</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Freiberg</surname>
<given-names>Jeffrey A.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hänsch</surname>
<given-names>Gertrud M.</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Filler</surname>
<given-names>Scott G.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Jabra-Rizk</surname>
<given-names>Mary Ann</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">‡</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Shirtliff</surname>
<given-names>Mark E.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">‡</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, Germany</aff>
<aff id="aff2"><label>2</label>
Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</aff>
<aff id="aff3"><label>3</label>
Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</aff>
<aff id="aff4"><label>4</label>
Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</aff>
<aff id="aff5"><label>5</label>
Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany</aff>
<aff id="aff6"><label>6</label>
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA</aff>
<aff id="aff7"><label>7</label>
Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA</aff>
<aff id="aff8"><label>8</label>
Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</aff>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Whiteley</surname>
<given-names>M.</given-names>
</name>
</contrib>
</contrib-group>
<author-notes><corresp id="cor1"><bold>Correspondence</bold>
Mark E. Shirtliff <email xlink:href="mshirtliff@umaryland.edu">mshirtliff@umaryland.edu</email>
Mary Ann Jabra-Rizk <email xlink:href="mrizk@umaryland.edu">mrizk@umaryland.edu</email>
</corresp>
<fn id="fn1" fn-type="equal"><label>†, ‡</label>
<p>These authors contributed equally to this paper.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>1</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the . </pmc-comment>
<volume>161</volume>
<issue>Pt 1</issue>
<fpage>168</fpage>
<lpage>181</lpage>
<history><date date-type="received"><day>25</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>16</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2015 The Authors</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="168_mic083485.pdf"></self-uri>
<abstract><p><italic>Candida albicans</italic>
and <italic>Staphylococcus aureus</italic>
are often co-isolated in cases of biofilm-associated infections. <italic>C. albicans</italic>
can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic <italic>S. aureus</italic>
infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which <italic>S. aureus</italic>
is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of <italic>Candida albicans. In vitro</italic>
and <italic>ex vivo</italic>
findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The <italic>C. albicans</italic>
cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for <italic>C. albicans</italic>
to transport <italic>S. aureus</italic>
into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that <italic>C. albicans</italic>
can facilitate the invasion of <italic>S. aureus</italic>
across mucosal barriers, leading to systemic infection in co-colonized patients.</p>
</abstract>
<funding-group><award-group><funding-source id="sp1">the National Institute of Allergy and Infectious Diseases, National Institutes of Health</funding-source>
<award-id rid="sp1">R01AI69568</award-id>
</award-group>
<award-group><funding-source id="sp2">the National Institute of Dental and Craniofacial Research, National Institutes of Health</funding-source>
<award-id rid="sp2">1R01DE20939</award-id>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>OpenAccessEmbargo</meta-name>
<meta-value>12</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><def-list list-type="simple" list-content="abbreviations"><title>Abbreviations: </title>
<def-item><term>d.p.i.</term>
<def><p>days post-inoculation</p>
</def>
</def-item>
<def-item><term>PNA-FISH</term>
<def><p>peptide-nucleic acid fluorescent <italic>in situ</italic>
hybridization</p>
</def>
</def-item>
<def-item><term>TSB</term>
<def><p>trypticase soy broth</p>
</def>
</def-item>
</def-list>
</notes>
</front>
</pmc>
</record>
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