Photodynamic Therapy with Pc 4 Induces Apoptosis of Candida albicans
Identifieur interne : 002147 ( Pmc/Curation ); précédent : 002146; suivant : 002148Photodynamic Therapy with Pc 4 Induces Apoptosis of Candida albicans
Auteurs : Minh Lam [États-Unis] ; Paul C. Jou [États-Unis] ; Ali A. Lattif [États-Unis] ; Yoojin Lee [États-Unis] ; Christi L. Malbasa [États-Unis] ; Pranab K. Mukherjee [États-Unis] ; Nancy L. Oleinick [États-Unis] ; Mahmoud A. Ghannoum [États-Unis] ; Kevin D. Cooper [États-Unis] ; Elma D. Baron [États-Unis]Source :
- Photochemistry and photobiology [ 0031-8655 ] ; 2011.
Abstract
The high prevalence of drug resistance necessitates the development of novel antifungal agents against infections caused by opportunistic fungal pathogens such as
Url:
DOI: 10.1111/j.1751-1097.2011.00938.x
PubMed: 21521233
PubMed Central: 3139787
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PMC:3139787Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Photodynamic Therapy with Pc 4 Induces Apoptosis of <italic>Candida albicans</italic>
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<author><name sortKey="Lam, Minh" sort="Lam, Minh" uniqKey="Lam M" first="Minh" last="Lam">Minh Lam</name>
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</author>
<author><name sortKey="Baron, Elma D" sort="Baron, Elma D" uniqKey="Baron E" first="Elma D." last="Baron">Elma D. Baron</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Case Comprehensive Cancer Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Case Comprehensive Cancer Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Case Skin Diseases Research Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Case Skin Diseases Research Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Dermatology, Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Photochemistry and photobiology</title>
<idno type="ISSN">0031-8655</idno>
<idno type="eISSN">1751-1097</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
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<front><div type="abstract" xml:lang="en"><p id="P1">The high prevalence of drug resistance necessitates the development of novel antifungal agents against infections caused by opportunistic fungal pathogens such as <italic>Candida albicans</italic>
. Elucidation of apoptosis in yeast-like fungi may provide a basis for future therapies. In mammalian cells, photodynamic therapy (PDT) has been demonstrated to generate reactive oxygen species, leading to immediate oxidative modifications of biological molecules and resulting in apoptotic cell death. In this report, we assess the <italic>in vitro</italic>
cytotoxicity and mechanism of PDT, using the photosensitizer Pc 4, in planktonic <italic>C. albicans</italic>
. Confocal image analysis confirmed that Pc 4 localizes to cytosolic organelles, including mitochondria. A colony formation assay showed that 1.0 μM Pc 4 followed by light at 2.0 J/cm<sup>2</sup>
reduced cell survival by 4 logs. XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxyanilide) assay revealed that Pc 4-PDT impaired fungal metabolic activity, which was confirmed using the FUN-1 (2-chloro-4-[2,3-dihydro-3-methyl-(benzo-1,3-thiazol-2-yl)-methylidene]-1-phenylquinolinium iodide) fluorescence probe. Furthermore, we observed changes in nuclear morphology characteristic of apoptosis, which were substantiated by increased externalization of phosphatidylserine and DNA fragmentation following Pc 4-PDT. These data indicate that Pc 4-PDT can induce apoptosis in <italic>C. albicans</italic>
. Therefore, a better understanding of the process will be helpful, since PDT may become a useful treatment option for candidiasis.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376425</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6457</journal-id>
<journal-id journal-id-type="nlm-ta">Photochem Photobiol</journal-id>
<journal-title-group><journal-title>Photochemistry and photobiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0031-8655</issn>
<issn pub-type="epub">1751-1097</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21521233</article-id>
<article-id pub-id-type="pmc">3139787</article-id>
<article-id pub-id-type="doi">10.1111/j.1751-1097.2011.00938.x</article-id>
<article-id pub-id-type="manuscript">NIHMS293109</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Photodynamic Therapy with Pc 4 Induces Apoptosis of <italic>Candida albicans</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lam</surname>
<given-names>Minh</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jou</surname>
<given-names>Paul C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lattif</surname>
<given-names>Ali A.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Yoojin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malbasa</surname>
<given-names>Christi L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mukherjee</surname>
<given-names>Pranab K.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oleinick</surname>
<given-names>Nancy L.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghannoum</surname>
<given-names>Mahmoud A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cooper</surname>
<given-names>Kevin D.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baron</surname>
<given-names>Elma D.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</aff>
<aff id="A2"><label>2</label>
Case Comprehensive Cancer Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</aff>
<aff id="A3"><label>3</label>
Case Skin Diseases Research Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</aff>
<aff id="A4"><label>4</label>
Center for Medical Mycology, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</aff>
<aff id="A5"><label>5</label>
Department of Radiation Oncology, University Hospitals Case Medical Center, 11100 Euclid Avenue, and Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA</aff>
<aff id="A6"><label>6</label>
Department of Dermatology, Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA</aff>
<author-notes><corresp id="CR1"><label>*</label>
Corresponding Author: Elma D. Baron, M.D. <email>elma.baron@case.edu</email>
Phone: 216-368-4971 Fax: 216-368-0212</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>5</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>6</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>7</month>
<year>2012</year>
</pub-date>
<volume>87</volume>
<issue>4</issue>
<fpage>904</fpage>
<lpage>909</lpage>
<abstract><p id="P1">The high prevalence of drug resistance necessitates the development of novel antifungal agents against infections caused by opportunistic fungal pathogens such as <italic>Candida albicans</italic>
. Elucidation of apoptosis in yeast-like fungi may provide a basis for future therapies. In mammalian cells, photodynamic therapy (PDT) has been demonstrated to generate reactive oxygen species, leading to immediate oxidative modifications of biological molecules and resulting in apoptotic cell death. In this report, we assess the <italic>in vitro</italic>
cytotoxicity and mechanism of PDT, using the photosensitizer Pc 4, in planktonic <italic>C. albicans</italic>
. Confocal image analysis confirmed that Pc 4 localizes to cytosolic organelles, including mitochondria. A colony formation assay showed that 1.0 μM Pc 4 followed by light at 2.0 J/cm<sup>2</sup>
reduced cell survival by 4 logs. XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxyanilide) assay revealed that Pc 4-PDT impaired fungal metabolic activity, which was confirmed using the FUN-1 (2-chloro-4-[2,3-dihydro-3-methyl-(benzo-1,3-thiazol-2-yl)-methylidene]-1-phenylquinolinium iodide) fluorescence probe. Furthermore, we observed changes in nuclear morphology characteristic of apoptosis, which were substantiated by increased externalization of phosphatidylserine and DNA fragmentation following Pc 4-PDT. These data indicate that Pc 4-PDT can induce apoptosis in <italic>C. albicans</italic>
. Therefore, a better understanding of the process will be helpful, since PDT may become a useful treatment option for candidiasis.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS</funding-source>
<award-id>P30 AR039750-10 || AR</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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