Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases
Identifieur interne : 002092 ( Pmc/Curation ); précédent : 002091; suivant : 002093Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases
Auteurs : Pei-Feng Liu [États-Unis] ; Wen-Hong Zhu [États-Unis] ; Chun-Ming Huang [États-Unis]Source :
- Current drug metabolism [ 1389-2002 ] ; 2009.
Abstract
The mouth is a favorable habitat for a great variety of bacteria. Microbial composition of dental plaque is the usual cause of various oral diseases in humans, including dental caries, periodontal disease and halitosis. In general, oral antibacterial agents such as antibiotics are commonly used to treat oral bacterial infection. Traditional periodontal surgery is painful and time-consuming. In addition, bacterial resistance and toxicity of antibiotics have become a global pandemic and unavoidable. Recently, vaccines for dental caries and periodontal disease have been developed and applied. Moreover, the use of photodynamic therapy has become an alternative to antibiotic drugs. The purpose of this article is to highlight the advantages of vaccine therapy and photodynamic therapy for oral microbial-related diseases compared to treatments with antimicrobial agents and traditional periodontal surgery.
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PubMed: 19149517
PubMed Central: 2776031
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University of California, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moores Cancer Center; University of California, San Diego, CA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current drug metabolism</title><idno type="ISSN">1389-2002</idno><idno type="eISSN">1875-5453</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The mouth is a favorable habitat for a great variety of bacteria. Microbial composition of dental plaque is the usual cause of various oral diseases in humans, including dental caries, periodontal disease and halitosis. In general, oral antibacterial agents such as antibiotics are commonly used to treat oral bacterial infection. Traditional periodontal surgery is painful and time-consuming. In addition, bacterial resistance and toxicity of antibiotics have become a global pandemic and unavoidable. Recently, vaccines for dental caries and periodontal disease have been developed and applied. Moreover, the use of photodynamic therapy has become an alternative to antibiotic drugs. The purpose of this article is to highlight the advantages of vaccine therapy and photodynamic therapy for oral microbial-related diseases compared to treatments with antimicrobial agents and traditional periodontal surgery.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100960533</journal-id><journal-id journal-id-type="pubmed-jr-id">21839</journal-id><journal-id journal-id-type="nlm-ta">Curr Drug Metab</journal-id><journal-title>Current drug metabolism</journal-title><issn pub-type="ppub">1389-2002</issn><issn pub-type="epub">1875-5453</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19149517</article-id><article-id pub-id-type="pmc">2776031</article-id><article-id pub-id-type="manuscript">NIHMS152656</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Pei-Feng</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Wen-Hong</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Chun-Ming</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A4" ref-type="aff">4</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Dermatology, Department of Medicine, University of California, San Diego, CA, USA</aff><aff id="A2"><label>2</label>VA San Diego Healthcare Center, San Diego, CA, USA</aff><aff id="A3"><label>3</label>Center on Proteolytic Pathways, Burnham Institute for Medical Research, La Jolla, CA, USA</aff><aff id="A4"><label>4</label>Moores Cancer Center; University of California, San Diego, CA, USA</aff><author-notes><corresp id="FN1"><label>*</label>Address correspondence to this author at Department of Medicine, Division of Dermatology, University of California, San Diego. Rm2317A, 3350 La Jolla Village, San Diego, CA, 92161, USA; Tel: 858-552-8585 ext 3708; Fax: 858-642-1435 <email>chunming@ucsd.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>11</month><year>2009</year></pub-date><volume>10</volume><issue>1</issue><fpage>90</fpage><lpage>94</lpage><abstract><p id="P1">The mouth is a favorable habitat for a great variety of bacteria. Microbial composition of dental plaque is the usual cause of various oral diseases in humans, including dental caries, periodontal disease and halitosis. In general, oral antibacterial agents such as antibiotics are commonly used to treat oral bacterial infection. Traditional periodontal surgery is painful and time-consuming. In addition, bacterial resistance and toxicity of antibiotics have become a global pandemic and unavoidable. Recently, vaccines for dental caries and periodontal disease have been developed and applied. Moreover, the use of photodynamic therapy has become an alternative to antibiotic drugs. The purpose of this article is to highlight the advantages of vaccine therapy and photodynamic therapy for oral microbial-related diseases compared to treatments with antimicrobial agents and traditional periodontal surgery.</p></abstract><kwd-group><kwd>Antimicrobial agent treatment</kwd><kwd>vaccine therapy</kwd><kwd>traditional periodontal surgery</kwd><kwd>photodynamic therapy</kwd></kwd-group><contract-num rid="AR1">R41 AR056169-01
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