Salivary Lysozyme and Prevalent Hypertension
Identifieur interne : 002082 ( Pmc/Curation ); précédent : 002081; suivant : 002083Salivary Lysozyme and Prevalent Hypertension
Auteurs : M. Qvarnstrom [Finlande] ; S. Janket [États-Unis] ; J. A. Jones [États-Unis] ; P. Nuutinen [Finlande] ; A. E. Baird [États-Unis] ; M. E. Nunn [États-Unis] ; T. E. Van Dyke [États-Unis] ; J. H. Meurman [Finlande]Source :
- Journal of dental research [ 0022-0345 ] ; 2008.
Abstract
Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p < 0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis—"high salivary lysozyme levels are associated with the odds of hypertension"—was confirmed.
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PubMed: 18434581
PubMed Central: 2895412
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Qvarnstrom</name><affiliation wicri:level="1"><nlm:aff id="A1">Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Janket, S" sort="Janket, S" uniqKey="Janket S" first="S." last="Janket">S. Janket</name><affiliation wicri:level="1"><nlm:aff id="A2">General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118</wicri:regionArea></affiliation></author><author><name sortKey="Jones, J A" sort="Jones, J A" uniqKey="Jones J" first="J. A." last="Jones">J. A. Jones</name><affiliation wicri:level="1"><nlm:aff id="A2">General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118</wicri:regionArea></affiliation></author><author><name sortKey="Nuutinen, P" sort="Nuutinen, P" uniqKey="Nuutinen P" first="P." last="Nuutinen">P. Nuutinen</name><affiliation wicri:level="1"><nlm:aff id="A3">Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cardiothoracic Surgery, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Baird, A E" sort="Baird, A E" uniqKey="Baird A" first="A. E." last="Baird">A. E. 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Meurman</name><affiliation wicri:level="1"><nlm:aff id="A7">University of Helsinki Central Hospital, and Institute of Dentistry, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki Central Hospital, and Institute of Dentistry, Helsinki</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of dental research</title><idno type="ISSN">0022-0345</idno><idno type="eISSN">1544-0591</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p < 0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis—"high salivary lysozyme levels are associated with the odds of hypertension"—was confirmed.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0354343</journal-id><journal-id journal-id-type="pubmed-jr-id">4700</journal-id><journal-id journal-id-type="nlm-ta">J Dent Res</journal-id><journal-title>Journal of dental research</journal-title><issn pub-type="ppub">0022-0345</issn><issn pub-type="epub">1544-0591</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18434581</article-id><article-id pub-id-type="pmc">2895412</article-id><article-id pub-id-type="manuscript">NIHMS206852</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Salivary Lysozyme and Prevalent Hypertension</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Qvarnstrom</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Janket</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>J.A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nuutinen</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Baird</surname><given-names>A.E.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Nunn</surname><given-names>M.E.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Van Dyke</surname><given-names>T.E.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Meurman</surname><given-names>J.H.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</aff><aff id="A2"><label>2</label>General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA</aff><aff id="A3"><label>3</label>Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A4"><label>4</label>National Institute of Neurologic Disorders and Stroke, NIH, Bethesda, MD, USA</aff><aff id="A5"><label>5</label>Health Policy and Health Services Research, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA</aff><aff id="A6"><label>6</label>Periodontology and Oral Biology, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA</aff><aff id="A7"><label>7</label>University of Helsinki Central Hospital, and Institute of Dentistry, Helsinki, Finland</aff><author-notes><corresp id="cor1"><label>*</label>corresponding author, <email>skjanket@bu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2010</year></pub-date><volume>87</volume><issue>5</issue><fpage>480</fpage><lpage>484</lpage><abstract><p id="P1">Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p < 0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis—"high salivary lysozyme levels are associated with the odds of hypertension"—was confirmed.</p></abstract><kwd-group><kwd>salivary lysozyme</kwd><kwd>hypertension</kwd><kwd>cytokines</kwd><kwd>advanced glycation end-products</kwd><kwd>endothelial dysfunction</kwd></kwd-group><contract-num rid="DE1">R01 DE015566-04
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