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Comparison of Mandibular Advancement Splint and Tongue Stabilizing Device in Obstructive Sleep Apnea: A Randomized Controlled Trial

Identifieur interne : 002072 ( Pmc/Curation ); précédent : 002071; suivant : 002073

Comparison of Mandibular Advancement Splint and Tongue Stabilizing Device in Obstructive Sleep Apnea: A Randomized Controlled Trial

Auteurs : Sheryn A. Deane [Australie] ; Peter A. Cistulli [Australie] ; Andrew T. Ng [Australie] ; Biao Zeng [Australie] ; Peter Petocz [Australie] ; M. Ali Darendeliler [Australie]

Source :

Sleep [ 0161-8105 ] ; 2009.

RBID : PMC:2675900

Abstract

Study Objectives:

To compare the efficacy of a mandibular advancement splint (MAS) and a novel tongue stabilizing device (TSD) in the treatment of obstructive sleep apnea (OSA).

Design:

A randomized crossover design was used.

Patients:

Twenty-seven patients (20 male, 7 female), recruited from a tertiary hospital sleep clinic.

Measurements and Results:

The apnea-hypopnea index (AHI) was reduced with MAS (11.68 ± 8.94, P = 0.000) and TSD (13.15 ± 10.77, P = 0.002) compared with baseline (26.96 ± 17.17). The arousal index decreased for MAS (21.09 ± 9.27, P = 0.004) and TSD (21.9 ± 10.56, P = 0.001) compared with baseline (33.23 ± 16.41). Sixty-eight percent of patients achieved a complete or partial response with MAS, compared with 45% with TSD. The Epworth Sleepiness Scale (ESS) score was decreased with MAS (P = <0.001) and TSD (P = 0.002). Subjective improvements in snoring and quality of sleep were reported, with a better response for MAS than TSD. Compliance was poorer for TSD, and the side effect profiles of the 2 modalities were different. All patients were satisfied with MAS compared to TSD, and 91% of patients preferred the MAS.

Conclusion:

Objective testing showed the MAS and TSD had similar efficacy in terms of AHI reduction. Patients reported improvements with both devices; however, better compliance and a clear preference for MAS was apparent when both devices were offered. Longer term studies are needed to clarify the role of TSD.

Citation:

Deane SA; Cistulli PA; Ng AT; Zeng B; Petocz P; Darendeliler MA. Comparison of mandibular advancement splint and tongue stabilizing device in obstructive sleep apnea: a randomized controlled trial. SLEEP 2009;32(5):648-653.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675900

PubMed: 19480232
PubMed Central: 2675900

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<author><name sortKey="Deane, Sheryn A" sort="Deane, Sheryn A" uniqKey="Deane S" first="Sheryn A." last="Deane">Sheryn A. Deane</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney Dental Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney Dental Hospital, Sydney</wicri:regionArea>
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<author><name sortKey="Cistulli, Peter A" sort="Cistulli, Peter A" uniqKey="Cistulli P" first="Peter A" last="Cistulli">Peter A. Cistulli</name>
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<author><name sortKey="Zeng, Biao" sort="Zeng, Biao" uniqKey="Zeng B" first="Biao" last="Zeng">Biao Zeng</name>
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<author><name sortKey="Darendeliler, M Ali" sort="Darendeliler, M Ali" uniqKey="Darendeliler M" first="M. Ali" last="Darendeliler">M. Ali Darendeliler</name>
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<author><name sortKey="Cistulli, Peter A" sort="Cistulli, Peter A" uniqKey="Cistulli P" first="Peter A" last="Cistulli">Peter A. Cistulli</name>
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<author><name sortKey="Ng, Andrew T" sort="Ng, Andrew T" uniqKey="Ng A" first="Andrew T." last="Ng">Andrew T. Ng</name>
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<author><name sortKey="Zeng, Biao" sort="Zeng, Biao" uniqKey="Zeng B" first="Biao" last="Zeng">Biao Zeng</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p> To compare the efficacy of a mandibular advancement splint (MAS) and a novel tongue stabilizing device (TSD) in the treatment of obstructive sleep apnea (OSA).</p>
</sec>
<sec><title>Design:</title>
<p> A randomized crossover design was used.</p>
</sec>
<sec><title>Patients:</title>
<p> Twenty-seven patients (20 male, 7 female), recruited from a tertiary hospital sleep clinic.</p>
</sec>
<sec><title>Measurements and Results:</title>
<p>The apnea-hypopnea index (AHI) was reduced with MAS (11.68 ± 8.94, P = 0.000) and TSD (13.15 ± 10.77, P = 0.002) compared with baseline (26.96 ± 17.17). The arousal index decreased for MAS (21.09 ± 9.27, P = 0.004) and TSD (21.9 ± 10.56, P = 0.001) compared with baseline (33.23 ± 16.41). Sixty-eight percent of patients achieved a complete or partial response with MAS, compared with 45% with TSD. The Epworth Sleepiness Scale (ESS) score was decreased with MAS (P = <0.001) and TSD (P = 0.002). Subjective improvements in snoring and quality of sleep were reported, with a better response for MAS than TSD. Compliance was poorer for TSD, and the side effect profiles of the 2 modalities were different. All patients were satisfied with MAS compared to TSD, and 91% of patients preferred the MAS.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Objective testing showed the MAS and TSD had similar efficacy in terms of AHI reduction. Patients reported improvements with both devices; however, better compliance and a clear preference for MAS was apparent when both devices were offered. Longer term studies are needed to clarify the role of TSD.</p>
</sec>
<sec><title>Citation:</title>
<p>Deane SA; Cistulli PA; Ng AT; Zeng B; Petocz P; Darendeliler MA. Comparison of mandibular advancement splint and tongue stabilizing device in obstructive sleep apnea: a randomized controlled trial. <italic>SLEEP</italic>
 2009;32(5):648-653.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id>
<journal-id journal-id-type="publisher-id">Sleep</journal-id>
<journal-title>Sleep</journal-title>
<issn pub-type="ppub">0161-8105</issn>
<issn pub-type="epub">1550-9109</issn>
<publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19480232</article-id>
<article-id pub-id-type="pmc">2675900</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Obstructive Sleep Apnea Syndrome</subject>
</subj-group>
</article-categories>
<title-group><article-title>Comparison of Mandibular Advancement Splint and Tongue Stabilizing Device in Obstructive Sleep Apnea: A Randomized Controlled Trial</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Deane</surname>
<given-names>Sheryn A.</given-names>
</name>
<degrees>MDSc Ortho</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cistulli</surname>
<given-names>Peter A</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ng</surname>
<given-names>Andrew T.</given-names>
</name>
<degrees>MBBS</degrees>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zeng</surname>
<given-names>Biao</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Petocz</surname>
<given-names>Peter</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Darendeliler</surname>
<given-names>M. Ali</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney Dental Hospital, Sydney, Australia</aff>
<aff id="aff2"><label>2</label>
Centre for Sleep Health & Research, Department of Respiratory Medicine, Royal North Shore Hospital, Woolcock Institute of Medical Research and University of Sydney, Sydney, Australia</aff>
<aff id="aff3"><label>3</label>
Centre for Sleep Disorders and Respiratory Failure, St George Hospital, Sydney, Australia</aff>
<aff id="aff4"><label>4</label>
Department of Statistics, Macquarie University, Sydney, Australia</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to: M. Ali Darendeliler, 
<addr-line>Department of Orthodontics, Faculty of Dentistry, Sydney Dental Hospital, The University of Sydney, Level 2, 2 Chalmers Street, Surry Hills NSW 2010 Australia</addr-line>
<phone>+61 2 93518314</phone>
<fax>+61 2 93518336</fax>
<email>adarende@mail.usyd.edu.au</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>5</month>
<year>2009</year>
</pub-date>
<volume>32</volume>
<issue>5</issue>
<fpage>648</fpage>
<lpage>653</lpage>
<history><date date-type="received"><month>9</month>
<year>2008</year>
</date>
<date date-type="rev-recd"><month>1</month>
<year>2009</year>
</date>
<date date-type="accepted"><month>2</month>
<year>2009</year>
</date>
</history>
<copyright-statement>© 2009 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2009</copyright-year>
<abstract><sec><title>Study Objectives:</title>
<p> To compare the efficacy of a mandibular advancement splint (MAS) and a novel tongue stabilizing device (TSD) in the treatment of obstructive sleep apnea (OSA).</p>
</sec>
<sec><title>Design:</title>
<p> A randomized crossover design was used.</p>
</sec>
<sec><title>Patients:</title>
<p> Twenty-seven patients (20 male, 7 female), recruited from a tertiary hospital sleep clinic.</p>
</sec>
<sec><title>Measurements and Results:</title>
<p>The apnea-hypopnea index (AHI) was reduced with MAS (11.68 ± 8.94, P = 0.000) and TSD (13.15 ± 10.77, P = 0.002) compared with baseline (26.96 ± 17.17). The arousal index decreased for MAS (21.09 ± 9.27, P = 0.004) and TSD (21.9 ± 10.56, P = 0.001) compared with baseline (33.23 ± 16.41). Sixty-eight percent of patients achieved a complete or partial response with MAS, compared with 45% with TSD. The Epworth Sleepiness Scale (ESS) score was decreased with MAS (P = <0.001) and TSD (P = 0.002). Subjective improvements in snoring and quality of sleep were reported, with a better response for MAS than TSD. Compliance was poorer for TSD, and the side effect profiles of the 2 modalities were different. All patients were satisfied with MAS compared to TSD, and 91% of patients preferred the MAS.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Objective testing showed the MAS and TSD had similar efficacy in terms of AHI reduction. Patients reported improvements with both devices; however, better compliance and a clear preference for MAS was apparent when both devices were offered. Longer term studies are needed to clarify the role of TSD.</p>
</sec>
<sec><title>Citation:</title>
<p>Deane SA; Cistulli PA; Ng AT; Zeng B; Petocz P; Darendeliler MA. Comparison of mandibular advancement splint and tongue stabilizing device in obstructive sleep apnea: a randomized controlled trial. <italic>SLEEP</italic>
 2009;32(5):648-653.</p>
</sec>
</abstract>
<kwd-group><kwd>mandibular advancement splint</kwd>
<kwd>tongue stabilizing device</kwd>
<kwd>obstructive sleep apnea</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Comparison of Mandibular Advancement Splint and Tongue Stabilizing Device in Obstructive Sleep Apnea: A Randomized Controlled Trial

Comparison of Mandibular Advancement Splint and Tongue Stabilizing Device in Obstructive Sleep Apnea: A Randomized Controlled Trial

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki