Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report
Identifieur interne : 001B85 ( Pmc/Curation ); précédent : 001B84; suivant : 001B86Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report
Auteurs : Whei-Lin Pan [Taïwan] ; Pi-Lun Chen [Taïwan] ; Cho-Ying Lin [Taïwan] ; Yi-Chun Pan [Taïwan] ; Yuh-Ren Ju [Taïwan] ; Chiu-Po Chan [Taïwan] ; Robert Ww Hsu [Taïwan]Source :
- Clinical Interventions in Aging [ 1176-9092 ] ; 2017.
Abstract
Bisphosphonates (BPs) suppress bone resorption and increase bone strength, thus reducing the risk of fracture. Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia. Here, we describe the case of a postmenopausal woman who took oral alendronate for >3 years for osteoporosis. The patient presented at the clinic with sharp jaw pain and swelling on the left mandible 4 months after extraction of the third molar. Clinical examinations identified an inflamed mucosal opening with pus over an area of necrotic bone. Initial images of cone beam computed tomography revealed a sequestrum at the extracted socket. The condition did not improve after 1 week of antibiotic treatment; therefore, the alendronate treatment was terminated and the patient was prescribed strontium ranelate instead. The patient gradually recovered and, at the 2-year follow-up, the site of BP-related osteonecrosis of the jaw healed completely as determined by both clinical and cone beam computed tomography measures. The bone mineral densities in the femoral neck and lumbar spine improved after 1 year, and were maintained at the 3-year follow-up. The serum C-terminal cross-linking telopeptide values also gradually increased from the initial 130 pg/mL to 320 pg/mL at the 3-year follow-up. Taken together, this case supports the use of strontium ranelate as an alternative treatment for postmenopausal women who receive long-term oral BP treatments and are at risk for serious complications of BP-related osteonecrosis of the jaw.
Url:
DOI: 10.2147/CIA.S141753
PubMed: 28744112
PubMed Central: 5513807
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last="Pan">Whei-Lin Pan</name><affiliation wicri:level="1"><nlm:aff id="af1-cia-12-1089">Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Periodontics, Chang Gung Memorial Hospital, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Pi Lun" sort="Chen, Pi Lun" uniqKey="Chen P" first="Pi-Lun" last="Chen">Pi-Lun Chen</name><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Cho Ying" sort="Lin, Cho Ying" uniqKey="Lin C" first="Cho-Ying" last="Lin">Cho-Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af1-cia-12-1089">Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Periodontics, Chang Gung Memorial Hospital, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Pan, Yi Chun" sort="Pan, Yi Chun" uniqKey="Pan Y" first="Yi-Chun" last="Pan">Yi-Chun Pan</name><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Ju, Yuh Ren" sort="Ju, Yuh Ren" uniqKey="Ju Y" first="Yuh-Ren" last="Ju">Yuh-Ren Ju</name><affiliation wicri:level="1"><nlm:aff id="af1-cia-12-1089">Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Periodontics, Chang Gung Memorial Hospital, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Chiu Po" sort="Chan, Chiu Po" uniqKey="Chan C" first="Chiu-Po" last="Chan">Chiu-Po Chan</name><affiliation wicri:level="1"><nlm:aff id="af1-cia-12-1089">Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Periodontics, Chang Gung Memorial Hospital, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Robert Ww" sort="Hsu, Robert Ww" uniqKey="Hsu R" first="Robert Ww" last="Hsu">Robert Ww Hsu</name><affiliation wicri:level="1"><nlm:aff id="af2-cia-12-1089">Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-cia-12-1089">Department of Orthopedics, Chang Gung Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Orthopedics, Chang Gung Memorial Hospital, Taipei</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Interventions in Aging</title><idno type="ISSN">1176-9092</idno><idno type="eISSN">1178-1998</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bisphosphonates (BPs) suppress bone resorption and increase bone strength, thus reducing the risk of fracture. Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia. Here, we describe the case of a postmenopausal woman who took oral alendronate for >3 years for osteoporosis. The patient presented at the clinic with sharp jaw pain and swelling on the left mandible 4 months after extraction of the third molar. Clinical examinations identified an inflamed mucosal opening with pus over an area of necrotic bone. Initial images of cone beam computed tomography revealed a sequestrum at the extracted socket. The condition did not improve after 1 week of antibiotic treatment; therefore, the alendronate treatment was terminated and the patient was prescribed strontium ranelate instead. The patient gradually recovered and, at the 2-year follow-up, the site of BP-related osteonecrosis of the jaw healed completely as determined by both clinical and cone beam computed tomography measures. The bone mineral densities in the femoral neck and lumbar spine improved after 1 year, and were maintained at the 3-year follow-up. The serum C-terminal cross-linking telopeptide values also gradually increased from the initial 130 pg/mL to 320 pg/mL at the 3-year follow-up. Taken together, this case supports the use of strontium ranelate as an alternative treatment for postmenopausal women who receive long-term oral BP treatments and are at risk for serious complications of BP-related osteonecrosis of the jaw.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marx, Re" uniqKey="Marx R">RE Marx</name></author><author><name sortKey="Stern, D" uniqKey="Stern D">D Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggiero, Sl" uniqKey="Ruggiero S">SL Ruggiero</name></author><author><name sortKey="Dodson, Tb" uniqKey="Dodson T">TB Dodson</name></author><author><name sortKey="Fantasia, J" uniqKey="Fantasia J">J Fantasia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paiva Fonseca, F" uniqKey="Paiva Fonseca F">F Paiva-Fonseca</name></author><author><name sortKey="Santos Silva, Ar" uniqKey="Santos Silva A">AR Santos-Silva</name></author><author><name sortKey="Della Coletta, R" uniqKey="Della Coletta R">R Della-Coletta</name></author><author><name sortKey="Vargas, Pa" uniqKey="Vargas P">PA Vargas</name></author><author><name sortKey="Lopes, Ma" uniqKey="Lopes M">MA Lopes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonnelye, E" uniqKey="Bonnelye E">E Bonnelye</name></author><author><name sortKey="Chabadel, A" uniqKey="Chabadel A">A Chabadel</name></author><author><name sortKey="Saltel, F" uniqKey="Saltel F">F Saltel</name></author><author><name sortKey="Jurdic, P" uniqKey="Jurdic P">P Jurdic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trouvin, Ap" uniqKey="Trouvin A">AP Trouvin</name></author><author><name sortKey="Goeb, V" uniqKey="Goeb V">V Goeb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reginster, Jy" uniqKey="Reginster J">JY Reginster</name></author><author><name sortKey="Kaufman, Jm" uniqKey="Kaufman J">JM Kaufman</name></author><author><name sortKey="Goemaere, S" uniqKey="Goemaere S">S Goemaere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longato, L" uniqKey="Longato L">L Longato</name></author><author><name sortKey="Cavalli, L" uniqKey="Cavalli L">L Cavalli</name></author><author><name sortKey="Marcucci, G" uniqKey="Marcucci G">G Marcucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutcheson, A" uniqKey="Hutcheson A">A Hutcheson</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A Cheng</name></author><author><name sortKey="Kunchar, R" uniqKey="Kunchar R">R Kunchar</name></author><author><name sortKey="Stein, B" uniqKey="Stein B">B Stein</name></author><author><name sortKey="Sambrook, P" uniqKey="Sambrook P">P Sambrook</name></author><author><name sortKey="Goss, A" uniqKey="Goss A">A Goss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plotkin, Li" uniqKey="Plotkin L">LI Plotkin</name></author><author><name sortKey="Manolagas, Sc" uniqKey="Manolagas S">SC Manolagas</name></author><author><name sortKey="Bellido, T" uniqKey="Bellido T">T Bellido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleisch, H" uniqKey="Fleisch H">H Fleisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mashiba, T" uniqKey="Mashiba T">T Mashiba</name></author><author><name sortKey="Mori, S" uniqKey="Mori S">S Mori</name></author><author><name sortKey="Burr, Db" uniqKey="Burr D">DB Burr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diniz Freitas, M" uniqKey="Diniz Freitas M">M Diniz-Freitas</name></author><author><name sortKey="Limeres, J" uniqKey="Limeres J">J Limeres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mkele, G" uniqKey="Mkele G">G Mkele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bain, S" uniqKey="Bain S">S Bain</name></author><author><name sortKey="Jerome, C" uniqKey="Jerome C">C Jerome</name></author><author><name sortKey="Shen, V" uniqKey="Shen V">V Shen</name></author><author><name sortKey="Dupin Roger, I" uniqKey="Dupin Roger I">I Dupin-Roger</name></author><author><name sortKey="Ammann, P" uniqKey="Ammann P">P Ammann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arlot, Me" uniqKey="Arlot M">ME Arlot</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Genant, Hk" uniqKey="Genant H">HK Genant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lima, H" uniqKey="Lima H">H Lima</name></author><author><name sortKey="Maia, J" uniqKey="Maia J">J Maia</name></author><author><name sortKey="Bandeira, F" uniqKey="Bandeira F">F Bandeira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Jh" uniqKey="Lin J">JH Lin</name></author><author><name sortKey="Russell, G" uniqKey="Russell G">G Russell</name></author><author><name sortKey="Gertz, B" uniqKey="Gertz B">B Gertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papapoulos, Se" uniqKey="Papapoulos S">SE Papapoulos</name></author><author><name sortKey="Cremers, Sc" uniqKey="Cremers S">SC Cremers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drake, Mt" uniqKey="Drake M">MT Drake</name></author><author><name sortKey="Clarke, Bl" uniqKey="Clarke B">BL Clarke</name></author><author><name sortKey="Khosla, S" uniqKey="Khosla S">S Khosla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khosla, S" uniqKey="Khosla S">S Khosla</name></author><author><name sortKey="Burr, D" uniqKey="Burr D">D Burr</name></author><author><name sortKey="Cauley, J" uniqKey="Cauley J">J Cauley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narongroeknawin, P" uniqKey="Narongroeknawin P">P Narongroeknawin</name></author><author><name sortKey="Danila, Mi" uniqKey="Danila M">MI Danila</name></author><author><name sortKey="Humphreys, Lg" uniqKey="Humphreys L">LG Humphreys</name></author><author><name sortKey="Barasch, A" uniqKey="Barasch A">A Barasch</name></author><author><name sortKey="Curtis, Jr" uniqKey="Curtis J">JR Curtis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marx, Re" uniqKey="Marx R">RE Marx</name></author><author><name sortKey="Cillo, Je" uniqKey="Cillo J">JE Cillo</name></author><author><name sortKey="Ulloa, Jj" uniqKey="Ulloa J">JJ Ulloa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwon, Yd" uniqKey="Kwon Y">YD Kwon</name></author><author><name sortKey="Kim, Dy" uniqKey="Kim D">DY Kim</name></author><author><name sortKey="Ohe, Jy" uniqKey="Ohe J">JY Ohe</name></author><author><name sortKey="Yoo, Jy" uniqKey="Yoo J">JY Yoo</name></author><author><name sortKey="Walter, C" uniqKey="Walter C">C Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazarovici, Ts" uniqKey="Lazarovici T">TS Lazarovici</name></author><author><name sortKey="Mesilaty Gross, S" uniqKey="Mesilaty Gross S">S Mesilaty-Gross</name></author><author><name sortKey="Vered, I" uniqKey="Vered I">I Vered</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name></author><author><name sortKey="Stoner, Ja" uniqKey="Stoner J">JA Stoner</name></author><author><name sortKey="Lee, Hm" uniqKey="Lee H">HM Lee</name></author><author><name sortKey="Nummikoski, Pv" uniqKey="Nummikoski P">PV Nummikoski</name></author><author><name sortKey="Reinhardt, Ra" uniqKey="Reinhardt R">RA Reinhardt</name></author><author><name sortKey="Golub, Lm" uniqKey="Golub L">LM Golub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enciso, R" uniqKey="Enciso R">R Enciso</name></author><author><name sortKey="Keaton, J" uniqKey="Keaton J">J Keaton</name></author><author><name sortKey="Saleh, N" uniqKey="Saleh N">N Saleh</name></author><author><name sortKey="Ahmadieh, A" uniqKey="Ahmadieh A">A Ahmadieh</name></author><author><name sortKey="Clark, Gt" uniqKey="Clark G">GT Clark</name></author><author><name sortKey="Sedghizadeh, Pp" uniqKey="Sedghizadeh P">PP Sedghizadeh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Interv Aging</journal-id><journal-id journal-id-type="iso-abbrev">Clin Interv Aging</journal-id><journal-id journal-id-type="publisher-id">Clinical Interventions in Aging</journal-id><journal-title-group><journal-title>Clinical Interventions in Aging</journal-title></journal-title-group><issn pub-type="ppub">1176-9092</issn><issn pub-type="epub">1178-1998</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28744112</article-id><article-id pub-id-type="pmc">5513807</article-id><article-id pub-id-type="doi">10.2147/CIA.S141753</article-id><article-id pub-id-type="publisher-id">cia-12-1089</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Whei-Lin</given-names></name><xref ref-type="aff" rid="af1-cia-12-1089">1</xref><xref ref-type="aff" rid="af2-cia-12-1089">2</xref><xref ref-type="corresp" rid="c1-cia-12-1089"></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Pi-Lun</given-names></name><xref ref-type="aff" rid="af2-cia-12-1089">2</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Cho-Ying</given-names></name><xref ref-type="aff" rid="af1-cia-12-1089">1</xref><xref ref-type="aff" rid="af2-cia-12-1089">2</xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Yi-Chun</given-names></name><xref ref-type="aff" rid="af2-cia-12-1089">2</xref></contrib><contrib contrib-type="author"><name><surname>Ju</surname><given-names>Yuh-Ren</given-names></name><xref ref-type="aff" rid="af1-cia-12-1089">1</xref><xref ref-type="aff" rid="af2-cia-12-1089">2</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Chiu-Po</given-names></name><xref ref-type="aff" rid="af1-cia-12-1089">1</xref><xref ref-type="aff" rid="af2-cia-12-1089">2</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Robert WW</given-names></name><xref ref-type="aff" rid="af2-cia-12-1089">2</xref><xref ref-type="aff" rid="af3-cia-12-1089">3</xref></contrib></contrib-group><aff id="af1-cia-12-1089"><label>1</label>Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan</aff><aff id="af2-cia-12-1089"><label>2</label>Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan</aff><aff id="af3-cia-12-1089"><label>3</label>Department of Orthopedics, Chang Gung Memorial Hospital, Taipei, Taiwan</aff><author-notes><corresp id="c1-cia-12-1089">Correspondence: Whei-Lin Pan, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, 105 Taipei, Taiwan, Tel +886 22 760 2407, Fax +886 22 756 2221, Email <email>helen481209@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>11</day><month>7</month><year>2017</year></pub-date><volume>12</volume><fpage>1089</fpage><lpage>1093</lpage><permissions><copyright-statement>© 2017 Pan et al. This work is published and licensed by Dove Medical Press Limited</copyright-statement><copyright-year>2017</copyright-year><license><license-p>The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><p>Bisphosphonates (BPs) suppress bone resorption and increase bone strength, thus reducing the risk of fracture. Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia. Here, we describe the case of a postmenopausal woman who took oral alendronate for >3 years for osteoporosis. The patient presented at the clinic with sharp jaw pain and swelling on the left mandible 4 months after extraction of the third molar. Clinical examinations identified an inflamed mucosal opening with pus over an area of necrotic bone. Initial images of cone beam computed tomography revealed a sequestrum at the extracted socket. The condition did not improve after 1 week of antibiotic treatment; therefore, the alendronate treatment was terminated and the patient was prescribed strontium ranelate instead. The patient gradually recovered and, at the 2-year follow-up, the site of BP-related osteonecrosis of the jaw healed completely as determined by both clinical and cone beam computed tomography measures. The bone mineral densities in the femoral neck and lumbar spine improved after 1 year, and were maintained at the 3-year follow-up. The serum C-terminal cross-linking telopeptide values also gradually increased from the initial 130 pg/mL to 320 pg/mL at the 3-year follow-up. Taken together, this case supports the use of strontium ranelate as an alternative treatment for postmenopausal women who receive long-term oral BP treatments and are at risk for serious complications of BP-related osteonecrosis of the jaw.</p></abstract><kwd-group><title>Keywords</title><kwd>bisphosphonate-related osteonecrosis of the jaw</kwd><kwd>BRONJ</kwd><kwd>bisphosphonates</kwd><kwd>strontium ranelate</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-cia-12-1089" position="float"><label>Figure 1</label><caption><p>Images of the areas affected by BRONJ.</p><p><bold>Notes:</bold> (<bold>A</bold>) The initial appearance surrounding the extraction socket of lower left third molar, showing red and swollen gingiva with pus draining through gingival fistulas. (<bold>B</bold>) Initial cross-sectional CBCT images showed rarefaction of trabecular bone with a large area of osteonecrotic lesion around the extraction socket (as indicated by the white arrow). (<bold>C</bold>) After 2 years of SR treatment, the gingiva over the extraction socket is healthy with no sign of gingival inflammation. (<bold>D</bold>) After 2 years of SR treatment, CBCT images demonstrated that the bone density increased and new spongy bone had begun to fill into the area previously occupied by dead bone.</p><p><bold>Abbreviations:</bold> BRONJ, bisphosphonate-related osteonecrosis of the jaw; CBCT, cone beam computed tomography; SR, strontium ranelate.</p></caption><graphic xlink:href="cia-12-1089Fig1"></graphic></fig><table-wrap id="t1-cia-12-1089" position="float"><label>Table 1</label><caption><p>Tests for osteoporosis risk assessment</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="left" rowspan="1" colspan="1">Initial-before the discontinuation of BPs</th><th valign="top" align="left" rowspan="1" colspan="1">1 year after switching from BP to SR</th><th valign="top" align="left" rowspan="1" colspan="1">3 years after switching from BP to SR</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>BMD T scores</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">In femoral neck</td><td valign="top" align="left" rowspan="1" colspan="1">−1.3</td><td valign="top" align="left" rowspan="1" colspan="1">−0.6</td><td valign="top" align="left" rowspan="1" colspan="1">−0.5</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">In lumbar spine</td><td valign="top" align="left" rowspan="1" colspan="1">−2.6</td><td valign="top" align="left" rowspan="1" colspan="1">−0.4</td><td valign="top" align="left" rowspan="1" colspan="1">−0.4</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">CTX (pg/mL)</td><td valign="top" align="left" rowspan="1" colspan="1">130</td><td valign="top" align="left" rowspan="1" colspan="1">280</td><td valign="top" align="left" rowspan="1" colspan="1">320</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-cia-12-1089"><p><bold>Abbreviations:</bold> BMD, bone mineral density; BPs, bisphosphonates; CTX, C-terminal cross-linking telopeptide; SR, strontium ranelate.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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