Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.
Identifieur interne : 001543 ( Pmc/Curation ); précédent : 001542; suivant : 001544Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.
Auteurs : P. Chen ; J J Farrar ; R J GencoSource :
- Infection and Immunity [ 0019-9567 ] ; 1980.
Abstract
A water-soluble extract of Actinomyces viscosus was tested for its capacity to induce deoxyribonucleic acid synthesis in spleen cells from normal mice and to augment the in vitro antibody-forming cell (AFC) response to the T-cell-dependent antigen, sheep erythrocytes (SRBC) by T-cell-deficient adherent spleen cell monolayers from the same mice. Our results indicated that the water-soluble extract induced an in vitro blastogenic response, as assessed by tritiated thymidine incorporation into mouse spleen cells. The water-soluble extract also augmented the antibody response to SRBC. However, after fractionation of the water-soluble extract on Biogel P-300, not all of the fractions induced a blastogenic response and augmented an AFC response to SRBC. This difference in the ability of A. viscosus fractions to induce in vitro responses suggests that the water-soluble extract has multiple immunological properties. Chemical analysis of the water-soluble extract indicated an enrichment for amino acids and amino sugar common to peptidoglycan.
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PubMed: 7189748
PubMed Central: 550914
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.</title><author><name sortKey="Chen, P" sort="Chen, P" uniqKey="Chen P" first="P" last="Chen">P. Chen</name></author><author><name sortKey="Farrar, J J" sort="Farrar, J J" uniqKey="Farrar J" first="J J" last="Farrar">J J Farrar</name></author><author><name sortKey="Genco, R J" sort="Genco, R J" uniqKey="Genco R" first="R J" last="Genco">R J Genco</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">7189748</idno><idno type="pmc">550914</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC550914</idno><idno type="RBID">PMC:550914</idno><date when="1980">1980</date><idno type="wicri:Area/Pmc/Corpus">001543</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001543</idno><idno type="wicri:Area/Pmc/Curation">001543</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001543</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.</title><author><name sortKey="Chen, P" sort="Chen, P" uniqKey="Chen P" first="P" last="Chen">P. Chen</name></author><author><name sortKey="Farrar, J J" sort="Farrar, J J" uniqKey="Farrar J" first="J J" last="Farrar">J J Farrar</name></author><author><name sortKey="Genco, R J" sort="Genco, R J" uniqKey="Genco R" first="R J" last="Genco">R J Genco</name></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1980">1980</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A water-soluble extract of Actinomyces viscosus was tested for its capacity to induce deoxyribonucleic acid synthesis in spleen cells from normal mice and to augment the in vitro antibody-forming cell (AFC) response to the T-cell-dependent antigen, sheep erythrocytes (SRBC) by T-cell-deficient adherent spleen cell monolayers from the same mice. Our results indicated that the water-soluble extract induced an in vitro blastogenic response, as assessed by tritiated thymidine incorporation into mouse spleen cells. The water-soluble extract also augmented the antibody response to SRBC. However, after fractionation of the water-soluble extract on Biogel P-300, not all of the fractions induced a blastogenic response and augmented an AFC response to SRBC. This difference in the ability of A. viscosus fractions to induce in vitro responses suggests that the water-soluble extract has multiple immunological properties. Chemical analysis of the water-soluble extract indicated an enrichment for amino acids and amino sugar common to peptidoglycan.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn></journal-meta><article-meta><article-id pub-id-type="pmid">7189748</article-id><article-id pub-id-type="pmc">550914</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Farrar</surname><given-names>J J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Genco</surname><given-names>R J</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>4</month><year>1980</year></pub-date><volume>28</volume><issue>1</issue><fpage>212</fpage><lpage>219</lpage><abstract><p>A water-soluble extract of Actinomyces viscosus was tested for its capacity to induce deoxyribonucleic acid synthesis in spleen cells from normal mice and to augment the in vitro antibody-forming cell (AFC) response to the T-cell-dependent antigen, sheep erythrocytes (SRBC) by T-cell-deficient adherent spleen cell monolayers from the same mice. Our results indicated that the water-soluble extract induced an in vitro blastogenic response, as assessed by tritiated thymidine incorporation into mouse spleen cells. The water-soluble extract also augmented the antibody response to SRBC. However, after fractionation of the water-soluble extract on Biogel P-300, not all of the fractions induced a blastogenic response and augmented an AFC response to SRBC. This difference in the ability of A. viscosus fractions to induce in vitro responses suggests that the water-soluble extract has multiple immunological properties. Chemical analysis of the water-soluble extract indicated an enrichment for amino acids and amino sugar common to peptidoglycan.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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