Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts
Identifieur interne : 000D88 ( Pmc/Curation ); précédent : 000D87; suivant : 000D89Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts
Auteurs : Hans H. Diebner [Allemagne] ; Birgit Marré [Allemagne] ; Ingo Roeder [Allemagne] ; Michael H. Walter [Allemagne]Source :
- Trials [ 1745-6215 ] ; 2016.
Abstract
In studies comparing different prosthetic treatment concepts the repeated loss of teeth was chosen as the primary outcome. The resulting data appear to represent a data structure of recurrent events. However, the application of an existing method for recurrent events is far from straightforward. Often only the first event or the final state is analyzed using Kaplan–Meier survival statistics, thereby giving a great deal of information away.
The paper presents a strategy for the analysis of recurrent data using a previously published study on the influence of different prosthetic treatment concepts for the shortened dental arch on tooth loss. A method based on cumulative sample history functions of recurrent events was adjusted for tooth loss. The shapes of these cumulative functions suggest a time dependency of the recurrence rate. To keep the model as simple as possible, a tripartite Poisson process (which assumes piecewise time-independent rates) was fitted to the cumulative mean functions stratified by treatment.
Within the middle interval of the three-phasic process, the treatment effects differ significantly, which is interpreted as a delay of tooth loss due to the use of one type of prosthesis (fixed) compared with the other (removable).
An analysis based on cumulative history functions is based on process, therefore, temporally changing characteristics are better captured than in methods for survival analyses. The presented approach offers useful new insight into the temporal behavior of ongoing tooth loss after prosthetic treatment.
The trial has been registered at controlled-trials.com under
The online version of this article (doi:10.1186/s13063-016-1360-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13063-016-1360-y
PubMed: 27185170
PubMed Central: 4869190
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Diebner</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Institute for Medical Informatics and Biometry, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Marre, Birgit" sort="Marre, Birgit" uniqKey="Marre B" first="Birgit" last="Marré">Birgit Marré</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Prosthetic Dentistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dental School, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Roeder, Ingo" sort="Roeder, Ingo" uniqKey="Roeder I" first="Ingo" last="Roeder">Ingo Roeder</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Institute for Medical Informatics and Biometry, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Walter, Michael H" sort="Walter, Michael H" uniqKey="Walter M" first="Michael H." last="Walter">Michael H. Walter</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Prosthetic Dentistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dental School, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27185170</idno><idno type="pmc">4869190</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869190</idno><idno type="RBID">PMC:4869190</idno><idno type="doi">10.1186/s13063-016-1360-y</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000D88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D88</idno><idno type="wicri:Area/Pmc/Curation">000D88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts</title><author><name sortKey="Diebner, Hans H" sort="Diebner, Hans H" uniqKey="Diebner H" first="Hans H." last="Diebner">Hans H. Diebner</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Institute for Medical Informatics and Biometry, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Marre, Birgit" sort="Marre, Birgit" uniqKey="Marre B" first="Birgit" last="Marré">Birgit Marré</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Prosthetic Dentistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dental School, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Roeder, Ingo" sort="Roeder, Ingo" uniqKey="Roeder I" first="Ingo" last="Roeder">Ingo Roeder</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Institute for Medical Informatics and Biometry, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author><author><name sortKey="Walter, Michael H" sort="Walter, Michael H" uniqKey="Walter M" first="Michael H." last="Walter">Michael H. Walter</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Prosthetic Dentistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dental School, Fetscherstrasse 74, Dresden, D–01307 Germany</nlm:aff><orgName type="university">Université technique de Dresde</orgName><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In studies comparing different prosthetic treatment concepts the repeated loss of teeth was chosen as the primary outcome. The resulting data appear to represent a data structure of recurrent events. However, the application of an existing method for recurrent events is far from straightforward. Often only the first event or the final state is analyzed using Kaplan–Meier survival statistics, thereby giving a great deal of information away.</p></sec><sec><title>Methods</title><p>The paper presents a strategy for the analysis of recurrent data using a previously published study on the influence of different prosthetic treatment concepts for the shortened dental arch on tooth loss. A method based on cumulative sample history functions of recurrent events was adjusted for tooth loss. The shapes of these cumulative functions suggest a time dependency of the recurrence rate. To keep the model as simple as possible, a tripartite Poisson process (which assumes piecewise time-independent rates) was fitted to the cumulative mean functions stratified by treatment.</p></sec><sec><title>Results</title><p>Within the middle interval of the three-phasic process, the treatment effects differ significantly, which is interpreted as a delay of tooth loss due to the use of one type of prosthesis (fixed) compared with the other (removable).</p></sec><sec><title>Conclusions</title><p>An analysis based on cumulative history functions is based on process, therefore, temporally changing characteristics are better captured than in methods for survival analyses. The presented approach offers useful new insight into the temporal behavior of ongoing tooth loss after prosthetic treatment.</p></sec><sec><title>Trial registration</title><p>The trial has been registered at controlled-trials.com under <ext-link ext-link-type="uri" xlink:href="http://www.isrctn.com/ISRCTN97265367">ISRCTN97265367</ext-link> (registration date 4 April 2008).</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13063-016-1360-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Luthardt, Rg" uniqKey="Luthardt R">RG Luthardt</name></author><author><name sortKey="Marre, B" uniqKey="Marre B">B Marre</name></author><author><name sortKey="Heinecke, A" uniqKey="Heinecke A">A Heinecke</name></author><author><name sortKey="Gerss, J" uniqKey="Gerss J">J Gerss</name></author><author><name sortKey="Aggstaller, H" uniqKey="Aggstaller H">H Aggstaller</name></author><author><name sortKey="Busche, E" uniqKey="Busche E">E Busche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, Mh" uniqKey="Walter M">MH Walter</name></author><author><name sortKey="Weber, A" uniqKey="Weber A">A Weber</name></author><author><name sortKey="Marre, B" uniqKey="Marre B">B Marre</name></author><author><name sortKey="Gitt, I" uniqKey="Gitt I">I Gitt</name></author><author><name sortKey="Gerss, J" uniqKey="Gerss J">J Gerss</name></author><author><name sortKey="Hannak, W" uniqKey="Hannak W">W Hannak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, Mh" uniqKey="Walter M">MH Walter</name></author><author><name sortKey="Hannak, W" uniqKey="Hannak W">W Hannak</name></author><author><name sortKey="Kern, M" uniqKey="Kern M">M Kern</name></author><author><name sortKey="Mundt, T" uniqKey="Mundt T">T Mundt</name></author><author><name sortKey="Gernet, W" uniqKey="Gernet W">W Gernet</name></author><author><name sortKey="Weber, A" uniqKey="Weber A">A Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gail, M" uniqKey="Gail M">M Gail</name></author><author><name sortKey="Santner, T" uniqKey="Santner T">T Santner</name></author><author><name sortKey="Brown, C" uniqKey="Brown C">C Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Wb" uniqKey="Nelson W">WB Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cook, Rj" uniqKey="Cook R">RJ Cook</name></author><author><name sortKey="Lawless, Jf" uniqKey="Lawless J">JF Lawless</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersen, Pk" uniqKey="Andersen P">PK Andersen</name></author><author><name sortKey="Gill, Rd" uniqKey="Gill R">RD Gill</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Trials</journal-id><journal-id journal-id-type="iso-abbrev">Trials</journal-id><journal-title-group><journal-title>Trials</journal-title></journal-title-group><issn pub-type="epub">1745-6215</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27185170</article-id><article-id pub-id-type="pmc">4869190</article-id><article-id pub-id-type="publisher-id">1360</article-id><article-id pub-id-type="doi">10.1186/s13063-016-1360-y</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Diebner</surname><given-names>Hans H.</given-names></name><address><email>hans.diebner@tu-dresden.de</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Marré</surname><given-names>Birgit</given-names></name><address><email>birgit.marre@uniklinikum-dresden.de</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Roeder</surname><given-names>Ingo</given-names></name><address><email>ingo.roeder@tu-dresden.de</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Walter</surname><given-names>Michael H.</given-names></name><address><email>michael.walter@uniklinikum-dresden.de</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><aff id="Aff1"><label></label>Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Institute for Medical Informatics and Biometry, Fetscherstrasse 74, Dresden, D–01307 Germany</aff><aff id="Aff2"><label></label>Department of Prosthetic Dentistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dental School, Fetscherstrasse 74, Dresden, D–01307 Germany</aff></contrib-group><pub-date pub-type="epub"><day>17</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>17</volume><elocation-id>244</elocation-id><history><date date-type="received"><day>30</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>23</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement>© Diebner et al. 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>In studies comparing different prosthetic treatment concepts the repeated loss of teeth was chosen as the primary outcome. The resulting data appear to represent a data structure of recurrent events. However, the application of an existing method for recurrent events is far from straightforward. Often only the first event or the final state is analyzed using Kaplan–Meier survival statistics, thereby giving a great deal of information away.</p></sec><sec><title>Methods</title><p>The paper presents a strategy for the analysis of recurrent data using a previously published study on the influence of different prosthetic treatment concepts for the shortened dental arch on tooth loss. A method based on cumulative sample history functions of recurrent events was adjusted for tooth loss. The shapes of these cumulative functions suggest a time dependency of the recurrence rate. To keep the model as simple as possible, a tripartite Poisson process (which assumes piecewise time-independent rates) was fitted to the cumulative mean functions stratified by treatment.</p></sec><sec><title>Results</title><p>Within the middle interval of the three-phasic process, the treatment effects differ significantly, which is interpreted as a delay of tooth loss due to the use of one type of prosthesis (fixed) compared with the other (removable).</p></sec><sec><title>Conclusions</title><p>An analysis based on cumulative history functions is based on process, therefore, temporally changing characteristics are better captured than in methods for survival analyses. The presented approach offers useful new insight into the temporal behavior of ongoing tooth loss after prosthetic treatment.</p></sec><sec><title>Trial registration</title><p>The trial has been registered at controlled-trials.com under <ext-link ext-link-type="uri" xlink:href="http://www.isrctn.com/ISRCTN97265367">ISRCTN97265367</ext-link> (registration date 4 April 2008).</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13063-016-1360-y) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Recurrent events</kwd><kwd>Cumulative sample history function</kwd><kwd>Shortened dental arch</kwd><kwd>Dental prosthesis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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