Oral symptoms and functional outcome related to oral and oropharyngeal cancer
Identifieur interne : 000D83 ( Pmc/Curation ); précédent : 000D82; suivant : 000D84Oral symptoms and functional outcome related to oral and oropharyngeal cancer
Auteurs : Jolanda I. Kamstra [Pays-Bas] ; Harriet Jager-Wittenaar [Pays-Bas] ; Pieter U. Dijkstra [Pays-Bas] ; Paulien M. Huisman [Pays-Bas] ; Rob P. Van Oort [Pays-Bas] ; Bernard F. A. M. Van Der Laan [Pays-Bas] ; Jan L. N. Roodenburg [Pays-Bas]Source :
- Supportive Care in Cancer [ 0941-4355 ] ; 2010.
Abstract
This study aimed to assess: (1) oral symptoms of patients treated for oral or oropharyngeal cancer; (2) how patients rank the burden of oral symptoms; (3) the impact of the tumor, the treatment, and oral symptoms on functional outcome.
Eighty-nine patients treated for oral or oropharyngeal cancer were asked about their oral symptoms related to mouth opening, dental status, oral sensory function, tongue mobility, salivary function, and pain. They were asked to rank these oral symptoms according to the degree of burden experienced. The Mandibular Function Impairment Questionnaire (MFIQ) was used to assess functional outcome. In a multivariate linear regression analyses, variables related to MFIQ scores (
Lack of saliva (52%), restricted mouth opening (48%), and restricted tongue mobility (46%) were the most frequently reported oral symptoms. Lack of saliva was most frequently (32%) ranked as the most burdensome oral symptom.
For radiated patients, an inability to wear a dental prosthesis, a T3 or T4 stage, and a higher age were predictive of MFIQ scores. For non-radiated patients, a restricted mouth opening, an inability to wear a dental prosthesis, restricted tongue mobility, and surgery of the mandible were predictive of MFIQ scores.
Lack of saliva was not only the most frequently reported oral symptom after treatment for oral or oropharyngeal cancer, but also the most burdensome. Functional outcome is strongly influenced by an inability to wear a dental prosthesis in both radiated and non-radiated patients.
Url:
DOI: 10.1007/s00520-010-0952-4
PubMed: 20706851
PubMed Central: 3151373
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oral symptoms and functional outcome related to oral and oropharyngeal cancer</title>
<author><name sortKey="Kamstra, Jolanda I" sort="Kamstra, Jolanda I" uniqKey="Kamstra J" first="Jolanda I." last="Kamstra">Jolanda I. Kamstra</name>
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<country xml:lang="fr">Pays-Bas</country>
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<author><name sortKey="Jager Wittenaar, Harriet" sort="Jager Wittenaar, Harriet" uniqKey="Jager Wittenaar H" first="Harriet" last="Jager-Wittenaar">Harriet Jager-Wittenaar</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery and Special Dentistry, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
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<wicri:regionArea>Department of Rehabilitation Medicine, Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
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<author><name sortKey="Huisman, Paulien M" sort="Huisman, Paulien M" uniqKey="Huisman P" first="Paulien M." last="Huisman">Paulien M. Huisman</name>
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<author><name sortKey="Van Oort, Rob P" sort="Van Oort, Rob P" uniqKey="Van Oort R" first="Rob P." last="Van Oort">Rob P. Van Oort</name>
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<author><name sortKey="Van Der Laan, Bernard F A M" sort="Van Der Laan, Bernard F A M" uniqKey="Van Der Laan B" first="Bernard F. A. M." last="Van Der Laan">Bernard F. A. M. Van Der Laan</name>
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<author><name sortKey="Roodenburg, Jan L N" sort="Roodenburg, Jan L N" uniqKey="Roodenburg J" first="Jan L. N." last="Roodenburg">Jan L. N. Roodenburg</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery and Special Dentistry, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
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<series><title level="j">Supportive Care in Cancer</title>
<idno type="ISSN">0941-4355</idno>
<idno type="eISSN">1433-7339</idno>
<imprint><date when="2010">2010</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>This study aimed to assess: (1) oral symptoms of patients treated for oral or oropharyngeal cancer; (2) how patients rank the burden of oral symptoms; (3) the impact of the tumor, the treatment, and oral symptoms on functional outcome.</p>
</sec>
<sec><title>Methods</title>
<p>Eighty-nine patients treated for oral or oropharyngeal cancer were asked about their oral symptoms related to mouth opening, dental status, oral sensory function, tongue mobility, salivary function, and pain. They were asked to rank these oral symptoms according to the degree of burden experienced. The Mandibular Function Impairment Questionnaire (MFIQ) was used to assess functional outcome. In a multivariate linear regression analyses, variables related to MFIQ scores (<italic>p</italic>
≤ 0.10) were entered as predictors with MFIQ score as the outcome.</p>
</sec>
<sec><title>Results</title>
<p>Lack of saliva (52%), restricted mouth opening (48%), and restricted tongue mobility (46%) were the most frequently reported oral symptoms. Lack of saliva was most frequently (32%) ranked as the most burdensome oral symptom.</p>
<p>For radiated patients, an inability to wear a dental prosthesis, a T3 or T4 stage, and a higher age were predictive of MFIQ scores. For non-radiated patients, a restricted mouth opening, an inability to wear a dental prosthesis, restricted tongue mobility, and surgery of the mandible were predictive of MFIQ scores.</p>
</sec>
<sec><title>Conclusions</title>
<p>Lack of saliva was not only the most frequently reported oral symptom after treatment for oral or oropharyngeal cancer, but also the most burdensome. Functional outcome is strongly influenced by an inability to wear a dental prosthesis in both radiated and non-radiated patients.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Support Care Cancer</journal-id>
<journal-title-group><journal-title>Supportive Care in Cancer</journal-title>
</journal-title-group>
<issn pub-type="ppub">0941-4355</issn>
<issn pub-type="epub">1433-7339</issn>
<publisher><publisher-name>Springer-Verlag</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20706851</article-id>
<article-id pub-id-type="pmc">3151373</article-id>
<article-id pub-id-type="publisher-id">952</article-id>
<article-id pub-id-type="doi">10.1007/s00520-010-0952-4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Oral symptoms and functional outcome related to oral and oropharyngeal cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kamstra</surname>
<given-names>Jolanda I.</given-names>
</name>
<address><phone>+31-50-3610297</phone>
<fax>+31-50-3611708</fax>
<email>j.i.kamstra@kchir.umcg.nl</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jager-Wittenaar</surname>
<given-names>Harriet</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dijkstra</surname>
<given-names>Pieter U.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huisman</surname>
<given-names>Paulien M.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Oort</surname>
<given-names>Rob P.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Laan</surname>
<given-names>Bernard F. A. M.</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Roodenburg</surname>
<given-names>Jan L. N.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Oral and Maxillofacial Surgery and Special Dentistry, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands</aff>
<aff id="Aff2"><label>2</label>
Department of Rehabilitation Medicine, Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff>
<aff id="Aff3"><label>3</label>
Clinic for Periodontology, Amsterdam, The Netherlands</aff>
<aff id="Aff4"><label>4</label>
Department of Otorhinolaryngology-Head & Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff>
</contrib-group>
<pub-date pub-type="epub"><day>13</day>
<month>8</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>8</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2011</year>
</pub-date>
<volume>19</volume>
<issue>9</issue>
<fpage>1327</fpage>
<lpage>1333</lpage>
<history><date date-type="received"><day>17</day>
<month>9</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>12</day>
<month>7</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2010</copyright-statement>
</permissions>
<abstract id="Abs1"><sec><title>Purpose</title>
<p>This study aimed to assess: (1) oral symptoms of patients treated for oral or oropharyngeal cancer; (2) how patients rank the burden of oral symptoms; (3) the impact of the tumor, the treatment, and oral symptoms on functional outcome.</p>
</sec>
<sec><title>Methods</title>
<p>Eighty-nine patients treated for oral or oropharyngeal cancer were asked about their oral symptoms related to mouth opening, dental status, oral sensory function, tongue mobility, salivary function, and pain. They were asked to rank these oral symptoms according to the degree of burden experienced. The Mandibular Function Impairment Questionnaire (MFIQ) was used to assess functional outcome. In a multivariate linear regression analyses, variables related to MFIQ scores (<italic>p</italic>
≤ 0.10) were entered as predictors with MFIQ score as the outcome.</p>
</sec>
<sec><title>Results</title>
<p>Lack of saliva (52%), restricted mouth opening (48%), and restricted tongue mobility (46%) were the most frequently reported oral symptoms. Lack of saliva was most frequently (32%) ranked as the most burdensome oral symptom.</p>
<p>For radiated patients, an inability to wear a dental prosthesis, a T3 or T4 stage, and a higher age were predictive of MFIQ scores. For non-radiated patients, a restricted mouth opening, an inability to wear a dental prosthesis, restricted tongue mobility, and surgery of the mandible were predictive of MFIQ scores.</p>
</sec>
<sec><title>Conclusions</title>
<p>Lack of saliva was not only the most frequently reported oral symptom after treatment for oral or oropharyngeal cancer, but also the most burdensome. Functional outcome is strongly influenced by an inability to wear a dental prosthesis in both radiated and non-radiated patients.</p>
</sec>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Functional outcome</kwd>
<kwd>Treatment related adverse events</kwd>
<kwd>Oral and oropharyngeal cancer</kwd>
<kwd>Oral symptoms</kwd>
<kwd>Radiotherapy</kwd>
<kwd>Mandibular function impairment questionnaire</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer-Verlag 2011</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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