Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer
Identifieur interne : 000D61 ( Pmc/Curation ); précédent : 000D60; suivant : 000D62Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer
Auteurs : Thomas Kuhnt [Allemagne] ; Andreas Stang [Allemagne] ; Andreas Wienke [Allemagne] ; Dirk Vordermark [Allemagne] ; Ramona Schweyen [Allemagne] ; Jeremias Hey [Allemagne]Source :
- Radiation Oncology (London, England) [ 1748-717X ] ; 2016.
Abstract
To identify potential risk factors for the development of jaw osteoradionecrosis (ORN) after 3D-conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) among patients with newly diagnosed head and neck cancer.
This study included 776 patients who underwent 3D-CRT or IMRT for head and neck cancer at the Department of Radiotherapy at the University Hospital Halle-Wittenberg between 2003 and 2013. Sex, dental status prior to radiotherapy, tumor site, bone surgery during tumor resection, concomitant chemotherapy, and the development of advanced ORN were documented for each patient. ORN was classified as grade 3, 4, or 5 according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer classification or grade 3 or 4 according to the late effects in normal tissues/subjective, objective, management, and analytic scale. The cumulative incidence of ORN was estimated. Cox regression analysis was used to identify prognostic risk factors for the development of ORN.
Fifty-one patients developed advanced ORN (relative frequency 6.6 %, cumulative incidence 12.4 %). The highest risk was found in patients who had undergone primary bone surgery during tumor resection (hazard ratio [HR] = 5.87; 95 % confidence interval [CI]: 3.09–11.19) and in patients with tumors located in the oral cavity (HR = 4.69; 95 % CI: 1.33–16.52). Sex, dentition (dentulous vs. edentulous), and chemotherapy had no clinically relevant influence.
In contrast to most previous studies, we noted a low cumulative incidence of advanced ORN. Patients with tumors located in the oral cavity and those who undergo bone surgery during tumor resection prior to RT may be considered a high-risk group for the development of ORN.
Url:
DOI: 10.1186/s13014-016-0679-6
PubMed: 27473433
PubMed Central: 4967325
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000D61
Links to Exploration step
PMC:4967325Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer</title>
<author><name sortKey="Kuhnt, Thomas" sort="Kuhnt, Thomas" uniqKey="Kuhnt T" first="Thomas" last="Kuhnt">Thomas Kuhnt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Diagnostic Imaging and Radiation Medicine, University Clinic, University Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Diagnostic Imaging and Radiation Medicine, University Clinic, University Leipzig, Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stang, Andreas" sort="Stang, Andreas" uniqKey="Stang A" first="Andreas" last="Stang">Andreas Stang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wienke, Andreas" sort="Wienke, Andreas" uniqKey="Wienke A" first="Andreas" last="Wienke">Andreas Wienke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Epidemiology, Biometry and Computer Science Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Epidemiology, Biometry and Computer Science Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vordermark, Dirk" sort="Vordermark, Dirk" uniqKey="Vordermark D" first="Dirk" last="Vordermark">Dirk Vordermark</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Radiotherapy, University Clinic, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiotherapy, University Clinic, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schweyen, Ramona" sort="Schweyen, Ramona" uniqKey="Schweyen R" first="Ramona" last="Schweyen">Ramona Schweyen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hey, Jeremias" sort="Hey, Jeremias" uniqKey="Hey J" first="Jeremias" last="Hey">Jeremias Hey</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27473433</idno>
<idno type="pmc">4967325</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967325</idno>
<idno type="RBID">PMC:4967325</idno>
<idno type="doi">10.1186/s13014-016-0679-6</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000D61</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D61</idno>
<idno type="wicri:Area/Pmc/Curation">000D61</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D61</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer</title>
<author><name sortKey="Kuhnt, Thomas" sort="Kuhnt, Thomas" uniqKey="Kuhnt T" first="Thomas" last="Kuhnt">Thomas Kuhnt</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Diagnostic Imaging and Radiation Medicine, University Clinic, University Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Diagnostic Imaging and Radiation Medicine, University Clinic, University Leipzig, Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stang, Andreas" sort="Stang, Andreas" uniqKey="Stang A" first="Andreas" last="Stang">Andreas Stang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wienke, Andreas" sort="Wienke, Andreas" uniqKey="Wienke A" first="Andreas" last="Wienke">Andreas Wienke</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Epidemiology, Biometry and Computer Science Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Epidemiology, Biometry and Computer Science Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vordermark, Dirk" sort="Vordermark, Dirk" uniqKey="Vordermark D" first="Dirk" last="Vordermark">Dirk Vordermark</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Radiotherapy, University Clinic, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiotherapy, University Clinic, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schweyen, Ramona" sort="Schweyen, Ramona" uniqKey="Schweyen R" first="Ramona" last="Schweyen">Ramona Schweyen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hey, Jeremias" sort="Hey, Jeremias" uniqKey="Hey J" first="Jeremias" last="Hey">Jeremias Hey</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Radiation Oncology (London, England)</title>
<idno type="eISSN">1748-717X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>To identify potential risk factors for the development of jaw osteoradionecrosis (ORN) after 3D-conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) among patients with newly diagnosed head and neck cancer.</p>
</sec>
<sec><title>Material and methods</title>
<p>This study included 776 patients who underwent 3D-CRT or IMRT for head and neck cancer at the Department of Radiotherapy at the University Hospital Halle-Wittenberg between 2003 and 2013. Sex, dental status prior to radiotherapy, tumor site, bone surgery during tumor resection, concomitant chemotherapy, and the development of advanced ORN were documented for each patient. ORN was classified as grade 3, 4, or 5 according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer classification or grade 3 or 4 according to the late effects in normal tissues/subjective, objective, management, and analytic scale. The cumulative incidence of ORN was estimated. Cox regression analysis was used to identify prognostic risk factors for the development of ORN.</p>
</sec>
<sec><title>Results</title>
<p>Fifty-one patients developed advanced ORN (relative frequency 6.6 %, cumulative incidence 12.4 %). The highest risk was found in patients who had undergone primary bone surgery during tumor resection (hazard ratio [HR] = 5.87; 95 % confidence interval [CI]: 3.09–11.19) and in patients with tumors located in the oral cavity (HR = 4.69; 95 % CI: 1.33–16.52). Sex, dentition (dentulous vs. edentulous), and chemotherapy had no clinically relevant influence.</p>
</sec>
<sec><title>Discussion and conclusion</title>
<p>In contrast to most previous studies, we noted a low cumulative incidence of advanced ORN. Patients with tumors located in the oral cavity and those who undergo bone surgery during tumor resection prior to RT may be considered a high-risk group for the development of ORN.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Willich, N" uniqKey="Willich N">N Willich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hey, J" uniqKey="Hey J">J Hey</name>
</author>
<author><name sortKey="Setz, J" uniqKey="Setz J">J Setz</name>
</author>
<author><name sortKey="Gerlach, R" uniqKey="Gerlach R">R Gerlach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nutting, Cm" uniqKey="Nutting C">CM Nutting</name>
</author>
<author><name sortKey="Morden, Jp" uniqKey="Morden J">JP Morden</name>
</author>
<author><name sortKey="Harrington, Kj" uniqKey="Harrington K">KJ Harrington</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hey, J" uniqKey="Hey J">J Hey</name>
</author>
<author><name sortKey="Seidel, J" uniqKey="Seidel J">J Seidel</name>
</author>
<author><name sortKey="Schweyen, R" uniqKey="Schweyen R">R Schweyen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koga, Dh" uniqKey="Koga D">DH Koga</name>
</author>
<author><name sortKey="Salvajoli, Jv" uniqKey="Salvajoli J">JV Salvajoli</name>
</author>
<author><name sortKey="Alves, Fa" uniqKey="Alves F">FA Alves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobson, As" uniqKey="Jacobson A">AS Jacobson</name>
</author>
<author><name sortKey="Zevallos, J" uniqKey="Zevallos J">J Zevallos</name>
</author>
<author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chrcanovic, Br" uniqKey="Chrcanovic B">BR Chrcanovic</name>
</author>
<author><name sortKey="Reher, P" uniqKey="Reher P">P Reher</name>
</author>
<author><name sortKey="Sousa, Aa" uniqKey="Sousa A">AA Sousa</name>
</author>
<author><name sortKey="Harris, M" uniqKey="Harris M">M Harris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delanian, S" uniqKey="Delanian S">S Delanian</name>
</author>
<author><name sortKey="Lefaix, Jl" uniqKey="Lefaix J">JL Lefaix</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curi, Mm" uniqKey="Curi M">MM Curi</name>
</author>
<author><name sortKey="Dib, Ll" uniqKey="Dib L">LL Dib</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reuther, T" uniqKey="Reuther T">T Reuther</name>
</author>
<author><name sortKey="Schuster, T" uniqKey="Schuster T">T Schuster</name>
</author>
<author><name sortKey="Mende, U" uniqKey="Mende U">U Mende</name>
</author>
<author><name sortKey="Kubler, A" uniqKey="Kubler A">A Kübler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chopra, S" uniqKey="Chopra S">S Chopra</name>
</author>
<author><name sortKey="Kamdar, D" uniqKey="Kamdar D">D Kamdar</name>
</author>
<author><name sortKey="Ugur, Oe" uniqKey="Ugur O">OE Ugur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monnier, Y" uniqKey="Monnier Y">Y Monnier</name>
</author>
<author><name sortKey="Broome, M" uniqKey="Broome M">M Broome</name>
</author>
<author><name sortKey="Betz, M" uniqKey="Betz M">M Betz</name>
</author>
<author><name sortKey="Bouferrache, K" uniqKey="Bouferrache K">K Bouferrache</name>
</author>
<author><name sortKey="Ozsahin, M" uniqKey="Ozsahin M">M Ozsahin</name>
</author>
<author><name sortKey="Jaques, B" uniqKey="Jaques B">B Jaques</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casares, C" uniqKey="Casares C">C Casares</name>
</author>
<author><name sortKey="Ramirez Camacho, R" uniqKey="Ramirez Camacho R">R Ramírez-Camacho</name>
</author>
<author><name sortKey="Trinidad, A" uniqKey="Trinidad A">A Trinidad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Studer, G" uniqKey="Studer G">G Studer</name>
</author>
<author><name sortKey="Studer, Sp" uniqKey="Studer S">SP Studer</name>
</author>
<author><name sortKey="Zwahlen, Ra" uniqKey="Zwahlen R">RA Zwahlen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steinhart, H" uniqKey="Steinhart H">H Steinhart</name>
</author>
<author><name sortKey="Schroeder, Hg" uniqKey="Schroeder H">HG Schroeder</name>
</author>
<author><name sortKey="Kleinsasser, O" uniqKey="Kleinsasser O">O Kleinsasser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kolokythas, A" uniqKey="Kolokythas A">A Kolokythas</name>
</author>
<author><name sortKey="Eisele, Dw" uniqKey="Eisele D">DW Eisele</name>
</author>
<author><name sortKey="El Sayed, I" uniqKey="El Sayed I">I El-Sayed</name>
</author>
<author><name sortKey="Schmidt, Bl" uniqKey="Schmidt B">BL Schmidt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Studer, G" uniqKey="Studer G">G Studer</name>
</author>
<author><name sortKey="Bredell, M" uniqKey="Bredell M">M Bredell</name>
</author>
<author><name sortKey="Studer, S" uniqKey="Studer S">S Studer</name>
</author>
<author><name sortKey="Huber, G" uniqKey="Huber G">G Huber</name>
</author>
<author><name sortKey="Glanzmann, C" uniqKey="Glanzmann C">C Glanzmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuhnt, T" uniqKey="Kuhnt T">T Kuhnt</name>
</author>
<author><name sortKey="Janich, M" uniqKey="Janich M">M Janich</name>
</author>
<author><name sortKey="Gotz, U" uniqKey="Gotz U">U Götz</name>
</author>
<author><name sortKey="Gerlach, R" uniqKey="Gerlach R">R Gerlach</name>
</author>
<author><name sortKey="Chiricuta, I" uniqKey="Chiricuta I">I Chiricuta</name>
</author>
<author><name sortKey="H Nsgen, G" uniqKey="H Nsgen G">G Hänsgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Georg, D" uniqKey="Georg D">D Georg</name>
</author>
<author><name sortKey="Kroupa, B" uniqKey="Kroupa B">B Kroupa</name>
</author>
<author><name sortKey="Georg, P" uniqKey="Georg P">P Georg</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Budach, V" uniqKey="Budach V">V Budach</name>
</author>
<author><name sortKey="Stuschke, M" uniqKey="Stuschke M">M Stuschke</name>
</author>
<author><name sortKey="Budach, W" uniqKey="Budach W">W Budach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grotz, Ka" uniqKey="Grotz K">KA Grötz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kielbassa, Am" uniqKey="Kielbassa A">AM Kielbassa</name>
</author>
<author><name sortKey="Hinkelbein, W" uniqKey="Hinkelbein W">W Hinkelbein</name>
</author>
<author><name sortKey="Hellwig, E" uniqKey="Hellwig E">E Hellwig</name>
</author>
<author><name sortKey="Meyer Luckel, H" uniqKey="Meyer Luckel H">H Meyer-Lückel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwartz, Hc" uniqKey="Schwartz H">HC Schwartz</name>
</author>
<author><name sortKey="Kagan, Ar" uniqKey="Kagan A">AR Kagan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="St Re, G" uniqKey="St Re G">G Støre</name>
</author>
<author><name sortKey="Boysen, M" uniqKey="Boysen M">M Boysen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, Sn" uniqKey="Rogers S">SN Rogers</name>
</author>
<author><name sortKey="Brown, Js" uniqKey="Brown J">JS Brown</name>
</author>
<author><name sortKey="Woolgar, Ja" uniqKey="Woolgar J">JA Woolgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Mamgani, A" uniqKey="Al Mamgani A">A Al-Mamgani</name>
</author>
<author><name sortKey="Van Rooij, P" uniqKey="Van Rooij P">P van Rooij</name>
</author>
<author><name sortKey="Verduijn, Gm" uniqKey="Verduijn G">GM Verduijn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenland, S" uniqKey="Greenland S">S Greenland</name>
</author>
<author><name sortKey="Rothman, Kj" uniqKey="Rothman K">KJ Rothman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziegler, A" uniqKey="Ziegler A">A Ziegler</name>
</author>
<author><name sortKey="Lange, S" uniqKey="Lange S">S Lange</name>
</author>
<author><name sortKey="Bender, R" uniqKey="Bender R">R Bender</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nabil, S" uniqKey="Nabil S">S Nabil</name>
</author>
<author><name sortKey="Samman, N" uniqKey="Samman N">N Samman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morrish, Rb" uniqKey="Morrish R">RB Morrish</name>
</author>
<author><name sortKey="Chan, E" uniqKey="Chan E">E Chan</name>
</author>
<author><name sortKey="Silverman, S" uniqKey="Silverman S">S Silverman</name>
</author>
<author><name sortKey="Meyer, J" uniqKey="Meyer J">J Meyer</name>
</author>
<author><name sortKey="Fu, Kk" uniqKey="Fu K">KK Fu</name>
</author>
<author><name sortKey="Greenspan, D" uniqKey="Greenspan D">D Greenspan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Ij" uniqKey="Lee I">IJ Lee</name>
</author>
<author><name sortKey="Koom, Ws" uniqKey="Koom W">WS Koom</name>
</author>
<author><name sortKey="Lee, Cg" uniqKey="Lee C">CG Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parliament, M" uniqKey="Parliament M">M Parliament</name>
</author>
<author><name sortKey="Alidrisi, M" uniqKey="Alidrisi M">M Alidrisi</name>
</author>
<author><name sortKey="Munroe, M" uniqKey="Munroe M">M Munroe</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Radiat Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Radiat Oncol</journal-id>
<journal-title-group><journal-title>Radiation Oncology (London, England)</journal-title>
</journal-title-group>
<issn pub-type="epub">1748-717X</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27473433</article-id>
<article-id pub-id-type="pmc">4967325</article-id>
<article-id pub-id-type="publisher-id">679</article-id>
<article-id pub-id-type="doi">10.1186/s13014-016-0679-6</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kuhnt</surname>
<given-names>Thomas</given-names>
</name>
<address><email>thomas.kuhnt@medizin.uni-leipzig.de</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stang</surname>
<given-names>Andreas</given-names>
</name>
<address><email>andreas.stang@uk-essen.de</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wienke</surname>
<given-names>Andreas</given-names>
</name>
<address><email>andreas.wienke@medizin.uni-halle.de</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vordermark</surname>
<given-names>Dirk</given-names>
</name>
<address><email>dirk.vordermark@medizin.uni-halle.de</email>
</address>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schweyen</surname>
<given-names>Ramona</given-names>
</name>
<address><email>ramona.schweyen@medizin.uni-halle.de</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hey</surname>
<given-names>Jeremias</given-names>
</name>
<address><email>jeremias.hey@medizin.uni-halle.de</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Diagnostic Imaging and Radiation Medicine, University Clinic, University Leipzig, Leipzig, Germany</aff>
<aff id="Aff2"><label>2</label>
Department of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany</aff>
<aff id="Aff3"><label>3</label>
Department of Medical Epidemiology, Biometry and Computer Science Martin-Luther-University Halle-Wittenberg, Halle, Germany</aff>
<aff id="Aff4"><label>4</label>
Department of Radiotherapy, University Clinic, Martin-Luther-University Halle-Wittenberg, Halle, Germany</aff>
<aff id="Aff5"><label>5</label>
Department of Prosthetic Dentistry, University School of Dental Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany</aff>
</contrib-group>
<pub-date pub-type="epub"><day>30</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>30</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>11</volume>
<elocation-id>101</elocation-id>
<history><date date-type="received"><day>7</day>
<month>2</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>23</day>
<month>7</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Introduction</title>
<p>To identify potential risk factors for the development of jaw osteoradionecrosis (ORN) after 3D-conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) among patients with newly diagnosed head and neck cancer.</p>
</sec>
<sec><title>Material and methods</title>
<p>This study included 776 patients who underwent 3D-CRT or IMRT for head and neck cancer at the Department of Radiotherapy at the University Hospital Halle-Wittenberg between 2003 and 2013. Sex, dental status prior to radiotherapy, tumor site, bone surgery during tumor resection, concomitant chemotherapy, and the development of advanced ORN were documented for each patient. ORN was classified as grade 3, 4, or 5 according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer classification or grade 3 or 4 according to the late effects in normal tissues/subjective, objective, management, and analytic scale. The cumulative incidence of ORN was estimated. Cox regression analysis was used to identify prognostic risk factors for the development of ORN.</p>
</sec>
<sec><title>Results</title>
<p>Fifty-one patients developed advanced ORN (relative frequency 6.6 %, cumulative incidence 12.4 %). The highest risk was found in patients who had undergone primary bone surgery during tumor resection (hazard ratio [HR] = 5.87; 95 % confidence interval [CI]: 3.09–11.19) and in patients with tumors located in the oral cavity (HR = 4.69; 95 % CI: 1.33–16.52). Sex, dentition (dentulous vs. edentulous), and chemotherapy had no clinically relevant influence.</p>
</sec>
<sec><title>Discussion and conclusion</title>
<p>In contrast to most previous studies, we noted a low cumulative incidence of advanced ORN. Patients with tumors located in the oral cavity and those who undergo bone surgery during tumor resection prior to RT may be considered a high-risk group for the development of ORN.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Osteoradionecrosis</kwd>
<kwd>Radiotherapy</kwd>
<kwd>Head and neck cancer</kwd>
<kwd>Dental status</kwd>
<kwd>Bone surgery</kwd>
<kwd>Tumor site</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D61 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000D61 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4967325 |texte= Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:27473433" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
This area was generated with Dilib version V0.6.32. |